RESUMEN
This study investigated the effects of a Developmental Learning Program upon self-concept of 40 children having trouble in school. While preliminary in nature, the results suggest that such a program may have a beneficial effect.
Asunto(s)
Discapacidades para el Aprendizaje/rehabilitación , Educación Compensatoria , Instituciones Académicas , Autoimagen , Niño , Conducta Infantil , HumanosAsunto(s)
Hepatitis C Crónica/metabolismo , Resistencia a la Insulina , gamma-Glutamiltransferasa/sangre , Antivirales/uso terapéutico , Biomarcadores/sangre , Hepatitis C Crónica/diagnóstico , Hepatitis C Crónica/tratamiento farmacológico , Hepatitis C Crónica/patología , Humanos , Hígado/patologíaRESUMEN
BACKGROUND/AIMS: Treatment with hepatitis B virus immune globulins (HBIG) or lamivudine has reduced the rate of hepatitis B recurrence after liver transplantation to approximately 50%. METHODS: To further decrease hepatitis B recurrence, 33 hepatitis B virus (HBV)-related cirrhotic patients were treated with lamivudine before liver transplantation and with lamivudine together with low-dose HBIG (46 500 IU the first month followed by 5,000 lU/monthly) after surgery. RESULTS: While on lamivudine, serum HBV DNA level decreased significantly in all patients and in 11 (33%) the Child-Pugh score improved. Twenty-six patients were transplanted. Among the 25 who survived for longer than 12 months, only one (4%) experienced a hepatitis B recurrence over an average follow-up of 31 months, a rate significantly lower (P = 0.0002) than the 50% recurrence rate among a historical control group of 12 patients. However, low-level HBV replication was detected sporadically throughout the follow-up in 64% of patients. CONCLUSIONS: Over the medium-term, combined prophylaxis with lamivudine and HBIG significantly decreases the risk of hepatitis B recurrence after liver transplantation. Though low-level HBV infection recurred in two thirds of patients, the pathogenic expression of HBV was prevented.