Entomophthoromycosis in South Bengal (Eastern India): a 9 years study.

Subcutaneous mycoses caused by the family Entomophthoraceae is very rare type of disease and is being reported sporadically from various Tropical countries including India. Here we report 8 cases of rhinoentomophthoromycosis caused by Conidiobolous coronatus and 7 cases of chronic subcutaneous phycomycosis caused by Basidiobolus ranarum. Cases were detected during a span of 9 years between 1991 to 1999, from 9 districts in and around Kolkata (Eastern India). Former type of lesions were detected among 20 to 65 age group of healthy individuals, predominantly males (7:1). In the latter type, male-female ratio was 2:5, and except for one all cases belonged to below 20 years age group of healthy individuals. Several cases were detected only after examination of repeat biopsy samples. With high degree of clinical suspicion, right approach is needed for laboratory confirmation of diagnosis.

Risk-based integrity and inspection modeling (RBIIM) of process components/system.

Process plants deal with hazardous (highly flammable and toxic) chemicals at extreme conditions of temperature and pressure. Proper inspection and maintenance of these facilities is paramount for the maintenance of safe and continuous operation. This article proposes a risk-based methodology for integrity and inspection modeling (RBIIM) to ensure safe and fault-free operation of the facility. This methodology uses a gamma distribution to model the material degradation and a Bayesian updating method to improve the distribution based on actual inspection results. The method deals with the two cases of perfect and imperfect inspections. The measurement error resulting from imperfect inspections is modeled as a zero-mean, normally distributed random process. The risk is calculated using the probability of failure and the consequence is assessed in terms of cost as a function of time. The risk function is used to determine an optimal inspection and replacement interval. The calculated inspection and replacement interval is subsequently used in the design of an integrity inspection plan. Two case studies are presented: the maintenance of an autoclave and the maintenance of a pipeline segment. For the autoclave, the interval between two successive inspections is found to be 19 years. For the pipeline, the next inspection is due after 5 years from now. Measurements taken at inspections are used in estimating a new degradation rate that can then be used to update the failure distribution function.

QSAR study on some pyridoacridine ascididemin analogues as anti-tumor agents.

Pyridoacridine ascididemin analogues have been reported as anticancer agents for their interesting antitumor activity against human cancer cells. A quantitative structure-activity relationship (QSAR) analysis of ascididemin analogues was attempted using the physicochemical parameters and the electrotopological state atom (ETSA) indices. This study indicates that the electron withdrawing substituents with higher MR (molar refractivity) value at R(1) position favor the anti-tumor activity and the presence of NHR (R is hydrogen or alkyl group) at the R(3) position has contribution to the anti-tumor activity. ETSA indices have been incorporated as independent variable in the QSAR model with physicochemical parameters. It clearly suggests the importance of atoms 2, 3, 4, 5, 6 and 7 to the anti-tumor activity.