Intracranial cellular schwannomas: a clinicopathological study of 20 cases.

AIMS: Cellular schwannoma is a specific subtype of schwannoma, prone to misinterpretation as a malignant neoplasm. Involvement of the intracranial compartment by these tumours is extremely rare. We aim to characterise this clinicopathological subgroup. METHODS AND RESULTS: We identified a total of 20 cellular schwannomas with predominant intracranial involvement. The mean age of the patients at the time of surgery was 37 years (range = 16-81), with a slight female predominance (1.5:1 ratio). The most common sites were the eighth (n = 8) and fifth (n = 6) cranial nerves. Three tumours involved the anterior cranial fossa/olfactory groove, and a single case involved the glossopharyngeal nerve. All tumours met established criteria for cellular schwannoma, and were composed of interlacing fascicles of spindle cells lacking Verocay bodies with minimal Antoni B pattern and variable chronic inflammation and foamy histiocytes. Rare findings included haemosiderin deposition (n = 6), necrosis (n = 4), brisk mitotic activity (>10 mitoses per 10 high-power fields) (n = 2), focal epithelioid morphology (n = 2), myxoid areas (n = 2), neuroblastoma-like pattern (n = 1) and granular cells (n = 1). Immunohistochemical stains demonstrated expression of Schwann cell markers (S100 protein, SOX10, collagen IV) and preserved H3 K27 trimethylation in all cases tested. Fourteen patients had postoperative follow-up, ranging from 2 months to 21 years (mean = 66 months). In patients with follow-up, local recurrence/persistence developed in six cases; five tumours were initially incompletely resected. No metastatic disease or deaths were reported. CONCLUSIONS: Intracranial cellular schwannomas share morphological and immunophenotypical features with cellular schwannomas at others sites may demonstrate locally aggressive growth but appear to lack metastatic potential.

Relative Age Effect in the Girls' Volleyball U18 World Championship.

The relative age effect (RAE), within the sporting scope, refers to the possible advantages of participation and performance of athletes born in the first months of the year of selection in relation to others within the same age category. The aim of the present study was to investigate the RAE in girls' volleyball players participating in the U-18 World Championship, analysing the differences between the medal teams and other teams in the tournament, and considering this phenomenon in relation to the continents. Data collection was obtained from the website of the International Volleyball Federation with a sample made of 1654 youth players in the last six world championships (2007, 2009, 2011, 2013, 2015 and 2017). A greater representation of athletes born in the first months of the year of all the world championships was observed. In the comparison among the continents, it was observed that in Africa, there was a more equal distribution of quartiles compared to America, Asia and Europe. It should be noted that there was a higher percentage of medalist athletes born at the beginning of the year in comparison to the countries that placed in the last three positions of the championship. Therefore, in U-18 female volleyball, there is an advantage to have the closest birth age at the beginning of the competitive biennium.