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1.

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Zheng, Yuxiang; Lin, Ting-Yu; Lee, Gina; Paddock, Marcia N; Momb, Jessica; Cheng, Zhe; Li, Qian; Fei, Dennis L; Stein, Benjamin D; Ramsamooj, Shivan; Zhang, Guoan; Blenis, John; Cantley, Lewis C.

Cell ; 175(6): 1546-1560.e17, 2018 11 29.

Artículo en Inglés | MEDLINE | ID: mdl-30500537

2.

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease.

Blenis, John.

Cell ; 171(1): 10-13, 2017 Sep 21.

Artículo en Inglés | MEDLINE | ID: mdl-28888322

3.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John.

Cell ; 171(7): 1545-1558.e18, 2017 Dec 14.

Artículo en Inglés | MEDLINE | ID: mdl-29153836

4.

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

Holz, Marina K; Ballif, Bryan A; Gygi, Steven P; Blenis, John.

Cell ; 184(8): 2255, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33861965

5.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi, Alfred; Fendt, Sarah-Maria; Li, Chenggang; Poulogiannis, George; Choo, Andrew Y; Chapski, Douglas J; Jeong, Seung Min; Dempsey, Jamie M; Parkhitko, Andrey; Morrison, Tasha; Henske, Elizabeth P; Haigis, Marcia C; Cantley, Lewis C; Stephanopoulos, Gregory; Yu, Jane; Blenis, John.

Cell ; 184(8): 2256, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33861966

6.

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Cho, Sungyun; Chun, Yujin; He, Long; Ramirez, Cuauhtemoc B; Ganesh, Kripa S; Jeong, Kyungjo; Song, Junho; Cheong, Jin Gyu; Li, Zhongchi; Choi, Jungmin; Kim, Joohwan; Koundouros, Nikos; Ding, Fangyuan; Dephoure, Noah; Jang, Cholsoon; Blenis, John; Lee, Gina.

Mol Cell ; 83(16): 3010-3026.e8, 2023 08 17.

Artículo en Inglés | MEDLINE | ID: mdl-37595559

7.

Raymond L. Erikson (1936-2020).

Neel, Benjamin G; Sweet, Laurel; Simmons, Daniel L; Blenis, John.

Cell ; 181(5): 961-963, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-33074798

8.

The intrinsic substrate specificity of the human tyrosine kinome.

Yaron-Barir, Tomer M; Joughin, Brian A; Huntsman, Emily M; Kerelsky, Alexander; Cizin, Daniel M; Cohen, Benjamin M; Regev, Amit; Song, Junho; Vasan, Neil; Lin, Ting-Yu; Orozco, Jose M; Schoenherr, Christina; Sagum, Cari; Bedford, Mark T; Wynn, R Max; Tso, Shih-Chia; Chuang, David T; Li, Lei; Li, Shawn S-C; Creixell, Pau; Krismer, Konstantin; Takegami, Mina; Lee, Harin; Zhang, Bin; Lu, Jingyi; Cossentino, Ian; Landry, Sean D; Uduman, Mohamed; Blenis, John; Elemento, Olivier; Frame, Margaret C; Hornbeck, Peter V; Cantley, Lewis C; Turk, Benjamin E; Yaffe, Michael B; Johnson, Jared L.

Nature ; 2024 May 08.

Artículo en Inglés | MEDLINE | ID: mdl-38720073

9.

An atlas of substrate specificities for the human serine/threonine kinome.

Johnson, Jared L; Yaron, Tomer M; Huntsman, Emily M; Kerelsky, Alexander; Song, Junho; Regev, Amit; Lin, Ting-Yu; Liberatore, Katarina; Cizin, Daniel M; Cohen, Benjamin M; Vasan, Neil; Ma, Yilun; Krismer, Konstantin; Robles, Jaylissa Torres; van de Kooij, Bert; van Vlimmeren, Anne E; Andrée-Busch, Nicole; Käufer, Norbert F; Dorovkov, Maxim V; Ryazanov, Alexey G; Takagi, Yuichiro; Kastenhuber, Edward R; Goncalves, Marcus D; Hopkins, Benjamin D; Elemento, Olivier; Taatjes, Dylan J; Maucuer, Alexandre; Yamashita, Akio; Degterev, Alexei; Uduman, Mohamed; Lu, Jingyi; Landry, Sean D; Zhang, Bin; Cossentino, Ian; Linding, Rune; Blenis, John; Hornbeck, Peter V; Turk, Benjamin E; Yaffe, Michael B; Cantley, Lewis C.

Nature ; 613(7945): 759-766, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36631611

10.

mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.

Cho, Sungyun; Lee, Gina; Pickering, Brian F; Jang, Cholsoon; Park, Jin H; He, Long; Mathur, Lavina; Kim, Seung-Soo; Jung, Sunhee; Tang, Hong-Wen; Monette, Sebastien; Rabinowitz, Joshua D; Perrimon, Norbert; Jaffrey, Samie R; Blenis, John.

Mol Cell ; 81(10): 2064-2075.e8, 2021 05 20.

Artículo en Inglés | MEDLINE | ID: mdl-33756105

11.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi, Alfred; Fendt, Sarah-Maria; Li, Chenggang; Poulogiannis, George; Choo, Andrew Y; Chapski, Douglas J; Jeong, Seung Min; Dempsey, Jamie M; Parkhitko, Andrey; Morrison, Tasha; Henske, Elizabeth P; Haigis, Marcia C; Cantley, Lewis C; Stephanopoulos, Gregory; Yu, Jane; Blenis, John.

Cell ; 153(4): 840-54, 2013 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-23663782

12.

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.

Ferrarone, John R; Thomas, Jerin; Unni, Arun M; Zheng, Yuxiang; Nagiec, Michal J; Gardner, Eric E; Mashadova, Oksana; Li, Kate; Koundouros, Nikos; Montalbano, Antonino; Mustafa, Meer; Cantley, Lewis C; Blenis, John; Sanjana, Neville E; Varmus, Harold.

Proc Natl Acad Sci U S A ; 121(21): e2403685121, 2024 May 21.

Artículo en Inglés | MEDLINE | ID: mdl-38743625

13.

Age-induced accumulation of methylmalonic acid promotes tumour progression.

Gomes, Ana P; Ilter, Didem; Low, Vivien; Endress, Jennifer E; Fernández-García, Juan; Rosenzweig, Adam; Schild, Tanya; Broekaert, Dorien; Ahmed, Adnan; Planque, Melanie; Elia, Ilaria; Han, Julie; Kinzig, Charles; Mullarky, Edouard; Mutvei, Anders P; Asara, John; de Cabo, Rafael; Cantley, Lewis C; Dephoure, Noah; Fendt, Sarah-Maria; Blenis, John.

Nature ; 585(7824): 283-287, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32814897

14.

Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport.

Yoon, Sang-Oh; Shin, Sejeong; Liu, Yuzhen; Ballif, Bryan A; Woo, Michele S; Gygi, Steven P; Blenis, John.

Mol Cell ; 83(22): 4190, 2023 Nov 16.

Artículo en Inglés | MEDLINE | ID: mdl-37980093

15.

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

He, Long; Gomes, Ana P; Wang, Xin; Yoon, Sang Oh; Lee, Gina; Nagiec, Michal J; Cho, Sungyun; Chavez, Andre; Islam, Tasnia; Yu, Yonghao; Asara, John M; Kim, Bo Yeon; Blenis, John.

Mol Cell ; 70(5): 949-960.e4, 2018 06 07.

Artículo en Inglés | MEDLINE | ID: mdl-29861159

16.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John.

Mol Cell ; 67(3): 512-527.e4, 2017 Aug 03.

Artículo en Inglés | MEDLINE | ID: mdl-28757207

17.

Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.

Park, Jin H; Lee, Gina; Blenis, John.

Trends Biochem Sci ; 45(5): 367-369, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32311329

18.

Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply.

Choo, Andrew Y; Kim, Sang Gyun; Vander Heiden, Matthew G; Mahoney, Sarah J; Vu, Hieu; Yoon, Sang-Oh; Cantley, Lewis C; Blenis, John.

Mol Cell ; 81(14): 3031, 2021 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-34270944

19.

mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy.

Tang, Hong-Wen; Weng, Jui-Hsia; Lee, Wen Xing; Hu, Yanhui; Gu, Lei; Cho, Sungyun; Lee, Gina; Binari, Richard; Li, Cathleen; Cheng, Min En; Kim, Ah-Ram; Xu, Jun; Shen, Zhangfei; Xu, Chiwei; Asara, John M; Blenis, John; Perrimon, Norbert.

Proc Natl Acad Sci U S A ; 118(10)2021 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-33649236

20.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada, Shogo; Neinast, Michael; Jang, Cholsoon; Ibrahim, Yasir H; Lee, Gina; Babu, Apoorva; Li, Jian; Hoshino, Atsushi; Rowe, Glenn C; Rhee, James; Martina, José A; Puertollano, Rosa; Blenis, John; Morley, Michael; Baur, Joseph A; Seale, Patrick; Arany, Zoltan.

Genes Dev ; 30(22): 2551-2564, 2016 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-27913603

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Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.

Raymond L. Erikson (1936-2020).

The intrinsic substrate specificity of the human tyrosine kinome.

An atlas of substrate specificities for the human serine/threonine kinome.

mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.

Age-induced accumulation of methylmalonic acid promotes tumour progression.

Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport.

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.

Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply.

mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.