1.
Int J Radiat Oncol Biol Phys
; 4(1-2): 109-13, 1978.
Artículo
en Inglés
| MEDLINE
| ID: mdl-632139
Asunto(s)
Neoplasias Experimentales/radioterapia , Piperazinas/uso terapéutico , Fármacos Sensibilizantes a Radiaciones/uso terapéutico , Razoxano/uso terapéutico , Animales , Femenino , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/radioterapia , Masculino , Melanoma/tratamiento farmacológico , Melanoma/radioterapia , Ratones , Ratones Endogámicos C57BL , Trasplante de Neoplasias , Neoplasias Experimentales/tratamiento farmacológico , Sarcoma 180/tratamiento farmacológico , Sarcoma 180/radioterapia
2.
Br J Cancer
; 44(1): 117-23, 1981 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7259958
RESUMEN
The combination of a single dose of razoxane (ICRF 159) with a single dose of electron radiation has been studied with the murine sarcoma S180. A drug dose of 30 mg/kg combined with radiation produced a greater tumour response than either agent alone, but it was not possible to establish whether the effect was more than additive. Direct measurements of tumour and s.c. oxygen concentrations and studies of tumour-cell respiration were carried out after various razoxane treatments in an attempt to elucidate mechanisms of action. There were no indications at the drug dose levels used in the radiation studies of any significant changes in tissue oxygenation or cellular respiration.