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1.
J Hum Nutr Diet ; 28 Suppl 2: 24-32, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25220046

RESUMEN

BACKGROUND: The prevention and treatment of overweight and obese individuals on a population-wide basis is challenging because patients have difficulties with adhering to weight loss programmes. The present study aimed to evaluate patients' adherence to the weight reduction programme by identifying factors predictive of both drop-out rate and weight loss success. METHODS: One-hundred and twenty-four obese patients participated in a 12-month weight reduction programme, involving group therapy during an intensive 5-day educational intervention, followed by five, 2-h follow-up visits. The primary outcome measures included drop-out rate and percentage weight loss. Sociodemographic and clinical characteristics, as well as type of diet, were explored as potential predictive factors. Type of diet was assigned based on randomisation. Regression analyses were conducted to identify predictive variables of drop-out and weight loss success. RESULTS: In total, 33.1% of all recruited participants were deemed successful because they reduced the initial weight by more than 5% after the 12-month intervention. The overall attrition rate was 32.3%. In a multiple regression model, initial weight loss and marital status were the strongest predictors of weight loss success after 1-year period (r(2) = 0.481, P < 0.001). In a separate analysis, subjects more likely to drop-out were those with a lower educational level [odds ratio (OR) = 3.26, 95% confidence interval (CI) = 1.22-8.70, P = 0.018] and a higher level of obesity (OR = 0.974, 95% CI = 0.95-0.99, P = 0.010). CONCLUSIONS: The present study demonstrates that initial weight loss at 1 month made the strongest unique contribution to the prediction of percentage weight loss after 12 months, whereas being married was a negative predictor. Those with a lower educational level and a higher level of obesity were more likely to drop-out.


Asunto(s)
Logro , Obesidad/terapia , Cooperación del Paciente , Pacientes Desistentes del Tratamiento , Pérdida de Peso , Programas de Reducción de Peso , Adulto , Terapia Conductista , Dieta , Escolaridad , Ejercicio Físico , Femenino , Humanos , Masculino , Estado Civil , Persona de Mediana Edad , Oportunidad Relativa , Método Simple Ciego , Resultado del Tratamiento
2.
Z Rheumatol ; 68(6): 495-7, 2009 Aug.
Artículo en Alemán | MEDLINE | ID: mdl-19444459

RESUMEN

Human brucellosis manifests as an acute or persistent febrile disease with a wide variety of symptoms. To our knowledge this is the first case report of brucellar monoarthritis of the hip in Croatia, with difficulties regarding its diagnosis and protracted clinical course.


Asunto(s)
Artritis/diagnóstico , Artritis/terapia , Brucelosis/diagnóstico , Brucelosis/terapia , Articulación de la Cadera/patología , Adulto , Artritis/etiología , Brucelosis/complicaciones , Humanos , Masculino
3.
Angiology ; 51(8): 667-75, 2000 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10959519

RESUMEN

Duplex Doppler ultrasonography has been validated as a noninvasive method to evaluate hemodynamic features of renal blood flow in renal and intrarenal arteries in patients with various renal diseases. The significance of duplex Doppler sonography in the evaluation of renal vascular resistance in essential hypertension has not yet been clearly determined. The aim of the present study was to evaluate the renal vascular resistance in patients with essential hypertension by measuring intrarenal arterial resistance (RI) and to correlate RI with renal functional tests and other clinical and laboratory data. Duplex Doppler ultrasonography was used to measure RIs in intrarenal arteries in 128 patients with essential hypertension and 61 age-matched normotensive control examinees. The renal vascular resistance index (RI) was determined by use of Doppler ultrasound. Hypertension was classified according to the 1997 Joint National Committee Guidelines (JNC-VI). Mean RI in hypertensive patients was 0.66 +/- 0.05 (+/- sd) and in healthy controls 0.60 +/- 0.03 (+/- sd) (p = 0.0001). RI correlated significantly with patient's age (r = 0.577, p = 0.001), duration of hypertension (r = 0.335, p= 0.001), stage of hypertension according to the JNC-VI classification (r = 0.315, p = 0.006), creatinine clearance (r = -0.383, p = 0.001), systolic blood pressure (SBP, r = 0.41, p = 0.001) and mean blood pressure (MBP, r = 0.30, p = 0.002). RI values did not correlate significantly with plasma renin concentration (r = -0.198 NS), diastolic blood pressure (DBP, r = 0.17, p = 0.06), and cardiac pulse (r = -0.10, p = 0.16). Multiple regression analysis showed that independent variables for RI were the patient's age (multiple R = 0.53, signif. F = 0.001) and systolic blood pressure (multiple R = 0.57, signif. F = 0.03). The renal Doppler resistance index (RI) is increased in essential hypertension and it correlates with renal functional tests as well as with patient's age, duration of hypertension, with a stage of hypertension according to the JNC-VI classification, and with systolic and mean blood pressure. The increased renal vascular resistance (RI) in hypertensive patients could be a sign of developing hypertensive nephrosclerosis and consequently renal failure. The utilization of the renal vascular resistance index (RI), provides a new noninvasive parameter in the followup of patients with essential hypertension.


Asunto(s)
Hipertensión/diagnóstico por imagen , Arteria Renal/diagnóstico por imagen , Circulación Renal/fisiología , Ultrasonografía Doppler Dúplex , Resistencia Vascular , Adulto , Anciano , Velocidad del Flujo Sanguíneo , Presión Sanguínea/fisiología , Femenino , Humanos , Hipertensión/sangre , Hipertensión/fisiopatología , Pruebas de Función Renal , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Arteria Renal/fisiopatología , Renina/sangre , Índice de Severidad de la Enfermedad , Resistencia Vascular/fisiología
4.
Acta Vet Hung ; 47(1): 65-75, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10213930

RESUMEN

The effect of feeding different levels (10 and 20%) of dehydrated olive cake pulp on certain blood parameters and on the catalytic activity of serum enzymes was studied in fattening rabbits. A total of 60 rabbits were divided into a control group (C) and two experimental groups (E1, E2), each comprising 10 males and 10 females. Rabbits of Group C received no dehydrated olive cake pulp in their diet, while rabbits of Group E1 and Group E2 were fed 10% and 20% dehydrated olive cake pulp, respectively. After Day 56 of the experiment, blood samples were obtained by cardiac puncture and certain blood parameters as well as the catalytic activity of serum enzymes were determined. Following the experimental feeding period no significant differences were found between Group C and Groups E1 and E2 in red blood cell (RBC) and white blood cell (WBC) count, haemoglobin concentration and haematocrit value. Similarly, after 56 days of experimental fattening no significant differences were found between the control group and the experimental groups in the catalytic activity of the serum enzymes alkaline phosphatase (AP), aspartate amino-transferase (AST), gamma-glutamyltransferase (GGT), and lactate dehydrogenase (LDH). However, Group E2 rabbits manifested a significantly higher alanine amino-transferase (ALT) activity in the serum than did rabbits of Group E1. The results indicate that the inclusion of dehydrated olive cake pulp in the diet at the rate of 10% or 20% caused no changes in the investigated blood parameters and serum enzyme activities of fattening rabbits.


Asunto(s)
Alimentación Animal , Frutas/metabolismo , Conejos/sangre , Conejos/crecimiento & desarrollo , Alanina Transaminasa/sangre , Fosfatasa Alcalina/sangre , Animales , Aspartato Aminotransferasas/sangre , Recuento de Eritrocitos/veterinaria , Femenino , Hematócrito/veterinaria , Hemoglobinas/análisis , L-Lactato Deshidrogenasa/sangre , Recuento de Leucocitos/veterinaria , Masculino , gamma-Glutamiltransferasa/sangre
5.
Coll Antropol ; 21(1): 229-33, 1997 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9225517

RESUMEN

Visual evoked potentials were examined in released prisoners of war (POWs) in order to evaluate the extent of neurological impairment after imprisonment in Serbian detention camps. On two occasions visual evoked potentials were determined in a group of 11 released prisoners of war (POWs): 157 days and 379 days after release from detention camp. During the first examination no significant differences were found in VEP parameters between the right and left eye. However, during the second examination significant differences were found in the latencies of waves P100 and N145, statistically significantly prolonged latencies of the P100 wave and significantly greater amplitudes of waves P50 and N75. The results can be regarded as progression of the VEP changes in the released POWs. It is hypothesized that these changes are a result of a demyelination process, caused by the altered immunological status of the POWs during posttraumatic stress syndrome.


Asunto(s)
Potenciales Evocados Visuales , Prisioneros , Guerra , Adulto , Croacia , Humanos , Trastornos por Estrés Postraumático/inmunología , Yugoslavia
6.
Coll Antropol ; 21(2): 517-24, 1997 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9439068

RESUMEN

The aim of this study was to examine relationships between total cholesterol, LDL, HDL cholesterol, triglycerides and age, gender, and cigarette smoking in 190 patients (132 men and 58 women) aged 34-87 years with first AMI. The control group included 103 patients (57 men and 46 women) aged 29-90 years without a history of angina pectoris or AMI. High total cholesterol (over 5.2 mmol/L) was observed in 75% of patients with AMI vs. 48% of patients in the control group (p < 0.001). Patients with AMI had significantly higher total cholesterol and LDL cholesterol levels than controls (p < 0.0001). HDL cholesterol levels were significantly lower among patients with AMI than among the control group patients (p < 0.0001). Serum total cholesterol and LDL cholesterol is higher in patients with AMI up to 60 years old, but lower in patients older than 60 years. Women aged less than 50 years had significantly higher HDL cholesterol (p < 0.001), lower LDL cholesterol (p < 0.001), and lower total cholesterol (p < 0.05) than those over 50 years. Smokers with AMI who smoked over 20 cigarettes per day had significantly higher total cholesterol, LDL cholesterol and triglycerides levels than the non-smokers (p < 0.05). These findings suggest important influences of hyperlipoproteinemia and cigarette smoking upon development of myocardial infarction, especially in younger patients.


Asunto(s)
Colesterol/sangre , Infarto del Miocardio/sangre , Fumar/efectos adversos , Triglicéridos/sangre , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Croacia/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/epidemiología , Factores Sexuales
7.
Acta Med Croatica ; 51(4-5): 215-9, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9473801

RESUMEN

In 49 printing-press workers occupationally exposed to toluene for approximately 21.6 years, the values of BEAP and VEP parameters were examined in relation to the length of exposure. With the exception of P2 wave, there was a significant increase in the latencies of all the BEAP waves examined as well as in the interpeak latency (IPL) P3-P4, whereas IPL P4-P5 decreased significantly with the length of exposure. The amplitude of all the VEP examined decreased significantly with the length of exposure. Toluene exposure was evaluated by measuring the concentration of toluene in peripheral blood and of hippuric acid in urine on Wednesday morning prior to the workshift, and of hippuric acid in urine after the workshift on the same day. According to the average concentration of hippuric acid in urine after the workshift, the levels of toluene exposure were estimated to range from 40-60 ppm. Evoked potentials were determined on Mondays 10-12 hours after a nonworking weekend.


Asunto(s)
Potenciales Evocados Auditivos del Tronco Encefálico/efectos de los fármacos , Potenciales Evocados Visuales/efectos de los fármacos , Exposición Profesional , Tolueno/toxicidad , Adulto , Humanos , Persona de Mediana Edad , Impresión , Factores de Tiempo
8.
Lijec Vjesn ; 118(1-2): 23-6, 1996.
Artículo en Croata | MEDLINE | ID: mdl-8759417

RESUMEN

The increased use of immunosuppressants in the treatment of malignant and non-malignant diseases in today's medicine has significantly contributed to the increased interest in infections caused by opportunistic microorganisms and rare parasites. A fifty-eight-year old male patient, professor, born in Bosnia, was admitted to the Institute due to poor general condition and decompensated steroid diabetes. He had been under immunosuppressant therapy for the previous 5 weeks. Six months before, he noticed squamous and crusted changes on capilli, and afterwards on his body too. As these changes did not respond to local therapy he was admitted to the Department of Dermatovenereology, Zagreb University School of Medicine. Histologic analysis indicated pemphigus erythematosus. He was treated with immunosuppressants (methylprednisolone + azathioprine). Endoscopic examinations revealed duodenal ulcer, in addition to diabetes which could not be regulated by oral hypoglycemics. He received antiulcerative therapy for ulcer treatment. Several hours upon admission the patient became highly febrile, and vomited a sanguinolent content. In spite of intensive therapy, he became comatose and died 20 hours later. On autopsy, generalized strongyloidosis of the lungs, liver, duodenum and small intestine, and a bleeding duodenal ulcer due to strongyloidosis were found. This review should remind us that hyperinfestation with strongyloides is a rare and severe complication, and could be expected in immunocompromised patients.


Asunto(s)
Huésped Inmunocomprometido , Infecciones Oportunistas , Strongyloides stercoralis , Estrongiloidiasis , Animales , Resultado Fatal , Humanos , Inmunosupresores/uso terapéutico , Masculino , Persona de Mediana Edad , Infecciones Oportunistas/patología , Pénfigo/terapia , Estrongiloidiasis/inmunología , Estrongiloidiasis/patología
9.
Lijec Vjesn ; 122(5-6): 110-8, 2000.
Artículo en Croata | MEDLINE | ID: mdl-11040532

RESUMEN

As an important drug consumer in Dubrava University Hospital, Department of Cardiac Surgery has been chosen for testing a new model of drug distribution system known as unit dose drug distribution system. During the first 39 weeks in 1996--comparative period, drugs were delivered from the Pharmacy to the Department of Cardiac Surgery in traditional way, known as floor stock system. Next 65 weeks, until the end of 1997--pilot study period, drugs were delivered directly from the Pharmacy to the patients, using unit dose drug distribution system. Consumption of drugs was measured every week by statistical unit DDD/100 hospital days (Defined Daily Dose) according to Anatomic-Therapeutic-Chemistry (ATC) classification of drugs. For statistical measurements, beside common arithmetic means, geometric means were used which are less sensitive to extreme values of drug consumption. During comparative period drug consumption was chaotic with great oscillations around mean value, while in pilot study period that process was without great oscillations around lower mean value and did not exceed the limits of process. Drug consumption was completely under control, so it was a predictable process. In the pilot study period total drug consumption was 39% less, while consumption of drugs from group C was 30% less. During comparative period group C makes 34%, while in the pilot study period it makes 38% of the total drug consumption. This model of drug distribution in hospital leads to a rationalization of drug consumption and great savings. The pharmacist-physician interactive role began to emerge as a direct result of these changes in the drug distribution system. Hospital pharmacist has become a visible member of health care team who is responsible for Quality of all medication-related activities and thus has taken opportunity for clinical pharmacy practice.


Asunto(s)
Utilización de Medicamentos , Sistemas de Medicación en Hospital , Humanos
10.
Lijec Vjesn ; 121(6): 175-80, 1999 Jun.
Artículo en Croata | MEDLINE | ID: mdl-10494151

RESUMEN

Diabetic foot occurs due to the loss of protective sense and circulation disorder and a marked proneness to infections. Mechanical stress of bone growths frequently leads to ulcerations. The prevention and timely treatment of diabetic foot requires the participation of both patients and all health care levels. This consensus is given for the purpose of procedure standardization. Education is the basis of prevention and should be carried out with every patient suffering from diabetes mellitus and those with a sensory defect in particular. Appropriate footwear significantly contributes to prevention and treatment of ulcers. As regards the treatment, the necessity of surgical approach with a long term and often manifold antibiotic therapy should be pointed out. Infections are usually mixed. The deeper the ulceration, the more likely the infection with anaerobes and Gram-negative bacteria occurs in addition to Gram-positive ones which are normally present in surface lesions. Strict metabolic control is a precondition for successful treatment. In conclusion, diabetic foot is a major health problem which requires multidisciplinary approach with permanent patient education as its essential part, and a specific cooperation of all levels and different health care specialties.


Asunto(s)
Pie Diabético , Pie Diabético/diagnóstico , Pie Diabético/prevención & control , Pie Diabético/terapia , Humanos
12.
Croat Med J ; 39(1): 19-22, 1998 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-9475802

RESUMEN

AIM: To investigate the possible effects of thyroid hormones on the lipoprotein (a) (Lp(a)) serum concentration. METHODS: Eleven patients with hyperthyroidism (Grave's disease), 18 patients with hypothyroidism and low Lp(a) (Hashimoto's disease), and 13 patients with hypothyroidism (Hashimoto's disease) and elevated Lp(a) were examined before and after thyroid hormone normalization. The measurements included total cholesterol, HDL cholesterol (including HDL2 and HDL3 subfractions), LDL cholesterol, VLDL cholesterol, triglycerides, apoproteins A1 and B, and Lp(a), thyrotropin (TSH) and thyroid hormones/total thyroxine (T4), triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3). RESULTS: In patients with hyperthyroidism, serum concentrations of total cholesterol, LDL cholesterol, and apo B significantly increased (p<0.05) after the treatment, whereas a moderate increase in HDL (HDL2 subfraction), triglyceride, and Lp(a) concentrations did not reach statistical significance. In both groups of patients with hypothyroidism, concentrations of total cholesterol, LDL cholesterol, apo B, and triglycerides significantly decreased after the treatment, whereas the changes in HDL (HDL2 and HDL3 subfractions), VLDL cholesterol, apo A1, and Lp(a) were not significant. CONCLUSION: Thyroid hormones had only a moderate effect on the metabolism of Lp(a).


Asunto(s)
Hipertiroidismo/sangre , Hipotiroidismo/sangre , Lipoproteína(a)/sangre , Adulto , Anciano , Apolipoproteínas/sangre , Colesterol/sangre , Femenino , Humanos , Hipertiroidismo/tratamiento farmacológico , Hipotiroidismo/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Hormonas Tiroideas/sangre , Triglicéridos/sangre
13.
Int J Cancer ; 29(6): 683-6, 1982 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-6125480

RESUMEN

Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic linear somatostatin per one kg body mass, administered in three or more portions, retards tumor growth in normoinsulinemic mice and the proliferation of tumors preconditioned by three serial passages in diabetics. After the first passage, somatostatin treatment has no effect on the already slow growth of the unconditioned tumor. Somatostatin-reduced tumor proliferation is accompanied by the strong suppression of insulin and SICRI levels, respectively; this effect is completely abolished by the administration of modest doses of crystalline insulin. It is concluded that somatostatin retards tumor growth by diminution of plasma levels of insulin and SICRI, respectively.


Asunto(s)
Diabetes Mellitus Experimental , Neoplasias Mamarias Experimentales/tratamiento farmacológico , Somatostatina/farmacología , Animales , Carcinoma/tratamiento farmacológico , Carcinoma/metabolismo , Reacciones Cruzadas , Femenino , Insulina/metabolismo , Secreción de Insulina , Neoplasias Mamarias Experimentales/metabolismo , Ratones , Ratones Endogámicos CBA , Trasplante de Neoplasias
14.
Blood ; 57(4): 805-8, 1981 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-6110447

RESUMEN

Daily injections of somatostatin into mice with myeloid leukemia retarded the tumor growth. This myeloid leukemia is an insulin-dependent tumor (in that it grows more slowly in hypoinsulinemic diabetic mice than in nondiabetic animals). Since somatostatin decreased the level of immunoreactive insulin in mice with myeloid leukemia, and since the treatment with insulin abrogated the antileukemic effect of somatostatin, we attribute retarded growth of this leukemia to decreased secretion of insulin, caused by somatostatin.


Asunto(s)
Transformación Celular Neoplásica/efectos de los fármacos , Leucemia Experimental/metabolismo , Somatostatina/farmacología , Animales , Relación Dosis-Respuesta a Droga , Insulina/metabolismo , Insulina/farmacología , Secreción de Insulina , Leucemia Experimental/mortalidad , Ratones , Ratones Endogámicos
15.
Int J Legal Med ; 109(3): 114-7, 1996.
Artículo en Inglés | MEDLINE | ID: mdl-8956983

RESUMEN

Visual evoked potentials (VEPs) of the pattern shift reversal type were determined in a representative group of 57 prisoners of war (POWs) released in 1992 from detention camps in former Yugoslavia. The parameters were correlated with the conditions in four camps (1-4). All subjects were male, with a mean age of 34.75 years (SD +/- 8.92), average length of imprisonment 192.7 days (SD +/- 77.6), mean loss of body mass during imprisonment 19.32% (SD +/- 9.54), and the average number of reported blows to the head and neck was 25.7 (SD +/- 20.3). VEPs were determined on average 290.5 days after the last craniocerebral trauma caused by blows to the head and neck (SD +/- 152.0) i.e., on average 218.5 days after release from the camp (SD +/- 164.3). Although all the 57 POWs reported being maltreated to a certain extent, 14 reported being subjected to particularly brutal forms of torture, 5 had been held in solitary confinement and 25 had lost consciousness at least once. Solitary confinement and loss of consciousness had the most significant effect on VEPs, and the altered VEP parameters correlated significantly with the craniocerebral trauma experienced, loss of body mass and the length of time since the last craniocerebral trauma until examination, and from release until examination. However, the length of imprisonment and treatment in the camps did not have a significant effect on VEP parameters. The study confirmed that under such conditions the age of the subject is a risk factor. The results of this study also confirmed that prisoners in one camp had been subjected to the worst maltreatment.


Asunto(s)
Encefalopatías/epidemiología , Potenciales Evocados Visuales , Prisioneros , Tortura , Guerra , Adulto , Encefalopatías/fisiopatología , Traumatismos Craneocerebrales/complicaciones , Medicina Legal , Humanos , Masculino , Prisioneros/psicología , Factores de Riesgo , Estadísticas no Paramétricas , Estrés Psicológico/complicaciones , Yugoslavia/epidemiología
16.
Acta Radiol ; 38(2): 296-302, 1997 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-9093169

RESUMEN

BACKGROUND: The purposes of this study were: to compare conventional and duplex Doppler ultrasonography in the detection of renal changes in diabetes mellitus; to investigate whether a correlation was found with various clinical stages; and to assess whether increased renal vascular resistance in asymptomatic patients correlated with mild renal functional impairment. MATERIAL AND METHODS: In 190 diabetic patients and 85 controls, conventional ultrasonography was used to assess renal length, parenchymal thickness, and cortical echogenicity. Renal vascular resistance was estimated by duplex Doppler measurements of intrarenal arterial resistive indices. According to clinical stage, the patients were classified into 3 groups. Resistive indices were compared between controls and patient groups and correlated with age and renal function. RESULTS: In asymptomatic diabetic nephropathy, renal length and parenchymal thickness were significantly increased compared to that of controls, reflecting hyperfiltration-induced nephromegaly. Differences between controls and patients with clinically manifest nephropathy were insignificant; only in advanced renal disease were both values significantly decreased. Cortical hyperechogenicity was noted only in very advanced disease. Resistive indices correlated well with renal function, and pathologic values (i.e. > or = 0.70) were observed in 15% in the asymptomatic group and in 87% in the group with advanced nephropathy. CONCLUSION: Renal changes in diabetic patients are detectable by conventional ultrasound only in very advanced stages of the disease. Pathologic resistive indices, however, may be detected in the earlier stages. Resistive indices correlate with serum creatinine levels and creatinine clearance rates. However, it remains unclear as to whether a diagnostic or prognostic benefit can be expected as compared to standard laboratory examinations.


Asunto(s)
Nefropatías Diabéticas/diagnóstico por imagen , Ultrasonografía Doppler Dúplex , Ultrasonografía Doppler , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Nefropatías Diabéticas/fisiopatología , Femenino , Humanos , Riñón/fisiopatología , Masculino , Persona de Mediana Edad , Resistencia Vascular
17.
Eur J Clin Chem Clin Biochem ; 35(7): 517-21, 1997 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-9263727

RESUMEN

Copper-zinc superoxide dismutase (Cu,Zn-superoxide dismutase) activity was evaluated in lymphocytes and polymorphonuclear cells of insulin-dependent (n = 33) and non-insulin-dependent (n = 34) diabetic patients. A commercial method for the measurement of superoxide dismutase activity was adapted for use on a discrete analyser and evaluated for interference by other antioxidants with superoxide anion-scavenging properties. In comparison to healthy control subjects (n = 32), a significantly lower Cu,Zn-superoxide dismutase activity was found in both lymphocytes and polymorphonuclear cells of insulin-dependent (2.08 +/- 0.58 vs. 1.70 +/- 0.46 U/mg protein, p < 0.05, and 1.06 +/- 0.46 vs. 0.64 +/- 0.40 U/mg protein, p < 0.001, respectively) and non-insulin-dependent diabetic patients (2.08 +/- 0.58 vs. 1.61 +/- 0.48 U/mg protein, p < 0.01, and 1.06 +/- 0.46 vs. 0.53 +/- 0.24 U/mg protein, p < 0.001, respectively). There was a week, but significant negative correlation between age and Cu,Zn-superoxide dismutase activity in lymphocytes and polymorphonuclear cells (r = -0.22 and r = -0.28, p < 0.05, respectively), whereas no influence of gender, diabetes duration and glycaemic control was observed. The results indicate that diabetes mellitus could elicit a significant disturbance in superoxide anion-scavenging potential of lymphocytes and polymorphonuclear cells.


Asunto(s)
Diabetes Mellitus Tipo 1/enzimología , Diabetes Mellitus Tipo 2/enzimología , Linfocitos/enzimología , Neutrófilos/enzimología , Superóxido Dismutasa/sangre , Adulto , Envejecimiento/sangre , Antioxidantes/metabolismo , Análisis Químico de la Sangre/métodos , Estudios de Casos y Controles , Diabetes Mellitus Tipo 1/complicaciones , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/metabolismo , Femenino , Depuradores de Radicales Libres/sangre , Humanos , Masculino , Persona de Mediana Edad , Estrés Oxidativo
18.
Am J Ind Med ; 30(1): 62-6, 1996 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8837684

RESUMEN

Brainstem auditory evoked potentials (BAEPs) were examined in 49 workers employed in a printing press, who were occupationally exposed to low concentrations of toluene for an average of 20.3 years, and in 59 subjects in a control group. In the group of exposed workers, a significant decrease was found in all wave amplitudes examined, a significant prolongation of P1 wave latency, and an increased interval of interpeak latencies (P3-P5), indicating that the extramedullary and high medullary part of the auditory pathway are biologically most frequently affected by chronic exposure to low concentrations of toluene. The level of exposure to toluene in both groups was evaluated by defining the concentration of toluene in peripheral blood and the concentration of hippuric acid and ortho-cresol in urine.


Asunto(s)
Potenciales Evocados Auditivos del Tronco Encefálico/efectos de los fármacos , Exposición Profesional , Solventes/efectos adversos , Tolueno/efectos adversos , Adulto , Contaminantes Ocupacionales del Aire/efectos adversos , Contaminantes Ocupacionales del Aire/análisis , Vías Auditivas/efectos de los fármacos , Cresoles/orina , Hipuratos/orina , Humanos , Bulbo Raquídeo/efectos de los fármacos , Persona de Mediana Edad , Impresión , Tiempo de Reacción/efectos de los fármacos , Reproducibilidad de los Resultados , Solventes/análisis , Tolueno/análisis , Tolueno/sangre
19.
Nephron ; 84(1): 71-4, 2000 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-10644911

RESUMEN

Underlying malignancy has been thought to be responsible for 5-10% of the cases of membranous nephropathy in adults, with the risk being highest in patients over the age of 60 years. Solid tumors such as carcinomas of lung or colon, are most often involved. It is presumed that tumor antigens are deposited in the glomeruli; this is followed by antibody deposition and complement activation, leading to epithelial cell and basement membrane injury and proteinuria due to the associated increase in glomerular permeability. We describe a patient with a resistant nephrotic syndrome and massive proteinuria due to membranous nephropathy associated with pleural mesothelioma.


Asunto(s)
Glomerulonefritis Membranosa/etiología , Mesotelioma/complicaciones , Neoplasias Pleurales/complicaciones , Adulto , Anciano , Complejo Antígeno-Anticuerpo/metabolismo , Glomerulonefritis Membranosa/inmunología , Glomerulonefritis Membranosa/patología , Humanos , Masculino , Mesotelioma/inmunología , Persona de Mediana Edad , Síndrome Nefrótico/etiología , Neoplasias Pleurales/inmunología , Pronóstico , Proteinuria/etiología
20.
Acta Radiol ; 42(5): 477-81, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11552885

RESUMEN

PURPOSE: To evaluate the feasibility and efficacy of US-guided percutaneous ethanol injection (PEI) in the treatment of autonomous and toxic thyroid adenomas. MATERIAL AND METHODS: PEI was performed in 42 patients with solitary, scintigraphically "hot" nodules (n=37) or toxic nodular goiter (n=5). The nodular volume ranged from 2.5 to 38 cm3 (mean volume, 20.7+/-14.1 cm3). Ethanol was injected using a free-hand technique, usually in multiple sessions, using color and power Doppler US guidance. Treatment success was evaluated following 3-4 months after PEI by scintigraphy, hormonal status, and US findings. RESULTS: The procedure was technically successful in 39 patients (93%). Three patients were lost to follow-up. Minor complications were pain (all patients), subcutaneous hematoma (n=6), and transitory dysphonia (n=1). A complete cure was achieved in 22 patients (52%), and a partial cure in 10 patients (24%). In 4 cases (9%), the result was unsatisfactory since only moderate hormonal remission was observed. A satisfactory results was thus achieved in 32/42 patients (76%). Significant nodular volume reduction was observed in all cases. Better results were observed in smaller nodules and in cases of autonomous adenomas. There were no cases of recurrent hyperthyreosis. CONCLUSION: US-guided PEI is an efficient and safe method in the treatment of autonomous thyroid nodules and it enables inactivation of nodules with minimal or transitory complications.


Asunto(s)
Adenoma/terapia , Etanol/administración & dosificación , Neoplasias de la Tiroides/terapia , Adenoma/diagnóstico por imagen , Adulto , Anciano , Etanol/efectos adversos , Femenino , Bocio Nodular/terapia , Humanos , Inyecciones/métodos , Masculino , Persona de Mediana Edad , Cintigrafía , Neoplasias de la Tiroides/diagnóstico por imagen , Resultado del Tratamiento , Ultrasonografía Doppler en Color
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