RESUMEN
The title mol-ecule, C15H12ClNO, features a di-hydro-quinolin-4(1H)-one moiety attached to a chloro-benzene ring. The heterocyclic ring has a half-chair conformation with the methine C atom lying 0.574â (3)â Å above the plane of the five remaining atoms (r.m.s. deviation = 0.0240â Å). The dihedral angles between the terminal benzene rings is 77.53â (9)°, indicating a significant twist in the mol-ecule. In the crystal, supra-molecular zigzag chains along the c-axis direction are sustained by N-Hâ¯O hydrogen bonds. These are connected into double chains by C-Hâ¯π inter-actions.
RESUMEN
In the title mol-ecule, C16H15NO, the tetra-hydro-pyridine ring is in a sofa conformation with the methine C atom forming the flap. The dihedral angle between the benzene rings is 80.85â (8)°. In the crystal, mol-ecules are arranged in alternating double layers parallel to (100) and are connected along [001] by N-Hâ¯O hydrogen bonds. In addition, weak C-Hâ¯π inter-actions are observed.
RESUMEN
Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.
Asunto(s)
Antibacterianos/química , Antibacterianos/farmacología , Imidazoles/química , Imidazoles/farmacología , Antibacterianos/síntesis química , Cristalografía por Rayos X , Imidazoles/síntesis química , Pruebas de Sensibilidad Microbiana , Modelos Moleculares , Relación Estructura-ActividadRESUMEN
The crystal packing of the title compound, C(6)H(11)N(2)O(+)·I(-), can be described as inter-calated layers lying parallel to (010), with the iodide ions located between the cations. A weak intra-molecular C-Hâ¯O hydrogen bond occurs within the cation. In the crystal, inter-molecular O-Hâ¯I hydrogen bonds result in the formation of a three-dimensional network and reinforce the cohesion of the ionic structure.