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1.
Int J Environ Health Res ; : 1-14, 2024 Jul 31.
Artículo en Inglés | MEDLINE | ID: mdl-39082160

RESUMEN

This cross-sectional study, conducted on 4003 participants aged between 18 and 45, aims to contribute to orthorexia nervosa (ON) research by examining the relationship between ON, body image and nutritional adequacy. The Orthorexia Nervosa-11 scale (ORTO-11) and body perception scale were applied to individuals, and food consumption records were taken with a 24-hour dietary recall method. The study found that more individuals with orthorexia nervosa (ON) considered themselves overweight compared to non-ON individuals. Evaluating diet quality, the mean adequacy ratio was significantly higher in ON individuals. Nutrient adequacy ratios for total fiber, magnesium, zinc, thiamine, folic acid, and vitamin C were higher, while those for carbohydrate and iron were lower in ON individuals. Additionally, increasing the number of snacks, protein, and total fiber adequacy decreased the ORTO-11 score. Distorted body image perception may be a risk factor for ON, but healthy eating fixation does not lead to nutrient inadequacy unless it involves progressive food restriction.

2.
Int J Vitam Nutr Res ; 90(3-4): 353-364, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31512572

RESUMEN

Objective: The aim of the present study is to perform a systemic review of the previous studies executed on the association between obesity and folate. Method: In the present research, the selected keywords were scanned on the PubMed, Web of Science, Cochrane and Lilac databases between May and June, 2017 through Gazi University's network. In total, 4236 clinical, randomized controlled, cross-sectional and prospective studies were determined and 17 of these that specifically fit the aims of the present research were reviewed. This study involved an electronic literature search of databases on folic acid and obesity published in the English language between 2000 and 2016. Results: Of the 17 studies, 5 were based on folic acid supplementation and 12 were related with participants' folate status. As a general consequence of both intake and serum/status measurements of folic acid supplementation: It was found that obesity-associated metabolic changes might affect individual folate use and obese individuals had lower serum folate levels, although there was no change in folate intake. Conclusion: Overweight and obese individuals have lower serum folate concentrations when compared with individuals with normal weight. It is explained by increased use of folic acid, urinary excretion, dilution of blood volume, different levels in different tissues and changes in the endocrine functions of folate. Individuals with higher Body Mass Indexes have less supplement use, unhealthier diets and donot consume sufficient vegetables and fruits, all of which can affect decrease in folate levels. Furthermore, adiposity may affect folate absorption by intestinal epithelium.


Asunto(s)
Ácido Fólico , Homocisteína/metabolismo , Obesidad , Estudios Transversales , Suplementos Dietéticos , Ácido Fólico/química , Ácido Fólico/metabolismo , Homocisteína/química , Humanos , Estudios Prospectivos
3.
Lipids Health Dis ; 18(1): 212, 2019 Dec 06.
Artículo en Inglés | MEDLINE | ID: mdl-31810473

RESUMEN

BACKGROUND: Variations in the fat mass and obesity-associated (FTO) gene (16q12.2) are associated with obesity in some populations. This study aimed to determine the relationship between FTO gene polymorphism and adiposity&related markers in Turkish adults was aimed. METHODS: The present study included 200 participants aged 18-65 years, who were genotyped for variants of the FTO gene (rs9939609). Anthropometric measurements were performed. Body compositions were analyzed with Tanita BC 545 N Inner ScanTM. Infrared analyzer (VISCANTM) was also used to determinate the degree of abdominal fat. Body mass index (BMI), body adiposity index (BAI) and lipid accumulation products (LAP) index which are used in body fat estimation were calculated. Body fat amounts were classified using gender-based cut-offs. Odds ratio (OR) and 95% confidence interval (CI) were calculated to determine the risk of having a high body fat amount associated with the risk allele. RESULTS: The frequency of the rs9939609 AA genotype was 19.0%, which was 42.5% for the AT genotype and 38.5% for the TT genotype (wild type). AA genotype was found to be higher in females than in males (26.0 and 12.0%, respectively). The total body fat amount of the individuals with AA genotype was high (28.5 ± 9.25%) compared to AT (27.0 ± 10.31%) and TT (23.7 ± 10.62%) genotype (p < 0.05). However, there was no difference in abdominal fat amounts (%) (AA:38.6%, AT:36.2%, TT:33.7%), internal fat levels and waist/hip ratios (p > 0.05). Significance of association between FTO genotypes and total body fat (%) was retained after adjustment for BMI and gender as well. BMI, LAP, and BAI index values were not different between different genotypes in all individuals and different genders (p > 0.05). CONCLUSION: Our study supports that the FTO rs9939609 polymorphism is associated with fat accumulation in the whole body without being associated with abdominal fat accumulation in Turkish adults.


Asunto(s)
Grasa Abdominal/metabolismo , Tejido Adiposo/metabolismo , Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética , Predisposición Genética a la Enfermedad , Obesidad/genética , Polimorfismo de Nucleótido Simple , Adolescente , Adulto , Anciano , Alelos , Composición Corporal/genética , Índice de Masa Corporal , Femenino , Expresión Génica , Frecuencia de los Genes , Humanos , Masculino , Persona de Mediana Edad , Obesidad/diagnóstico , Obesidad/metabolismo , Turquía , Circunferencia de la Cintura , Relación Cintura-Cadera
4.
Ecol Food Nutr ; 58(5): 470-480, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31124383

RESUMEN

Nutritional programs are one of the most important public health policies in order to prevent obesity. School teachers are role models for students and their nutrition knowledge about these policies can affect children's dietary habits. The aim of this observational descriptive study was to evaluate the school teachers' awareness about nutrition programs for the prevention of obesity of the Ministry of Education in Turkey. It was conducted to 87,070 classroom teachers working at state schools from all the cities of Turkey. Data collection was obtained with a plain web-based survey, and national nutrition programs (Nutrition-Friendly School Program, White-Flag Protocol, and circular letter on foods can be sold in school canteens) were questioned. Mean age of teachers was 38.3 ± 9.30 years and 50.4% of them were male. It was determined that only 66.2% of the teachers know whether their school is nutrition-friendly. Frequency of knowing "White-Flag" Protocol was 80.1%. Present study showed that educational programs about nutrition policies are required in order to increase knowledge among school teachers and thus, prevent childhood obesity.


Asunto(s)
Programas Nacionales de Salud , Obesidad Infantil/prevención & control , Maestros , Adulto , Anciano , Recolección de Datos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Encuestas y Cuestionarios , Turquía , Adulto Joven
5.
Tuberk Toraks ; 64(4): 289-298, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28393718

RESUMEN

Chronic obstructive pulmonary disease (COPD) is a complex disease that is associated with devastating outcomes resulting from lung involvement and several comorbidities. Comorbidities could impact on symptomology, quality of life, the complications, the management, economic burden and the mortality of the disease. The importance of comorbidities originates from their impact on the outcome of COPD. The most frequent comorbidities in COPD are cardiovascular, endocrinological, musculoskeletal, phycological disorders and lung cancer. Almost 50% of the COPD patients have 3 or more comorbidities. The recent Global Initiative of Obstructive Lung Disease (GOLD) Guideline suggested proactive search and the treatment of the comorbidities. However, there is no certain evidence demonstrating that active treatment of comorbidities improve the outcomes of COPD. However, it is well known that several comorbidities such as cardiovascular disease and lung cancer have greater impact on mortality caused by COPD. Several studies have shown that Charlson Comorbidity index or more recenty COPD Specific Comorbidity Index (COTE) has been found to be related with mortality of COPD. This concise review intended to summarize the most frequent comorbidities in association with their impact on COPD.


Asunto(s)
Enfermedades Cardiovasculares/complicaciones , Neoplasias Pulmonares/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Calidad de Vida , Comorbilidad , Humanos
6.
Public Health Nutr ; 17(12): 2692-9, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24476606

RESUMEN

OBJECTIVE: To explore the influences of migration to a Western country on obesity and related risk factors by comparing measures of body composition and energy balance-related behaviours between Turkish adolescents in Turkey (TR-TR) and adolescents from Turkish immigrant ethnicity in the Netherlands (TR-NL). DESIGN: Cross-sectional survey or baseline intervention data from six Dutch school-based studies and one Turkish study. SETTING: Primary and secondary schools. SUBJECTS: A total of 915 (49 % girls; mean age 13·1 (sd 0·8) years) TR-TR adolescents and 433 (51 % girls; mean age 11·7 (sd 1·3) years) TR-NL adolescents were included. Outcome measures were self-reported sugar-containing beverage consumption, fruit and vegetable intake, screen time, physical activity, measured body height and weight, BMI, waist and hip circumferences, and skinfold thicknesses. RESULTS: Our data showed that more TR-NL adolescents were overweight (31 % v. 26 %) and obese (9 % v. 6 %) and had significantly higher mean BMI (21·1 v. 20·0 kg/m2), waist circumference (72·2 v. 71·3 cm) and suprailiac skinfold thickness (19·8 v. 13·1 mm) than TR-TR adolescents. TR-NL adolescents reported significantly higher sugar-containing beverage consumption (1173 v. 115 ml/d), less fruit and vegetable intake (295 v. 647 g/d), less screen time (253 v. 467 min/d) and higher physical activity levels (61 v. 27 min/d) than TR-TR adolescents. CONCLUSIONS: Immigrant adolescents in the Netherlands were more often overweight and had a less favourable dietary pattern than their peers in Turkey, while their physical activity and screen time patterns were more favourable. These results suggest that adolescents from Turkish immigrant ethnicity in the Netherlands have adopted lifestyles towards the host culture.


Asunto(s)
Composición Corporal , Dieta , Emigrantes e Inmigrantes , Ejercicio Físico , Conducta Alimentaria , Conductas Relacionadas con la Salud , Obesidad/epidemiología , Adolescente , Índice de Masa Corporal , Estudios Transversales , Ingestión de Energía , Metabolismo Energético , Femenino , Humanos , Masculino , Países Bajos/epidemiología , Sobrepeso/epidemiología , Instituciones Académicas , Conducta Sedentaria , Grosor de los Pliegues Cutáneos , Turquía/epidemiología , Turquía/etnología , Circunferencia de la Cintura
7.
Nutr Bull ; 49(1): 40-51, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38115211

RESUMEN

This study aimed to (1) evaluate the nutritional status, prevalence of malnutrition and dietary habits in individuals using substances and (2) examine the possible effects of substance use on the perception of five basic tastes. Ninety male individuals with substance use disorder (SUD) (heroin = 78, cocaine = 12) and 32 non-users participated in the study conducted at Manisa Alcohol and Substance Addiction Treatment Center (AMATEM), Turkey. To determine the quality of the diet, the mean nutrient adequacy ratio (MAR) was calculated based on 24-h recall food consumption records of the individuals. Subjective Global Assessment (SGA) was employed to determine nutritional status, and anthropometric measurements were also taken from the individuals. The taste detection and recognition thresholds were determined with solutions with different concentrations for bitter, sour, sweet, umami and salty tastes and scored, with higher scores indicating lower thresholds. Mild-moderate malnutrition was determined in 50% of the individuals with SUD based on SGA. The body mass index (BMI) of individuals with SUD was found to be 21.2 ± 1.88 kg/m2 , and 24.1 ± 1.64 kg/m2 for non-users (p < 0.001). Diet quality, evaluated by MAR, was lower in individuals with SUD (54.7 ± 18.9%) than in non-users (93.5 ± 9.0%) (p < 0.001). The taste detection and taste recognition thresholds of individuals with SUD were impaired, and the threshold scores for sour, salty, sweet and umami taste recognition were significantly lower compared with non-users, with the lowest substance user threshold scores observed for the sweet recognition threshold. Standardised nutritional and behavioural interventions designed by dietitians should be provided for drug users in treatment centres and integrated with medical treatment practices.


Asunto(s)
Desnutrición , Trastornos Relacionados con Sustancias , Humanos , Masculino , Gusto , Estado Nutricional , Dieta , Disgeusia , Desnutrición/diagnóstico , Trastornos Relacionados con Sustancias/epidemiología , Valor Nutritivo
8.
J Am Nutr Assoc ; : 1-11, 2024 Nov 05.
Artículo en Inglés | MEDLINE | ID: mdl-39499665

RESUMEN

OBJECTIVES: There is no consensus on the ideal frequency of meals for the prevention and treatment of obesity. While some studies have reported that increasing meal frequency might be beneficial in the treatment of obesity due to its positive effects on glycemic regulation, appetite and diet quality, other studies have reported negative effects. In this study, it was aimed to examine the effect of meal frequency on body composition, anthropometric measurements, some of the biochemical parameters and diet quality in overweight/obese adults. METHODS: A total of 91 individuals, all overweight/obese, between the ages of 18-64, including 46 consuming 2 main meals (2MMG) and 45 consuming 3 main meals (3MMG) participated in the study. General characteristics and dietary habits of the individuals were obtained with a questionnaire. A 3-day food consumption record was taken to determine their daily energy and nutrient intake and to evaluate their diet quality with the "Healthy Eating Index 2015". Anthropometric measurements of the individuals were performed, body compositions were analyzed and some blood parameters were evaluated. RESULTS: The median values of body weight, lean body mass (kg), total body water, basal metabolic rate and hip circumference of men in the 3MMG were found to be higher than men in the 2MMG (p < 0.05). The anthropometric measurements and body composition components of women were similar between the two groups (p > 0.05). The renal urea nitrogen and total cholesterol values of women in 2MMG were higher than those of women in the 3MMG. In the regression analysis, a 1-unit increase in the number of main meals was determined to lead to a 9.3 points increase in the total score of HEI 2015. CONCLUSIONS: Regular consumption of main meals may have positive effects on diet quality, some of the biochemical parameters, basal metabolic rate and body composition in overweight/obese adults. In this group, which is known to have incorrect food preferences in general, it is important to plan the number of meals and the content of these meals correctly.

9.
Curr Nutr Rep ; 13(3): 444-454, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38805166

RESUMEN

PURPOSE OF REVIEW: Type 2 diabetes, characterized by inadequate insulin secretion and resistance, is increasingly prevalent. To effectively manage type 2 diabetes, identifying new therapeutic targets is crucial. MicroRNAs, short noncoding RNA molecules, play a pivotal role in regulating ß-cell function, insulin production, and resistance, and show promise as biomarkers for predicting type 2 diabetes onset. Phytochemicals, known for their antioxidant activities, may influence microRNA expression, potentially improving insulin sensitivity and mitigating associated complications. This review aims to explore the significance of microRNA in type 2 diabetes, their potential as biomarkers, and how certain phytochemicals may modulate microRNA expressions to reduce or prevent diabetes and its complications. RECENT FINDINGS: Current research suggests that microRNAs show promise as novel therapeutic biomarkers for diagnosing type 2 diabetes and monitoring diabetic complications. Additionally, phytochemicals may regulate microRNAs to control type 2 diabetes, presenting a potential therapeutic strategy. The multifactorial effects of phytochemicals on type 2 diabetes and its complications through microRNAs warrant further research to elucidate their mechanisms. Comprehensive clinical trials are needed to assess the safety and efficacy of phytochemicals and their combinations. Given their ability to modulate microRNAs expression, incorporating phytochemical-rich foods into the diet may be beneficial.


Asunto(s)
Diabetes Mellitus Tipo 2 , MicroARNs , Fitoquímicos , Diabetes Mellitus Tipo 2/tratamiento farmacológico , MicroARNs/genética , Humanos , Fitoquímicos/farmacología , Biomarcadores , Antioxidantes/farmacología , Resistencia a la Insulina
10.
Curr Nutr Rep ; 13(4): 729-750, 2024 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-39251542

RESUMEN

PURPOSE: This systematic review aims to examine the relationship between serum folate level and folic acid supplements with glycemic control parameters (fasting blood glucose (FBG), insulin level, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and Hemoglobin A1C (HbA1c)) in adult individuals with current studies. METHODS: In this study, which was designed as a systematic review, the searches were performed on Web of Science, Science Direct, Medline, Wiley, and Cochrane Library databases between April 10, 2023, and May 10, 2023, and the searches were updated between October 16, 2023, and November 14, 2023. Of the 1855 studies obtained from the screening, 17 met the criteria and were included in the systematic review. The PROSPERO system registered the study protocol (ID: CRD42023472434). RECENT FINDINGS: Although no significant correlation was found between serum folate levels and glycemic control parameters in most of the cross-sectional studies included in this systematic review, most of the randomized controlled trials showed that glycemic control parameters (FBG, insulin, HOMA-IR) decreased significantly in the intervention group receiving folic acid supplementation compared to the control group. However, study durations were short, and HbA1c needed to be evaluated in most studies. This makes it difficult to get information about the long-term effects of folic acid supplementation. More comprehensive studies should be conducted to draw more precise conclusions about the relationship between folic acid levels and folic acid supplementation with glycemic control parameters.


Asunto(s)
Glucemia , Suplementos Dietéticos , Ácido Fólico , Hemoglobina Glucada , Control Glucémico , Resistencia a la Insulina , Insulina , Humanos , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Ácido Fólico/administración & dosificación , Ácido Fólico/sangre , Hemoglobina Glucada/metabolismo , Control Glucémico/métodos , Insulina/sangre , Ensayos Clínicos Controlados Aleatorios como Asunto , Vitaminas/administración & dosificación , Vitaminas/sangre
11.
J Pediatr Endocrinol Metab ; 34(2): 151-162, 2021 Feb 23.
Artículo en Inglés | MEDLINE | ID: mdl-33185580

RESUMEN

Obesity, a complex, multi-factor and heterogeneous condition, is thought to result from the interaction of environmental and genetic factors. Considering the result of adolescence obesity in adulthood, the role of genetic factors comes to the fore. Recently, many genome-wide association studies (GWAS) have been conducted and many loci associated with adiposity have been identified. In adolescents, the strongest association with obesity has been found in single nucleotide polymorphisms (SNP) in the FTO gene. Besides FTO, GWAS showed consistent effects between variants in MC4R, TMEM18, TNNI3K, SEC16B, GNPDA2, POMC and obesity. However, these variants may not have similar effects for all ethnic groups. Although recently genetic factors are considered to contribute to obesity, relatively little is known about the specific loci related to obesity and the mechanisms by which they cause obesity.


Asunto(s)
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética , Predisposición Genética a la Enfermedad , Obesidad Infantil/epidemiología , Polimorfismo de Nucleótido Simple , Adolescente , Estudio de Asociación del Genoma Completo , Humanos , Obesidad Infantil/genética , Obesidad Infantil/patología
12.
Acta Neurobiol Exp (Wars) ; 81(1): 21-33, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33949169

RESUMEN

Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies concluded that vitamin E can play a protective role in neurodegeneration with respect to diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke and amyotrophic lateral sclerosis (ALS). Vitamin E supplementation was also associated with risk factors for some neurodegenerative diseases. In this review, we discuss the possible effects of vitamin E on the development and course of AD, PD, stroke and ALS, and the potential mechanisms involved.Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies concluded that vitamin E can play a protective role in neurodegeneration with respect to diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke and amyotrophic lateral sclerosis (ALS). Vitamin E supplementation was also associated with risk factors for some neurodegenerative diseases. In this review, we discuss the possible effects of vitamin E on the development and course of AD, PD, stroke and ALS, and the potential mechanisms involved.


Asunto(s)
Enfermedades Neurodegenerativas/metabolismo , Accidente Cerebrovascular/metabolismo , Vitamina E/metabolismo , Enfermedad de Alzheimer/metabolismo , Esclerosis Amiotrófica Lateral/metabolismo , Animales , Humanos , Enfermedad de Parkinson/metabolismo
13.
Clin Biochem ; 59: 17-24, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30003880

RESUMEN

Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.


Asunto(s)
Osteopontina/metabolismo , Osteopontina/fisiología , Animales , Biomarcadores/sangre , Biomarcadores/orina , Calcinosis/metabolismo , Fracturas Óseas/metabolismo , Humanos , Artropatías/metabolismo , Macrófagos/fisiología , Osteopontina/sangre , Placa Aterosclerótica/metabolismo , Transducción de Señal , Linfocitos T/fisiología , Factor de Necrosis Tumoral alfa/sangre , Factor de Necrosis Tumoral alfa/metabolismo , Enfermedades Vasculares/metabolismo
14.
Clin Biochem ; 60: 38-43, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30114399

RESUMEN

BACKGROUND AND AIM: The nephrolithiasis has a multifactorial etiology resulting from the interaction of metabolic, genetic and environmental factors. Parameters such as nutrition and urinary osteopontin (OPN) level may affect kidney stone formation. The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis. MATERIALS AND METHODS: This study was conducted on 88 volunteers including 44 healthy individuals and 44 patients diagnosed with nephrolithiasis and aging between 20 and 65 years. Some serum parameters and urinary OPN levels of the individuals were analyzed. Several anthropometric measurements of the individuals were taken and calculated their body mass index. Additionally, 24-hour dietary recall and water intakes were recorded and the participants completed food-frequency questionnaire for the evaluation of their nutritional status. RESULTS: Urinary OPN (ng/mL) levels of patients were lower than that of control group (p<0.05). Dietary energy, carbohydrate, poly-unsaturated fatty acid (PUFA) and n-6 fatty acids intakes and urinary OPN levels of male patients were positively correlated (p<0.05). Additionally, there was a negative correlation between their urinary OPN (ng/mL) and serum creatinine (mg/dL) levels of female patients (p<0.05). Body weight, waist circumference, hip circumference and body muscle mass values of healthy males were positively correlated with their urinary OPN levels (p<0.05). CONCLUSIONS: Results of the study showed that low urinary OPN levels were correlated with increased kidney stone risk, and dietary habits can affect urinary OPN level.


Asunto(s)
Composición Corporal , Dieta , Nefrolitiasis/diagnóstico , Nefrolitiasis/orina , Estado Nutricional , Osteopontina/orina , Adulto , Anciano , Biomarcadores/orina , Creatinina/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nefrolitiasis/sangre , Adulto Joven
15.
Acta Neurobiol Exp (Wars) ; 78(3): 187-197, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30295676

RESUMEN

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food­drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food­drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews, reports, and original articles on general or specific drug interactions with food, in patients with a variety of neurological and psychological diseases. Based on our review, we found that food­drug interactions may alter the expected impact of drug, or cause the development of a drug toxicity. Nutritional status of the patients may also be affected, particularly a change in body weight caused by a change appetite. Metabolism, absorption, and excretion of foods may also be altered, and nutritional insufficiencies may occur. Recent studies show that diet can have a strong influence on gut microbiota and thus, alter drug pharmacokinetics. Therefore, microbiota alterations should also be considered while assessing food­drug interactions. Knowledge of food­drug interactions is critical for improving health of patients with neurological and psychological diseases, and also for improving effectiveness of treatments.


Asunto(s)
Anticonvulsivantes , Antidepresivos , Antipsicóticos , Dopaminérgicos , Interacciones Alimento-Droga , Enfermedades del Sistema Nervioso/tratamiento farmacológico , Humanos
16.
Rev. Nutr. (Online) ; 32: e190029, 2019. tab
Artículo en Inglés | LILACS | ID: biblio-1041329

RESUMEN

ABSTRACT Objective To determine the effect of nutritional habits on kidney stone formation and recurrence. Methods This study was conducted on 44 healthy individuals and 44 patients diagnosed with nephrolithiasis and aging between 20 and 65 years. Participants shared their salt consumption habits, daily fluid consumption amounts and general information about themselves in a questionnaire form. In addition, food and beverage consumption frequencies of participants were recorded through a food frequency questionnaire. Results Salt consumption frequencies of patients are higher than that of healthy individuals in both genders (p<0.05). It was found out that male individuals in the patient group salt dishes without tasting more frequently (p<0.05). Daily total water consumption of both genders in patient group is lower than that of healthy individuals (p<0.05). Meat consumption of male patients (51.6±31.35g/day) was found to be higher than that of healthy group (34.1±22.58g/day) (p<0.05). Additionally, individuals in the patient group consume less stinging nettle, corn, plum, loquat, orange juice and lemonade than healthy individuals (p<0.05). Conclusion Results of the study showed that total fluid intake, salt consumption habits, and vegetable, fruit and beverage consumption may be correlated with stone formation risk and nutrition habits may affect stone recurrence.


RESUMO Objetivo Determinar o efeito de hábitos nutricionais na formação e recorrência de cálculos renais. Métodos Este estudo foi realizado em 44 indivíduos saudáveis e 44 pacientes com diagnóstico de nefrolitíase e envelhecimento entre 20 e 65 anos. Os participantes compartilharam seus hábitos de consumo de sal, quantidades diárias de consumo de líquidos e informações gerais sobre si mesmos em um questionário. Além disso, as frequências de consumo de alimentos e bebidas dos participantes foram registradas por meio de um questionário de frequência alimentar. Resultados As frequências de consumo de sal dos pacientes são maiores que as de indivíduos saudáveis em ambos os sexos (p<0,05). Verificou-se que os indivíduos do sexo masculino no grupo de pacientes salgam os pratos sem degustar com maior frequência (p<0,05). O consumo diário total de água de ambos os sexos no grupo de pacientes é menor que o dos indivíduos saudáveis (p<0,05). O consumo de carne de pacientes do sexo masculino (51,6±31,35g/dia) foi maior que o do grupo saudável (34,1±22,58g/dia) (p<0,05). Além disso, indivíduos do grupo de pacientes consomem menos urtiga, milho, ameixa, nêspera, suco de laranja e limonada do que indivíduos saudáveis (p<0,05). Conclusão Os resultados do estudo mostraram que a ingestão total de líquidos, os hábitos de consumo de sal e o consumo de vegetais, frutas e bebidas podem estar correlacionados com o risco de formação de pedra e os hábitos de nutrição podem afetar a recorrência da pedra.


Asunto(s)
Humanos , Masculino , Femenino , Conducta Alimentaria , Bebidas , Cálculos Renales , Ingestión de Alimentos , Encuestas y Cuestionarios , Cloruro de Sodio Dietético , Alimentos
18.
Exp Ther Med ; 7(6): 1617-1624, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24926354

RESUMEN

Orexin-A and ghrelin are two important polypeptides that stimulate food intake, however, there is a lack of sufficient information concerning their plasma levels in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the association between plasma orexin-A and ghrelin levels with food consumption and body composition in patients with stable phase COPD. In total, 40 patients (age, 44-80 years; male, 31; female 9) who were in the stable phase of COPD were included in the study. Blood samples for plasma orexin-A and ghrelin analysis were collected after 8-12 h of fasting; certain anthropometric measurements were obtained and a 24-h dietary recall was recorded. The mean plasma orexin-A levels in the male and female patients were 1.3±0.37 and 1.4±0.13 ng/ml, respectively, while the mean plasma ghrelin levels were 25.9±7.31 and 27.3±8.54 ng/ml, respectively. No significant correlation was observed between the body mass index and plasma orexin-A and ghrelin levels or between the plasma ghrelin levels and dietary nutrient intake (P>0.05). The plasma orexin-A levels were demonstrated to be higher in patients with a higher dietary total fibre intake (r=0.303, P=0.022). A similar correlation was observed between plasma orexin-A levels and dietary intake of soluble (r=0.033, P=0.029) and insoluble (r=0.335, P=0.024) fibre, as well as between the daily consumption of calcium and the levels of plasma orexin-A (r=0.065, P=0.046). Therefore, the results of the present study indicated that a positive correlation existed between dietary nutrient intake and plasma orexin-A levels in patients with COPD.

19.
Arch Gerontol Geriatr ; 55(1): 106-11, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-21763016

RESUMEN

The aim of this study was to determine the relationship between daily dietary mineral (Na, K, Ca and Mg) intake and BP in the elderly. This study was conducted on 390 elderly volunteers (≥ 65 years). Subjects were randomly selected from the general population of Ankara, Turkey. Anthropometric measurements, lipid profiles, and mean systolic and diastolic BP (SBP and DBP) of all the participants were measured. To determine the mineral intake of the participants, food consumption was measured with a 24-h dietary recall. The 49.3% of participants were found to be hypertensive, 25.1% to be pre-hypertensive and 25.6% were normotensive according to the JNC-7 Guidelines, except for daily Mg and Na intake, the energy, macronutrient and micronutrient intake of groups were not significantly different (p>0.05). A significant inverse correlation between daily Ca intake and SBP was found in the pre-hypertensive group when age and gender adjusted regression analyses were performed (B=-0.006, p<0.05). Na intake and Na/K ratio were directly associated with SBP in the hypertensive group. In conclusion, SBP was found to be most related to dietary Na and Ca intake, and Na-to-K ratio in the elderly population.


Asunto(s)
Presión Sanguínea , Calcio de la Dieta/efectos adversos , Dieta , Hipertensión/epidemiología , Potasio en la Dieta/efectos adversos , Prehipertensión/epidemiología , Sodio en la Dieta/efectos adversos , Anciano , Calcio de la Dieta/administración & dosificación , Femenino , Humanos , Lípidos/sangre , Masculino , Persona de Mediana Edad , Minerales/administración & dosificación , Minerales/efectos adversos , Potasio en la Dieta/administración & dosificación , Sodio en la Dieta/administración & dosificación , Turquía
20.
Nutr Res Pract ; 5(4): 322-8, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21994527

RESUMEN

The aim of this study was to use the Healthy Eating Index-2005 (HEI-2005) to assess diet quality and determine the relationship between the HEI-2005 and the energy and nutrient intakes of adolescents. A cross-sectional study was conducted on 1,104 healthy adolescents, mean age of 15.8 ± 1.24 years. Dietary intake was measured with the 24-hour dietary recall method, and dietary quality was assessed by means of the HEI-2005. Diet quality scores ranged from 23.7 to 77.5. The mean score was found to be 51.5 ± 9.07 according to the HEI-2005. There were no differences according to gender; 42.8% had a poor diet and 57.2% had a diet that needs improvement. No subjects had a "good diet". Lower mean subgroup scores were found for whole grains, total vegetables, total fruits, dairy products, and meat and beans. Fruits and vegetables scores were significantly high in girls, whereas sodium, oil, and meat and beans scores were significantly high in boys. Total HEI-2005 scores were increasingly associated with parental education level when age and gender were adjusted. There was a negative correlation between HEI-2005 scores and age, total energy intake, and fat intake. Positive correlation was only observed in the HEI-2005 scores for protein and dietary fibre intakes. Consequently, the overall diet quality and nutritional habits of Turkish adolescents need modification and improvement. In the family, measures should be initiated by the government, including advertisements and campaigns.

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