RESUMEN
A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0.1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.
Asunto(s)
Anemia de Células Falciformes/diagnóstico , Hemoglobinometría , Humanos , Métodos , Solubilidad , Talasemia/diagnósticoAsunto(s)
Colinesterasas/sangre , Trastornos Nutricionales/enzimología , Pruebas Enzimáticas Clínicas , Humanos , Kwashiorkor/enzimología , Hígado/enzimología , Hígado/metabolismo , Trastornos Nutricionales/sangre , Trastornos Nutricionales/diagnóstico , Pronóstico , Inanición/sangre , Inanición/enzimologíaAsunto(s)
Anemia de Células Falciformes/epidemiología , Factores de Edad , Niño , Preescolar , Heterocigoto , Humanos , Lactante , Recién Nacido , Estadística como Asunto , ZambiaRESUMEN
A survey for abnormal haemoglobins in Zambia has demonstrated Haemoglobin S-including 187 cases of sickle-cell anaemia, Haemoglobin J Oxford on one occasion, and a new Haemoglobin Zambia in four unrelated families. No evidence for beta-thalassaemia was found, but Haemoglobin H disease and other evidence for alpha-thalassaemia were found.