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1.
Neuromodulation ; 24(2): 259-264, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32744789

RESUMEN

OBJECTIVE: Deep brain stimulation (DBS) for pain has largely been implemented in an uncontrolled manner to target the somatosensory component of pain, with research leading to mixed results. We have previously shown that patients with poststroke pain syndrome who were treated with DBS targeting the ventral striatum/anterior limb of the internal capsule (VS/ALIC) demonstrated a significant improvement in measures related to the affective sphere of pain. In this study, we sought to determine how DBS targeting the VS/ALIC modifies brain activation in response to pain. MATERIALS AND METHODS: Five patients with poststroke pain syndrome who were blinded to DBS status (ON/OFF) and six age- and sex-matched healthy controls underwent functional magnetic resonance imaging (fMRI) measuring blood oxygen level-dependent activation in a block design. In this design, each participant received heat stimuli to the affected or unaffected wrist area. Statistical comparisons were performed using fMRI z-maps. RESULTS: In response to pain, patients in the DBS OFF state showed significant activation (p < 0.001) in the same regions as healthy controls (thalamus, insula, and operculum) and in additional regions (orbitofrontal and superior convexity cortical areas). DBS significantly reduced activation of these additional regions and introduced foci of significant inhibitory activation (p < 0.001) in the hippocampi when painful stimulation was applied to the affected side. CONCLUSIONS: These findings suggest that DBS of the VS/ALIC modulates affective neural networks.


Asunto(s)
Estimulación Encefálica Profunda , Estriado Ventral , Humanos , Cápsula Interna/diagnóstico por imagen , Imagen por Resonancia Magnética , Dolor
2.
J Int Neuropsychol Soc ; 22(2): 105-19, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26888611

RESUMEN

OBJECTIVES: Connectionist theories of brain function took hold with the seminal contributions of Norman Geschwind a half century ago. Modern neuroimaging techniques have expanded the scientific interest in the study of brain connectivity to include the intact as well as disordered brain. METHODS: In this review, we describe the most common techniques used to measure functional and structural connectivity, including resting state functional MRI, diffusion MRI, and electroencephalography and magnetoencephalography coherence. We also review the most common analytical approaches used for examining brain interconnectivity associated with these various imaging methods. RESULTS: This review presents a critical analysis of the assumptions, as well as methodological limitations, of each imaging and analysis approach. CONCLUSIONS: The overall goal of this review is to provide the reader with an introduction to evaluating the scientific methods underlying investigations that probe the human connectome.


Asunto(s)
Encéfalo , Conectoma/métodos , Electrofisiología , Neuroimagen , Encéfalo/anatomía & histología , Encéfalo/diagnóstico por imagen , Encéfalo/fisiología , Conectoma/instrumentación , Electrofisiología/instrumentación , Electrofisiología/métodos , Humanos
3.
Mult Scler ; 21(14): 1794-801, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26106010

RESUMEN

BACKGROUND: Imaging can provide noninvasive neural markers of disease progression in multiple sclerosis (MS) that are related to behavioral and cognitive symptoms. Past work suggests that diffusion tensor imaging (DTI) provides a measure of white matter pathology, including demyelination and axonal counts. OBJECTIVES: In the current study, the authors investigate the relationship of DTI measures in the cingulum bundle to common deficits in MS, including episodic memory, working memory, and information processing speed. METHODS: Fifty-seven patients with MS and 17 age- and education-matched controls underwent high-spatial resolution diffusion scans and cognitive testing. Probabilistic tracking was used to generate tracks from the posterior cingulate cortex to the entorhinal cortex. RESULTS: Radial and axial diffusivity values were significantly different between patients and controls (p < 0.031), and in patients bilateral diffusion measures were significantly related to measures of episodic memory and speed of processing (p < 0.033). CONCLUSIONS: The tractography-based measures of posterior cingulum integrity reported here support further development of DTI as a viable measure of axonal integrity and cognitive function in patients with MS.


Asunto(s)
Trastornos del Conocimiento/fisiopatología , Imagen de Difusión Tensora/métodos , Esclerosis Múltiple/patología , Sustancia Blanca/patología , Adulto , Trastornos del Conocimiento/etiología , Progresión de la Enfermedad , Femenino , Giro del Cíngulo/patología , Humanos , Masculino , Memoria Episódica , Memoria a Corto Plazo/fisiología , Persona de Mediana Edad , Esclerosis Múltiple/complicaciones , Vías Nerviosas/patología , Desempeño Psicomotor/fisiología
4.
BMC Neurol ; 15: 63, 2015 Apr 24.
Artículo en Inglés | MEDLINE | ID: mdl-25902768

RESUMEN

BACKGROUND: Motor and non-motor impairments affect quality of life in individuals with Parkinson's disease. Our preliminary research indicates that forced exercise cycling, a mode of exercise in which a participant's voluntary rate of exercise is augmented on a stationary cycle, results in global improvements in the cardinal symptoms of Parkinson's disease. The objective of the Cyclical Lower Extremity Exercise (CYCLE) trial for Parkinson's disease is to determine the effects of forced exercise cycling on motor and non-motor performance when compared to voluntary rate cycling and a non-exercise control group. Additionally, we plan to identify any associated changes in neural activity determined by functional magnetic resonance imaging. METHODS/DESIGN: A total of 100 individuals with mild to moderate idiopathic Parkinson's disease will participate in a single-center, parallel-group, rater-blind study. Participants will be randomized 2:2:1 into a forced exercise, voluntary exercise, or no-exercise control group, respectively. Both exercise groups will cycle 3 times per week for 8 weeks at identical aerobic intensities for 40 minutes, but participants in the forced exercise group will cycle 30% faster than their voluntary rate by means of an augmented motorized bicycle. Neuroimaging, clinical, and biomechanical assessments of motor and non-motor performance will be made at baseline both 'on' and 'off' medication, after four weeks of exercise (midpoint), end of treatment, 4 weeks after end of treatment, and 8 weeks after end of treatment. DISCUSSION: CYCLE trial will play a critical role in determining the effectiveness of two different types of aerobic exercise, forced and voluntary, on motor and non-motor performance in individuals with Parkinson's disease. Additionally, the coupling of clinical, biomechanical, and neuroimaging outcomes has the potential to provide insight into mechanisms underlying change in function as a result of exercise. TRIAL REGISTRATION: Clinicaltrials.gov registration number NCT01636297.


Asunto(s)
Terapia por Ejercicio/métodos , Enfermedad de Parkinson/terapia , Acelerometría , Adulto , Anciano , Fenómenos Biomecánicos , Ejercicio Físico , Humanos , Extremidad Inferior/fisiopatología , Imagen por Resonancia Magnética , Persona de Mediana Edad , Monitoreo Ambulatorio , Destreza Motora , Calidad de Vida , Proyectos de Investigación
5.
Neuroimage ; 101: 21-34, 2014 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-24969568

RESUMEN

Head motion in functional MRI and resting-state MRI is a major problem. Existing methods do not robustly reflect the true level of motion artifact for in vivo fMRI data. The primary issue is that current methods assume that motion is synchronized to the volume acquisition and thus ignore intra-volume motion. This manuscript covers three sections in the use of gold-standard motion-corrupted data to pursue an intra-volume motion correction. First, we present a way to get motion corrupted data with accurately known motion at the slice acquisition level. This technique simulates important data acquisition-related motion artifacts while acquiring real BOLD MRI data. It is based on a novel motion-injection pulse sequence that introduces known motion independently for every slice: Simulated Prospective Acquisition CorrEction (SimPACE). Secondly, with data acquired using SimPACE, we evaluate several motion correction and characterization techniques, including several commonly used BOLD signal- and motion parameter-based metrics. Finally, we introduce and evaluate a novel, slice-based motion correction technique. Our novel method, SLice-Oriented MOtion COrrection (SLOMOCO) performs better than the volumetric methods and, moreover, accurately detects the motion of independent slices, in this case equivalent to the known injected motion. We demonstrate that SLOMOCO can model and correct for nearly all effects of motion in BOLD data. Also, none of the commonly used motion metrics was observed to robustly identify motion corrupted events, especially in the most realistic scenario of sudden head movement. For some popular metrics, performance was poor even when using the ideal known slice motion instead of volumetric parameters. This has negative implications for methods relying on these metrics, such as recently proposed motion correction methods such as data censoring and global signal regression.


Asunto(s)
Encéfalo/fisiología , Interpretación Estadística de Datos , Imagen por Resonancia Magnética/métodos , Imagen por Resonancia Magnética/normas , Movimiento (Física) , Adulto , Cadáver , Femenino , Voluntarios Sanos , Humanos , Masculino
6.
Magn Reson Med ; 70(6): 1653-61, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23878098

RESUMEN

PURPOSE: The multiband (MB) excitation and reconstruction technique was both developed and evaluated for accelerated data acquisition of arterial spin labeling (ASL) to cover whole brain perfusion maps. THEORY AND METHODS: MB excitation was incorporated into a pulsed ASL (PASL) technique and compared with conventional single-band excitation PASL from healthy subjects, using a 32-channel head receiver coil at 3 T. The MB de-aliasing performance and effectiveness in perfusion measurement were measured with varying MB acceleration factors and gaps between MB excitations. RESULTS: The MB PASL perfusion maps were in good agreement with the conventional single-band PASL maps at matched slices. The imaging coverage could be effectively extended with the MB technique by a factor up to 5. A gap as small as 3 cm between MB excitations resulted in a comparable ASL signal loss and temporal-signal-to-noise ratio with single-band PASL. CONCLUSION: The MB ASL technique is an effective method to evaluate whole brain perfusion because it minimizes the temporal spread of labeled spins across slices, resulting in more accurate perfusion measurements.


Asunto(s)
Algoritmos , Arterias Cerebrales/anatomía & histología , Arterias Cerebrales/fisiología , Circulación Cerebrovascular/fisiología , Interpretación de Imagen Asistida por Computador/métodos , Angiografía por Resonancia Magnética/métodos , Adulto , Velocidad del Flujo Sanguíneo/fisiología , Femenino , Humanos , Aumento de la Imagen/métodos , Persona de Mediana Edad , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Marcadores de Spin
7.
MAGMA ; 26(5): 443-50, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23354513

RESUMEN

OBJECT: Dual-echo fast spin-echo (FSE) sequences are used in T2 relaxometry studies of neurological disorders because of shorter clinical scanning times and protocol simplicity. However, FSE sequences have possible spatial frequency-dependent effects, and derived T2 values may include errors that depend on the spatial frequency characteristics of the brain region of interest. MATERIALS AND METHODS: Dual-echo FSE and multi-echo spin-echo (MESE) sequences were acquired in nine subjects. The T2 decay curves for FSE and MESE sequences were estimated and percent error maps were generated. T2 error values were obtained along each patient's corticospinal tract (CST). Whole-brain white matter (WM) and gray matter (GM) T2 error values were also obtained. The paired t test was performed to evaluate differences in T2 values in the CST between FSE and MESE sequences. RESULTS: Histograms of error values in CST and in whole-brain WM and GM structures revealed systematic errors in FSE sequences. Significant differences (P < 0.001) in CST T2 values were also observed between FSE and MESE sequences. CONCLUSION: Our findings indicate that T2 values derived from FSE sequences are prone to large errors, even in low spatial frequency regions such as the CST, when compared to MESE sequences. Future studies should be aware of this limitation of FSE sequences.


Asunto(s)
Encéfalo/patología , Imagen Eco-Planar/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Anciano , Anciano de 80 o más Años , Esclerosis Amiotrófica Lateral/patología , Imagen de Difusión Tensora/métodos , Progresión de la Enfermedad , Análisis de Fourier , Humanos , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Tractos Piramidales/patología , Reproducibilidad de los Resultados , Factores de Tiempo
8.
Brain Connect ; 13(8): 453-463, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-36772802

RESUMEN

Background: Transcranial direct current stimulation (tDCS) targeting the primary motor cortex is modestly effective for promoting upper-limb motor function following stroke. The premotor cortex (PMC) represents an alternative target based on its higher likelihood of survival and dense motor-network connections. Objective: The objective of this study was to determine whether ipsilesional PMC tDCS affects motor network functional connectivity (FC) in association with reduction in motor impairment, and to determine whether this relationship is influenced by baseline motor severity. Methods: Participants with chronic stroke were randomly assigned to receive active-PMC or sham-tDCS with rehabilitation for 5 weeks. Resting-state functional magnetic resonance imaging was acquired to characterize change in FC across motor-cortical regions. Results: Our results indicated that moderate-to-severe participants who received active-tDCS had greater increases in PMC-to-PMC interhemispheric FC compared to those who received sham; this increase was correlated with reduction in proximal motor impairment. There was also an increase in intrahemispheric dorsal premotor cortex-primary motor cortex FC across participants regardless of severity or tDCS group assignment; this increase was correlated with a reduction in proximal motor impairment in only the mild participants. Conclusions: Our findings have significance for developing targeted brain stimulation approaches. While participants with milder impairments may inherently recruit viable substrates within the ipsilesional hemisphere, stimulation of PMC may enhance interhemispheric FC in association with recovery in more impaired participants. Trial Registration: ClinicalTrials.gov Identifier: NCT01539096; Registration date: February 21, 2012.


Asunto(s)
Corteza Motora , Accidente Cerebrovascular , Estimulación Transcraneal de Corriente Directa , Humanos , Estimulación Transcraneal de Corriente Directa/métodos , Encéfalo , Imagen por Resonancia Magnética , Accidente Cerebrovascular/diagnóstico por imagen , Accidente Cerebrovascular/terapia , Accidente Cerebrovascular/complicaciones , Extremidad Superior , Estimulación Magnética Transcraneal/métodos
9.
J ECT ; 28(4): 234-41, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-22820953

RESUMEN

OBJECTIVE: Past neuroimaging work has suggested that increased activation to cognitive and emotional tasks and decreased connectivity in frontal regions are related to cognitive inefficiency in depression; normalization of these relationships has been associated with successful treatment. The present study investigated brain function before and after electroconvulsive therapy (ECT) in patients with major depressive disorder (MDD) and demonstrated the effect of treatment on cortical activation patterns. METHODS: Six ECT-naive patients with depression (mean ± SD age, 39.0 ± 5.4 years) were treated with ECT. Within 1 week before and 1 to 3 weeks after ECT, the patients underwent a magnetic resonance imaging session with functional magnetic resonance image scanning during working memory and affective tasks and during rest. Changes in voxelwise statistical maps of brain response to each task in regions identified to be relevant from past studies of depression were compared with changes in depression severity as measured by the Hamilton Depression Rating Score. Changes in functional connectivity between brain regions were also compared with changes in depression severity. RESULTS: Activation during both tasks was generally found to be decreased after ECT. Remission of depression was significantly associated with reduced affective deactivation after ECT in the orbitofrontal cortex (P = 0.03). Whole-brain functional connectivity of the anterior cingulate cortex showed a consistent increase in connectivity to the right dorsolateral prefrontal cortex and posterior cingulate cortex after ECT. CONCLUSIONS: These results suggest that successful ECT for MDD is associated with decreased activation to cognitive and emotional tasks and an increase in resting connectivity.


Asunto(s)
Encéfalo/fisiopatología , Depresión/fisiopatología , Depresión/terapia , Terapia Electroconvulsiva , Adulto , Mapeo Encefálico , Trastorno Depresivo Mayor/fisiopatología , Trastorno Depresivo Mayor/psicología , Emociones/fisiología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Vías Nerviosas/fisiología , Pruebas Neuropsicológicas , Corteza Prefrontal/fisiología , Corteza Prefrontal/fisiopatología , Escalas de Valoración Psiquiátrica
10.
PLoS One ; 16(6): e0251338, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34101741

RESUMEN

Cognitive impairment is a common symptom in individuals with Multiple Sclerosis (MS), but meaningful, reliable biomarkers relating to cognitive decline have been elusive, making evaluation of the impact of therapeutics on cognitive function difficult. Here, we combine pathway-based MRI measures of structural and functional connectivity to construct a metric of functional decline in MS. The Structural and Functional Connectivity Index (SFCI) is proposed as a simple, z-scored metric of structural and functional connectivity, where changes in the metric have a simple statistical interpretation and may be suitable for use in clinical trials. Using data collected at six time points from a 2-year longitudinal study of 20 participants with MS and 9 age- and sex-matched healthy controls, we probe two common symptomatic domains, motor and cognitive function, by measuring structural and functional connectivity in the transcallosal motor pathway and posterior cingulum bundle. The SFCI is significantly lower in participants with MS compared to controls (p = 0.009) and shows a significant decrease over time in MS (p = 0.012). The change in SFCI over two years performed favorably compared to measures of brain parenchymal fraction and lesion volume, relating to follow-up measures of processing speed (r = 0.60, p = 0.005), verbal fluency (r = 0.57, p = 0.009), and score on the Multiple Sclerosis Functional Composite (r = 0.67, p = 0.003). These initial results show that the SFCI is a suitable metric for longitudinal evaluation of functional decline in MS.


Asunto(s)
Encéfalo/diagnóstico por imagen , Disfunción Cognitiva/diagnóstico por imagen , Esclerosis Múltiple/diagnóstico por imagen , Red Nerviosa/diagnóstico por imagen , Neuroimagen/métodos , Sustancia Blanca/diagnóstico por imagen , Adulto , Encéfalo/patología , Disfunción Cognitiva/patología , Conectoma , Progresión de la Enfermedad , Femenino , Giro del Cíngulo/diagnóstico por imagen , Giro del Cíngulo/patología , Humanos , Estudios Longitudinales , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/complicaciones , Esclerosis Múltiple/patología , Red Nerviosa/patología , Pruebas Neuropsicológicas , Sustancia Blanca/patología
11.
Hum Brain Mapp ; 29(7): 818-27, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18438889

RESUMEN

Recent studies indicate that functional connectivity using low-frequency BOLD fluctuations (LFBFs) is reduced between the bilateral primary sensorimotor regions in multiple sclerosis. In addition, it has been shown that pathway-dependent measures of the transverse diffusivity of water in white matter correlate with related clinical measures of functional deficit in multiple sclerosis. Taken together, these methods suggest that MRI methods can be used to probe both functional connectivity and anatomic connectivity in subjects with known white matter impairment. We report the results of a study comparing anatomic connectivity of the transcallosal motor pathway, as measured with diffusion tensor imaging (DTI) and functional connectivity of the bilateral primary sensorimotor cortices (SMC), as measured with LFBFs in the resting state. High angular resolution diffusion imaging was combined with functional MRI to define the transcallosal white matter pathway connecting the bilateral primary SMC. Maps were generated from the probabilistic tracking employed and these maps were used to calculate the mean pathway diffusion measures fractional anisotropy FA, mean diffusivity MD, longitudinal diffusivity lambda(1), and transverse diffusivity lambda(2). These were compared with LFBF-based functional connectivity measures (F(c)) obtained at rest in a cohort of 11 multiple sclerosis patients and approximately 10 age- and gender-matched control subjects. The correlation between FA and F(c) for MS patients was r = -0.63, P < 0.04. The correlation between all subjects lambda(2) and F(c) was r = 0.42, P < 0.05. The correlation between all subjects lambda(2) and F(c) was r = -0.50, P < 0.02. None of the control subject correlations were significant, nor were FA, lambda(1), or MD significantly correlated with F(c) for MS patients. This constitutes the first in vivo observation of a correlation between measures of anatomic connectivity and functional connectivity using spontaneous LFBFs.


Asunto(s)
Mapeo Encefálico , Vías Eferentes/fisiopatología , Imagen por Resonancia Magnética , Corteza Motora/fisiopatología , Esclerosis Múltiple/fisiopatología , Cuerpo Calloso/fisiopatología , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Persona de Mediana Edad
12.
Brain Connect ; 7(3): 182-196, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-28142257

RESUMEN

The pain matrix is comprised of an extensive network of brain structures involved in sensory and/or affective information processing. The thalamus is a key structure constituting the pain matrix. The thalamus serves as a relay center receiving information from multiple ascending pathways and relating information to and from multiple cortical areas. However, it is unknown how thalamocortical networks specific to sensory-affective information processing are functionally integrated. Here, in a proof-of-concept study in healthy humans, we aimed to understand this connectivity using transcranial direct current stimulation (tDCS) targeting primary motor (M1) or dorsolateral prefrontal cortices (DLPFC). We compared changes in functional connectivity (FC) with DLPFC tDCS to changes in FC with M1 tDCS. FC changes were also compared to further investigate its relation with individual's baseline experience of pain. We hypothesized that resting-state FC would change based on tDCS location and would represent known thalamocortical networks. Ten right-handed individuals received a single application of anodal tDCS (1 mA, 20 min) to right M1 and DLPFC in a single-blind, sham-controlled crossover study. FC changes were studied between ventroposterolateral (VPL), the sensory nucleus of thalamus, and cortical areas involved in sensory information processing and between medial dorsal (MD), the affective nucleus, and cortical areas involved in affective information processing. Individual's perception of pain at baseline was assessed using cutaneous heat pain stimuli. We found that anodal M1 tDCS and anodal DLPFC tDCS both increased FC between VPL and sensorimotor cortices, although FC effects were greater with M1 tDCS. Similarly, anodal M1 tDCS and anodal DLPFC tDCS both increased FC between MD and motor cortices, but only DLPFC tDCS modulated FC between MD and affective cortices, like DLPFC. Our findings suggest that M1 stimulation primarily modulates FC of sensory networks, whereas DLPFC stimulation modulates FC of both sensory and affective networks. Our findings when replicated in a larger group of individuals could provide useful evidence that may inform future studies on pain to differentiate between effects of M1 and DLPFC stimulation. Notably, our finding that individuals with high baseline pain thresholds experience greater FC changes with DLPFC tDCS implies the role of DLPFC in pain modulation, particularly pain tolerance.


Asunto(s)
Corteza Motora/fisiología , Vías Nerviosas/fisiología , Percepción del Dolor/fisiología , Corteza Prefrontal/fisiología , Estimulación Transcraneal de Corriente Directa , Adulto , Estudios Cruzados , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Método Simple Ciego
13.
Brain Connect ; 6(3): 255-65, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26824737

RESUMEN

Bipolar disorder (BP) is characterized by periods of depression (BPD) and (hypo)mania (BPM), but the underlying state-related brain circuit abnormalities are not fully understood. Striatal functional activation and connectivity abnormalities have been noted in BP, but consistent findings have not been reported. To further elucidate striatal abnormalities in different BP states, this study investigated differences in resting-state functional connectivity of six striatal subregions in BPD, BPM, and healthy control (HC) subjects. Ninety medication-free subjects (30 BPD, 30 BPM, and 30 HC), closely matched for age and gender, were scanned using 3T functional magnetic resonance imaging (fMRI) acquired at resting state. Correlations of low-frequency blood oxygen level dependent signal fluctuations for six previously described striatal subregions were used to obtain connectivity maps of each subregion. Using a factorial design, main effects for differences between groups were obtained and post hoc pairwise group comparisons performed. BPD showed increased connectivity of the dorsal caudal putamen with somatosensory areas such as the insula and temporal gyrus. BPM group showed unique increased connectivity between left dorsal caudate and midbrain regions, as well as increased connectivity between ventral striatum inferior and thalamus. In addition, both BPD and BPM exhibited widespread functional connectivity abnormalities between striatal subregions and frontal cortices, limbic regions, and midbrain structures. In summary, BPD exhibited connectivity abnormalities of associative and somatosensory subregions of the putamen, while BPM exhibited connectivity abnormalities of associative and limbic caudate. Most other striatal subregion connectivity abnormalities were common to both groups and may be trait related.


Asunto(s)
Trastorno Bipolar/fisiopatología , Cuerpo Estriado/fisiopatología , Adulto , Mapeo Encefálico/métodos , Estudios de Casos y Controles , Corteza Cerebral/fisiopatología , Conectoma , Femenino , Lóbulo Frontal/fisiopatología , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Potenciales de la Membrana , Vías Nerviosas/fisiopatología , Putamen/fisiopatología , Tálamo/fisiopatología
14.
Neuropsychopharmacology ; 41(13): 3016-3024, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-27356764

RESUMEN

Research on resting functional brain networks in bipolar disorder (BP) has been unable to differentiate between disturbances related to mania or depression, which is necessary to understand the mechanisms leading to each state. Past research has also been unable to elucidate the impact of BP-related network disturbances on the organizational properties of the brain (eg, communication efficiency). Thus, the present work sought to isolate network disturbances related to BP, fractionate these into components associated with manic and depressive symptoms, and characterize the impact of disturbances on network function. Graph theory was used to analyze resting functional magnetic resonance imaging data from 60 medication-free patients meeting the criteria for BP and either a current hypomanic (n=30) or depressed (n=30) episode and 30 closely age/sex-matched healthy controls. Correction for multiple comparisons was carried out. Compared with controls, BP patients evidenced hyperconnectivity in a network involving right amygdala. Fractionation revealed that (hypo)manic symptoms were associated with hyperconnectivity in an overlapping network and disruptions in the brain's 'small-world' network organization. Depressive symptoms predicted hyperconnectivity in a network involving orbitofrontal cortex along with a less resilient global network organization. Findings provide deeper insight into the differential pathophysiological processes associated with hypomania and depression, along with the particular impact these differential processes have on network function.


Asunto(s)
Trastorno Bipolar/complicaciones , Encéfalo/patología , Depresión/complicaciones , Modelos Neurológicos , Descanso , Adolescente , Adulto , Trastorno Bipolar/diagnóstico por imagen , Encéfalo/diagnóstico por imagen , Depresión/diagnóstico por imagen , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Vías Nerviosas/patología , Oxígeno/sangre , Escalas de Valoración Psiquiátrica , Adulto Joven
15.
Brain Connect ; 6(1): 25-36, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26414696

RESUMEN

Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activation-based seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.


Asunto(s)
Mapeo Encefálico , Terapia por Ejercicio , Corteza Motora/fisiopatología , Red Nerviosa/fisiopatología , Enfermedad de Parkinson/terapia , Adulto , Anciano , Terapia por Ejercicio/métodos , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Red Nerviosa/fisiología , Vías Nerviosas/fisiopatología , Enfermedad de Parkinson/fisiopatología , Tálamo/fisiopatología
16.
Parkinsonism Relat Disord ; 24: 56-62, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26857399

RESUMEN

INTRODUCTION: Studies in animal models of Parkinson's disease (PD) have suggested that the rate of exercise performance is important in treatment efficacy and neuroprotection. In humans with PD, lower-extremity forced-exercise (FE) produced global improvements in motor symptoms based on clinical ratings and biomechanical measures of upper extremity function. METHODS: fMRI was used to compare the underlying changes in brain activity in PD patients following the administration of anti-parkinsonian medication and following a session of FE. RESULTS: Nine individuals with PD completed fMRI scans under each condition: off anti-PD medication, on anti-PD medication, and off medication + FE. Unified Parkinson's Disease Rating Motor Scale scores improved by 50% in the FE condition compared to the off-medication condition. The pattern of fMRI activation after FE was similar to that seen with anti-PD medication. Direct comparison of the fMRI activation patterns showed high correlation between FE and anti-PD medication. CONCLUSION: These findings suggest that medication and FE likely utilize the same pathways to produce symptomatic relief in individuals with PD.


Asunto(s)
Corteza Cerebral/diagnóstico por imagen , Terapia por Ejercicio , Actividad Motora/fisiología , Enfermedad de Parkinson/rehabilitación , Adulto , Anciano , Análisis de Varianza , Antiparkinsonianos/uso terapéutico , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Oxígeno/sangre , Enfermedad de Parkinson/diagnóstico por imagen , Enfermedad de Parkinson/terapia , Estadística como Asunto
17.
PLoS One ; 10(2): e0116320, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25707006

RESUMEN

In echo-planar imaging (EPI), such as commonly used for functional MRI (fMRI) and diffusion-tensor imaging (DTI), compressed distortion is a more difficult challenge than local stretching as spatial information can be lost in strongly compressed areas. In addition, the effects are more severe at ultra-high field (UHF) such as 7T due to increased field inhomogeneity. To resolve this problem, two EPIs with opposite phase-encoding (PE) polarity were acquired and combined after distortion correction. For distortion correction, a point spread function (PSF) mapping method was chosen due to its high correction accuracy and extended to perform distortion correction of both EPIs with opposite PE polarity thus reducing the PSF reference scan time. Because the amount of spatial information differs between the opposite PE datasets, the method was further extended to incorporate a weighted combination of the two distortion-corrected images to maximize the spatial information content of a final corrected image. The correction accuracy of the proposed method was evaluated in distortion-corrected data using both forward and reverse phase-encoded PSF reference data and compared with the reversed gradient approaches suggested previously. Further we demonstrate that the extended PSF method with an improved weighted combination can recover local distortions and spatial information loss and be applied successfully not only to spin-echo EPI, but also to gradient-echo EPIs acquired with both PE directions to perform geometrically accurate image reconstruction.


Asunto(s)
Imagen Eco-Planar , Encéfalo/anatomía & histología , Humanos
18.
Neuroimage Clin ; 8: 543-53, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26110112

RESUMEN

Mild to moderate traumatic brain injury (TBI) due to blast exposure is frequently diagnosed in veterans returning from the wars in Iraq and Afghanistan. However, it is unclear whether neural damage resulting from blast TBI differs from that found in TBI due to blunt-force trauma (e.g., falls and motor vehicle crashes). Little is also known about the effects of blast TBI on neural networks, particularly over the long term. Because impairment in working memory has been linked to blunt-force TBI, the present functional magnetic resonance imaging (fMRI) study sought to investigate whether brain activation in response to a working memory task would discriminate blunt-force from blast TBI. Twenty-five veterans (mean age = 29.8 years, standard deviation = 6.01 years, 1 female) who incurred TBI due to blast an average of 4.2 years prior to enrollment and 25 civilians (mean age = 27.4 years, standard deviation = 6.68 years, 4 females) with TBI due to blunt-force trauma performed the Sternberg Item Recognition Task while undergoing fMRI. The task involved encoding 1, 3, or 5 items in working memory. A group of 25 veterans (mean age = 29.9 years, standard deviation = 5.53 years, 0 females) and a group of 25 civilians (mean age = 27.3 years, standard deviation = 5.81 years, 0 females) without history of TBI underwent identical imaging procedures and served as controls. Results indicated that the civilian TBI group and both control groups demonstrated a monotonic relationship between working memory set size and activation in the right caudate during encoding, whereas the blast TBI group did not (p < 0.05, corrected for multiple comparisons using False Discovery Rate). Blast TBI was also associated with worse performance on the Sternberg Item Recognition Task relative to the other groups, although no other group differences were found on neuropsychological measures of episodic memory, inhibition, and general processing speed. These results could not be attributed to caudate atrophy or the presence of PTSD symptoms. Our results point to a specific vulnerability of the caudate to blast injury. Changes in activation during the Sternberg Item Recognition Task, and potentially other tasks that recruit the caudate, may serve as biomarkers for blast TBI.


Asunto(s)
Traumatismos por Explosión/fisiopatología , Lesión Encefálica Crónica/fisiopatología , Núcleo Caudado/fisiopatología , Imagen por Resonancia Magnética/métodos , Trastornos de la Memoria/fisiopatología , Memoria a Corto Plazo/fisiología , Adulto , Campaña Afgana 2001- , Traumatismos por Explosión/complicaciones , Lesión Encefálica Crónica/complicaciones , Femenino , Humanos , Guerra de Irak 2003-2011 , Masculino , Trastornos de la Memoria/etiología , Veteranos , Adulto Joven
19.
Brain Connect ; 4(7): 558-65, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25117651

RESUMEN

This work presents a pathway-dependent anatomic and functional connectivity analysis in 19 patients with relapse-remitting multiple sclerosis (MS) and 16 age-, education-, and gender-matched controls. An MS population is used in this study as a model for anatomic connectivity, permitting us to observe relationships between anatomic and functional connectivity more easily. A combined resting-state functional magnetic resonance imaging (fMRI) and whole-brain, high angular resolution diffusion imaging analysis is performed in three independent, monosynaptic pathways. The pathways chosen were transcallosal pathway connecting the bilateral primary sensorimotor regions, right and left posterior portion of the Papez circuit, connecting the posterior cingulate cortex and hippocampus. The Papez circuit is known to be involved in memory function, one of the most frequently impacted cognitive domains in patients with MS. We show that anatomic connectivity, as measured with diffusion-weighted imaging, and functional connectivity, as measured with resting-state fMRI, are significantly reduced in patients as compared with controls for at least some of the pathways considered. In addition when all pathway measures are combined, anatomic and functional connectivity are significantly correlated in patients with MS as well as healthy controls. We suggest that anatomic and functional connectivity are related for monosynaptic pathways and that radial diffusivity, as a diffusion-tensor-based measure of white matter integrity, is a robust measure of anatomic connectivity in the general population.


Asunto(s)
Encéfalo/patología , Encéfalo/fisiopatología , Esclerosis Múltiple Recurrente-Remitente/patología , Esclerosis Múltiple Recurrente-Remitente/fisiopatología , Adulto , Mapeo Encefálico , Imagen de Difusión por Resonancia Magnética , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Vías Nerviosas/fisiopatología
20.
Front Neurol ; 5: 272, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25566178

RESUMEN

Measures of brain connectivity are currently subject to intense scientific and clinical interest. Multiple measures are available, each with advantages and disadvantages. Here, we study epilepsy patients with intracranial electrodes, and compare four different measures of connectivity. Perhaps the most direct measure derives from intracranial electrodes; however, this is invasive and spatial coverage is incomplete. These electrodes can be actively stimulated to trigger electrophysical responses to provide the first measure of connectivity. A second measure is the recent development of simultaneous BOLD fMRI and intracranial electrode stimulation. The resulting BOLD maps form a measure of effective connectivity. A third measure uses low frequency BOLD fluctuations measured by MRI, with functional connectivity defined as the temporal correlation coefficient between their BOLD waveforms. A fourth measure is structural, derived from diffusion MRI, with connectivity defined as an integrated diffusivity measure along a connecting pathway. This method addresses the difficult requirement to measure connectivity between any two points in the brain, reflecting the relatively arbitrary location of the surgical placement of intracranial electrodes. Using a group of eight epilepsy patients with intracranial electrodes, the connectivity from one method is compared to another method using all paired data points that are in common, yielding an overall correlation coefficient. This method is performed for all six paired-comparisons between the four methods. While these show statistically significant correlations, the magnitudes of the correlation are relatively modest (r (2) between 0.20 and 0.001). In summary, there are many pairs of points in the brain that correlate well using one measure yet correlate poorly using another measure. These experimental findings present a complicated picture regarding the measure or meaning of brain connectivity.

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