RESUMEN
A detailed investigation on the anti-inflammatory activity of the butanol fraction of a methanol extract (BMEL) of the defatted leaves of Paederia foetida was undertaken to find the pharmacological basis for the ethnomedical use of the plant. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. It did not, however, affect adrenal weight and ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. BMEL antagonised hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilising activity. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. The results indicate that there is some rationale behind the ethnomedical use of the plant for treating inflammatory disorders.
Asunto(s)
Antiinflamatorios/uso terapéutico , Granuloma/prevención & control , Extractos Vegetales/uso terapéutico , 1-Butanol , Fosfatasa Ácida/sangre , Glándulas Suprarrenales/efectos de los fármacos , Glándulas Suprarrenales/metabolismo , Animales , Antiinflamatorios/aislamiento & purificación , Antiinflamatorios/farmacología , Ácido Ascórbico/metabolismo , Aspartato Aminotransferasas/sangre , Aspartato Aminotransferasas/metabolismo , Proteínas Sanguíneas/metabolismo , Butanoles/química , Fraccionamiento Químico , Modelos Animales de Enfermedad , Membrana Eritrocítica/efectos de los fármacos , Femenino , Hemólisis/efectos de los fármacos , Humanos , Hígado/efectos de los fármacos , Hígado/enzimología , Masculino , Medicina Tradicional , Metanol/química , Tamaño de los Órganos/efectos de los fármacos , Orosomucoide/metabolismo , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Ratas , Bazo/efectos de los fármacosRESUMEN
Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.
Asunto(s)
Sistema Nervioso Central/efectos de los fármacos , Etilenodiaminas/farmacología , Amidas/farmacología , Amidas/toxicidad , Analgésicos/farmacología , Animales , Etilenodiaminas/toxicidad , Femenino , Dosificación Letal Mediana , Masculino , Ratones , Actividad Motora/efectos de los fármacos , Ratas , Reflejo/efectos de los fármacosRESUMEN
The methanol extract of the defatted leaves of Gymnosporia montana was evaluated for hepatoprotective activity by noting its effect on carbon tetrachloride (CCl4)-induced changes in liver cytoarchitecture and alterations in certain biochemical parameters. The main parameters studied were transaminase activity, lipid constituents of serum and liver, orosomucoid level in serum, and liver glycogen and phospholipid contents. The extract administration led to a significant reversal of the majority of the altered biochemical parameters. Besides, a significant antagonism of the CCl4-induced changes in the liver cytoarchitecture was also observed. The results confirm the presence of hepatoprotective activity in the plant material.