Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Más filtros

Banco de datos
Tipo de estudio
País/Región como asunto
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
J Exp Med ; 220(5)2023 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-36880831

RESUMEN

X-linked recessive deficiency of TLR7, a MyD88- and IRAK-4-dependent endosomal ssRNA sensor, impairs SARS-CoV-2 recognition and type I IFN production in plasmacytoid dendritic cells (pDCs), thereby underlying hypoxemic COVID-19 pneumonia with high penetrance. We report 22 unvaccinated patients with autosomal recessive MyD88 or IRAK-4 deficiency infected with SARS-CoV-2 (mean age: 10.9 yr; 2 mo to 24 yr), originating from 17 kindreds from eight countries on three continents. 16 patients were hospitalized: six with moderate, four with severe, and six with critical pneumonia, one of whom died. The risk of hypoxemic pneumonia increased with age. The risk of invasive mechanical ventilation was also much greater than in age-matched controls from the general population (OR: 74.7, 95% CI: 26.8-207.8, P < 0.001). The patients' susceptibility to SARS-CoV-2 can be attributed to impaired TLR7-dependent type I IFN production by pDCs, which do not sense SARS-CoV-2 correctly. Patients with inherited MyD88 or IRAK-4 deficiency were long thought to be selectively vulnerable to pyogenic bacteria, but also have a high risk of hypoxemic COVID-19 pneumonia.


Asunto(s)
COVID-19 , Factor 88 de Diferenciación Mieloide , Niño , Humanos , Proteínas Adaptadoras Transductoras de Señales , COVID-19/complicaciones , Factor 88 de Diferenciación Mieloide/genética , SARS-CoV-2 , Receptor Toll-Like 7
2.
Diagn Microbiol Infect Dis ; 86(1): 58-60, 2016 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-27352730

RESUMEN

Molecular epidemiology allows us to know local HIV transmission and to design strategies of prevention. We studied 25 HIV newly diagnosed patients with the E138A mutation since the year 2010. Most transmission networks involved young and promiscuous men who have sex with men. Recent infection was only documented in patients grouped into the smaller clusters.


Asunto(s)
Infecciones por VIH/epidemiología , Infecciones por VIH/virología , Transcriptasa Inversa del VIH/genética , VIH/clasificación , VIH/genética , Mutación Missense , Adolescente , Adulto , Análisis por Conglomerados , Femenino , VIH/enzimología , VIH/aislamiento & purificación , Infecciones por VIH/transmisión , Humanos , Masculino , Persona de Mediana Edad , Epidemiología Molecular , España/epidemiología , Adulto Joven
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA