Impact of intravenous accessibility and prehospital epinephrine use on survival outcomes of adult nontraumatic out-of-hospital cardiac arrest patients.

BACKGROUND: This study compared out-of-hospital cardiac arrest (OHCA) patient outcomes based on intravenous (IV) access and prehospital epinephrine use. METHODS: A retrospective study in Ulsan, South Korea, from January 2017 to December 2022, analyzed adult nontraumatic OHCA cases. Patients were grouped: Group 1 (no IV attempts), Group 2 (failed IV access), Group 3 (successful IV access without epinephrine), and Group 4 (successful IV access with epinephrine), with comparisons using logistic regression analysis. RESULTS: Among 2,656 patients, Group 4 had significantly lower survival to hospital discharge (adjusted OR 0.520, 95% CI 0.346-0.782, p = 0.002) and favorable neurological outcomes (adjusted OR 0.292, 95% CI 0.140-0.611, p = 0.001) than Group 1. Groups 2 and 3 showed insignificant survival to hospital discharge (adjusted OR 0.814, 95% CI 0.566-1.171, p = 0.268) and (adjusted OR 1.069, 95% CI 0.810-1.412, p = 0.636) and favorable neurological outcomes (adjusted OR 0.585, 95% CI 0.299-1.144, p = 0.117) and (adjusted OR 1.075, 95% CI 0.689-1.677, p = 0.751). In the shockable rhythm group, Group 3 had better survival to hospital discharge (adjusted OR 1.700, 95% CI 1.044-2.770, p = 0.033). CONCLUSIONS: Successful IV access with epinephrine showed worse outcomes in both rhythm groups than no IV attempts. Outcomes for failed IV and successful IV access without epinephrine were inconclusive. Importantly, successful IV access without epinephrine showed favorable survival to hospital discharge in the shockable rhythm group, warranting further research into IV access for fluid resuscitation in shockable rhythm OHCA patients.

Effect of Anchor-Guiding Sleeve Length on the Accuracy of Computer-Guided Flapless Implant Surgery.

The objective of this study was to evaluate the effect of anchor-guiding sleeve length on the accuracy of computer-guided flapless implant surgery in edentulous cases. Twelve identical polyurethane edentulous mandibular models were equally divided into short and long anchor-guiding sleeve groups based on the type of anchor-guiding sleeve. After implant placement and scan body connections, digital impressions were taken using the intraoral scanner. Using the software's measurement function, the deviation parameters between the planned and actual position of the placed implants were calculated and compared using the Mann-Whitney U test. In the short anchor-guiding sleeve group, the median angular deviation was 4.05° (range, 2.87°-7.55°). The median linear deviation was 1.17 mm (range, 0.24-2.17 mm) for the implant apex and 0.82 mm (range, 0.43-1.67 mm) for the implant shoulder. The median deviation of the depth was 0.31 mm (range, 0.20-0.79 mm). In the long anchor-guiding sleeve group, the median angular deviation was 2.70° (range, 1.77°-4.08°). The median linear deviation was 0.88 mm (range, 0.21-1.77 mm) for the implant apex and 0.63 mm (range, 0.11-1.97 mm) for the implant shoulder. The median deviation of the depth was 0.24 mm (range, 0.09-0.53 mm). There were significant differences between the 2 groups in the angular and linear deviations at the implant apex and the shoulder and depth deviation. The accuracy of the muco-supported surgical guide was improved using the long anchor-guiding sleeve, thus providing more accurate flapless implant placement in edentulous models. However, model experiments do not always produce predictable and possible uncontrolled cause-and-effect outcomes under natural clinical conditions. Therefore, further in vivo investigations are required to determine whether the results of this study are consistent with clinical findings.

The Comparison of Emergency Medical Service Responses to and Outcomes of Out-of-hospital Cardiac Arrest before and during the COVID-19 Pandemic in an Area of Korea.

BACKGROUND: Since the declaration of the coronavirus disease 2019 (COVID-19) pandemic, COVID-19 has affected the responses of emergency medical service (EMS) systems to cases of out-of-hospital cardiac arrest (OHCA). The purpose of this study was to identify the impact of the COVID-19 pandemic on EMS responses to and outcomes of adult OHCA in an area of South Korea. METHODS: This was a retrospective observational study of adult OHCA patients attended by EMS providers comparing the EMS responses to and outcomes of adult OHCA during the COVID-19 pandemic to those during the pre-COVID-19 period. Propensity score matching was used to compare the survival rates, and logistic regression analysis was used to assess the impact of the COVID-19 pandemic on the survival of OHCA patients. RESULTS: A total of 891 patients in the pre-COVID-19 group and 1,063 patients in the COVID-19 group were included in the final analysis. During the COVID-19 period, the EMS call time was shifted to a later time period (16:00-24:00, P < 0.001), and the presence of an initial shockable rhythm was increased (pre-COVID-19 vs. COVID-19, 7.97% vs. 11.95%, P = 0.004). The number of tracheal intubations decreased (5.27% vs. 1.22%, P < 0.001), and the use of mechanical chest compression devices (30.53% vs. 44.59%, P < 0.001) and EMS response time (median [quartile 1-quartile 3], 7 [5-10] vs. 8 [6-11], P < 0.001) increased. After propensity score matching, the survival at admission rate (22.52% vs. 18.24%, P = 0.025), survival to discharge rate (7.77% vs. 5.52%, P = 0.056), and favorable neurological outcome (5.97% vs. 3.49%, P < 0.001) decreased. In the propensity score matching analysis of the impact of COVID-19, odds ratios of 0.768 (95% confidence interval [CI], 0.592-0.995) for survival at admission and 0.693 (95% CI, 0.446-1.077) for survival to discharge were found. CONCLUSION: During the COVID-19 period, there were significant changes in the EMS responses to OHCA. These changes are considered to be partly due to social distancing measures. As a result, the proportion of patients with an initial shockable rhythm in the COVID-19 period was greater than that in the pre-COVID-19 period, but the final survival rate and favorable neurological outcome were lower.

Digital workflow for fabricating a verification device for an all-on-4 abutment: A dental technique.

The all-on-4 implant concept has been used to overcome anatomic limitations and has been reported to have high success rates. A verification device is commonly used to transfer the position of the angled distal abutment accurately. This article describes a digital workflow for fabricating a verification device to position the angled distal abutment with a hexagon connection during computer-guided flapless surgery.

Natural Bone Healing In Compromised Sockets After Tooth Extraction: Digital Measurement Methods With Cone-Beam Computed Tomography.

This study aimed to evaluate bone regeneration within infected extraction sockets with bone defects using cone-beam computed tomography (CBCT) at a 1-year follow-up after implant placement in a prosthetically driven implant position. Forty-eight patients requiring premolar or molar tooth extraction due to bone defects caused by periodontal diseases were included. Vertical and horizontal bone volumes were assessed by overlapping the CBCT scan images with the full digital process. At 1-year post-extraction, a prosthetically-driven implant was planned using virtual implant planning software. At 1 year after extraction, CBCT revealed significant horizontal and vertical bone gains; an overall mean buccolingual bone width gain of 5.46 ± 2.87 mm, and an overall mean vertical bone gain of 0.27 ± 1.28 mm for the lingual bone plate level and 3.50 ± 1.81 mm for the buccal bone plate level were observed. Except for 4 (out of 48) sites, implants were virtually positioned in the center of the edentulous spaces. In summary, despite the dimensional changes after tooth extraction in compromised posterior sockets, there was sufficient bone for placing an implant using the prosthetically driven approach.

Digital workflow for fabricating an overdenture by using an implant surgical template and intraoral scanner.

Implant-supported overdentures can significantly increase function and satisfaction during the first year and can last for 5 to 10 years. The 2-implant-supported mandibular overdenture is recommended as a standard treatment for edentulous patients. In the recent years, studies have reported the use of digital complete dentures. However, as a modified technique for complete dentures, few studies have evaluated the use of digital techniques in the fabrication of overdentures. The purpose of this article was to introduce a digital workflow for fabricating overdentures by using information from the existing dentures.

Stress Distribution on the Prosthetic Screws in the All-on-4 Concept: A Three-Dimensional Finite Element Analysis.

The all-on-4 concept, which is used to rehabilitate edentulous patients, can present with mechanical complications such as screw loosening and fracture. The purpose of this study was to evaluate the stress patterns induced in the prosthetic screws by the different prosthetic screw and abutment designs in the all-on-4 concept using finite element analysis. Von Mises stress values on 6 groups of each screw type, including short and narrow screw, short abutment; short and wide screw, short abutment; long and wide screw, short abutment; short and narrow screw, long abutment; short and wide screw, long abutment; and long and wide screw, long abutment, were compared under a cantilever loading of 200 N that was applied on the farther posterior to the position of the connection between the distal implant and the metal framework. Posterior prosthetic screws showed higher stress values than anterior prosthetic screws. The stress values in posterior prosthetic screws decreased as the length and diameter increased. In conclusion, the long and wide screw design offers advantages in stress distribution when compared with the short and narrow design.

A digital technique for fabricating an interim implant-supported fixed prosthesis immediately after implant placement in patients with complete edentulism.

The conversion of a denture into an interim implant-supported, screw-retained restoration has become the standard method for immediate interim restoration in patients with complete edentulism. The most critical steps of the denture conversion process are the creation of appropriate denture access holes to prevent displacement of the denture by the interim cylinders and removal of the denture flanges to facilitate both good esthetics and accessibility for oral hygiene after the denture is connected to the interim cylinders. This article presents a digital technique for designing and fabricating an interim implant-supported, fixed prosthesis for edentulous patients. The interim prosthesis has cylinder access holes that are digitally prefabricated and a denture flange part that is designed to be easily sectioned. This technique facilitates more straightforward and efficient immediate restoration for edentulous patients after implant placement.

Accuracy of computer-guided implant placement in anterior regions.

STATEMENT OF PROBLEM: Implant placement in the anterior regions is often challenging because of limited space and bone volume availability. PURPOSE: The purpose of this clinical study was to investigate the accuracy of computer-guided surgery with a long drill key to place implants in the anterior regions. MATERIAL AND METHODS: Computer-guided implant surgery was performed for 32 participants requiring implants in anterior regions. The procedure involved using a 12-mm-long drill key to guide the 2.0-mm-diameter drill. Deviations between the planned and actual implant positions were evaluated by using cone beam computed tomography (CBCT) scans obtained before and after surgery. A t test was used for comparisons between the planned and placed implants and to determine the influence of the arch (maxilla/mandible) and time (immediate/delayed) on accuracy. RESULTS: A total of 40 implants (20 implants in the maxilla and 20 implants in the mandible) were placed. The mean linear deviation was 0.46 mm (range, 0 to 1.15 mm) for the implant shoulder and 0.67 mm (range, 0.14 to 1.19 mm) for the implant apex. The mean angular deviation was 1.40 degrees (range, 0.30 to 2.57 degrees). The mean depth deviation was 0.15 mm (range, 0.10 to 0.82 mm). CONCLUSIONS: This clinical study showed that the accuracy of computer-guided implant placement may be enhanced by using a long drill key and may thus enable more accurate implant placement in anterior regions.

Digital Workflow for Computer-Guided Implant Surgery in Edentulous Patients with an Intraoral Scanner and Old Complete Denture.

A double-scan procedure is commonly performed in the process of fabricating an implant surgical template; however, this entails the disadvantage of recording 2 cone beam computed tomography (CBCT) scans requiring additional time, effort, and costs. The purpose of this article is to introduce a digital protocol to acquire adequate preoperative diagnostic information for a fully edentulous patient, using the existing complete denture with a metal framework, an intraoral scanner, and CBCT.

A Technique for Digital Impression and Bite Registration for a Single Edentulous Arch.

Few studies have reported the application of digital technology for the process of impression and interocclusal recordings in edentulous patients. This article describes a digitizing system for generating digital edentulous models with a jaw relationship by taking direct digital impressions and a virtual bite registration using intraoral digital scanning. A specialized scan retractor was used to make digital impressions of edentulous jaws in patients' mouths using an intraoral scanner. Virtual bite registration was obtained with optical scanning of the buccal surfaces of both jaws at the occlusal vertical dimension. The registration was then used as a reference for aligning both jaws. Digital edentulous models that include the jaw relationship would be clinically beneficial for the fabrication of complete dentures in edentulous patients.

Crestal Sinus Augmentation in the Presence of Severe Sinus Mucosal Thickening: A Report of 3 Cases.

PURPOSE: In the presence of severe sinus mucosal thickening, the ostium can be blocked when the sinus membrane is lifted, causing drainage disturbances and sinusitis. Here, we present 3 cases in which maxillary sinus floor elevation was performed using a crestal approach in the presence of severe sinus mucosal thickening (>10 mm). MATERIALS AND METHODS: The effects of maxillary sinus floor elevation using the crestal approach technique on sinus mucosal thickening and bone formation in the sinus were evaluated using cone beam computed tomography. RESULTS: None of the patients exhibited an increase in sinus membrane thickness. No complications were encountered during the follow-up periods, and bone formation was observed around the implants at the sinus floor. All implants were functioning successfully. CONCLUSIONS: Maxillary sinus floor elevation using the crestal approach technique in the presence of severe sinus mucosal thickening allows for minimally invasive sinus grafting and simultaneous implant placement and does not increase sinus membrane thickness.

Digital immediate denture: A clinical report.

Fabricating an immediate complete denture in the conventional manner may be complicated and difficult. The purpose of this article was to describe a fully digital workflow used to fabricate an immediate complete denture before removing the teeth and without the use of conventional impressions or stone casts. The digital data for the workflow were acquired using an intraoral scanner and were then used to design the denture base and teeth after deleting any remaining tooth images from the virtual 3-dimensional image of the jaw. The resulting data were exported to a milling machine for denture fabrication.

Digital intraoral scanning technique for edentulous jaws.

Few studies have evaluated direct digital scans of edentulous jaws using intraoral scanners because it is difficult to scan edentulous sites that are smooth and devoid of features. A scanning technique is introduced for making direct digital scans of edentulous jaws with intraoral scanners in patients with a broad palate.

A CAD-CAM technique for conversion of interim-to-definitive restoration in patients with complete edentulism.

An interim restoration is a prototype for the definitive prosthesis and preserves the occlusal information and the original vertical dimension of the occlusion. Several techniques have been developed to transfer the information from implant-supported fixed interim to definitive restoration. However, these conventional techniques have limitations, and they are time-consuming, require making impressions and stone casts, and mounting in an articulator. The purpose of this article was to describe a digital technique to accurately transfer the information from complete-arch implant interim restoration to definitive restorations without using definitive casts.

Digital Workflow for Computer-Guided Implant Surgery in Edentulous Patients: A Case Report.

PURPOSE: The purpose of this article was to describe a fully digital workflow used to perform computer-guided flapless implant placement in an edentulous patient without the use of conventional impressions, models, or a radiographic guide. MATERIALS AND METHODS: Digital data for the workflow were acquired using an intraoral scanner and cone-beam computed tomography (CBCT). The image fusion of the intraoral scan data and CBCT data was performed by matching resin markers placed in the patient's mouth. RESULTS: The definitive digital data were used to design a prosthetically driven implant position, surgical template, and computer-aided design and computer-aided manufacturing fabricated fixed dental prosthesis. CONCLUSION: The authors believe this is the first published case describing such a technique in computer-guided flapless implant surgery for edentulous patients.

Removal of Supernumerary Teeth Utilizing a Computer-Aided Design/Computer-Aided Manufacturing Surgical Guide.

Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery. This report describes 2 cases of removal of a mesiodens-1 from a child and 1 from an adolescent-using a surgical guide; these would have been difficult to remove with conventional surgical methods.

Feasibility and Safety of Mild Therapeutic Hypothermia in Poor-Grade Subarachnoid Hemorrhage: Prospective Pilot Study.

Therapeutic hypothermia (TH) improves the neurological outcome in patients after cardiac arrest and neonatal hypoxic brain injury. We studied the safety and feasibility of mild TH in patients with poor-grade subarachnoid hemorrhage (SAH) after successful treatment. Patients were allocated randomly to either the TH group (34.5°C) or control group after successful clipping or coil embolization. Eleven patients received TH for 48 hours followed by 48 hours of slow rewarming. Vasospasm, delayed cerebral ischemia (DCI), functional outcome, mortality, and safety profiles were compared between groups. We enrolled 22 patients with poor-grade SAH (Hunt & Hess Scale 4, 5 and modified Fisher Scale 3, 4). In the TH group, 10 of 11 (90.9%) patients had a core body temperature of < 36°C for > 95% of the 48-hour treatment period. Fewer patients in the TH than control group (n = 11, each) had symptomatic vasospasms (18.1% vs. 36.4%, respectively) and DCI (36.3% vs. 45.6%, respectively), but these differences were not statistically significant. At 3 months, 54.5% of the TH group had a good-to-moderate functional outcome (0-3 on the modified Rankin Scale [mRS]) compared with 9.0% in the control group (P = 0.089). Mortality at 1 month was 36.3% in the control group compared with 0.0% in the TH group (P = 0.090). Mild TH is feasible and can be safely used in patients with poor-grade SAH. Additionally, it may reduce the risk of vasospasm and DCI, improving the functional outcomes and reducing mortality. A larger randomized controlled trial is warranted.

Crestal Sinus Augmentation in the Presence of an Antral Pseudocyst.

PURPOSE: Antral pseudocysts classically have a well-defined, hyperdense, unilocular, dome-shaped appearance in radiographs. The best therapeutic approach for treating these cysts in the context of sinus floor augmentation remains controversial. This article presents a new technique that allows both sinus membrane elevation and cyst removal through a crestal approach in patients with pseudocysts in the maxillary sinus. MATERIALS AND METHODS: The technique combined aspiration of the cysts during sinus floor elevation with a sinus augmentation procedure using a hydraulic sinus elevation system. Aspiration of the cyst fluid was performed through the crestal osteotomy site after sinus floor elevation. RESULTS: Two patients showed a significant amount of bone formation around the implant at the sinus floor without evidence of a recurrent cyst after the procedure. CONCLUSIONS: The technique allows the minimally invasive removal of antral pseudocysts at the time of sinus grafting and simultaneous implant placement, preserving the integrity of the sinus membrane.

Titanium-Silver Alloy Miniplates for Mandibular Fixation: In Vitro and In Vivo Study.

PURPOSE: Titanium (Ti) alloys have received considerable attention as materials for oral and maxillofacial surgery, which require high mechanical strength, osteosynthesis, and biocompatibility. The objective was to implant miniplates fabricated from commercially pure Ti (CP Ti) and newly developed Ti-silver (Ag) alloy in fractured mandibles of adult dogs after preliminary mechanical and biological characterization. MATERIALS AND METHODS: The surface characteristics, biocompatibility, and pre-osteoblast adhesion and proliferation of CP Ti (grade 3) and Ti-Ag (2 at% Ag) alloys were evaluated. Next, the bending strength of 6- and 8-hole miniplates fabricated from CP Ti and Ti-Ag was compared according to ISO (International Organization for Standardization) 9585. Six-hole miniplates were implanted for 12 weeks in fractured mandibles of adult dogs. The Ag ion concentration in each alloy and implanted bone block with soft tissue was measured by inductively coupled plasma mass spectroscopy after euthanasia according to ISO 10993-12. RESULTS: Precipitated Ag was detected in Ti-Ag by alpha- and beta-phase Ti in x-ray powder diffraction. The biocompatibility with pre-osteoblasts of Ti-Ag and CP Ti was comparable in terms of cytotoxicity, cell adhesion, and proliferation (P > .05). Ti-Ag miniplates had up to 3-fold greater bending strength than CP Ti miniplates (P < .05). An in vivo study showed that CP Ti and Ti-Ag miniplates had comparable soft and hard tissue regeneration ability (P > .05). Ag ions were detected in Ti-Ag alloys and applied mandible blocks. CONCLUSIONS: The results of this study suggest that Ti-Ag alloys can be used to produce miniplates with high mechanical properties, as well as considerable biocompatibility, osteosynthesis ability, and Ag ion-release properties. Further studies, including preclinical investigations, are required to enable clinical use of Ti-Ag bone plates.