Haemorrhage in neonatal hepatic necrosis due to herpes infection.

A case of early neonatal severe bleeding and persistent hypoglycemia with a fatal outcome is reported. The autopsy examination revealed the features of neonatal hepatic necrosis. Further study by the electron microscopy indicated the presence of herpes type particles in the nucleus and cytoplasm of the remaining liver cells. Serological study of the maternal blood, post partum, revelaed positive reaction to Herpes simplex virus type 2 at low titer. It is believed that intrauterine herpes infection was responsible for the severe hepatic damage manifesting in complex clinical findings.

Intracerebral hemorrhage due to nosocomial aspergillosis following neurosurgery.

A unique case of nosocomial aspergillosis following neurosurgery in a 10 year old girl was documented. She presented with intracerebral hemorrhage after three weeks of operation for evacuation of craniopharyngioma. To our knowledge, this is the first reported case of intracerebral hemorrhage due to nosocomial aspergillosis following neurosurgery.

Causes of perinatal death defined by autopsy at Ramathibodi Hospital.

Most causes of death during the fetal period are still unknown in all birth weight groups. Intrauterine anoxia evidence by clinical data and autopsy finding is the leading known cause in infants 1,001-2,500 g and over 2,500 g. In the early neonatal period in infants 1,001-2,500 g and over 2,500 g, the most common cause of death is congenital malformation which was also found as the main cause in the late neonatal over 2,500 g group. More than half of the deaths in the late neonatal period 1,001-2,500 g group, were caused by infection. Congenital syphilis and tetanus neonatorum which existed in the first study were not found in this study which reflects improved medical care.

Parvovirus B19 caused fetal death: a case report in Thailand.

This was a case of an intrauterine parvoviral B19 infection resulting in hydrops fetalis and enlarged placenta. Histologically, the virus was found to be in nucleated red cells of the fetus which was confirmed by electron microscopy. Careful placental examination at the gross and microscopic levels yielded the correct diagnosis.

Listeriosis of the placenta: clinicopathologic study of seven cases.

OBJECTIVE: The purpose of our study was to evaluate the usefulness of placental examination in the diagnosis of prenatal listeriosis. STUDY DESIGN: Over a 7-year period, 4597 placentas with clinical indications for examination were retrospectively studied for morphologic evidence of listeriosis. The microbiology laboratory file records of positive Listeria monocytogenes cultures were used to confirm the diagnosis. The clinical records were studied for manifestations of the infection both in the neonates and in the mothers. RESULTS: Seven placentas were identified as having listeriosis. The presence of macroabscesses, as opposed to microabscesses, was the most characteristic finding in this study, and the silver impregnation method was more reliable in identification of the bacilli in the tissue sections than the tissue Gram stains. CONCLUSIONS: Listeriosis could be diagnosed by placental examination alone, and this examination frequently strengthened the clinical diagnosis. When the infection was not suspected clinically, the examination helped us reach the correct diagnosis.