RESUMEN
Osteosarcopenia is a common condition among elderly and postmenopausal female patients. Site-specific bone mineral density is more predictive of bone-related complications. Few studies have investigated muscle-bone associations. Our results demonstrated that in women, significant positive associations between paraspinal muscles FCSA and vBMD exist at different lumbosacral levels. These regional differences should be considered when interpreting bone-muscle associations in the lumbar spine. INTRODUCTION: There is increasing evidence between bone and muscle volume associations. Previous studies have demonstrated comorbidity between osteoporosis and sarcopenia. Recent studies showed that sarcopenic subjects had a fourfold higher risk of concomitant osteoporosis compared to non-sarcopenic individuals. Although site-specific bone mineral density (BMD) assessments were reported to be more predictive of bone-related complications after spinal fusions than BMD assessments in general, there are few studies that have investigated level-specific bone-muscle interactions. The aim of this study is to investigate the associations between muscle functional cross-sectional area (FCSA) on magnetic resonance imaging (MRI) and site-specific quantitative computed tomography (QCT) volumetric bone mineral density (vBMD) in the lumbosacral region among spine surgery patients. METHODS: We retrospectively reviewed a prospective institutional database of posterior lumbar fusion patients. Patients with available MRI undergoing posterior lumbar fusion were included. Muscle measurements and FCSA were conducted and calculated utilizing a manual segmentation and custom-written program at the superior endplate of the L3-L5 vertebrae level. vBMD measurements were performed and calculated utilizing a QCT pro software at L1-L2 levels and bilateral sacral ala. We stratified by sex for all analyses. RESULTS: A total of 105 patients (mean age 61.5 years and 52.4% females) were included. We found that female patients had statistically significant lower muscle FCSA than male patients. After adjusting for age and body mass index (BMI), there were statistically significant positive associations between L1-L2 and S1 vBMD with L3 psoas FCSA as well as sacral ala vBMD with L3 posterior paraspinal and L5 psoas FCSA. These associations were not found in males. CONCLUSIONS: Our results demonstrated that in women, significant positive associations between the psoas and posterior paraspinal muscle FCSA and vBMD exist in different lumbosacral levels, which are independent of age and BMI. These regional differences should be considered when interpreting bone and muscle associations in the lumbar spine.
Asunto(s)
Región Lumbosacra , Osteoporosis , Femenino , Humanos , Masculino , Anciano , Persona de Mediana Edad , Densidad Ósea , Músculos Paraespinales/diagnóstico por imagen , Estudios Retrospectivos , Estudios Prospectivos , Tomografía Computarizada por Rayos X/métodos , Vértebras Lumbares/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Osteoporosis/diagnóstico por imagen , Osteoporosis/etiologíaRESUMEN
We investigated the effect of posterior lumbar fusion surgery on the regional volumetric bone mineral density (vBMD) measured by quantitative computed tomography. Surgery negatively affected the regional vBMD in adjacent levels. Interbody fusion was independently associated with vBMD decline and preoperative epidural steroid injections (ESIs) were associated with less postoperative vBMD decline. INTRODUCTION: Few studies investigate postoperative BMD changes after lumbar fusion surgery utilizing quantitative computed tomography (QCT). Additionally, it remains unclear what preoperative and operative factors contribute to postoperative BMD changes. The purpose of this study is to investigate the effect of lumbar fusion surgery on regional volumetric bone mineral density (vBMD) in adjacent vertebrae and to identify potential modifiers for postoperative BMD change. METHODS: The data of patients undergoing posterior lumbar fusion with available pre- and postoperative CTs were reviewed. The postoperative changes in vBMD in the vertebrae one or two levels above the upper instrumented vertebra (UIV+1, UIV+2) and one level below the lower instrumented vertebra (LIV+1) were analyzed. As potential contributing factors, history of ESI, and the presence of interbody fusion, as well as various demographic/surgical factors, were included. RESULTS: A total of 90 patients were included in the study analysis. Mean age (±SD) was 62.1 ± 11.7. Volumetric BMD (±SD) in UIV+1 was 115.4 ± 36.9 mg/cm3 preoperatively. The percent vBMD change in UIV+1 was - 10.5 ± 12.9% (p < 0.001). UIV+2 and LIV+1 vBMD changes showed similar trends. After adjusting with the interval between surgery and the secondary CT, non-Caucasian race, ESI, and interbody fusion were independent contributors to postoperative BMD change in UIV+1. CONCLUSIONS: Posterior lumbar fusion surgery negatively affected the regional vBMDs in adjacent levels. Interbody fusion was independently associated with vBMD decline. Preoperative ESIs were associated with less postoperative vBMD decline, which was most likely a result of a preoperative decrease in vBMD due to ESIs.
Asunto(s)
Densidad Ósea , Vértebras Lumbares/diagnóstico por imagen , Periodo Posoperatorio , Fusión Vertebral , Anciano , Humanos , Vértebras Lumbares/cirugía , Región Lumbosacra/cirugía , Persona de Mediana Edad , Fusión Vertebral/efectos adversos , Tomografía Computarizada por Rayos XRESUMEN
The cases of sixty patients in whom a burst fracture of a thoracic or lumbar vertebral body had been treated with posterior instrumentation and arthrodesis less than two weeks after the injury were retrospectively reviewed. Thirty of the patients had an associated laminar fracture. Eleven of the thirty, all of whom had a lumbar fracture and a preoperative neurological deficit, were noted at operation to have dural laceration. In four of the patients who had dural laceration, neural elements were entrapped between the fragments from the laminar fracture. None of the remaining thirty patients who did not have a laminar fracture had dural laceration (p = 0.0002). Univariate and multivariate statistical analysis revealed no significant association of the dural laceration with the patients' age or sex, or with the radiographic characteristics of the spine. There was a significant association between dural laceration and neurological deficit (p = 0.0001). In our series, the presence of a preoperative neurological deficit in a patient who had a burst fracture and an associated laminar fracture was a sensitive (100 per cent) and specific (74 per cent) predictor of dural laceration. The presence of this fracture pattern and an associated neurological deficit also predicted a risk of dural laceration with entrapped neural elements. This information may influence decisions as to whether an anterior or a posterior surgical approach should be used in such patients.
Asunto(s)
Duramadre/lesiones , Fracturas Óseas/diagnóstico por imagen , Vértebras Lumbares/lesiones , Vértebras Torácicas/lesiones , Adolescente , Adulto , Anciano , Femenino , Fracturas Óseas/complicaciones , Humanos , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Paraplejía/etiología , Radiografía , Estudios Retrospectivos , Vértebras Torácicas/diagnóstico por imagen , Vejiga Urinaria Neurogénica/etiologíaRESUMEN
Twelve patients who had a malignant tumor of the distal end of the femur were treated with a Van Nes tibial rotationplasty. The survival rates were comparable with those for above-the-knee amputees and patients who had an endoprosthetic replacement. The results of functional testing showed that these patients performed as well as those who had endoprosthetic replacement and better than those who had above-the-knee amputation. Rotationplasty is therefore a favorable alternative to amputation or endoprosthetic replacement, either as a primary or as a salvage procedure.
Asunto(s)
Neoplasias Femorales/cirugía , Tibia/cirugía , Adolescente , Amputación Quirúrgica , Miembros Artificiales , Niño , Preescolar , Femenino , Neoplasias Femorales/mortalidad , Neoplasias Femorales/fisiopatología , Estudios de Seguimiento , Marcha , Humanos , Pierna/cirugía , Masculino , Métodos , Consumo de Oxígeno , Prótesis e ImplantesRESUMEN
STUDY DESIGN: Retrospective review of a large series of patients who underwent spinal surgery at a single institution during a 10-year period. OBJECTIVES: To further clarify the frequency of incidental durotomy during spine surgery, its treatment, associated complications, and results of long-term clinical follow-up. SUMMARY OF BACKGROUND DATA: Incidental durotomy is a relatively common occurrence during spinal surgery. There remains significant concern about it despite reports of good associated clinical outcomes. There have been few large clinical series on the subject. METHODS: A retrospective review was conducted of clinical and surgical records and radiographic data for consecutive patients who underwent spinal surgery performed by the two senior surgeons from January 1989 through December 1998. RESULTS: A total of 2144 patients were reviewed, and 74 were found to have dural tears occurring during or before surgery. Incidental durotomy occurred at the time of surgery in 66 patients (3.1% overall incidence). Incidence varied according to the specific procedure performed but was highest in the group that underwent revision surgery. The incidence of clinically significant durotomies occurring during surgery but not identified at the time was 0.28%. All dural tears that occurred during surgery and were recognized (60 of 66) were repaired primarily. Pseudomeningoceles developed in five of the remaining six patients. All six patients had subsequent surgical repair of dural defects because of failure of conservative therapy. A mean follow-up of 22.4 months was available and showed good long-term clinical results for all patients. CONCLUSIONS: Incidental durotomy, if recognized and treated appropriately, does not lead to long-term sequelae.
Asunto(s)
Duramadre/lesiones , Complicaciones Intraoperatorias/epidemiología , Procedimientos Ortopédicos/efectos adversos , Columna Vertebral/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Duramadre/cirugía , Femenino , Cefalea/diagnóstico , Cefalea/etiología , Cefalea/cirugía , Humanos , Incidencia , Complicaciones Intraoperatorias/diagnóstico , Complicaciones Intraoperatorias/etiología , Masculino , Persona de Mediana Edad , Reoperación/estadística & datos numéricos , Estudios Retrospectivos , Infección de la Herida Quirúrgica/diagnóstico , Infección de la Herida Quirúrgica/tratamiento farmacológico , Infección de la Herida Quirúrgica/etiología , Resultado del TratamientoRESUMEN
Computer-assisted frameless stereotactic image guidance allows precise preoperative planning and intraoperative localisation of the image. It has been developed and tested in the laboratory. We evaluated the efficacy, clinical results and complications of placement of a pedicle screw in the lumbar spine using this technique. A total of 62 patients (28 men, 34 women) had lumbar decompression and spinal fusion with segmental pedicle screws. Postoperative CT scans were taken of 35 patients to investigate the placement of 330 screws. None showed penetration of the medial or inferior wall of a pedicle. Registration was carried out 66 times. The number of fiducial points used on each registration averaged 5.8 (4 to 7) The mean registration error was 0.75 mm (0.32 to 1.72). This technique provides a safe and reliable guide for placement of transpedicular screws in the lumbar spine.
Asunto(s)
Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Intensificación de Imagen Radiográfica/métodos , Fusión Vertebral/instrumentación , Técnicas Estereotáxicas , Adulto , Anciano , Anciano de 80 o más Años , Algoritmos , Tornillos Óseos/efectos adversos , Electromiografía , Femenino , Humanos , Inestabilidad de la Articulación/cirugía , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio , Reproducibilidad de los Resultados , Fusión Vertebral/métodos , Estenosis Espinal/cirugía , Tomografía Computarizada por Rayos XRESUMEN
Although a cure for spinal cord injuries does not currently exist, advances have been made in the field of spinal cord regeneration. This article discusses the pathophysiology of spinal cord injury, animal models, and strategies for restoration and regeneration of the spinal cord.
Asunto(s)
Regeneración Nerviosa/fisiología , Traumatismos de la Médula Espinal/fisiopatología , Animales , Axones/fisiología , Modelos Animales de Enfermedad , Humanos , Nervios Periféricos/trasplante , Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/terapiaRESUMEN
Controversy exists over the safety of performing one-stage bilateral total hip arthroplasty. A prospective protocol was established in 35 patients to evaluate the perioperative morbidity of one-stage bilateral arthroplasty as compared with unilateral controls. Although there was no increase in the frequency of respiratory morbidity in bilateral procedures, respiratory depression is common with both procedures. The authors believe this is consistent with varying degrees of the adult respiratory distress syndrome and that the term fat embolism syndrome is misleading and should be abandoned.
Asunto(s)
Artroplastia/métodos , Prótesis de Cadera , Hipoxia/fisiopatología , Complicaciones Intraoperatorias/fisiopatología , Adulto , Anciano , Enfermedad Coronaria/fisiopatología , Embolia Grasa/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Oxígeno/sangre , Estudios Prospectivos , Embolia Pulmonar/fisiopatología , Síndrome de Dificultad Respiratoria/fisiopatología , Factores de RiesgoRESUMEN
A current focus of treatment for degenerative disk disease is the restoration of the intervertebral disk. This article summarizes the structure and function of the intervertebral disk, the pathogenesis of its degeneration, and the clinical relevance of degenerative disk disease. Current literature relating to intervertebral disk replacement and regeneration is reviewed.
Asunto(s)
Técnicas de Cultivo , Disco Intervertebral/cirugía , Regeneración/fisiología , Enfermedades de la Columna Vertebral/cirugía , Trasplantes , Animales , Terapia Genética , Sustancias de Crecimiento/fisiología , Humanos , Disco Intervertebral/fisiopatología , Enfermedades de la Columna Vertebral/fisiopatologíaRESUMEN
Gene therapy is a novel therapeutic modality for repair and regeneration of musculoskeletal tissues, including the spine. Various methods for therapeutic gene transfer are presented in this article. Several studies in which gene transfer has been used specifically to enhance spine fusion in animal models are reviewed.
Asunto(s)
Terapia Genética/métodos , Fusión Vertebral/métodos , Factor de Crecimiento Transformador beta , Proteínas Adaptadoras Transductoras de Señales , Animales , Proteína Morfogenética Ósea 2 , Proteínas Morfogenéticas Óseas/genética , Proteínas Portadoras/genética , Proteínas del Citoesqueleto , Modelos Animales de Enfermedad , Técnicas de Transferencia de Gen , Humanos , Péptidos y Proteínas de Señalización Intracelular , Proteínas con Dominio LIMRESUMEN
Open injuries of the brachial plexus are rare. One such case, that of a 68-year-old impaled on a fence spike, is presented here. Certain principles to guide evaluation and treatment are discussed. Concomitant injury to the pleura or to vascular structures requires immediate attention; the extent and type of plexus damage may be determined from physical findings and the nature of injury. The results of plexus reconstruction are variable and routine exploration may be detrimental. The Brooks classification is reviewed.
Asunto(s)
Plexo Braquial/lesiones , Heridas Penetrantes/complicaciones , Anciano , Axila/lesiones , Plexo Braquial/cirugía , Humanos , Masculino , Enfermedades del Sistema Nervioso Periférico/etiología , Enfermedades del Sistema Nervioso Periférico/cirugía , Fracturas del Hombro/etiología , Heridas Penetrantes/cirugíaRESUMEN
There is a high incidence of cervical involvement in patients with rheumatoid disease. Early evaluation of the neck, close follow-up with dynamic radiographs of the cervical spine, and careful neurological assessment are important in the care of these patients. Surgical stabilization should be considered early even in the absence of neurological findings when significant instability is noted since outcome is related to preoperative neurological function. The type of fusion performed is determined by a careful assessment of the location of instability, patient factors, and the experience of the surgeon with various techniques. The type of postoperative immobilization should be decided on an individual basis depending on the quality of fixation achieved at surgery. Patients must be observed closely in the postoperative period for development of early complications and followed-up for the appearance of pseudarthrosis or late instabilities.
Asunto(s)
Artritis Reumatoide/cirugía , Artrodesis , Vértebras Cervicales , Artritis Reumatoide/diagnóstico por imagen , Artrodesis/métodos , Humanos , Radiografía , Enfermedades de la Columna Vertebral/cirugíaRESUMEN
The purpose of this study was to investigate the clinical predictors of surgical outcome in patients with cervical spondylotic myelopathy (CSM). We reviewed a consecutive series of 248 patients (71 women and 177 men) with CSM who had undergone surgery at our institution between January 2000 and October 2010. Their mean age was 59.0 years (16 to 86). Medical records, office notes, and operative reports were reviewed for data collection. Special attention was focused on pre-operative duration and severity as well as post-operative persistence of myelopathic symptoms. Disease severity was graded according to the Nurick classification. Our multivariate logistic regression model indicated that Nurick grade 2 CSM patients have the highest chance of complete symptom resolution (p < 0.001) and improvement to normal gait (p = 0.004) following surgery. Patients who did not improve after surgery had longer duration of myelopathic symptoms than those who did improve post-operatively (17.85 months (1 to 101) vs 11.21 months (1 to 69); p = 0.002). More advanced Nurick grades were not associated with a longer duration of symptoms (p = 0.906). Our data suggest that patients with Nurick grade 2 CSM are most likely to improve from surgery. The duration of myelopathic symptoms does not have an association with disease severity but is an independent prognostic indicator of surgical outcome.
Asunto(s)
Vértebras Cervicales/cirugía , Enfermedades de la Médula Espinal/cirugía , Espondilosis/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Recuperación de la Función , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto JovenAsunto(s)
Aneurisma Infectado/etiología , Enfermedades de la Aorta/etiología , Osteomielitis/complicaciones , Enfermedades de la Columna Vertebral/complicaciones , Anciano , Aneurisma Infectado/cirugía , Aorta Abdominal , Enfermedades de la Aorta/cirugía , Prótesis Vascular , Femenino , Humanos , Vértebras Lumbares/patología , Persona de Mediana EdadAsunto(s)
Laparoscopía/métodos , Prótesis e Implantes , Enfermedades de la Columna Vertebral/cirugía , Fusión Vertebral/instrumentación , Trasplante Óseo , Femenino , Humanos , Vértebras Lumbares/fisiopatología , Vértebras Lumbares/cirugía , Masculino , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Dimensión del Dolor , Pronóstico , Diseño de Prótesis , Sensibilidad y Especificidad , Enfermedades de la Columna Vertebral/diagnóstico , Fusión Vertebral/métodos , Trasplante Homólogo , Resultado del TratamientoRESUMEN
Eighteen patients with spinal deformity secondary to a neuromuscular disorder were treated with posterior fusion using Cotrel-Dubousset instrumentation (CDI) to the pelvis. The mean frontal plane curve was 70 degrees preoperatively and 38 degrees postoperatively. The mean loss of correction was 3 degrees at an average follow-up of 28 months. Pelvic obliquity improved in nine patients from a preoperative mean of 22 degrees to 11 degrees at follow-up. Lumbar lordosis was maintained with preoperative and postoperative means of -36 degrees. Complications included perioperative hardware failure in one case and one late, deep infection. There were no neurologic complications, pseudarthroses, or rod breakage. Posterior spinal fusion with CDI to the pelvis is an effective treatment for patients with neuromuscular scoliosis.
Asunto(s)
Cifosis/cirugía , Escoliosis/cirugía , Fusión Vertebral/métodos , Adolescente , Adulto , Femenino , Estudios de Seguimiento , Humanos , Fijadores Internos , Cifosis/etiología , Región Lumbosacra , Masculino , Enfermedades Neuromusculares/complicaciones , Huesos Pélvicos/cirugía , Falla de Prótesis , Escoliosis/etiología , Fusión Vertebral/instrumentaciónRESUMEN
Postoperative infection remains a troublesome but not uncommon complication after spinal surgery. Most previous reports, however, are small or involve cases with more than one surgeon often at different institutions. This study represents a single surgeon's 9-year experience with postoperative infection at one institution. The authors describe the features of wound infection after spinal surgery with reference to diagnosis, microbiology, and treatment and they describe a protocol for effective management of postoperative spinal wound infection. The records of the senior author (F.P.C.) during a 9-year period for cases of postoperative wound infection were reviewed. Of 2,391 operative procedures, 46 cases of wound infection were identified, yielding an overall infection rate of 1.9%. Patients' preoperative risk factors, original diagnosis prompting the surgery, onset of infection, presentation, treatment, and outcome were analyzed. The mean age of the 23 men and 23 women was 57.2 years. The preoperative diagnoses included lumbar degenerative scoliosis or spinal stenosis in 28 cases, disk prolapse in 8 cases, metastatic disease in 4 cases, degenerative disk disease in 1 case, and a group of 5 miscellaneous cases. Seventeen (37%) of the patients underwent at least one previous spinal surgery at the same site. Twenty-three patients had a fusion, of whom 22 also had instrumentation. Forty-three (93%) of the patients had significant wound drainage after an average of 15 days (range, 5-80 days). The other three patients were examined approximately 2 years after the surgery. Fourteen of the patients also had pyrexia (temperature >37.5 degrees C) at presentation. Staphylococcus aureus alone was cultured in 29 patients, whereas another six patients had a different single organism. In nine patients, more than one organism was cultured during their hospital stay. Surgical treatment included primary closure in only seven patients, with most undergoing wound drainage and debridement followed by delayed closure. Instruments were removed in the three patients with late presentation who had solid fusion at operation. Viable bone graft and instrumentation were left in situ in all patients who were seen before fusion. All wounds healed without sequelae, except for three that required flap closure. Pseudarthrosis was noted in three patients after more than 1 year of follow-up in this series. Postoperative spinal wound infection is a potentially devastating problem. In this series, infection was more common in patients undergoing fusion with instrumentation and in patients with cancer metastatic to the spine. An aggressive surgical approach, including repeated debridement followed by delayed closure, is justified. Instrumentation may be safely left in situ to provide stability for fusion.
Asunto(s)
Procedimientos Ortopédicos/efectos adversos , Enfermedades de la Columna Vertebral/cirugía , Columna Vertebral/microbiología , Columna Vertebral/cirugía , Infección de la Herida Quirúrgica/epidemiología , Discectomía/efectos adversos , Fijación de Fractura/efectos adversos , Humanos , Estudios Retrospectivos , Factores de Riesgo , Fusión Vertebral/efectos adversos , Columna Vertebral/patología , Infecciones Estafilocócicas/etiología , Infecciones Estafilocócicas/terapia , Resultado del TratamientoRESUMEN
Two hundred twenty-four consecutive patients underwent elective posterior lumbar spinal surgery over a 3 1/2-year span at the University of Miami/Jackson Memorial Medical Center. Patients ranged in age from 17 to 87 years, and 58% were male. Fifty-eight patients underwent revision surgery, and 65 patients required fusions, including 35 necessitating internal fixation. One hundred seventy-four patients (78%) were requested to participate in a preoperatively donated autologous blood (PDAB) program. Six of these patients were excluded from participation, and 168 patients banked 425 U of autologous blood. Eighty percent of the patients participating in the PDAB program received some or all of their donated blood. Intraoperative blood salvage was used in 37% of cases. Seven patients received homologous blood: four in addition to salvaged and donated blood, two that were unable to donate blood due to positive hepatitis B serology, and one erroneously. The combined use of PDAB and intraoperative salvage program allowed autologous blood replacement to meet the total transfusion requirements of 96% of the patients who predeposited blood, including 94% of those undergoing spinal fusions. Autologous blood comprised 99% of the total blood replacement used in this series, and 95% of the patients requiring blood transfusions received only autologous blood. Establishment of a protocol judiciously using PDAB in conjunction with intraoperative blood salvage can result in virtual elimination of the need for homologous blood transfusion in elective lumbar spine surgery.