First trimester serum apolipoproteins in the prediction of late-onset preeclampsia.

Late-onset preeclampsia occurring after 34 weeks of gestation is the most common form of preeclampsia, but little is known about either etiology or prevention. Current detection methods for preeclampsia in early pregnancy have not shown promising results in detecting late-onset preeclampsia. The aim of this study was to assess whether apolipoproteins in combination with maternal medical history and biophysical factors can be used as an early detection method for late-onset preeclampsia. This nested case-cohort study was based at Odense University Hospital, Denmark. Women attending their first trimester scan were invited to participate if they understood Danish or English, were above the age of 18, and had singleton pregnancies. Blood pressure, maternal medical history, uterine artery pulsatility indices, and blood samples were collected at inclusion. Outcome data were collected from participants' medical files postpartum, and cases were selected when preeclampsia diagnostics were present. Serum samples were analyzed by targeted mass spectrometry using a biomarker panel consisting of 12 apolipoproteins. Logistic regression analyses were performed and finally receiver operating curves were completed. The cohort consisted of 27 cases and 194 normotensive controls, randomized from 340 eligible participants. Significant differences were found between the two groups' baseline characteristics but none of the apolipoproteins showed significant difference (p < 0.05). The ROC-curve combining maternal characteristics, mean arterial pressure and two apolipoproteins showed the best sensitivity of 55.5% at a 10% false-positive rate and an area under the curve of 0.873. In conclusion, apolipoproteins did not improve the detection of late-onset preeclampsia in a combined screening model.

Cross-cultural adaption, translation and reliability tests of the Danish version of the Pregnancy Exercise Self-Efficacy Scale.

OBJECTIVE: Self-efficacy has been shown to influence initiating and maintaining physical activity. Pregnancy often leads to a decline in physical activity and exercise self-efficacy assessments could be a tool to help women stay active during pregnancy. The Pregnancy Exercise Self-Efficacy Scale (P-ESES) is an English questionnaire assessing the self-efficacy in pregnant women to perform physical activity. The aim of this study was to translate the P-ESES questionnaire into a valid and reliable Danish version, P-ESES-DK. STUDY DESIGN: The study included a qualitative design for the validation of the questionnaire and a prospective longitudinal observational study for the reliability testing. MAIN OUTCOME MEASURES: The questionnaire was translated into Danish in a four-stage process with translation, back-translation and synthesis. The pre-final version was tested by eight women and changes were made to complete the final version of P-ESES-DK. The reliability testing was performed using a test-retest analysis of P-ESES-DK with 75 Danish pregnant women. Reliability was assessed using Intraclass Correlation Coefficient (ICC), Cronbach's alpha and agreement was visualized using a Bland-Altman plot. RESULTS: The questionnaire was found to have a good content validity. The assessment of the test re-test reliability showed an ICC of 0.809 and a Cronbach's alpha of the test and re-test were 0.839 and 0.869, respectively. The Bland-Altman plot showed that 93.9% of the answers were within the 95% limits of agreement. CONCLUSIONS: The Danish version of P-ESES was found to be both reliable and valid. Thus, it can be used as a helpful tool to measure self-efficacy related to physical activity during pregnancy.