EEG studies of two multiple personalities and a control.

There are few reports of EEG findings in patients with multiple personalities. In our study, EEGs were visually scanned and frequency analyzed in two patients with multiple personalities and one control. Auditory and visual evoked responses were also obtained from one of the patients and the control. The visually scanned EEGs and the evoked responses demonstrated few differences among the various personalities in each patient, whereas the frequency analysis showed the greatest number of significant differences among the "personalities" in the control. These data suggest that EEG differences among personalities in a person with multiple personalities involve intensity of concentration, mood changes, degree of muscle tension, and duration of recording, rather than some inherent difference between the brains of persons with multiple personalities and those of normal persons.

Effect of indomethacin on preovulatory changes in the ultrastructure of rabbit Graafian follicles.

This investigation uses electron microscopy to examine the effect of prostaglandins on follicular tissue during the ovulatory process. The ultrastructure of follicles from indomethacin-treated rabbits was compared to the ultrastructure of normal ovulatory follicles in order to determine the morphological differences between follicles with negligible and normal prostaglandin synthesis, respectively. The most obvious difference between the two groups of follicles was that the tissue at the apex of normal follicles began to thin out significantly by 9 h post coitus (near the time of ovulation), whereas the follicles from indomethacin-treated animals showed no signs of thinning, even as late as 12 h post coitus. It appeared that the fibroblasts in the follicles with limited prostaglandin synthesis failed to undergo the normal ovulatory transformation from a quiescent to a proliferative state. Otherwise, the prostaglandin-deficient follicles had a number of morphological features similar to those which usually occur in ovulatory tissue. There was detectable loosening of the connective tissue elements and some indication of edema at the apex of the mature follicles. Also, granulocytes became localized in the vascular compartment of these follicles. In addition, there tended to be an increase in the multivesicular structures which protrude from the fibroblasts, as well as an increase in the dense granules which accumulate in the cytoplasm of the surface epithelial cells. Collectively, these data suggest that normal prostaglandin synthesis in ovulatory follicles may be important in the connective tissue decomposition and ultimate thinning of the follicle wall.

Validity of the Dissociative Experiences Scale in screening for multiple personality disorder: a multicenter study.

OBJECTIVE: The Dissociative Experiences Scale has proved a reliable and valid instrument to measure dissociation in many groups, but its capacity to distinguish patients with multiple personality disorder from patients with other psychiatric disorders has not yet been conclusively tested. METHOD: A discriminant analysis was performed to classify 1,051 subjects as having or not having multiple personality disorder. Another discriminant analysis was performed on a subgroup of 883 subjects more closely representing patients in a typical psychiatric facility in terms of base rates of dissociative disorders. A cutoff score of 30 was also used to classify subjects, and Bayes's theorem, which allows for the calculation of the positive predictive value and the negative predictive value of a screening test, was applied. RESULTS: According to discriminant analysis of the total study group, the scale's sensitivity was 76% and its specificity was also 76%; according to discriminant analysis of the more representative subgroup, the scale's sensitivity was 76% and its specificity was 85%. Use of the cutoff score of 30 produced similar results. Results of the application of Bayes's theorem showed that 17% of the subjects scoring 30 or higher would actually have multiple personality disorder and 99% of those scoring less than 30 would not have multiple personality disorder. CONCLUSIONS: These results indicate that the Dissociative Experiences Scale performs quite well as a screening instrument to identify subjects with multiple personality disorder. In addition, the consistency of responses to scale items across centers indicates that the symptoms reported by patients with multiple personality disorder are highly similar across diverse geographic centers. This consistency supports the reliability and validity of the diagnosis of multiple personality disorder across centers.

Multiple personality: diagnostic considerations.

Multiple personality is a syndrome characterized by 2 or more alternating personality states and amnesia. Multiple personality must be differentiated from fugue, possession syndromes, mediumships, hysterical personality, schizophrenia, hypnotic states, organic brain syndrome and simulation. A review of the literature, discussion of diagnosis, and 4 illustrative cases are presented.

Psychosexual disturbances in multiple personality: characteristics, etiology, and treatment.

In a series of 20 patients with multiple personality, there was a 75% incidence of sexual abuse and a 55% incidence of physical abuse during childhood. Six of the 17 female patients (35%) had been raped in adolescence or adulthood. Patients were matched for age and sex with a nondissociative disorder control group. Although 55% of the multiple personality group had psychosexual disturbances, this was just barely significant when compared with the control group. Multiple personality appears to be an adaptive response to various traumata and enables the individual superficially to function sexually because sexual functioning is often dissociated and managed by an alternate personality.

The differential diagnosis of multiple personality. A comprehensive review.

This review offers guidelines for the diagnosis of multiple personality disorder and other dissociative disorders and presents diagnostic criteria for psychotic disorders, factitious disorders, affective disorders, anxiety disorders, psychosexual disorders, and others that may or may not coexist with multiple personalities.

Iatrogenesis and malingering of multiple personality disorder in the forensic evaluation of homicide defendants.

In this article I have addressed the possibility of iatrogenesis and/or malingering of MPD in 19 individuals who were charged with homicide. Due to the fragmentary nature of most of these case reports, it is not possible to state definitively who had genuine MPD and who did not. There is a strong possibility that a substantial proportion were malingering, however, because of their rather atypical presentations. Data from other sources suggest that the use of hypnosis in individuals accused of homicide may iatrogenically produce MPD-like phenomena when coupled with the defendant's desire to escape criminal responsibility. Finally, I have offered guidelines for the forensic evaluation of homicide defendants in whom MPD is suspected. Although hypnosis should generally be avoided in such defendants if it is used, rather strict guidelines should be followed. Clinicians using hypnosis with such individuals should be forewarned that such use will be strongly challenged in court and could pose an extreme threat to the defense position.

The dissociative disorders. Rarely considered and underdiagnosed.

A wide variety of dissociative disorders, including dissociative amnesia, dissociative fugue, depersonalization disorder, dissociative identity disorder, and various forms of dissociative disorder not otherwise specified. In many instances, these disorders are either underdiagnosed or misdiagnosed secondary to the clinician's mistaken belief that dissociative disorders are rare. Recent research shows that dissociative disorders may comprise 5% to 10% of psychiatric populations. This article reviews the epidemiology and clinical symptomatology of these disorders. In addition, various screening and diagnostic instruments, such as the DES, Structured Clinical Interview for Dissociative Disorders, and MMPI, are discussed.

Post-traumatic aspects of the treatment of victims of sexual abuse and incest.

This study assesses the frequency of childhood abuse and adult traumatization and the presence of symptomatology of post-traumatic stress and dissociation across different DSM-III diagnostic categories including affective disorder, schizophrenia, eating disorders, PTSD, borderline personality disorder, and multiple personality disorder. Findings revealed high levels of child abuse among patients with dissociative disorder and borderline personality disorder. The patients with dissociative disorders were found to have an increased incidence of rape and wife battery in adulthood. Patients with dissociative and post-traumatic stress disorders were found to experience similar symptomatology. The findings from this study highlight the need to assess all psychiatric patients for a history of physical and sexual trauma. Major treatment issues in patients who suffer from either type of trauma include the development of trust and the abreaction and working through of traumatic memories. Conjoint sessions with concerned others may be beneficial.

Child abuse and multiple personality disorder: review of the literature and suggestions for treatment.

The syndrome of multiple personality is associated with a high incidence of physical and/or sexual abuse in childhood. Occasionally those with multiple personality abuse their own children. Multiple personality is difficult to diagnose both because of the nature of the syndrome and because of professional reluctance. Although multiple personality is most difficult to diagnose during childhood because of the subtlety of the syndrome, the much higher morbidity found in adult cases makes it imperative that it be diagnosed and treated early in order to avoid further abuse and greater morbidity and to shorten treatment time. This review describes the history, clinical features and treatment of multiple personality, particularly in children, in addition to exploring the professional reluctance to make the diagnosis.

The use of hypnosis in a deaf patient with multiple personality disorder: a case report.

We present the first report of multiple personality disorder (MPD) in a prelingually deaf patient and the first description of alter personalities as the source of auditory hallucinations in a nonpsychotic deaf person. This young woman's history and clinical symptoms of MPD did not differ from those of hearing patients. A hypnotic trance was induced by instructing the patient in muscle relaxation, modeling relaxation with exhalation, and having the patient focus her gaze on the hypnotist repeatedly fingerspelling R-E-L-A-X. Hypnosis facilitated automatic handwriting, allowed the first meeting with an alter personality, and speeded the diagnostic process. Fingerspelling has not previously been reported in hypnosis of the deaf. It is a practical means of induction for a therapist who lacks fluent signing skills. It provides a narrow fix of gaze and avoids induction by physical stimulation, a process that some abused patients find upsetting.

Religious psychodynamics in multiple personalities: suggestions for treatment.

A study of God images, personality splits, and religious lives of seven women with multiple personality disorder shows different God images in primary and secondary personalities. Splits in God images reflect the dynamics of personality splits and splits in parental images. Suggestions are made for dealing with religious material in therapy.

The differential diagnosis of epilepsy, pseudoseizures, dissociative identity disorder, and dissociative disorder not otherwise specified.

The authors review the co-occurrences of dissociative symptoms and disorders with epilepsy and pseudo-seizures and examine newer diagnostic instruments that assist in accurate diagnosis of persons with concomitant seizure behaviors and dissociative symptoms. They also review seizure behaviors and electroencephalographic findings in persons with dissociative identity disorder (DID) and dissociative disorder not otherwise specified (DDNOS) and dissociative symptoms in persons with epilepsy and with pseudoseizures. Dissociative symptoms in 15 patients with epilepsy and 15 with pseudo-seizures were examined using the Dissociative Experiences Scale (DES) and the Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D). On the SCID-D, pseudo-seizure patients had significantly higher dissociative symptom scores than epileptic patients, but DES scores did not reliably distinguish epileptic and pseudo-seizure patients. Misdiagnosis of persons with seizures and dissociative symptoms can be avoided by careful adherence to DSM dissociative disorder criteria, the use of video-EEG monitoring, and systematic assessment of dissociative symptoms with the SCID-D.

Use of the MMPI to distinguish genuine from factitious multiple personality disorder.

MMPI special scales were repeatedly administered to several personality states of a woman alleging to have Multiple Personality Disorder. Her inability to produce a consistent response set on retesting helped to unmask a case of factitious multiple personality.

Psychogenic or dissociative fugue: a clinical investigation of five cases.

Dissociative fugue (formerly psychogenic fugue) is a rare and little understood dissociative disorder. Following a review of the pertinent literature, five cases of dissociative fugue are described. These cases were systematically studied with a comprehensive history, mental status examination, physical and neurological evaluation, review of previous medical and psychiatric records, and psychological testing including MMPI, WAIS-R, electroencephalogram, and Dissociative Experiences Scale. An unexpected finding was that, in some cases, associated criminal activity may allow the person with dissociative fugue to continue to function in spite of their loss of memory and original identity.

Accuracy of the MMPI in identifying multiple personality disorder.

A number of previous studies have delineated Minnesota Multiphasic Personality Inventory (MMPI) characteristics in patients with multiple personality. To test the accuracy of the MMPI in identifying such patients, the authors blindly rated 63 MMPIs as being either multiple personality or not. The over-all hit rate for the entire sample was 71.4%, with a 68% hit rate for correctly identified patients with multiple personality. These hit rates compare favorably with the hit rates in similar studies of other psychiatric disorders and further demonstrate the clinical usefulness of the MMPI in the diagnosis of multiple personality.