[Use of French version of Ureteral Stent Symptom Questionnaire for tolerance evaluation of ureteral double J-stent]. / Évaluation de la tolérance de la sonde JJ par l'utilisation de l'autoquestionnaire USSQ.

OBJECTIVES: To evaluate the quality of life of the holders of a ureteral double J stent (US) using the USSQ questionnaire (Ureteral Stent Symptom Questionnaire), validated in French in 2010. METHODS: Between January 2009 and December 2011, 249 patients underwent flexible ureteroscopy for urolithiais in our service. Among them, 160 received a US in perioperative, and they were sent self-questionnaire USSQ-FR retrospectively. The questionnaire includes 38 questions, concerning the perioperative period with US, and 4 weeks after its removal, grouped into 6 sections: urinary symptoms, pain, general health, professional resounding, sexual resounding, and other problems. A subgroup analysis was performed, comparing US used in emergency and planned US, active patients or retired, male or female. Statistical analysis used the Chi(2) test for paired data, the Fisher exact test and the Kruskal Wallis test. RESULTS: Of the 157 questionnaires sent (two patients who died, one mentally retarded), we obtained 80 responses. Quality of life appears to be significantly altered in all areas explored by the questionnaire. Urinary symptoms: 26.9 versus 19.9 score (P<0.0001), pain: 16.1 versus 10.7 (P=0.003), general health: 13.9 versus 9.1 (P<0.0001), professional practice: 6.1 versus 3.6 (P=0.0002), female: 3.3 versus 1.8 (P=0.001). There was no significant difference if the US was placed in emergency or programmatically, if patients were professionally active or retired. In addition, women had a significantly impaired quality of life compared to men for urinary symptoms, general health and professional practice. CONCLUSION: US are responsible for a significant impairment of quality of life for patients. The validated, self-administered, USSQ-FR questionnaire is a reliable tool for this evaluation. LEVEL OF EVIDENCE: 5.

[Pigtail suture stent: decisive progress towards double-pigtail stent tolerance and unexpected properties of the suture in the ureter]. / Sondes JFil et MiniJFil: progrès décisifs dans la tolérance des sondes urétérales et propriétés inattendues du fil urétéral.

OBJECTIVE: Double-pigtail stent intolerance reduces the quality of life of patients. By decreasing the amount of material within the bladder, it should be possible to attenuate the symptoms linked to the stent. We evaluated the tolerance of a new stent with a dedicated questionnaire. PATIENTS ET METHODS: The major innovation of the pigtail suture stent (PSS and MiniPSS) was in the replacement of the lower part of the double-pigtail stent with a 0.3 F suture. One hundred and eight patients agreed to be fitted with a PSS. The double-pigtail stents of 24 patients complaining strongly of symptoms were replaced with PSS (group 1) and sixty-eight other patients were fitted directly with the PSS after an endoscopic intervention on the ureter (groups 2 and 3). Sixteen patients with non-obstructive kidney stone received MiniPSS (group 4). RESULTS: Completed questionnaires were obtained from 94 patients. In group 1, the replacement of the double-pigtail stent with a PSS significantly decreased urinary symptom scores (34.4±9.0 vs 20.3±7.4, P<0.0000007), and pain scores (10.1±5.1 vs 4.8±3.2, P=0.0001). The scores of the two first groups fitted with a PSS were similar. Following PSS or MiniPSS implantation, a clear dilation of the ureteral meatus was probably induced by the sutures, facilitating the introduction of an ureteroscope or a flexible ureteroscope sheath (12 F). Following extracorporeal shockwave lithotripsy, the stone fragments gradually slid down the PSS sutures, without renal colic. CONCLUSION: The PSS seems to improve the tolerance of ureteral stent. Unexpectedly, following PSS implantation, we observe a clear dilation of the ureter. We believe that use of a double-pigtail stent should no longer be considered the only way to drain the ureter. Instead, the form of the stent should depend on the patient's disease. LEVEL OF EVIDENCE: 5.

[Epidemiology of urinary stones in the French military during the operation Serval]. / Épidémiologie de la lithiase urinaire chez les militaires français au cours de l'opération Serval.

OBJECTIVES: The renal colic crisis is a pathology frequently encountered in foreign operations recently conducted by the French army and often requires a medical repatriation in mainland France. Soldiers deployed in arid areas are at increased risk of developing urolithiasis. The purpose of our study is to analyze the risk factors, the frequency and the methods of management of symptomatic urinary stone disease for French military returnees for renal colic during Serval operation. METHODS: Our study focused on French soldiers repatriated from Mali for a renal colic care between January 11th and November 30th, 2013. For each patient, we recorded: age, sex, deployment date, crisis date, personal and family histories of urolithiasis, initial medical treatment, diagnosis and treatment to return to France. RESULTS: Three hundred and forty-eight soldiers were evacuated during Serval operation, among which 41 were due to the occurrence of renal colic crisis (11.7%). Twenty-nine percent of patients had a personal history of kidney stone disease symptomatically. The average residence time when the crisis appears is 60 days (10-120 days). Ninety-five percent of patients were asymptomatic at their arrival in France and 39% of patients had no stone found in CT scan. The average size of the stones found on the imaging was 2.71 mm (1-8mm). One patient required drainage by JJ ureteral endoprothese in order to have a quick ureteroscopy for recovery of its capacity. CONCLUSION: The French military sent to Serval operation are exposed to multiple contributing factors of urolithiasis as the dehydration and the strong temperature. The analysis of our series reveals that the history of renal stone disease is the main factor favoring and the medical treatment is effective in almost all renal colic cases. The operational impact associated with this common condition in the Sahel region deserves an awareness of field practitioners to the screening and management of this disease in a precarious situation and a reflection of the staffs concerning the access onto the operating theater to appropriate diagnostic and therapeutic means that could facilitate the return to the combat unit.

[Use of [-2] pro PSA and phi index for early detection of prostate cancer: a prospective of 452 patients]. / Place du -2proPSA et de l'index phi dans la détection précoce du cancer de prostate : évaluation sur une série de 452 patients.

INTRODUCTION: Early detection of prostate cancer (Pca) is a real challenge to reduce morbidity and mortality while avoiding over-diagnosis and over-treatment. The prostate specific antigen (PSA) is characterized by its imperfections justifying the evaluation of new serum or urinary specific markers allowing a better selection of patients at risk of developing aggressive Pca. AIM: To compare the value of -2pro PSA and phi index to total and free PSA. METHODS: Serum sampled from 452 patients from two university centers were used to determine levels of PSA before performing biopsies. The patients were included in this study based on the PSA serum concentration between 1.6 ng/mL and 8 ng/mL according to the WHO international standard. All biopsies were performed according to a standardized protocol consisting of 12 cores or more. Sera were analyzed centrally in one of the two institutions with on a single analyzer. Sera from 243 prostate cancer and 208 negative biopsies patients have been taken into account. RESULTS: Sera were analyzed blinded for total PSA, free PSA and [-2] proPSA using Access(®) immunoassay method from Beckman Coulter. The Prostate Health Index (phi) was calculated using the formula phi=([-2] proPSA/fPSA)×sqrt (PSA). The median value of the phi index is significantly (P>0.0001) higher for patients with cancer (phi=65.8) compared to patients with negative biopsies (phi=40.6). At a given sensitivity, the phi index significantly increases the specificity of detection of prostate cancer compared to other markers. CONCLUSION: The phi index currently appears as the best predictor of prostate cancer for patients with a total PSA between 1.6 and 8 ng/mL according to the WHO standard. The improvement in specificity of the phi index over tPSA could reduce significantly the numbers of unnecessary biopsies. Whether this new biomarker could be an indicator of aggressive prostate cancer remains to be confirmed.

[Growing teratoma syndrome]. / Le growing teratoma syndrome.

Growing teratoma syndrome (GTS) is a rare entity, characterized by enlarging masses of the retroperitoneum or other location occurring during or after systemic chemotherapy for the treatment of non-seminomatous germ cell of the testis (NSGCT). Three criteria define this syndrome: enlarging metastatic masses, normalized serum markers and no component of viable germ cell tumor in this mature teratoma. Prognostic is excellent after the resection of these masses, but this surgery has to be as much complete as possible. Surgical excision of large GTS lesions is technically challenging, a serious intraoperative complications may occur, that's why the treatment must not be delayed.

[Predictive value of the asymptomatic prostatic inflammation in the development of prostate cancer]. / Valeur prédictive de l'inflammation prostatique asymptomatique dans la survenue du cancer de la prostate.

OBJECTIVE: Several studies have tried to show a link between inflammation and cancer. In prostate cancer (PCa) development, this question is still not completely elucidated. The aim of the study was to investigate, whether the presence of inflammation in the first series of prostate biopsies was a factor of risk. PATIENTS AND METHODS: In this retrospective study, we examined prostate biopsy specimen of 220 consecutive patients, who had undergone repeat prostate biopsies in our department. The first screening round was performed between 2000 and 2005. These first prostate biopsies were examined by two pathologists blinded to the patient's follow-up. Inflammation and several histological criterions were evaluated: acute/chronic and focal/diffuse inflammation, atrophy, high grade PIN (HGPIN) and ASAP. We compared PCa incidences rates (IR) for the different histologic markers using chi(2) analysis and estimated the relative risk (RR) of PCa. RESULTS: Two hundred and one patients were included definitively with a median follow-up of 2.1 years (42 days - 8.9 years, period between the first and the last biopsy). One hundred and twenty-six patients (62.7%) were identified with inflammation in the first biopsies (inflammatory group [IG]). Ninety-seven patients (48.3%) had PCa, 58 from the IG. PCa IR did not differ significantly between patients with or without inflammation (RR: 0.9, p=0.6). CONCLUSIONS: According to these data, the presence and type of histological inflammation on initial prostate biopsies did not seem to be a risk factor for the development of PCa.

[Total urethral rupture during sexual intercourse]. / Faux-pas du coït et rupture urétrale complète.

The authors report the case of a bilateral rupture of the corpora cavernosa associated to a total disruption of the urethra resulting from blunt trauma during sexual intercourse. This association is a rare urologic case of emergency which most often take place during sexual intercourse (0.4% of the urologic cases of emergency). When both corpora cavernosa and urethra are fully disrupted, an internal penis amputation appears, compromising the vascularization and the erectional and micturitional prognosis. The rupture of the urethra is the first complication to search. Early diagnosis and surgical treatment allow a precise assessment of the lesions and a good functional result.

[Correct use of prostate-specific antigen in office practice]. / Du bon usage de l'antigène spécifique prostatique en pratique de ville.

OBJECTIVE: To standardize interpretation and comments of prostate-specific antigen (PSA) assay results by clinical pathology laboratories in office practice. MATERIAL: From September 2004 to May 2006, interpretation and comments of PSA assay results performed by 100 different laboratories were analysed retrospectively. RESULTS: Nineteen different PSA assay kits were used. The so-called "normal" value for total PSA was less than 4 ng/ml for two-thirds of kits. Determination of the free PSA/total PSA ratio (91 cases) was based on a cut-off value ranging from 10 to 25% and the frequent laboratory comments (89 cases) more often referred to benign prostatic hyperplasia (51 case) than prostate cancer (nine cases). CONCLUSION: The marked diversity of PSA assay techniques currently used and the divergent interpretations by various laboratories lead to problems of interpretation for both practitioners and patients.

[Management of testicular seminoma with elevation of alpha fetoprotein. A case report]. / Prise en charge d'un séminome testiculaire avec élévation de l'alpha-foetoprotéine. A propos d'un cas.

The authors report a case of stage N3 pure testicular seminoma associated with paradoxical elevation of alphafoetoprotein (AFP). Despite the absence of histological arguments after review of the slides, this lesion was considered to be a stage pT1 N3 M0 S3 non seminomatous germ cell tumour with a poor prognosis. Simple surveillance was proposed following normalization of tumour markers, regression of retroperitoneal masses and negative PET scan. Laboratory and then clinical relapse at three months was treated by salvage chemotherapy followed by retroperitoneal lymph node dissection. The presence of embryonic carcinoma in one of the residual masses led to a revision of the initial histological diagnosis. The rare data of the literature indicate a variable approach according to alphafoetoprotein levels.

[Management of the unstable patient with multiple trauma]. / Prise en charge chirurgicale du polytraumatisé en situation précaire.

The management of the patient with multiple trauma in unstable condition must be adapted to the means available (or unavailable) on site, i.e., trained personnel, material means, and the possibility of evacuation to a trauma center. This may require a multi-stage surgical strategy based on clinical examination and available imaging resources. Patients with multiple trauma in unstable condition should be brought to the operating room promptly for life-saving or stabilizing interventions (Extreme Urgency). The patient may then undergo further stabilization of vascular volume, coagulation, and metabolic deficits while simultaneously undergoing a more detailed clinical and radiologic evaluation; he may then return to the operating room within six hours for more definitive repair of urgent lesions (First Urgency). Once the patient is stable enough for evacuation, he should be transferred to a trauma center for definitive surgical care.

Grade IV renal trauma management. A revision of the AAST renal injury grading scale is mandatory.

INTRODUCTION: The AAST renal injury grading scale is currently the most important variable predicting the need for kidney repair or removal, morbidity and mortality after blunt or penetrating kidney injuries. The 2011 revised version included renal pelvis, uretero-pelvic junction and segmental vascular injuries as grade IV, limiting grade V to severe hilar injuries. However, patients requiring surgery cannot be properly identified because of hemodynamic instability due to grade IV renal injuries. This study proposes an add-on for the AAST grade IV renal injury scale to improve the management of these patients. METHOD: We searched the Medline and Scopus databases up to September 2014. Searches were not restricted by date, language or publication status. Pediatric studies were excluded. RESULTS: 71 articles were found, 57 were pertinent, including 6 directly related to the topic. 3 risk factors were identified to be associated with surgery for hemodynamic instability: perirenal hematoma >3.5 cm, intravascular contrast extravasation and medial renal laceration. Presence of two or more of these criteria has been validated in two other studies to predict the need for intervention. Patients with >25 % devascularized fragments also have poor prognosis and should be treated more aggressively. CONCLUSION: These elements should be included in future classification reassessment to efficiently determine the time for surgery in grade IV renal traumas, generally leading to nephrectomy.

[Thyroid metastasis of a kidney cancer]. / Métastases thyroïdiennes d'un cancer du rein.

The authors report a case of multiple thyroid metastases in a patient who had undergone excision of a renal adenocarcinoma eight years previously. At the first operation, there had been no sign of any metastases. A benign thyroid adenoma was also found.

[Oddi sphincterotomy by surgical retroperitoneal approach to the 2d part of the duodenum]. / Sphinctérotomie oddienne par abord chirurgical rétropéritonéal du deuxième duodénum.

Retroperitoneal sphincterotomy using lombotomy is an original surgical approach for treatment of retained stones of the common bile duct. Indication for this technique can be found in patients for whom a transperitoneal approach is contre-indicated and when endoscopic sphincterotomy is impossible.