Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Más filtros

Banco de datos
Tipo de estudio
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
Bioorg Med Chem Lett ; 61: 128605, 2022 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-35123007

RESUMEN

Nucleoside analogues represent an historically accomplished class of antiviral drug. Notwithstanding this, new molecular scaffolds are required to overcome their limitations and evolve pharmacophore space within this established field. Herein, we develop concise synthetic access to a new 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleoside chemotype, including the ProTide form of the uridine analogue. Biological evaluation of these materials in the Hepatitis C replicon assay shows little activity for the canonical pyrimidine forms, but the phosphoramidate of 2'-deoxy-2'-fluoro-2'-C-methyl-ß-d-4'-thiouridine has an EC50 of 2.99 µM. Direct comparison to the established Hepatitis C drug Sofosbuvir shows a 100-fold drop in activity upon substituting the furanose chalcogen; the reasons for this are as yet unclear.


Asunto(s)
Antivirales/farmacología , Diseño de Fármacos , Hepacivirus/efectos de los fármacos , Tionucleósidos/farmacología , Antivirales/síntesis química , Antivirales/química , Relación Dosis-Respuesta a Droga , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Relación Estructura-Actividad , Tionucleósidos/síntesis química , Tionucleósidos/química , Replicación Viral/efectos de los fármacos
2.
Org Biomol Chem ; 20(7): 1401-1406, 2022 02 16.
Artículo en Inglés | MEDLINE | ID: mdl-34806745

RESUMEN

Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. 4'-Thionucleosides, that incorporate bioisosteric replacement of furanose oxygen with sulfur, represent an important chemotype within this field. Established herein is synthetic capability towards a common 4-thioribose building block that enables access to thio-ribo and thio-arabino pyrimidine nucleosides, alongside their 4'-sulfinyl derivatives. In addition, this building block methodology is templated to deliver 4'-thio and 4'-sulfinyl analogues of the established anticancer drug gemcitabine. Cytotoxic capability of these new analogues is evaluated against human pancreatic cancer and human primary glioblastoma cell lines, with observed activities ranging from low µM to >200 µM; explanation for this reduced activity, compared to established nucleoside analogues, is yet unclear. Access to these chemotypes, with thiohemiaminal linkages, will enable a wider exploration of purine and triphosphate analogues and the application of such materials for potential resistance towards relevant hydrolytic enzymes within nucleic acid biochemistries.


Asunto(s)
Nucleósidos
3.
Molecules ; 25(9)2020 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-32354007

RESUMEN

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, these materials do have limitations and the development of next generation compounds remains a topic of significant interest and necessity. Herein, we discuss recent advances in the chemical synthesis and biological evaluation of nucleoside analogues as potential anticancer agents. Focus is paid to 4'-heteroatom substitution of the furanose oxygen, 2'-, 3'-, 4'- and 5'-position ring modifications and the development of new prodrug strategies for these materials.


Asunto(s)
Antineoplásicos/síntesis química , Diseño de Fármacos , Ensayos de Selección de Medicamentos Antitumorales , Nucleósidos/análogos & derivados , Adenosina/análogos & derivados , Adenosina/síntesis química , Adenosina/farmacología , Animales , Antineoplásicos/farmacología , Línea Celular Tumoral , Furanos/química , Humanos , Células K562 , Ratones , Estructura Molecular , Nucleósidos/síntesis química , Oxígeno/química , Profármacos/síntesis química , Profármacos/farmacología , Nucleósidos de Purina/síntesis química , Nucleósidos de Purina/farmacología , Pirimidinonas/síntesis química , Pirimidinonas/farmacología , Tionucleósidos/síntesis química , Tionucleósidos/farmacología , Vitamina E/administración & dosificación
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA