RESUMEN
OBJECTIVE: Gastrointestinal stromal tumors (GISTs), often sporadic, arise from interstitial Cajal cells of the gastrointestinal tract or their stem cell-like precursors. Apart from tumor-associated syndromes, it has been reported that GISTs are also associated with other tumors. There is no clear information about the etiology of these synchronous tumors. In this study, we wanted to present the clinicopathological features of 13 cases diagnosed as synchronous GIST with other tumors. METHODS: Demographic characteristics of the cases, risk of progressive disease score, tumor localization, size, and the mitotic activity of tumors along with survival status were evaluated. RESULTS: Thirteen of 101 cases diagnosed with GIST had a primary tumor synchronous with GIST. Synchronous GISTs were located in the stomach and small intestine. Most of the cases were detected incidentally in the intraoperative and post-operative periods. Risk scores for progressive disease were categorized as low (n=1), very low (n=1), and no risk (n=11). Non-GIST tumors were located in the stomach, transverse colon, left colon, rectum, gallbladder, kidney, and retroperitoneal space. Histological tumor types were adenocarcinoma, diffuse large B-cell lymphoma, mesothelioma, and neuroendocrine tumor. Life expectancy was found to be significantly lower in synchronous GISTs. CONCLUSION: In cases operated for non-GIST tumors, the possibility of incidental detection of GIST should always be kept in mind.
RESUMEN
Intramedullary ependymomas should be treated with surgical resection. Different surgical techniques are described for these tumors, such as skipped and long-segment myelotomies. A 31-year-old male patient with a giant thoracic spinal cord ependymoma extending from the level of T5 to T10 was operated on with a skipped myelotomy technique. Although the patient had urinary incontinence and muscle weakness in both legs, the patient's complaints were nearly completely resolved in the fourth postoperative month. Operating with the smallest possible myelotomy has given us preferable results; however, more studies are needed to hypothesize the superiority of this technique over conventional myelotomy.
RESUMEN
BACKGROUND: The main problem with the use of diced cartilage grafts is related to the difficulties encountered in shaping the graft and unpredictible graft resorption. The aim of this study was to evaluate the permanence and viability of diced cartilage grafts shaped with the help of biodegradable, three-dimensionally-printed polycaprolactone molds. METHODS: Three groups were studied in each of the eight rabbits: block cartilage (group 1), diced cartilage (group 2), and diced cartilage shaped with polycaprolactone molds (group 3). A total of 24 cartilage grafts were obtained at the end of the 12-week follow-up period, and 10 different histopathologic parameters were analyzed in each cartilage graft. RESULTS: Diced cartilages shaped with a three-dimensionally-printed polycaprolactone mold showed increased regeneration potential of chondrocytes, vascularization, and collagen production. Use of polycaprolactone molds did not cause any additional risk of inflammation, fibrosis, or metaplastic bone formation. CONCLUSIONS: In this study, it has been shown that three-dimensionally-printed polycaprolactone molds can be used safely in shaping diced cartilage grafts. In light of this study, it will be possible to produce hybrid grafts that can be used safely in many operations such as nasal reconstruction, rhinoplasty, auricle reconstruction, and repair of orbital floor fractures with the help of molds produced in more complex ways. CLINICAL RELEVANCE STATEMENT: Three-dimensionally-printed polycaprolactone molds can be used to shape diced cartilages in the areas of both aesthetic and reconstructive surgery.