RESUMEN
59 patients with far advanced chronic pulmonary tuberculosis were treated, after a three months daily period of RMP/EMB and a third drug, with RMP 1.2 g and EMB 50 mg/kg twice weekly for the following 9 months and there after with EMB 50 mg/kg twice weekly for another 12 months. Sputumconversion was achieved in all patients within four months. Except for one bacteriological relapse during the 10th month of therapy all patients were TB-negative up to the end of at least four years (4-6 1/2 years) after onset of treatment. In nearly 78% of the patients the treatment was fully accepted and well tolerated during the first year. 8 patients had systemic reactions due to RMP between the 7th and 12th month. Only in 5 patients RMP had to be substituted by another drug. The regimen has proved to be highly effective, well acceptable and tolerable. It could be administered fully supervised.
Asunto(s)
Etambutol/uso terapéutico , Rifampin/uso terapéutico , Tuberculosis Pulmonar/tratamiento farmacológico , Adulto , Anciano , Quimioterapia Combinada , Etambutol/administración & dosificación , Femenino , Estudios de Seguimiento , Humanos , Masculino , Métodos , Persona de Mediana Edad , Periodicidad , Rifampin/administración & dosificaciónRESUMEN
89 patients with sputum-positive silico-tuberculosis got a fully supervised administered antituberculous treatment with intermittent regimens during the years 1969-1974. 65 of the patients had a history of former antituberculous treatment. In only 5 patients the treatment was unsuccessful. Four of the relapses were observed between the 6th and 11th month of treatment. One patient had a relapse 56 months after the onset of chemotherapy. The results indicate that only the quality of the anti-TB treatment is of importance for the course of the tuberculous component in silico-tuberculosis. The results are comparable with those of uncomplicated TB of the lungs.
Asunto(s)
Antituberculosos/uso terapéutico , Silicotuberculosis/tratamiento farmacológico , Adulto , Anciano , Femenino , Alemania Oriental , Humanos , Masculino , Métodos , Persona de Mediana Edad , Periodicidad , Estudios Retrospectivos , Silicotuberculosis/mortalidad , Esputo/análisisRESUMEN
After application of Pethidine to the mother for the purpose of obstetric analgesia we couldn't find any changes in the fetal tcPO2-behaviour. As well 95 term infants with and without previous Pethidine-application to the mother showed no disturbance of cardio-pulmonary adaptation in hyperoxia-test.