Are anomalous perceptual experiences necessary for delusions?

Several theories of delusions suggest that anomalous perceptual experience is necessary for delusion formation. This study evaluated levels of anomalous perceptual experience in a large group of nonclinical participants from the general population (N = 337), a group of psychotic inpatients (N = 20), and 2 groups of hallucinating (N = 24) and nonhallucinating (N = 24) deluded patients. The aims of the study were to evaluate the hypothesis that pathological levels of anomalous perceptual experience were necessarily associated with delusions. Using the Cardiff Anomalous Perceptions Scale, the main finding was that as a group, nonhallucinating deluded patients were not significantly different from nonclinical participants on any of the anomalous perceptual experience indices. We conclude that anomalous perceptual experience, as measured by the Cardiff Anomalous Perceptions Scale, is not necessary for the presence of delusions.

Explaining delusions: a cognitive perspective.

There is now considerable evidence for reasoning, attention, metacognition and attribution biases in delusional patients. Recently, these findings have been incorporated into a number of cognitive models that aim to explain delusion formation, maintenance and content. Although delusions are commonly conceptualized as beliefs, not all models make reference to models of normal belief formation. This review considers those models that explain delusions as a breakdown of normal belief formation (belief-positive models), approaches that explain the pathology only (belief-negative models) and approaches that view delusions as one end of a distribution of anomalous mental phenomena (the continuum view). A cognitive theory that includes the 'pragmatic pathology' of delusions will be able to address both the phenomenology and the treatment of delusion-related distress.

Relative suppression of magical thinking: a transcranial magnetic stimulation study.

The tendency to perceive meaning in noise (apophenia) has been linked to "magical thinking" (MT), a distinctive form of thinking associated with a range of normal cognitive styles, anomalous perceptual experiences and frank psychosis. Important aspects of MT include the propensity to imbue meaning or causality to events that might otherwise be considered coincidental. Structures in the lateral temporal lobes have been hypothesised to be involved in both the clinical and nonclinical aspects of MT. Accordingly, in this study we used single-pulse transcranial magnetic stimulation (TMS) to stimulate either the left or right lateral temporal areas, or the vertex, of 12 healthy participants (balanced for similar levels of MT, delusional ideation and temporal lobe disturbance) while they were required to indicate if they had "detected" pictures, claimed to be present by the experimenters, in visual noise. Relative to the vertex, TMS inhibition of the left lateral temporal area produced significant reduced tendency to report meaningful information, suggesting that left lateral temporal activation may be more important in MT and therefore producing and supporting anomalous beliefs and experiences. The effect cannot simply be explained by TMS induced cognitive slowing as reaction times were not affected.

Hereditary prosopagnosia: the first case series.

Prosopagnosia is defined as a specific type of visual agnosia characterised by a discernible impairment in the capacity to recognise familiar people by their faces. We present seven family pedigrees with 38 cases in two to four generations of suspected hereditary prosopagnosia, detected using a screening questionnaire. Men and women are impaired and the anomaly is regularly transmitted from generation to generation in all pedigrees studied. Segregation is best explained by a simple autosomal dominant mode of inheritance, suggesting that loss of human face recognition can occur by the mutation of a single gene. Eight of the 38 affected persons were tested on the Warrington Recognition Memory Test for Faces (RMF; Warrington, 1984), famous and family faces tests, learning tests for internal and external facial features and a measure of mental imagery for face and non-face images. As a group, the eight participants scored significantly below an age- and education-matched comparison group on the most relevant test of face recognition; and all were impaired on at least one of the tests. The results provide compelling evidence for significant genetic contribution to face recognition skills and contribute to the promise offered by the emerging field of cognitive neurogenetics.

Delusions: A suitable case for imaging?

This review is intended to outline the need/opportunities for imaging research in the area of delusions. In particular, delusions of misidentification are offered as possible examples of how both spatial and temporal brain imaging may throw light upon the theoretical, parallel processes of identification and emotional arousal occurring when a familiar face is encountered. Other types of Delusional Misidentifications are also briefly explored. The review then turns to related phenomena, including the ways imaging may help elucidate different types of covert face recognition; and also further explain the distinctive (but not entirely independent) processes underlying face, voice and object recognition. Throughout the review the aim is to emphasise the potential value to cognitive neuropsychiatry of good imaging techniques.

Diagnosing delusions: a review of inter-rater reliability.

Although several studies have examined the reliability of diagnosing delusions there is no comprehensive review of the literature. Therefore, the reliability of diagnosing 'delusions in general' and the subcategory of 'bizarre delusions' was reviewed, including both structured interview and standardized instrument methods. The literature suggests that delusions in general can be diagnosed reliably with both structured interview and standardized instruments. However, bizarre delusions are not reliably diagnosed by either, suggesting that this concept may have little clinical validity. Nevertheless, many of the studies reviewed are poorly designed or subject to significant confounds. Criteria are suggested for adequate future studies.

The Cardiff Anomalous Perceptions Scale (CAPS): a new validated measure of anomalous perceptual experience.

The study describes the Cardiff Anomalous Perceptions Scale (CAPS), a new validated measure of perceptual anomalies. The 32-item CAPS measure is a reliable, self-report scale, which uses neutral language, demonstrates high content validity, and includes subscales that measure distress, intrusiveness, and frequency of anomalous experience. The CAPS was completed by a general population sample of 336 participants and 20 psychotic inpatients. Approximately 11% of the general population sample scored above the mean of the psychotic patient sample, although, as a group, psychotic inpatients scored significantly more than the general population on all CAPS subscales. A principal components analysis of the general population data revealed 3 components: "clinical psychosis" (largely Schneiderian first-rank symptoms), "temporal lobe disturbance" (largely related to temporal lobe epilepsy and related seizure-like disturbances) and "chemosensation" (largely olfactory and gustatory experiences), suggesting that there are multiple contributory factors underlying anomalous perceptual experience and the "psychosis continuum."

Asperger syndrome: tests of right hemisphere functioning and interhemispheric communication.

The primary aim of this investigation was to assess to what extent Rourke's (1989, 1995) nonverbal learning disabilities syndrome (NLD) model resembles the pattern of assets and deficits seen in people with Asperger syndrome (AS). NLD can be characterized by a cluster of deficits primarily affecting nonverbal aspects of functioning, in the presence of proficiency in single word reading and a superior verbal memory. The neurological underpinnings of this syndrome may be dysfunction of white matter affecting right hemisphere functioning and interhemispheric communication. To explore this hypothesis, eight participants with AS (ages 10 to 41 years) were assessed in the following areas: the pragmatics of language and communication, verbal and visual memory, visual-spatial abilities, and bimanual motor skills. Results confirmed the close similarity in the neuropsychologic profiles of NLD and AS.

A preliminary study of right hemisphere cognitive deficits and impaired social judgments among young people with Asperger syndrome.

Seven children and young adults with definite signs of Asperger syndrome were administered a battery of tests designed to test: intelligence; left and right cerebral hemisphere functioning; ability to discriminate eye gaze; and social judgment. The subjects revealed a non significant tendency to have a higher verbal IQ than visual IQ; and their right hemisphere functioning seemed impaired. They were also poorer at discriminating eye gaze and revealed difficulties in making hypothetical social judgments. The data are considered with reference to Rourke's (1988) work on non-verbal learning disabilities together with the ideas of Tantam (1992) on the "social gaze response" and Baron-Cohen's (1993) Eye-Detection Detector model. The possible links between social judgment and theory of mind (Frith, 1991) are briefly explored.

Associative priming in faces: semantic relatedness or simple co-occurrence?

In two experiments, we explored the effects of co-occurrence and semantic relationships in the associative priming of faces. In Experiment 1, pairs of computer-generated human faces were presented simultaneously (i.e., they co-occurred) with no associated semantic information attached to them. A significant facilitation effect in the subsequent recognition of these paired faces (priming) was observed. Thus, repeatedly presenting faces together while keeping semantic information to a minimum appears to be enough to produce associative priming. In Experiment 2, the computer-generated faces were associated with semantic information and again presented ipairs. Priming effects arising from co-occurrence and semantic relatedness were observed. The results from these experiments show that semantic relatedness is not the sole cause of the association between faces; co-occurrence plays a crucial role too. This conclusion has significant implications for the current computational models of face processing.

'Internet delusions': a case series and theoretical integration.

BACKGROUND: Delusions involving the internet have been reported as examples of the influence of cultural innovations on delusion formation, although there has been some debate as to whether such innovations simply affect surface content, or whether they have more substantial clinical or psychopathological implications. SAMPLING AND METHODS: Four cases of patients with delusions involving the internet were identified following a general request to local consultant psychiatrists for referrals. RESULTS: The internet had a specific effect on aetiology in one case, and knowledge of the internet seemed to constrain the type of delusion formed in two others. The presence of an internet-related delusion in the final case was used to frame a successful clinical intervention based on the 'collaborative empiricism' method, using cognitive behavioural therapy and collaborative use of the internet to resolve the delusional belief. CONCLUSIONS: Cultural technical innovations may have specific influences on the form, origin and content of delusional beliefs. For some patients the presence of internet-themed delusions may be a good prognostic indicator since, given the rich sources of information available, they may be well suited to treatment with cognitive behavioural therapy.

Exploring a neural-network account of age-of-acquisition effects using repetition priming of faces.

The question of whether age-of-acquisition (AoA), frequency, and repetition priming effects occur at a common stage or at different stages of processing is addressed. Two single-stage accounts (i.e., cumulative frequency and a neural-network simulation) are considered in regard to their predictions concerning the interactions between AoA and frequency with aging and priming effects. A repetition-priming face-classification task was conducted on both older and younger participants to test these predictions. Consistent with the predictions of the neural-network simulation, AoA had an effect on reaction times that could not be explained by cumulative frequency alone. Also, as predicted by the simulation, the size of the priming effect was determined by the cumulative frequency of the item. It is discussed how this evidence is supportive of the notion that AoA , frequency, and priming all have effects at a common and single stage during face processing.