RESUMEN
THE AIM OF THE STUDY: Was to assess the clinical effectiveness of the course of ketoprofen lysine salt after its oral application in postmenopausal women with vitamin D deficiency in the complex therapy of inflammatory periodontal diseases. MATERIALS AND METHODS: The study comprised 100 women with decreased bone mineral density and chronic generalized mild to moderate periodontitis. The average age was 55.3±1.9 years with menopause lasting for more than 5 years (6.0±0.8) and the average age for the onset of menopause of 48.9±1.5 years. The study participants were divided into four groups (two main groups and two comparison groups). The patients underwent periodontal treatments and received native vitamin D prescriptions in accordance with clinical guidelines and treatment protocols. RESULTS: Serum vitamin D for the patents of the first and second groups was 11.4±1.9. Vitamin D level in the comparison groups was 34.6±3.2. The study reveals the direct correlation of chronic periodontitis, the level of bone mineral density and vitamin D deficiency in older female patients. The effects are proved by reduction of indices like PMA, Mulleman bleeding index and periodontal index for all study groups. Correlation of anti-inflammatory activity of the solution with the reduction in pockets depths was 0.46 mm along with improvements in syalometry. Organoleptic properties of the tested oral solution of ketoprofen lysine salt were positively evaluated by all participants, subjective assessments of «color¼, «treatment effect¼ and «prolonged analgesic effect¼ received the highest scores. CONCLUSION: Ketoprofen lysine salt solution has shown significant anti-inflammatory, antioedemic and hemostatic activity of the drug in therapy of chronic generalized mild to moderate periodontitis in older female patients.