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1.
J Endocrinol Invest ; 34(1): 3-7, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20220292

RESUMEN

AIM: The objective of the present study was to evaluate the role of visfatin in gestational diabetes mellitus. MATERIALS AND METHODS: Forty-five pregnant women at 24 to 28 weeks' gestation were assigned to consume an initial screening test using a 1-h 50-g glucose load, and then a 3-h 100-g glucose load. The study group consisted of 23 patients who were diagnosed with gestational diabetes mellitus and the control group consisted of 22 healthy pregnant women. We studied the levels of visfatin and the other parameters of inflammation, glucose and lipid metabolism between the 24th and 28th week of gestation and also between the 6th and 10th week after delivery. RESULTS: Plasma visfatin and glucose levels at 60 min after a 50-g and a 100-g glucose load between the 24th and 28th week of gestation were significantly higher in the gestational diabetes group than in the control group. There were no statistical differences in visfatin levels between the groups at 6-10 weeks post-partum. CONCLUSION: Visfatin levels were significantly elevated in women with gestational diabetes mellitus and during the course of pregnancy and increased visfatin concentrations were reduced within 6 to 10 weeks after delivery.


Asunto(s)
Citocinas/fisiología , Diabetes Gestacional/etiología , Nicotinamida Fosforribosiltransferasa/fisiología , Adulto , Glucemia/análisis , Índice de Masa Corporal , Estudios de Casos y Controles , Citocinas/sangre , Parto Obstétrico , Diabetes Gestacional/sangre , Femenino , Edad Gestacional , Prueba de Tolerancia a la Glucosa , Humanos , Nicotinamida Fosforribosiltransferasa/sangre , Periodo Posparto/sangre , Embarazo
2.
J Endocrinol Invest ; 28(9): 810-4, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16370560

RESUMEN

The genetic factors determining bone mineral density (BMD) are not well characterized. Many studies have investigated the relationship between the fokI polymorphism of vitamin D receptor (VDR) gene in diverse populations and gender, resulting in conflicting outcomes. Because peak bone mass in men is closely related to sufficient androgen release, the contribution of VDR gene on BMD might have been masked by hormonal status of adulthood. We therefore investigated the relationship between the fokI polymorphism of VDR and BMD in male patients with idiopathic hypogonadotrophic hypogonadism (IHH). Sixty-five untreated male patients with IHH and 39 healthy matched controls were evaluated. fokI polymorphism ("f" allele) was detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism using restriction endonuclease fokI, and BMD was measured by dual Energy X-ray absorpsiometry in lumbar spine, femur and radius. The distribution of FF, Ff, and ff alleles in patients with IHH and controls were not different (patients; 46%, 51%, 3% and controls; 51.3%, 46.1%, 2.6%, respectively). BMD levels in patients with IHH were significantly lower than controls. We categorized patients and control subjects in subgroups according to whether they had homozygous FF and heterozygous Ff genotype. No differences in BMD were seen between control subgroups, but total femur and femoral neck BMD were significantly lower in patients bearing heterozygous Ff genotype with IHH than homozygous FF ones (p=0.017 and p=0.009, respectively). Ff genotype might run down the BMD in cortical bone of femur, which needs to be proved in further studies.


Asunto(s)
Densidad Ósea/genética , Codón Iniciador , Desoxirribonucleasas de Localización Especificada Tipo II/genética , Hipogonadismo/genética , Polimorfismo Genético , Receptores de Calcitriol/genética , Adulto , Estudios de Casos y Controles , Desoxirribonucleasas de Localización Especificada Tipo II/metabolismo , Fémur/fisiología , Frecuencia de los Genes , Heterocigoto , Homocigoto , Humanos , Masculino , Receptores de Calcitriol/metabolismo
3.
J Endocrinol Invest ; 27(11): 1029-33, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15754734

RESUMEN

Idiopathic hypogonadotropic hypogonadism (IHH) is a well-known disorder apart from its pathogenesis, which is still mostly unclear, even though a diverse subgroup of patients with hypogonadotropic hypogonadism and hyposmia/anosmia--the Kallman syndrome--have been partly linked to a mutated gene, known as kal-1 gene. In this study, we aimed to evaluate the sellar region of patients with IHH on magnetic resonance (MR). Pituitary MR of 120 male patients with IHH, diagnosed by a thorough endocrinologic assessment, were compared with pituitary MR of 49 healthy cases selected randomly who underwent detailed endocrinologic and neurologic evaluation and were assessed as healthy. Patients with IHH were diagnosed with microadenomas and irregularly contrasting pituitary (ICP), 18.2 and 10.7%, respectively. Although some anatomic variations were seen in healthy controls, microadenomas and ICP had solely been observed in patients with IHH and none in controls. Intact appearence of hypophysis in patients with IHH was significantly lower than in randomly selected healthy male subjects (p = 0.021). Mean infundibulum width of hypophysis and transverse diameter of posterior hypophysis were significantly broader in patients with IHH than in controls (both having p < 0.001), while mean hypophysis height and volume did not differ between groups. Results showed unusual incidence of pituitary abnormalities on pituitary MR in male patients with IHH. In conclusion, MR imaging is particularly useful in defining the morphological aspects of the hypothalamo - pituitary region in some endocrine disorders and other researchers might want to bear our findings in mind when performing MR evaluation of similar patient subgroups.


Asunto(s)
Adenoma/patología , Síndrome de Kallmann/patología , Hipófisis/patología , Neoplasias Hipofisarias/patología , Adenoma/complicaciones , Adulto , Antropometría , Estudios de Casos y Controles , Humanos , Imagen por Resonancia Magnética , Masculino , Hipófisis/anatomía & histología , Neoplasias Hipofisarias/complicaciones , Estudios Retrospectivos
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