Investigation and Analysis of Reference Intervals for Blood Cell Parameters in a Healthy Population from Daxingan Region Inner Mongolia.

BACKGROUND: Blood cell parameters in a healthy population of different ages and genders from the Daxingan region of Inner Mongolia were evaluated to establish reference intervals (RIs) for venous blood parameters for healthy individuals from this region. METHODS: Venous blood specimens were collected from 1757 healthy individuals aged 7-65 years and analyzed by an XE-5000 automated hematology analyzer. Results were statistically analyzed by gender and age group. RIs for venous blood parameters of children were compared to the National Clinical Laboratory Procedures and those of adults were compared to the Health Industry Standards of the People's Republic of China (WST405-2012). RESULTS: In the Daxingan region, WBC, RBC, MCV, and NEUT%, MONO%, and EO% of healthy children were significantly different between genders (p < 0.05). Other parameters were not significantly different (p > 0.05). All parameters of adults were significantly different between different genders (p < 0.05) except for LYMPH% and BASO%. Comparison of mean values between children and adults of the same gender revealed significant differences in each blood cell parameter (p < 0.05). RBC, MCV, MCH, MCHC, PLT, MONO%, and BASO% of adult men were significantly different between different age groups (p < 0.05), and HGB, HCT, and EO% of adult women were significantly different between different age groups (p < 0.05). For children, only the mean of MCHC and EO% were close to the National Clinical Laboratory Procedures. Mean of RBC, HGB, PLT, LYMPH%, and MONO% were higher and the remaining parameters were lower than the National Clinical Laboratory Procedures. Compared with WST405-2012 for adults, PLT of women aged 18-40 years and NEUT% of adults were higher, whereas the mean of EO% and BASO% were significantly lower. CONCLUSIONS: RIs for venous blood parameters change with age, geographic region, ethnic group, and gender. There is a great necessity to establish RIs for venous blood parameters among the healthy population in the Daxingan region.

Reference Intervals for Routine Blood Tests in 468 Healthy Mongolian Children.

BACKGROUND: To establish reference intervals for routine blood parameters of healthy Mongolian children in the Inner Mongolia Daxingan region. METHODS: Venous blood samples from 468 children aged 7 - 13 years were analyzed with a Sysmex XE-5000 Automated Hematology Analyzer. Statistical analysis was used to compare findings with the National Clinical Laboratory Procedures and to analyze according to gender and ethnic group. RESULTS: The reference range for each blood cell parameter is as follows: WBC (x 109/L): 3.44 - 9.27 for males, 3.79 - 9.79 for females; RBC (x 1012/L): 4.25 - 5.36 for males, 4.20 - 5.21 for females; HGB (g/L): 118 - 149. HCT (%): 34.9 - 43.4; MCV (fl): 75.1 - 88.2 for males, and 76.6 - 90.6 for females; MCH (pg): 25.5 - 30.3 for males, and 25.7 - 31.0 for females; MCHC (g/L): 327 - 356 for males, 323 - 353 for females; PLT (109): 109 - 209; NEUT %: 34.6 - 71.9; LYMPH %: 19.8 - 56.8; MONO %: 2.8 - 9.5 for males, and 3.1 - 7.9 for females; EO %: 0.0 - 3.6; BASO %: 0.0 - 1.0 for males, and 0.0 - 0.9 for females. There were significant differences between genders with respect to the WBC, RBC, MCV, MCH, MCHC, MONO %, and BASO % parameters (p < 0.05), but not other parameters (p > 0.05). CONCLUSIONS: The blood parameters of children can vary with geography, nationality, gender, and other variables. Therefore, it is necessary to obtain reference intervals for Mongolian children according to their gender and age.