A review on organophosphate esters: Physiochemical properties, applications, and toxicities as well as occurrence and human exposure in dust environment.

Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers in the world. The use of OPEs has increased rapidly due to the prohibition of polybrominated diphenyl ethers. However, OPEs are mainly added to various materials by physical mixing, they are therefore easy to be released into the environment through volatilization, leaching, and abrasion during their production, use, transportation, and after disposal. Dust, as an important medium for human exposure to OPEs, has attracted extensive attention. Here, this article reviewed the current knowledge on the physiochemical properties, consumptions and applications, and ecotoxicities of OPEs, also synthesized the available data on the occurrence of 13 OPEs in outdoor and indoor dust environments around the world over the past decade. The results showed that the sum of OPEs (ΣOPEs) was the highest in outdoor dust from an e-waste disposal area in Tianjin of China (range: 1390-42700 ng/g dw; mean: 11500 ng/g dw). The highest ΣOPEs was found in Japan for home dust (range: 9300-11000000 ng/g dw; mean: 266543 ng/g dw), Sweden for office dust (range: 14000-1600000 ng/g dw; mean: 360100 ng/g dw) and daycare center dust (range: 40000-4600000 ng/g dw; mean: 1990800 ng/g dw), and Brazil for car dust (range: 108000-2050000 ng/g dw; mean: 541000 ng/g dw). The use pattern of OPEs differed in different regions and countries. The exposure and risk assessment based on the data of OPEs in home dust indicated that the average daily intakes of OPEs via dust ingestion for children and adults were lower than the corresponding reference doses; and that the current human exposure to OPEs through indoor dust ingestion were not likely to pose risks to human health. Finally, the review pointed out the gaps of current research and provided the directions for further study on OPEs in dust environment.

Characteristics, sources, bio-accessibility, and health risks of organophosphate esters in urban surface dust, soil, and dustfall in the arid city of Urumqi in China.

Sixty-eight paired samples of urban surface dust and soil as well as four samples of atmospheric dustfall were collected from the arid city of Urumqi in Northwest China. Thirteen organophosphate esters (OPEs) in these samples were analyzed for the characteristics, sources, bio-accessibility, and health risks of OPEs. The studied OPEs were widely detected in the urban surface dust, soil, and dustfall, with Σ13OPEs (total concentration of 13 OPEs) of 1362, 164.0, and 1367 ng/g, respectively, dominated by tris(2-chloroethyle) phosphate (TCEP), tri(2-chloroisopropyl) phosphate (TCiPP), tri(1, 3-dichloroisopropyl) phosphate (TDCiPP) and tris(2-butoxyethyl) phosphate (TBOEP), TBOEP and tri(2-ethylhexyl) phosphate (TEHP), and TCEP, TCiPP, TBOEP, triphenyl phosphate and TEHP, respectively. The low and high frequency magnetic susceptibility of surface dust and urban soil might indicate the pollution of OPEs in them. Elevated levels of the Σ13OPEs in the surface dust and urban soil were found in the west, south, and northeast of Urumqi city. The total deposition flux of dustfall-bound 13 OPEs ranged from 86.5 to 143 ng/m2/day, with a mean of 105 ng/m2/day. OPEs in the surface dust and urban soil were associated with the emissions of indoor and outdoor products containing OPEs, the dry and wet deposition of atmosphere, and the emissions of traffic. Trimethyl phosphate, triethyl phosphate, tripropyl phosphate, tri-isobutyl phosphate, TCEP, TCiPP, TDCiPP, and TBOEP in surface dust and urban soil had relatively high bio-accessibility. The bio-accessibility of OPEs was mainly affected by the physio-chemical properties of OPEs. The non-cancer and cancer risks of human exposure to OPEs in surface dust and urban soil were relatively low or negligible. The current research results may provide scientific supports for prevention and control of pollution and risks of OPEs.