A practical route for the highly stereoselective synthesis of tetrasubstituted fluoroalkenes.

A series of tetrasubstituted fluoroalkene derivatives were synthesized by the reaction of α-fluoro-ß-carbonyl benzothiazol-2-yl sulfones with various nucleophiles in good yields with high stereoselectivities. The predominant cis configuration of fluorine and alkynyl groups was observed. A single isomer was obtained when a ketone, acetate or amide was used as the substrate in the presence of a base.