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1.
Sensors (Basel) ; 21(7)2021 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-33806123

RESUMEN

Recent research works on intelligent traffic signal control (TSC) have been mainly focused on leveraging deep reinforcement learning (DRL) due to its proven capability and performance. DRL-based traffic signal control frameworks belong to either discrete or continuous controls. In discrete control, the DRL agent selects the appropriate traffic light phase from a finite set of phases. Whereas in continuous control approach, the agent decides the appropriate duration for each signal phase within a predetermined sequence of phases. Among the existing works, there are no prior approaches that propose a flexible framework combining both discrete and continuous DRL approaches in controlling traffic signal. Thus, our ultimate objective in this paper is to propose an approach capable of deciding simultaneously the proper phase and its associated duration. Our contribution resides in adapting a hybrid Deep Reinforcement Learning that considers at the same time discrete and continuous decisions. Precisely, we customize a Parameterized Deep Q-Networks (P-DQN) architecture that permits a hierarchical decision-making process that primarily decides the traffic light next phases and secondly specifies its the associated timing. The evaluation results of our approach using Simulation of Urban MObility (SUMO) shows its out-performance over the benchmarks. The proposed framework is able to reduce the average queue length of vehicles and the average travel time by 22.20% and 5.78%, respectively, over the alternative DRL-based TSC systems.

2.
PLoS One ; 9(2): e86456, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24498276

RESUMEN

UNLABELLED: Prediction and classification techniques have been well studied by machine learning researchers and developed for several real-word problems. However, the level of acceptance and success of prediction models are still below expectation due to some difficulties such as the low performance of prediction models when they are applied in different environments. Such a problem has been addressed by many researchers, mainly from the machine learning community. A second problem, principally raised by model users in different communities, such as managers, economists, engineers, biologists, and medical practitioners, etc., is the prediction models' interpretability. The latter is the ability of a model to explain its predictions and exhibit the causality relationships between the inputs and the outputs. In the case of classification, a successful way to alleviate the low performance is to use ensemble classiers. It is an intuitive strategy to activate collaboration between different classifiers towards a better performance than individual classier. Unfortunately, ensemble classifiers method do not take into account the interpretability of the final classification outcome. It even worsens the original interpretability of the individual classifiers. In this paper we propose a novel implementation of classifiers combination approach that does not only promote the overall performance but also preserves the interpretability of the resulting model. We propose a solution based on Ant Colony Optimization and tailored for the case of Bayesian classifiers. We validate our proposed solution with case studies from medical domain namely, heart disease and Cardiotography-based predictions, problems where interpretability is critical to make appropriate clinical decisions. AVAILABILITY: The datasets, Prediction Models and software tool together with supplementary materials are available at http://faculty.uaeu.ac.ae/salahb/ACO4BC.htm.


Asunto(s)
Algoritmos , Inteligencia Artificial , Teorema de Bayes , Biología Computacional/métodos , Investigación Biomédica/métodos , Humanos , Modelos Biológicos , Reproducibilidad de los Resultados
3.
PLoS One ; 6(7): e21821, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21814556

RESUMEN

UNLABELLED: Transmembrane helix (TMH) topology prediction is becoming a focal problem in bioinformatics because the structure of TM proteins is difficult to determine using experimental methods. Therefore, methods that can computationally predict the topology of helical membrane proteins are highly desirable. In this paper we introduce TMHindex, a method for detecting TMH segments using only the amino acid sequence information. Each amino acid in a protein sequence is represented by a Compositional Index, which is deduced from a combination of the difference in amino acid occurrences in TMH and non-TMH segments in training protein sequences and the amino acid composition information. Furthermore, a genetic algorithm was employed to find the optimal threshold value for the separation of TMH segments from non-TMH segments. The method successfully predicted 376 out of the 378 TMH segments in a dataset consisting of 70 test protein sequences. The sensitivity and specificity for classifying each amino acid in every protein sequence in the dataset was 0.901 and 0.865, respectively. To assess the generality of TMHindex, we also tested the approach on another standard 73-protein 3D helix dataset. TMHindex correctly predicted 91.8% of proteins based on TM segments. The level of the accuracy achieved using TMHindex in comparison to other recent approaches for predicting the topology of TM proteins is a strong argument in favor of our proposed method. AVAILABILITY: The datasets, software together with supplementary materials are available at: http://faculty.uaeu.ac.ae/nzaki/TMHindex.htm.


Asunto(s)
Algoritmos , Aminoácidos/metabolismo , Proteínas de la Membrana/química , Proteínas de la Membrana/genética , Secuencia de Aminoácidos , Aminoácidos/química , Biología Computacional , Humanos , Datos de Secuencia Molecular , Mutación/genética , Estructura Secundaria de Proteína , Sensibilidad y Especificidad , Análisis de Secuencia de Proteína , Programas Informáticos
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