[Plasma histamine levels in various chronic diseases of the colon]. / Uroven' gistamina v plazme krovi pri razlichnykh khronicheskikh zabolevaniiakh tolstoi kishki.

Patients suffering from chronic colitis, chronic stasis disease and nonspecific ulcerous colitis were examined for blood plasma histamine. The level of blood plasma histamine was found to be dependent on the intensity of the pathological process. The role of histamine in the development of disorders of neurohumoral regulation, microcirculation and motor and evacuatory function of the colon is discussed.

[The diagnostic and therapeutic significance of thrombocyte functional activity and the factors in its regulation in chronic diseases of the large intestine]. / Diagnosticheskoe i terapevticheskoe znachenie funktsional'noi aktivnosti trombotsitov i faktorov ee reguliatsii pri khronicheskikh zabolevaniiakh tolstoi kishki.

To elucidate diagnostic value of platelet functional activity in chronic colon disease, we studied ADP-induced platelet aggregation (PA, in vitro) and cAMP concentration in blood plasma. If patients had chronic catarrhal, ulcerative colitis or chronic colon stasis, their serum cAMP appeared low, while initial rate of ADP-induced PA was high. The above alterations varied with the disease severity, in exacerbation and remission. CAMP, histamine and epinephrine were tried as regulators of platelet activity. Phosphodiesterase inhibitor trental proved efficient in the treatment of chronic colon diseases. It has improved clinical condition of the patients, inhibited the initial rate of ADP-induced PA, secured its partial or complete reversibility through a rise in plasma and platelet cAMP concentrations.

[The functional activity of the thrombocytes in chronic diseases of the large intestine]. / Funktsional'naia aktivnost' trombotsitov pri khronicheskikh zabolevaniiakh tolstoi kishki.

Chronic diseases of the large intestine--catarrhal colitis, colonic stasis, unspecific ulcerative colitis, and amebiasis of the large intestine are attended by marked changes in the functional activity of blood platelets and factors of its regulation. They reflect the dynamics of the disease before and after operative and nonoperative treatment. A recurrence of the disease is linked with activation of blood platelets. Trental and contrycal are used for correction of the disorders, which improves the condition of some of the patients. The authors discuss the importance of biogenic amines, cAMP, and functional activity of the blood platelets as universal mechanisms of the development of chronic diseases of the large intestine.

[The intestinal microflora in nonspecific ulcerative colitis]. / Mikroflora kishechnika pri nespetsificheskom iazvennom kolite.

On the basis of a complex clinical examination of patients with ulcer lesions of the large intestine it is concluded that differential diagnosis of ulcerative colitis should be based no microbiological, serological, immunological, endoscopic methods of examination. Complex conservative treatment should include both routine measures and bacterial agents.