1.
Bioorg Med Chem Lett
; 14(22): 5503-7, 2004 Nov 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15482913
RESUMEN
Compounds that contain an alpha,beta-unsaturated carbonyl moiety are often flagged as potential Michael acceptors. All alpha,beta-unsaturated carbonyl moieties are not equivalent, however, and we sought to better understand this system and its potential implications in drug-like molecules. Measurement of the (13)C NMR shift of the beta-carbon and correlation to in vitro results allowed compounds in our collection to be categorized as potential Michael acceptors, potential substrates for NADPH, or as photoisomerizable.