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1.
Hautarzt ; 52(10): 899-902, 2001 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-17690823

RESUMEN

A 43 year old woman suffered from an intermittent painful livedo racemosa at the back since her childhood. Her clinical course was complicated by ulcerations. In careful clinical investigations no signs of an underlying disease could be found, in particular a Sneddon syndrome could be excluded. By means of both conservative and surgical treatments, initial healing of the ulcerations was achieved but relapses occurred. Cyclic infusions of iloprost achieved long-term clearing of the ulcerations and disappearance of the pain. To the best of our knowledge the effectiveness of this treatment has not been described for this disease in the literature.


Asunto(s)
Iloprost/administración & dosificación , Enfermedades Cutáneas Vasculares/tratamiento farmacológico , Enfermedades Cutáneas Vasculares/patología , Úlcera Cutánea/tratamiento farmacológico , Úlcera Cutánea/patología , Adulto , Dorso , Femenino , Humanos , Infusiones Intravenosas , Inhibidores de Agregación Plaquetaria/administración & dosificación , Resultado del Tratamiento
2.
Br J Dermatol ; 142(4): 680-7, 2000 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-10792217

RESUMEN

We have characterized the cell-mediated and humoral immune response of patients with atopic dermatitis (AD) and healthy controls in response to two novel staphylococcal antigens (NP-tase, p70) and the superantigen staphylococcal enterotoxin B (SEB). The parameters studied were IgE, interleukin (IL)-4 and interferon (IFN)-gamma synthesis by peripheral blood mononuclear cells (PBMC) after stimulation with NP-tase, p70 and SEB in vitro. Both antigens, as well as SEB, induced IL-4 and IFN-gamma secretion in patients and controls. However, patients with AD showed a significantly diminished IFN-gamma production in response to NP-tase or SEB. Furthermore, we demonstrated a good correlation between antigen-stimulated IgE production and the IL-4/IFN-gamma ratio in vitro. A distinct subgroup of PBMC showed impaired IFN-gamma synthesis and enhanced IL-4 secretion after incubation with p70 or NP-tase. These data support evidence that a subgroup of patients with AD, synthesizing low levels of IFN-gamma after stimulation with staphylococcal antigens, may have impaired abilities to clear Staphylococcus aureus colonization. Persistent staphylococcal antigens could then be responsible for inflammatory and allergic skin reactions in patients with AD. We therefore conclude that, besides superantigens, staphylococcal antigens may also play a part in the pathogenesis of AD.


Asunto(s)
Proteínas Bacterianas/inmunología , Proteínas Portadoras/inmunología , Dermatitis Atópica/inmunología , Monoéster Fosfórico Hidrolasas/inmunología , Staphylococcus aureus/inmunología , Adulto , Estudios de Casos y Controles , Dermatitis Atópica/metabolismo , Femenino , Humanos , Inmunoglobulina E/biosíntesis , Interferón gamma/biosíntesis , Interleucina-4/biosíntesis , Péptidos y Proteínas de Señalización Intracelular , Activación de Linfocitos , Masculino
3.
Acta Derm Venereol ; 81(4): 294-7, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11720181

RESUMEN

Microvascular damage occurs in systemic sclerosis and is associated with increased serum levels of endothelial adhesion molecules and endothelium-associated cytokines, including vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, endothelin-1 and vascular endothelial growth factor (VEGF). Iloprost, a prostacyclin analogue, induces clinical benefit in patients suffering from scleroderma-related Raynaud's phenomenon. This study was performed to investigate the effect of iloprost infusions on endothelium activation. Serum samples from 12 patients with systemic sclerosis were examined using specific enzyme-linked immunoassays. The serum levels of sICAM-1, sVCAM-1 and soluble E-selectin were initially elevated and significantly reduced after iloprost infusions. The serum concentrations of VEGF and endothelin-1 revealed decreased levels after therapy too. These results indicate that the well-known clinical benefit of iloprost infusions on Raynaud's phenomenon is serologically detectable by a reduction of serum levels of endothelium-associated adhesion molecules, cytokines and growth factors reflecting an improvement in endothelial function.


Asunto(s)
Moléculas de Adhesión Celular/sangre , Citocinas/sangre , Factores de Crecimiento Endotelial/sangre , Endotelina-1/sangre , Iloprost/farmacología , Linfocinas/sangre , Inhibidores de Agregación Plaquetaria/farmacología , Enfermedad de Raynaud/tratamiento farmacológico , Esclerodermia Sistémica/tratamiento farmacológico , Adulto , Anciano , Selectina E/sangre , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , Iloprost/administración & dosificación , Infusiones Intravenosas , Molécula 1 de Adhesión Intercelular/sangre , Masculino , Persona de Mediana Edad , Inhibidores de Agregación Plaquetaria/administración & dosificación , Enfermedad de Raynaud/sangre , Enfermedad de Raynaud/etiología , Esclerodermia Sistémica/sangre , Esclerodermia Sistémica/complicaciones , Resultado del Tratamiento , Molécula 1 de Adhesión Celular Vascular/sangre , Factor A de Crecimiento Endotelial Vascular , Factores de Crecimiento Endotelial Vascular
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