Asunto(s)
Péptido C/sangre , Diabetes Mellitus/sangre , Péptidos/sangre , Adolescente , Adulto , Anciano , Glucemia/análisis , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , RadioinmunoensayoAsunto(s)
Anticuerpos Monoclonales , Endocrinología , Animales , Anticuerpos Monoclonales/inmunología , Especificidad de Anticuerpos , Enfermedades Autoinmunes/etiología , Enfermedades Autoinmunes/inmunología , Hormonas/metabolismo , Hormonas/fisiología , Humanos , Radioinmunoensayo/métodos , Receptores de Superficie Celular/biosíntesis , Receptores de Superficie Celular/inmunología , Relación Estructura-ActividadAsunto(s)
Glucemia/metabolismo , Grano Comestible , Fabaceae , Glucosa/farmacología , Insulina/sangre , Plantas Medicinales , Adulto , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
AIMS/HYPOTHESIS: Rates of vascular complications of diabetes in a cohort of mainland Chinese patients with diabetes, ascertained and examined by similar methodology, are compared with those of the WHO Multinational Study of Vascular Disease in Diabetes (WHO MSVDD). METHODS: The standardised procedures carried out in the WHO MSVDD were followed in assembling and examining a Chinese cohort of 447 diabetic patients recruited in Beijing and Tianjin [2]. RESULTS: Compared with the WHO MSVDD centres, the Chinese cohort was slightly older, had a shorter duration of known diabetes and had fewer insulin-treated patients. Arterial pressure, total blood cholesterol and body mass index were substantially lower. Large vessel disease rate for age, sex and duration adjusted data (17.9 % ) was about half that of the combined WHO MSVDD centres (33.5 % p < 0.001). However, retinopathy (47.4% vs 35.8% p < 0.001) and proteinuria (57.1 vs 24.9 % p < 0.001) rates were significantly higher. CONCLUSION/INTERPRETATION: Relatively low arterial pressures and blood cholesterol are likely contributors to the notably low arterial disease rates in this Chinese diabetic cohort; they reflect low rates in the Chinese mainland general population and resemble the Tokyo and Hong Kong centres of the WHO MSVDD. The high rates of retinopathy and proteinuria could relate to later diagnosis, degree of hyperglycaemia and/or increased susceptibiltiy to microangiopathy.
Asunto(s)
Angiopatías Diabéticas/epidemiología , Organización Mundial de la Salud , Adulto , Amputación Quirúrgica/estadística & datos numéricos , Angina de Pecho/epidemiología , Presión Sanguínea , Índice de Masa Corporal , China/epidemiología , Colesterol/sangre , Estudios de Cohortes , Angiopatías Diabéticas/fisiopatología , Retinopatía Diabética/epidemiología , Electrocardiografía , Femenino , Humanos , Cooperación Internacional , Pierna/cirugía , Masculino , Persona de Mediana Edad , Infarto del Miocardio/epidemiología , Proteinuria/epidemiología , Factores de Riesgo , Accidente Cerebrovascular/epidemiologíaRESUMEN
A new technique for the determination of the serum level of thyroid stimulating immunoglobulins (TSI) is described. TSI may be detected by measuring cyclic AMP increases in cultures of isolated thyroid epithelial cells in response to added normal or patient's serum. Our results showed that the serum level in the normal control group was mostly lower than 110%, however, in 9.1% of normal human sera, TSI showed a positive result. In abnormal position, activity of TSI was higher than 110% of the rate of the normal control group. The positive result was 86% and the serum TSI levels were 270 +/- 176.6% in patients with Graves' disease before receiving antithyroid drug. After treatment with antithyroid drugs from one to thirty months, the positive results dropped to 35% and the serum TSI level decreased to 117.0 +/- 113%, which was significantly lower than that in untreated patients. In conclusion, TSI can be detected in the majority of the sera in patients with Graves' disease using this technique. It is helpful to the diagnosis and treatment of the Graves' disease.