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1.
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.
J Am Chem Soc
; 142(23): 10358-10372, 2020 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32412754
2.
Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer.
Commun Biol
; 7(1): 497, 2024 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38658677
3.
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST.
Clin Cancer Res
; 26(14): 3751-3759, 2020 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32220888
4.
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Sci Transl Med
; 12(541)2020 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32350132
5.
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J Med Chem
; 61(19): 8797-8810, 2018 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30204441
6.
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα.
J Med Chem
; 56(3): 712-21, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23360348
7.
Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.
Am J Respir Crit Care Med
; 171(8): 858-67, 2005 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15665321
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