RESUMEN
The aetiology of appendicular abscess is predominantly microbial with aerobic and anaerobic bacteria from gut flora. In this study, by using specific laboratory tools, we co-detected Methanobrevibacter oralis and Methanobrevibacter smithii among a mixture of enterobacteria including Escherichia coli, Enterococcus faecium and Enterococcus avium in four unrelated cases of postoperative appendiceal abscesses. These unprecedented observations raise a question on the role of methanogens in peri-appendicular abscesses, supporting antibiotics as an alternative therapeutic option for appendicitis, including antibiotics active against methanogens such as metronidazole or fusidic acid.
Asunto(s)
Absceso/diagnóstico , Absceso/microbiología , Apendicitis/complicaciones , Methanobrevibacter/clasificación , Absceso/tratamiento farmacológico , Adolescente , Adulto , Antibacterianos/uso terapéutico , Apendicitis/diagnóstico , Apendicitis/tratamiento farmacológico , Cultivo de Sangre , Manejo de la Enfermedad , Susceptibilidad a Enfermedades , Femenino , Humanos , Masculino , Methanobrevibacter/genética , Methanobrevibacter/aislamiento & purificación , Methanobrevibacter/ultraestructura , Persona de Mediana Edad , Tipificación Molecular , ARN Ribosómico 16S/genética , Tomografía Computarizada por Rayos X , Adulto JovenRESUMEN
Untreated tonsillar phlegmon is a life-threatening condition commonly caused by Streptococcus pyogenes and Fusobacterium necrophorum, among other pathogens. Here, using specific laboratory tools, we detected Methanobrevibacter smithii in addition to S. pyogenes. This unprecedented observation questions the role of methanogens in phlegmon and the optimal treatment of this mixed infection.