1.
Infection
; 49(4): 757-762, 2021 Aug.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33825125
RESUMEN
Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
Asunto(s)
COVID-19/inmunología , Monocitos/inmunología , SARS-CoV-2/fisiología , Lectina 1 Similar a Ig de Unión al Ácido Siálico/sangre , Anciano , Femenino , Hospitalización , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Lectina 1 Similar a Ig de Unión al Ácido Siálico/biosíntesis , Regulación hacia Arriba
2.
Am J Respir Crit Care Med
; 207(2): e1-e3, 2023 01 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36174190