Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
1.
J Pediatr ; 237: 183-189.e6, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34144033

RESUMEN

OBJECTIVES: To describe the prevalence of cerebral palsy (CP) at age 2 years in infants born before 33 weeks of gestation and to analyze the fetal neuroprotective effect of the antenatal administration of magnesium sulfate (MgSO4) treatment on CP. STUDY DESIGN: Preterm infants born before 33 weeks of gestation and discharged from the Rouen University Hospital's Neonatal Intensive Care Unit between 2007 and 2015 were included. At age 2 years, pediatricians of the perinatal network of Eure and Seine-Maritime counties administered standardized questionnaires analyzing motor, cognitive, and behavioral items, derived from the Denver and Amiel-Tison scales. A routine protocol based on MgSO4 infusion was introduced in 2010. The primary outcome measure was the occurrence of CP according to the Surveillance of Cerebral Palsy in Europe network definition. RESULTS: A total of 1759 very preterm infants were included, among whom 138 (7.8%) died and 148 (9.1%) were lost to follow-up. Assuming that those lost to follow-up had no CP, at 2 years, 55 of 1621 infants (3.4%; 95% CI, 2.6%-4.4%) had CP. After statistical adjustment for birth term and antenatal corticosteroid use, a significant decrease in CP was observed after implementation of a protocol of MgSO4 administration in mothers before imminent preterm birth at <33 weeks of gestation (aOR, 0.53; 95% CI, 0.29-0.98; P = .04). CONCLUSIONS: The prevalence of CP at 2 years after very preterm birth was low. The implementation of a neuroprotective protocol with MgSO4 was associated with reduced CP occurrence; however, several relevant limitations must be considered for interpretation.


Asunto(s)
Parálisis Cerebral/epidemiología , Sulfato de Magnesio/uso terapéutico , Nacimiento Prematuro/prevención & control , Atención Prenatal , Tocolíticos/uso terapéutico , Parálisis Cerebral/prevención & control , Preescolar , Femenino , Francia , Humanos , Recien Nacido Prematuro , Estudios Longitudinales , Masculino , Fármacos Neuroprotectores , Embarazo , Estudios Prospectivos
3.
Ocul Immunol Inflamm ; 28(8): 1293-1297, 2020 Nov 16.
Artículo en Inglés | MEDLINE | ID: mdl-33021856

RESUMEN

A 53-year-old man presented with acute loss of vision, negative scotoma and dyschromatopsia in his left eye. He reported contact with people with severe respiratory syndrome - coronavirus-2 (SARS-CoV-2) 8 days prior symptoms. Funduscopic examination revealed several retinal hemorrhages. Spectral-domain optical coherence tomography showed lesions consistent with acute macular neuroretinopathy and paracentral acute middle maculopathy. Quickly after his presentation, SARSCov-2 was confirmed by chest computed tomography-scan and RT-PCR in this patient. Thrombotic complications associated with Covid-19 infection have high incidence and may involve the retina. We described a case of retinal involvement associated with Covid-19 infection. PRÉCIS: Funduscopic examination revealed retinal hemorrhages in a man with loss of vision. Optical coherence tomography showed an acute macular neuroretinopathy and paracentral acute middle maculopathy. Coronavirus disease was confirmed by chest computed tomography-scan and RT-PCR.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus/complicaciones , Angiografía con Fluoresceína/métodos , Mácula Lútea/patología , Neumonía Viral/complicaciones , Enfermedades de la Retina/etiología , Tomografía de Coherencia Óptica/métodos , Agudeza Visual , Enfermedad Aguda , COVID-19 , Infecciones por Coronavirus/epidemiología , Fondo de Ojo , Humanos , Masculino , Persona de Mediana Edad , Oftalmoscopía , Pandemias , Neumonía Viral/epidemiología , Enfermedades de la Retina/diagnóstico , SARS-CoV-2
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA