RESUMEN
INTRODUCTION: Magnetic resonance imaging (MRI) is required for the investigation of surgically intractable epilepsy. In addition to the standard MRI techniques, perfusion sequences can be added to improve visualization of underlying pathological changes. Arterial spin-labeling (ASL) MRI perfusion does not require contrast administration and, for this reason, may have advantages in these patients. METHODS: We report here on 16 patients with epilepsy who underwent MRI of the brain with ASL and positron emission tomography (PET). RESULTS: Despite a slightly reduced resolution with ASL, we found a correlation between ASL, PET and electrophysiological data, with hypoperfusion on ASL that corresponded with hypoperfusion on interictal PET. CONCLUSION: Given the correlation between ASL and PET and electrophysiology, perfusion with ASL could become part of the standard work-up in patients with epilepsy.
Asunto(s)
Encéfalo/patología , Epilepsia/diagnóstico , Angiografía por Resonancia Magnética/métodos , Adolescente , Adulto , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Marcadores de Spin , Adulto JovenRESUMEN
OBJECTIVES: To demonstrate the use of perfusion CT in patients presenting with a suspected diagnosis of stroke to avoid the administration of inappropriate thrombolytic therapy in stroke-mimicking conditions such as status epilepticus. MATERIAL AND METHODS: We reviewed the imaging studies of four patients presenting with symptoms suggestive of stroke, but finally diagnosed with status epilepticus. Imaging was by a 16-section multidetector CT scanner using a protocol consisting of non-contrast CT, CT angiography and perfusion CT. Color-coded maps allowed calculation of the CBV (cerebral blood volume), CBF (cerebral blood flow) and MTT (mean transit time). RESULTS: In all four cases, perfusion CT revealed increases in CBF and CBV as well as a decreased MTT, consistent with hyperperfusion linked to status epilepticus with focal deficit-in contrast to the hypoperfusion observed in stroke patients. CONCLUSION: The use of perfusion CT accurately detected hyperperfusion in status epilepticus presenting as stroke. In such cases, perfusion CT imaging avoided the administration of potentially harmful thrombolytic therapy to patients experiencing seizures due to different underlying etiologies.
Asunto(s)
Estado Epiléptico/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Adulto , Anciano , Circulación Cerebrovascular , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Interpretación de Imagen Radiográfica Asistida por Computador , Accidente Cerebrovascular/diagnóstico por imagen , Accidente Cerebrovascular/tratamiento farmacológico , Terapia Trombolítica/métodosRESUMEN
INTRODUCTION: We illustrate here the most common MRI artifacts found on routine 3T clinical neuroradiology that can simulate pathology and interfere with diagnosis. MATERIALS AND METHODS: Our group has worked with a 3-T Magnetom Trio (Siemens, Erlangen, Germany) system for two years, with 50% of our time devoted to clinical work and 50% dedicated to research; 65% of the clinical time is dedicated to neuroradiology (2705 patients) and the remaining time to whole-body MRI. We have detected these artifacts during our case readings and have selected the most representative of each type to illustrate here. RESULTS: We have observed magnetic susceptibility artifacts (29%), pulsation artifacts (57%), homogeneity artifacts (3%), motion artifacts (6%), truncation artifacts (3%) and, finally, artifacts due to poor or inadequate technique in the examined region. CONCLUSION: High-field imaging offers the benefit of a higher signal-to-noise ratio, thus making possible the options of a higher imaging matrix, thinner slices, the use of spectroscopy and diffusion tensor imaging in the routine clinical neuroradiology with a reduction in time spent. It is vital to be able to recognize these artifacts in everyday practice as they can mimic pathological appearances, thus causing diagnostic errors that could lead to unnecessary treatment. Indeed, most of these artifacts could be avoided with an adequate technique.
Asunto(s)
Artefactos , Encéfalo/patología , Imagen por Resonancia Magnética/métodos , Canal Medular/patología , Médula Espinal/patología , Humanos , Procesamiento de Imagen Asistido por ComputadorRESUMEN
OBJECTIVE: To evaluate the prognostic accuracy of combining perfusion CT (PCT) and thrombolysis in brain ischemia (TIBI) ultrasonographic grade in the triage of stroke patients who will benefit from thrombolysis and in predicting the clinical outcome. METHODS: We conducted a prospective study of all consecutive stroke patients admitted to our hospital from March 2003 to July 2007, presenting with signs of acute stroke within the therapeutic window, who had undergone either intravenous or combined intravenous and intra-arterial thrombolysis. All patients were evaluated by a complete stroke CT protocol, transcranial color-coded duplex sonographic monitoring, follow-up imaging (CT or MRI) and clinical outcome at 3 months, as assessed by the modified Rankin scale (mRS). RESULTS: A total of 34 patients were included with a mean NIHSS on admission of 14.2. This study revealed that PCT had 95% sensitivity and 71% specificity in the evaluation of therapy benefit as well as 75% sensitivity and 39% specificity in predicting clinical outcome. The extent of ischemic tissue according to PCT and TIBI grade were significantly correlated (p<0.05). Using the MTT-TTP approach was an alternative to the classical MTT-CBV approach for determining tissue at risk. The clinical outcome assessed by the mRS was considered favorable (mRS 0-2) in 16 patients and unfavorable (mRS>2) in 18 patients. CONCLUSION: PCT was the most accurate predictor of both thrombolytic therapy benefit and clinical outcome. The TIBI score was useful for determining whether or not to perform intravenous therapy alone or as a combined therapy.
Asunto(s)
Isquemia Encefálica/diagnóstico , Isquemia Encefálica/terapia , Imagen de Perfusión , Accidente Cerebrovascular/diagnóstico , Terapia Trombolítica , Tomografía Computarizada por Rayos X , Adulto , Anciano , Anciano de 80 o más Años , Isquemia Encefálica/complicaciones , Circulación Cerebrovascular , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/terapia , Resultado del Tratamiento , Ultrasonografía Doppler TranscranealRESUMEN
We report the case of a 10-year-old boy with pharmacoresistant epilepsy, symptomatic of a right temporoparietal hemorrhagic lesion, who displayed an eating passion as described for the gourmand syndrome (GS) in adults and discuss the role of epilepsy in GS. This patient presented with a significant change in his eating habits (abnormal preoccupation with the preparation and eating of fine-quality food) concordant with the onset of his seizure disorder, without any previous history of eating disorders or psychiatric illness. This observation corroborates the important role of the right cerebral hemisphere in disturbed eating habits, including the relatively benign GS, and, possibly rarely, in less benign eating disorders such as anorexia and obesity.
Asunto(s)
Epilepsia/diagnóstico , Trastornos de Alimentación y de la Ingestión de Alimentos/diagnóstico , Anticonvulsivantes/uso terapéutico , Apetito/fisiología , Hemorragia Cerebral/complicaciones , Hemorragia Cerebral/fisiopatología , Niño , Dominancia Cerebral/fisiología , Resistencia a Medicamentos , Epilepsia/tratamiento farmacológico , Epilepsia/fisiopatología , Conducta Alimentaria/fisiología , Trastornos de Alimentación y de la Ingestión de Alimentos/tratamiento farmacológico , Trastornos de Alimentación y de la Ingestión de Alimentos/fisiopatología , Humanos , Masculino , Pruebas Neuropsicológicas , Lóbulo Parietal/fisiopatología , Lóbulo Temporal/fisiopatologíaRESUMEN
Major progress has recently been made in the neuro-imaging of stroke as a result of improvements in imaging hardware and software. Imaging may be based on either magnetic resonance imaging (MRI) or computed tomography (CT) techniques. Imaging should provide information on the entire vascular cervical and intracranial network, from the aortic arch to the circle of Willis. Equally, it should also give information on the viability of brain tissue and brain hemodynamics. CT has the advantage in the detection of acute hemorrhage whereas MRI offers more accurate pathophysiological information in the follow-up of patients.
Asunto(s)
Isquemia Encefálica/diagnóstico , Diagnóstico por Imagen/métodos , Accidente Cerebrovascular/diagnóstico , Angiografía Cerebral/métodos , Humanos , Imagen por Resonancia Magnética/métodos , Marcadores de Spin , Tomografía Computarizada por Rayos X/métodosRESUMEN
Pilocytic astrocytoma (WHO Grade 1) is a low-grade glioma with a favorable prognosis most commonly diagnosed in patients aged below 20. It is the most common glioma in children, and cases discovered in elderly patients are rare. We report the highly unusual case of an 85-year-old man whose neurological signs included Parkinsonism, and in whom post mortem examination revealed a pilocytic astrocytoma of the brainstem. We also discuss the clinical, neuroradiological and neuropathological differential diagnosis.
Asunto(s)
Astrocitoma/diagnóstico , Neoplasias del Tronco Encefálico/diagnóstico , Factores de Edad , Anciano de 80 o más Años , Astrocitoma/patología , Neoplasias del Tronco Encefálico/patología , Diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Enfermedad de Parkinson/diagnósticoRESUMEN
UNLABELLED: Multiple structural and functional imaging modalities are available to localize the epileptogenic focus. In pre-surgical evaluation of children with pharmacoresistant epilepsy, investigations with the maximum yield should be considered in order to reduce the complexity of the workup. OBJECTIVE: To determine the extent to which PET, ictal/interictal SPECT and its co-registration with the patient's MRI contributes to correct localization of the epileptogenic focus, surgical intervention and to the post surgical outcome in paediatric patients. METHODS: The study population included children and adolescents with pharmacoresistant epilepsy (n = 50) who underwent preoperative evaluation, surgery and had postoperative follow-up for at least 12 months. Outcome was measured by postoperative seizure frequency using Engel's classification. RESULTS: Thirty-nine patients (78%) became completely seizure free after surgical intervention. The likelihood to benefit from surgical treatment was significantly higher if localization with more imaging modalities (MRI, PET, SPECT) were concordant with respect to the resected brain area (p < 0.01). Preoperative PET examination provided better localizing information in patients with extratemporal epilepsy and/or dysplastic lesions, whereas SPECT was found to be superior to PET in patients with temporal lobe epilepsy and/or tumors (p < 0.05). No significant difference was noted in the surgical outcome in younger or older age group, in children with or without special education needs. CONCLUSION: In paediatric epilepsy pre-surgical evaluation, the combined use of multiple functional imaging modalities for a precise localisation of the epileptogenic focus is worthwhile for both extratemporal and temporal lobe epilepsy, also when EEG and MRI alone are non-contributive, given the potential benefit of complete postoperative seizure control.
Asunto(s)
Epilepsia/diagnóstico , Imagen por Resonancia Magnética , Tomografía de Emisión de Positrones , Tomografía Computarizada de Emisión de Fotón Único , Adolescente , Factores de Edad , Niño , Preescolar , Electroencefalografía , Epilepsia/patología , Epilepsia/cirugía , Femenino , Humanos , Lactante , Masculino , Cuidados Preoperatorios , Resultado del Tratamiento , Grabación en VideoRESUMEN
OBJECTIVES: Management of traumatic lesions of the brachial plexus mainly depends on whether the injury is pre- (nerve root avulsion) or postganglionic (trunks and cords). The aim of this study was to assess the diagnostic and prognostic value of MRI in such lesions, and to determine any correlations among radiological, clinical and electroneuromyographical (EMG) data from both the initial and follow-up studies. MATERIAL AND METHODS: Nine patients with acute traumatic lesions of the brachial plexus were investigated by MRI and EMG. Five further patients served as controls. The MRI protocol included fast spin-echo (FSE) T2-weighted and STIR sequencing. These scans were independently interpreted by two senior radiologists. Their findings were then validated during consensus meetings of surgeons, radiologists and neurologists to identify the exact localization and mechanism of each lesion, and to determine the advantages and drawbacks of each technique. RESULTS: Among the nine patients, MRI scans were judged as normal in three whereas EMG showed distal lesions in two of them. In a further three patients, STIR MRI sequences demonstrated high signal intensities from the trunks and cords of C5 to T1. Among these three patients, MRI at three months showed persistence of these signal anomalies in one patient, and partial regression in the two others. In the remaining three patients, three-dimensional T2-weighted sequences showed nerve root avulsion, consistent with the initial EMG findings. CONCLUSION: MRI is the best technique to demonstrate nerve root avulsion. However, unlike EMG, MRI does not allow visualization of distal lesions of the brachial plexus. Differentiation between edema (reversible) and demyelination (irreversible) of trunk and cord lesions remains difficult, and requires EMG or late MRI.
Asunto(s)
Neuropatías del Plexo Braquial/diagnóstico , Plexo Braquial/lesiones , Imagen por Resonancia Magnética , Radiculopatía/diagnóstico , Adolescente , Adulto , Anciano , Plexo Braquial/patología , Plexo Braquial/fisiopatología , Neuropatías del Plexo Braquial/etiología , Electromiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Radiculopatía/etiología , Reproducibilidad de los ResultadosRESUMEN
Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.
Asunto(s)
Dermatomiositis/complicaciones , Inmunosupresores/uso terapéutico , Leucoencefalopatía Multifocal Progresiva/tratamiento farmacológico , Leucoencefalopatía Multifocal Progresiva/etiología , Antagonistas Adrenérgicos alfa/uso terapéutico , Citarabina/uso terapéutico , Femenino , Humanos , Masculino , Mianserina/análogos & derivados , Mianserina/uso terapéutico , Persona de Mediana Edad , Mirtazapina , Resultado del TratamientoRESUMEN
Among 504 cases of AIDS diagnosed between 1983 and 1990, there were 86 patients (17%) with toxoplasma encephalitis (TE). All were symptomatic at the time of diagnosis. General signs such as fever, neck stiffness, or headache were present in 87.2%, and 75.6% had focal signs. The primary means of diagnosis was computerized tomographic scanning, revealing 169 lesions of which 80% were immediately contrast-enhancing. All patients had IgG antibodies against Toxoplasma gondii either before (74 of 75 evaluable patients) or at the time of diagnosis of TE (73 of 75). Elevated antibody titers were present in 44% of evaluable patients, compared to 11% of patients with AIDS and other opportunistic infections. Initial treatment was pyrimethamine plus sulfonamides in 65 patients, and pyrimethamine plus clindamycin in 12 patients, with other combinations or no treatment accounting for the remainder. Life-table analysis of the time to discontinuation of treatment because of suspected side effects suggested that sulfadiazine was significantly more toxic, with 48% of patients experiencing an interruption in treatment after 30 days, than pyrimethamine (12%) or clindamycin (24%). The 30-day mortality rate was 12%, and median survival was 310 days after diagnosis, 530 in patients treated with zidovudine and 190 days in those not so treated. Of 82 evaluable patients, 16 relapsed once and 4 of these more than once. The risk of relapse was 27% 1 year after diagnosis of a first episode of TE.
Asunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Toxoplasmosis Cerebral/epidemiología , Síndrome de Inmunodeficiencia Adquirida/sangre , Síndrome de Inmunodeficiencia Adquirida/tratamiento farmacológico , Adulto , Antibacterianos/administración & dosificación , Antibacterianos/efectos adversos , Antibacterianos/uso terapéutico , Anticuerpos Antiprotozoarios/sangre , Biopsia , Linfocitos T CD4-Positivos , Líquido Cefalorraquídeo/química , Femenino , Hospitales Universitarios , Humanos , Inmunoglobulina G/inmunología , Recuento de Leucocitos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Tasa de Supervivencia , Suiza/epidemiología , Tomografía Computarizada por Rayos X , Toxoplasmosis Cerebral/diagnóstico , Toxoplasmosis Cerebral/tratamiento farmacológico , Zidovudina/uso terapéuticoRESUMEN
We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms. Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy. This case report of fulminant ADEM treated successfully with early high-dose intravenous methylprednisolone, although uncontrolled, suggests that this agent should be studied in other cases.
Asunto(s)
Antiinflamatorios/efectos adversos , Encefalomielitis Aguda Diseminada/tratamiento farmacológico , Metilprednisolona/efectos adversos , Adulto , Antiinflamatorios/uso terapéutico , Relación Dosis-Respuesta a Droga , Encefalomielitis Aguda Diseminada/diagnóstico , Humanos , Inyecciones Intravenosas , Imagen por Resonancia Magnética , Masculino , Metilprednisolona/uso terapéutico , Inducción de RemisiónRESUMEN
BACKGROUND: Various structural and functional changes, such as focal edema, blood flow, and metabolism, occur in the cerebral cortex after focal status epilepticus. These changes can be assessed noninvasively by means of MRI techniques, such as fluid-attenuated inversion recovery (FLAIR), EEG-triggered functional MRI (EEG-fMRI), and proton MR spectroscopy (MRS). METHODS: The authors report on a 40-year-old patient with nonlesional partial epilepsy in the left posterior quadrant in whom these MRI techniques were applied in an active seizure focus and repeated during a follow-up of 1 year. RESULTS: FLAIR imaging taken at the time of status epilepticus showed a signal hyperintensity in the occipital region. (1)H-MRS of this cortical region showed elevated lactate, decreased N:-acetylaspartate (NAA), and elevated choline (Cho). In the same region, EEG-fMRI revealed an area of signal enhancement. After seizure control, recovery of lactate and Cho was observed, whereas the NAA level remained reduced. The structural abnormality demonstrated on FLAIR disappeared within 3 months. CONCLUSIONS: Repetitive MRI with sensitive sequences during clinically critical periods may disclose the structural correlate in a previously nonlesional epilepsy case. Corresponding to the clinical evolution, reversible and irreversible focally abnormal metabolism can be determined with (1)H-MRS, reflecting both increased neuronal activity and neuronal damage.
Asunto(s)
Encéfalo/metabolismo , Encéfalo/fisiopatología , Epilepsias Parciales/metabolismo , Epilepsias Parciales/patología , Adulto , Electroencefalografía , Humanos , Imagen por Resonancia Magnética , Espectroscopía de Resonancia Magnética , Masculino , Protones , Factores de TiempoRESUMEN
OBJECTIVE: To determine the volumes of subcortical nuclei in patients with chronic epilepsy. BACKGROUND: Animal and human data suggest a crucial role for subcortical structures in the modulation of seizure activity, mostly as seizure-suppressing relays. Although cortical epileptogenic foci can vary in localization and extent, it nevertheless appears that these structures subsequently influence seizure propagation in a universal fashion. There is, however, little knowledge about the size of implicated subcortical structures in patients with epilepsy. METHOD: Using high-resolution MRI, the volumes of selected subcortical nuclei, such as the thalamus, caudate nucleus, putamen, and pallidum, were measured in both hemispheres of 27 patients with temporal lobe epilepsy. Fourteen healthy volunteers served as controls. Statistical analysis was done for both normalized volumes (by total brain volume) and unnormalized volumes. RESULTS: Overall, the patient group had smaller thalamic and striatal volumes in both hemispheres, mostly ipsilateral to the epileptic focus. No significant correlations were noted between volume measurements and age, age at onset, duration of epilepsy, or total seizure frequency, including frequency of generalized seizures. The putamen and thalamus seemed to be affected predominantly in patients with a history of febrile convulsions, whereas patients without febrile convulsions had smaller caudate nuclei bilaterally. CONCLUSIONS: Volumetric measurements of subcortical nuclei reveal atrophy of distinct subcortical nuclei in the patient group, predominantly ipsilateral to the focus. This finding probably reflects persistent abnormalities and not secondary change. In addition, the structural differences between patients with and patients without previous febrile convulsions suggest that these conditions may have different causes.
Asunto(s)
Ganglios Basales/patología , Epilepsia del Lóbulo Temporal/patología , Imagen por Resonancia Magnética , Tálamo/patología , Adulto , Atrofia , Humanos , Convulsiones Febriles/patologíaRESUMEN
Among several brain radiopharmaceuticals for SPECT imaging, 99mTc complexes of HMPAO and ECD are the most widely used. They are considered to be equal in their capacity to reflect regional cerebral blood flow; but discrepancies between HMPAO and ECD brain uptake have been reported in stroke patients. This paper reports our observations regarding discrepancies between HMPAO and ECD SPECT in 14 of 23 patients with suspected brain tumors or presumed metabolic cerebral abnormalities. We obtained similar conflicting results, namely focal HMPAO hyperactivities and isoactive ECD SPECT. The majority of these discrepancies were found in patients with brain tumors (10 of 13 patients), while only 4 of the 10 remaining patients with nontumoral process showed similar discrepant results. The physiopathology behind these observations is discussed here, and it is likely to be related to the specific response to cellular metabolic disorders rather than to perfusion disturbances.
Asunto(s)
Neoplasias Encefálicas/diagnóstico por imagen , Cisteína/análogos & derivados , Compuestos de Organotecnecio , Oximas , Tomografía Computarizada de Emisión de Fotón Único , Adulto , Anciano , Anciano de 80 o más Años , Circulación Coronaria , Desoxiglucosa/análogos & derivados , Femenino , Radioisótopos de Flúor , Fluorodesoxiglucosa F18 , Humanos , Masculino , Persona de Mediana Edad , Exametazima de Tecnecio Tc 99m , Radioisótopos de TalioRESUMEN
PURPOSE: Neurological impairment, mental dysfunction, and brain imaging changes caused by severe hypoxia have been described by several authors. However, the occurrence of transitory, long lasting, or permanent brain damage has been debated. Although climbing to 8000 m is reserved to a small number of climbers, there are hundreds of lowlanders spending relatively short holidays climbing peaks up to 6000 m in the Andes or in the Himalayas. They are usually not well acclimated and often suffer from acute mountain sickness (AMS). The aim of this study was to examine the effect of a single high altitude exposure on the changes in brain MRI and neuropsychological testing in climbers. METHODS: Brain MRI, medical history, and a battery of neuropsychological tests were obtained in eight male climbers between 31 and 48 yr of age a few days before and between 5 and 10 d after returning to sea level following ascent to altitudes of over 6000 m without oxygen. RESULTS: The mean AMS symptom score recorded at 5500 m was three in all climbers, headache being the predominant symptom. CONCLUSION: We did not observe the changes in brain imaging and in neuropsychological testing observed by other authors. The residual central nervous system impairment following return from high altitude was not observed in our study, and the good results in neuropsychological testing were well correlated with the unchanged brain MRI imaging.
Asunto(s)
Mal de Altura/diagnóstico , Mal de Altura/psicología , Daño Encefálico Crónico/diagnóstico , Daño Encefálico Crónico/psicología , Imagen por Resonancia Magnética , Montañismo , Pruebas Neuropsicológicas , Adulto , Humanos , Masculino , Persona de Mediana Edad , Estadísticas no ParamétricasRESUMEN
The spectrum of clinical manifestations of multiple sclerosis (MS) may include rare cases where cerebral lesions simulate brain tumors or abscesses on neuroimaging. We report here on a 43-year-old woman with numerous ring-enhancing cystic lesions in the white matter of cerebral hemispheres, brainstem and cerebellum. The radiological picture was overwhelmingly in favor of a metastatic or infectious etiology, but brain biopsy showed subacute demyelination with central necrosis.
Asunto(s)
Neoplasias Encefálicas/patología , Imagen por Resonancia Magnética , Esclerosis Múltiple/patología , Tomografía Computarizada por Rayos X , Adulto , Axones/patología , Biopsia , Neoplasias Encefálicas/diagnóstico , Corteza Cerebral/patología , Diagnóstico Diferencial , Femenino , Humanos , Esclerosis Múltiple/diagnóstico , Vaina de Mielina/patologíaRESUMEN
Gangliogliomas are tumors of mixed glial and neuronal phenotype that usually have a benign clinical course. Rare cases display anaplastic features at the time of first presentation or progress to anaplastic gliomas over extended times. We report on a ganglioglioma of the spinal cord that recurred as a malignant glioma one and a half years after resection. The initial neoplasm was composed of a mixture of well-differentiated ganglionic and astrocytic cells. The recurrent tumor was an anaplastic small-cell glioma. The sole unusual aspect in the initial neoplasm was an abundance of small vessels with calcified walls, which mimicked a vascular malformation.
Asunto(s)
Transformación Celular Neoplásica/patología , Ganglioglioma/patología , Recurrencia Local de Neoplasia/patología , Neoplasias de la Médula Espinal/patología , Adulto , Diagnóstico Diferencial , Femenino , Ganglioglioma/metabolismo , Humanos , Inmunohistoquímica , Imagen por Resonancia Magnética , Recurrencia Local de Neoplasia/metabolismo , Neoplasias de la Médula Espinal/metabolismoRESUMEN
MRI volumetric measurements of the ipsi- and contralateral hippocampal volume (HV) were performed in a group of 37 patients with lesional and non-lesional temporal (TLE), and extratemporal lobe (ETLE) lobe epilepsy. Twenty-six patients underwent surgery and the resected tissues subjected to histopathological examination. Psychosocial scores were calculated on the basis of employment, partnership/family status and presence of a positive psychiatric history. Poorest values were obtained for the group with right lesional and non-lesional TLE (RTLE, p < 0.001). In this group, significant positive correlations between psychosocial functioning and the left hippocampal volume or age of onset were observed. We found that the left hippocampal volume in RTLE was smaller with increasing epilepsy duration. We conclude that patients with RTLE represent a particular group with regard to the structural and psychosocial consequences of chronic epilepsy. With regard to histopathological analysis, no particular type of lesion was identified as the major determinant of the results described above.