RESUMEN
The mucin profile of 24 endoscopic biopsies of heterotopic gastric mucosa (HGM) of the upper esophagus in adults and a control group of ten cases of Meckel's diverticula containing heterotopic gastric mucosa were studied with two combined histochemical methods: alcian blue pH 2.5/PAS and high iron diamine/alcian blue pH 2.5. The clinical and light microscopic features of the 24 HGM cases were also reviewed. In addition to overall secretion of neutral mucins by the 24 HGM cases, mucin histochemistry showed prominent secretion of acidic mucins in 19 of 24 HGM cases (79%), with sulphomucins in 11 of 24 HGM cases (45.8%). This mucin profile of HGM was unlike that of either normal gastric mucosa or heterotopic gastric mucosa in Meckel's diverticula. Moreover, a comparison between the mucin profile and clinical features of HGM and Barrett's esophagus showed certain similarities. The data suggest a physiopathologic link between HGM and Barrett's esophagus.
Asunto(s)
Coristoma/patología , Neoplasias Esofágicas/patología , Mucosa Gástrica , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Esófago de Barrett/patología , Coristoma/análisis , Neoplasias Esofágicas/análisis , Femenino , Mucosa Gástrica/patología , Humanos , Masculino , Persona de Mediana Edad , Mucinas/análisisAsunto(s)
Neoplasias del Colon/prevención & control , Pólipos del Colon/prevención & control , Colonoscopía/métodos , Neoplasias Colorrectales/genética , Adulto , Neoplasias del Colon/genética , Pólipos del Colon/genética , Femenino , Humanos , Masculino , Tamizaje Masivo , Persona de Mediana Edad , Estudios Prospectivos , Estudios RetrospectivosAsunto(s)
Coristoma/patología , Neoplasias Esofágicas/patología , Estómago , Adulto , Anciano , Esofagoscopía , Femenino , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Angiodisplasia/cirugía , Enfermedades Duodenales/cirugía , Fallo Renal Crónico/terapia , Terapia por Láser/métodos , Gastropatías/cirugía , Angiodisplasia/etiología , Enfermedades del Colon/etiología , Enfermedades del Colon/cirugía , Enfermedades Duodenales/etiología , Femenino , Estudios de Seguimiento , Humanos , Fallo Renal Crónico/complicaciones , Masculino , Persona de Mediana Edad , Diálisis Renal , Estudios Retrospectivos , Gastropatías/etiologíaAsunto(s)
Colitis Isquémica/etiología , Deficiencia de Proteína S/complicaciones , Adulto , Femenino , HumanosRESUMEN
A patient is reported with chronic abdominal pain, diarrhoea, and associated radiological and endoscopic abnormalities of the sigmoid colon. Light and electron microscopic study of colorectal mucosa showed abnormal collagenous thickening of the subepithelial basement membrane. The authors felt that the clinical and morphological features justified a diagnosis of collagenous colitis. Review of the literature suggested that collagenous colitis was still an unrecognised entity.