NIR-Absorbing 1,1,4,4-Tetracyanobuta-1,3-diene- and Dicyanoquinodimethane-Functionalized Donor-Acceptor Phenothiazine Derivatives: Synthesis and Characterization.

A series of symmetrical and unsymmetrical donor-acceptor type phenothiazine derivatives 1-18 were designed and synthesized via Pd-catalyzed Sonogashira cross-coupling and [2 + 2] cycloaddition-retroelectrocyclization reactions. The incorporation of cyano-based acceptors 1,1,4,4-tetracyanobutadiene (TCBD) and dicyanoquinodimethane (DCNQ) in the phenothiazine derivatives resulted in systematic variation in the photophysical, thermal, and electrochemical properties. The electronic absorption spectra of the phenothiazine derivatives with strong acceptors 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, and 18 show red-shifted absorption as compared to phenothiazine derivatives 1, 4, 7, 10, 13, and 16 in the near-IR region due to a strong intramolecular charge transfer (ICT) transition. The electrochemical analysis of the phenothiazine derivatives 2, 3, 5, 6, 8, 9, 11, 12, 14, 15, 17, and 18 reveals two reduction waves at low potential due to the TCBD and DCNQ acceptors. The mono-TCBD-functionalized phenothiazine 2 shows higher thermal stability compared to other phenothiazine derivatives. The computational studies on phenothiazines 1-18 reveal the LUMO is substantially stabilized as acceptor strength increases, which lowers the HOMO-LUMO gap.

A holistic review on trend, occurrence, factors affecting pesticide concentration, and ecological risk assessment.

Demographic outbursts and increased food demands invoke excessive use of pesticides in the agricultural field for increasing productivity which leads to the relentless decline of riverine health and its tributaries. These tributaries are connected to a plethora of point and non-point sources that transport pollutants including pesticides into the Ganga river's mainstream. Simultaneous climate change and lack of rainfall significantly increase pesticide concentration in the soil and water matrix of the river basin. This paper is intended to review the paradigm shift of pesticide pollution in the last few decades in the river Ganga and its tributaries. Along with this, a comprehensive review suggests the ecological risk assessment method which facilitates policy development, sustainable riverine ecosystem management, and decision-making. Before 2011, the total mixture of Hexachlorocyclohexane was found at 0.004-0.026 ng/mL in Hooghly, but now, the concentration has increased up to 0.465-4.132 ng/mL. Aftermath of critical review, we observed maximum residual commodities and pesticide contamination reported in Uttar Pradesh > West Bengal > Bihar > Uttara Khand possibly because of agricultural load, increasing settlement, and incompetency of sewage treatment plant in the reclamation of pesticide contamination.

Dynamics of microbial populations and diversity in NAPL contaminated peat soil under varying water table conditions.

Despite the risks that hydrocarbon contamination from pipeline leaks or train derailments impose on the health of peatlands in hydrocarbon production areas and transportation corridors, assessing the effect of such contaminations on the health and sustainability of peatlands has received little attention. This study investigates the impacts of hydrocarbons on peat microbial communities. Column experiments were conducted on non-aqueous phase liquid (NAPL) contaminated undisturbed peat core (0-35 cm) under static and fluctuating water table conditions. Water table fluctuations reduced residual NAPL saturation from 8.1-11.3% to 7.7-9.5%. Biodegradation of n-C8 and n-C12 along with oxidation of CH4 together produced high CO2 concentrations in the headspace. Clear patterns in dynamics in the microbial community structure were observed, with a more pronounced population growth. However, a significant loss of microbial richness was observed in contaminated columns. The result indicates that the phylum Proteobacteria benefited most from NAPL; however, their families differed between static and fluctuating water table conditions. This study established strong evidence that peat microbes and water table fluctuation can be an excellent tool for hydrocarbon removal and its control in peatlands.

Reversible magnetic resonance imaging changes in a case of neuroleptic malignant syndrome.

Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency associated with the use of mainly typical antipsychotic drugs. It is characterized by fever, altered mental status, generalized rigidity, autonomic instability, myoclonus, raised creatine phosphokinase, rhabdomyolysis, and leukocytosis. Neuroimaging (brain computed tomography/magnetic resonance imaging [MRI]) is usually normal in most of the cases of NMS. Magnetic resonance imaging findings have not been well elucidated in NMS as yet. Very few cases have been reported worldwide. We herein, report a case of a 42-year-old patient of NMS, who presented to us with reversible changes in MRI brain. This case report highlights the possible MRI changes in NMS and their plausible mechanism.

Acute Vertebrobasilar Territory Infarcts due to Heat Stroke.

Heat stroke is common in tropical country like India especially during the summer season. We report an unusual case of acute vertebrobasilar territory infarcts due to heat stroke. A middle-aged man developed hyperpyrexia (42.2°C) after strenuous fieldwork in a hot summer day. Next morning, he was found in altered sensorium. The brain imaging showed acute posteromedial midbrain and cerebellar infarcts. A diagnosis of acute ischemic stroke due to heat stroke was made, and the patient was put under the intensive care unit. Two weeks later, the patient became conscious, but had slurred speech and incoordination in all the 4 limbs. Six months after rehabilitation, the patient still have scanning speech and limb ataxia. Acute ischemic stroke worsened the prognosis in our patient. Acute infarct is a very rare neurologic manifestation of heat stroke. This case report emphasizes the importance of suspecting acute infarct in heat stroke patient.

Stroke after piercing barbed wire injury: a time for introspection.

Traumatic internal carotid artery (ICA) dissections are uncommon and an easily overlooked consequence of trauma with significant morbidity and mortality. These dissections may result from a direct blow to the anterolateral aspect of the neck or an extreme extension and rotation of the neck. Normally, various sporting activities such as scuba diving, winter sports, rugby, baseball, golf, taekwondo, and triathlon have rarely been associated with ICA dissection. Herein, we describe a case of young veterinary nursing personnel who developed stroke because of ICA dissection resulting from quite an unusual mode of injury caused by piercing barbed wire over his neck during his routine rounds for examining the animals.

Recurrent spontaneous spinal epidural hematoma leading to compressive myelopathy.

Spontaneous spinal epidural hematoma accounts for most cases of spinal epidural hematoma, but very few cases of recurrent spontaneous spinal epidural hematoma have been published to date. We herein report a case of a 20-year-old man who presented with 10-day history of pain in the interscapular region, followed by paraparesis and sensory loss below umbilicus along with urinary retention. The patient gave history of 2 similar episodes in the last 3 months, with complete spontaneous recovery. His magnetic resonance imaging of dorsal spine was suggestive of subacute spinal epidural hematoma. On reviewing previous 2 magnetic resonance images of dorsal spine, it was apparent that the patient had recurrent hematoma at the same site. Thus, a provisional diagnosis of recurrent spontaneous spinal hematoma at the level of upper dorsal spine was kept and was managed accordingly. Patient with recurrent spontaneous spinal epidural hematoma should be educated about the nature of the disease and advised to consult a neurosurgeon as early as possible in case of a relapse, so that they can undergo surgical management preferably within 8 hours and not later than 36 hours.

Cysticercotic encephalitis: a life threatening form of neurocysicercosis.

Neurocysticercosis is the most frequent neuroparasitosis and is caused by Taenia solium larvae (cysticerci). Its most common presenting feature is seizure, although it may present as headache,focal deficits, hydrocephalous, or as features of raised intracranial pressure. We herein report a case of 40-year-old male who presented with features of acute encephalitis and raised intracranial pressure with magnetic resonance imaging suggestive of multiple neurocysticerci with diffuse cerebral edema. A diagnosis of cysticercotic encephalitis was made, which is a syndrome of encephalitis with clinical and radiologic evidences of diffuse cerebral edema caused by parenchymal cysticercosis. It is important for the clinicians to be aware of this medical emergency requiring urgent attention as delay may lead to fatal outcome.

Posterior cerebral artery stroke presenting as alexia without agraphia.

Alexia without agraphia (pure alexia) was the first of the disconnection syndromes to be described by Dejerine who reported a patient of alexia without agraphia secondary to an embolic occipital lobe infarct. We herein report a 55-year-old man who presented with alexia without agraphia with magnetic resonance imaging suggestive of left posterior cerebral artery infarct involving left occipital lobe and splenium of corpus callosum. Alexia without agraphia is a relatively uncommon clinical condition, which should always be thought in a patient presenting with difficulty in reading with normal visual acuity. Ophthalmologists should also be aware of this disconnection syndrome as many patients initially take their advice due to predominant visual complaints. Early diagnosis and treatment of this condition help in ensuring the patient and attendants about nonprogressive nature of the disease and may prevent further episodes of stroke.

Field-scale assessment of soil, water, plant, and soil microbiome in and around Rania-Khan Chandpur Chromium contaminated site, India.

Rania-Khan Chandpur site, (Kanpur Dehat, Uttar Pradesh, India), one of the highly Chromium (Cr) contaminated sites in India due to Chromite Ore Processing Residue (COPR), has been investigated at the field-scale. We found that the area around the COPR dumps was hazardously contaminated with the Cr where its concentrations in the surface water and groundwater were > 40 mgL-1, its maximum contents in the COPRs and in the soils of the adjoining lands were 9.6 wt% and 3.83 wt%, respectively. By exploring the vegetation and microbial distribution across the site, we advocate the appropriateness of Cynodon dactylon, Chrysopogon zizanioides, Cyperus sp., and Typha angustifolia as the most suitable phytoremediation agent because their association with Cr remediating bacterial species (Pseudomonas sp., Clostridium sp. and Bacillus sp.) was strong. Using this remarkable information for the bioremediation projects, this site can be re-vegetated and bioaugmented to remediate Cr in soils, waterlogged ditches, surface water, and in groundwater systems.

Novel treatment with double scope technique for disconnected pancreatic duct syndrome with external pancreatic fistula.

Background and study aims External pancreatic fistula in association with disconnected pancreatic duct syndrome is a common sequelae of the percutaneous step-up approach for infected pancreatic necrosis and is associated with significant morbidity. The present study aimed to report the initial outcome of a novel technique of two-scope guided tractogastrostomy for management of this condition. Patients and methods The present study was a retrospective analysis of data from patients with external pancreatic fistula and disconnected pancreatic duct syndrome, who underwent two-scope-guided tractogastrostomy. All the patients had a 24F or larger drain placed in the left retroperitoneum. Transgastric echo endoscopy and sinus tract endoscopy were performed simultaneously to place a stent between the gastric lumen and the sinus tract. Technical success was defined as placement of the stent between the tract and the stomach. Clinical success was defined as successful removal of the percutaneous drain without the occurrence of pancreatic fluid collection, ascites, external fistula, or another intervention 12 weeks after the procedure. Results Three patients underwent two scope-guided tractogastrostomy. Technical and clinical success were achieved in all the patients. No procedure-related side effects or recurrence occurred in any of the patients. Conclusions Two-scope-guided tractogastrostomy for treatment of external pancreatic fistula due to disconnected pancreatic duct syndrome is a feasible technique and can be further evaluated.

The Tei index and asymptomatic myocarditis in children with severe dengue.

This study aimed to assess myocardial involvement in infants and children with severe dengue (as per the new World Health Organization [WHO] classification 2009) using the Tei index. This prospective observational study was conducted in the Department of Pediatrics, PGIMER and the associated Dr. RML Hospital, New Delhi from August to December 2010. The study included 67 children (ages 3 months-14 years) who satisfied the WHO criteria for the diagnosis of probable dengue fever with warning signs or severe dengue and tested positive for dengue via immunoglobulin-M (IgM) capture enzyme-linked immunoassay (MAC-ELISA). The patients were subjected to a complete blood count, liver function tests, renal profile, electrocardiography, myocardial band enzymes of creatine phosphokinase (CPK-MB), chest x-ray, abdomen ultrasonography, and two-dimensional echocardiography with color-flow Doppler mapping. Ejection fraction and Tei index measurements were performed. Significantly fewer patients with severe dengue were found to have myocardial involvement at admission by ejection fraction (48 %) and E/E' (37 %), than by the Tei index (70 %). Of the 67 patients with severe dengue, one died, giving a case fatality rate of 1.5 %. At discharge, the Tei index persisted on the high side for patients with myocardial involvement, whereas the ejection fraction improved for the majority of them. Most of the patients with severe dengue had asymptomatic myocarditis, as evident by a deranged Tei index, which improved but did not normalize by the time of discharge, necessitating a longer follow-up period. For the majority of the patients, inotropic support was not required to maintain hemodynamic stability.

Bioremediation of Organic Pollutants in Soil-Water System: A Review.

Soil-water pollution is of serious concern worldwide. There is a public outcry against the continually rising problems of pollution to ensure the safest and healthiest subsurface environment for living beings. A variety of organic pollutants causes serious soil-water pollution, toxicity and, therefore, the removal of a wide range of organic pollutants from contaminated matrix through the biological process rather than physico-chemical methods is an urgent need to protect the environment and public health. Being an ecofriendly technology, bioremediation can solve the problems of soil-water pollution due to hydrocarbons as it is a low-cost and self-driven process that utilises microorganisms and plants or their enzymes to degrade and detoxify pollutants and thus, promote sustainable development. This paper describes the updates on the bioremediation and phytoremediation techniques which have been recently developed and demonstrated at the plot-scale. Further, this paper provides details of wetland-based treatment of BTEX contaminated soils and water. The knowledge acquired in our study contributes extensively towards understanding the impact of dynamic subsurface conditions on engineered bioremediation techniques.

Multiphase flow behavior of diesel in bog, fen, and swamp peats.

Hydrocarbon fate and transport in various categories of peatlands is complicated by the botanical origin, and thus variations in the hydraulic structures and surface chemistry of its peat soils. There has been no systematic evaluation of the role of different peat types on hydrocarbon migration. Thus, two-phase, and three-phase flow experiments were performed for living and partially decomposed peat cores from bog, fen, and swamp peatlands. Numerical simulations of water drainage were performed using HYDRUS-1D, diesel-water and diesel-water-air flow using MATLAB Reservoir Simulation Toolbox (MRST). Five water table (WT) fluctuations were imposed to explore its potential to reduce residual diesel saturation in peat columns. Our results demonstrate a good match of the relative water permeability (krw) - saturation (S) relations estimated using the unsaturated hydraulic conductivity-S relation derived from HYDRUS-1D modeling of two-phase flow, and krw - S from MRST for three-phase flow, for all tested peat columns. Thus, we recommended using two-phase system based krw - S predictions if multiphase data are unavailable for peatland sites' spill management plans. We found the discharge of water and diesel both increase with increasing hydraulic conductivity, while residual water and diesel were within the range of 0.42-0.52 and of 0.04-0.11, respectively. High diesel discharge rates suggest that quick spill-response is required to manage its spread in peatlands. Up to 29% of residual diesel saturation was yielded by the five WT fluctuations, and thus we strongly recommend WT manipulation as a first step towards diesel decontamination progression in peatlands.

Adsorptive behavior of micro(nano)plastics through biochar: Co-existence, consequences, and challenges in contaminated ecosystems.

The abundance of micro(nano)plastics in natural ecosystems is a crucial global challenge, as these small-sized plastic particles originate from land-based and marine-based activities and are widely present in marine, freshwater, and terrestrial ecosystems. Micro(nano)plastics can significantly be reduced through various methods, such as biological, chemical, and physical techniques. Biochar is a low-cost adsorbent and is considered an efficient material and its application is ecologically effective carbon-negative for remediation of organic and inorganic pollutants. Therefore, this review critically discusses the fate and transport of micro(nano)plastics and their interactions with different biochar in aqueous and column porous media. This review outlines the implications of biochar with the co-existence of micro(nano)plastics in efforts to understand their coupled effects on soil physicochemical properties, microbial communities, and plant growth, along with the removal of heavy metals and other toxic contaminants. In batch experiments, biochar synthesized from various biomasses such as corn straw, hardwood, pine and spruce bark, corncob, and Prosopis juliflora had shown high level of removal efficiency (>90 %) for microplastic adsorption under varying environmental conditions viz., pH, temperature, ionic strength, particle size, and dose due to chemical bonding and electrostatic attractions. Increased temperature of the aqueous solutions encouraged higher adsorption, while higher pH and dissolved organic matter and nutrients may show decreased adsorption capacities for micro(nano)plastics using biochar. Compared to other available physical, chemical, and biological methods, biochar-amended sand filters in column experiments have been very efficient in removing micro(nano)plastics. In saturated column porous media, various microplastics could be inhibited using biochar due to decreased electrostatic repulsion, steric hindrance, and competitive sorption due to humic acid, ionic strength, and cations. Finally, this review provides in-depth insights on further investigations and recommendations for overall micro(nano)plastics removal using biochar-based materials.

Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish.

ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish. AIM OF THE STUDY: The present study was designed to evaluate the anti-nociceptive potential of standardized methanolic extract of Bacopa monnieri in experimental adult zebrafish (Danio rerio) model of pain. MATERIALS AND METHODS: The methanolic extract of Bacopa monnieri (BME) was standardized to bacoside-A using chromatographic method. Subsequently, BME (0.75, 1.25 and 5.0 mg/ml) was evaluated for anti-nociceptive activity using adult zebrafish model. RESULTS: Standardized BME showed antioxidant effect through radical quenching activity in in vitro study. BME at 1.25 mg/ml significantly decreased the nociceptive effect induced by different noxious agents like acetic acid where as BME at 2.5 mg/ml exhibited significant antinociceptive activity against glutamate, formalin, capsaicin, cinnamaldehyde when compared to control and sham group animals. CONCLUSION: BME exerted antinociceptive activity in adult zebrafish. It could be presumed that BME may involve glutamatergic receptor, ASIC and TRP channel activity in its anti-nociceptive effect. BME could be considered as a potential therapeutic option in the management of pain.

Augmenting the productivity of tubular solar still using low-cost energy storage materials.

Productivity improvement is one of the high-priority areas in the development of solar stills. The present work describes the use of some low-cost energy storage materials such as sand, gravels, and black granite as potential candidates to improve the productivity of the tubular solar still (TSS). The experimental studies have been carried out at Nagpur (21.1241° N, 79.0023° E) to investigate the effects of these materials on the productivity of the TSS. Three separate TSS experimental setups have been made for each energy storage materials. These include (a) 5 kg of fine sand (0.125-0.25-mm grain size), (b) small gravels (20-30 mm), and (c) black granite (5-mm thickness) placed in the absorber basin of individual TSS setup, separately. The experiments have been performed by varying basin water depth at 0.5 cm, 1 cm, and 2 cm, for each case. The results show that for water depth of 0.5 cm, productivity of TSS-Black granite is enhanced by 10.5% and 34.88% as compared to TSS-Gravel case and TSS-Sand case, respectively. Thermal efficiency and exergy efficiency of TSS-Black granite at 0.5-cm water depth is enhanced by (32.4%, 9.8%) and (92.1%, 21.9%) as compared to TSS-Sand case and TSS-Gravel case, respectively. Furthermore, it has been estimated that the cost of production of freshwater using TSS-Black granite is lowest among all selected combinations.

A comprehensive study on aquatic chemistry, health risk and remediation techniques of cadmium in groundwater.

Cadmium (Cd), a non-essential trace element, it's intrusion in groundwater has ubiquitous implications on the environment and human health. This review is an approach to comprehensively emphasize on i) chemistry and occurrence of Cd in groundwater and its concomitant response on human health ii) sustainable Cd remediation techniques, iii) and associated costs. Current study is depending on meta-analysis of Cd contaminations in groundwater and discusses its distributions around the globe. Literature review primarily comprises from the last three decades online electronic published database, which mainly includes i) research literatures, ii) government reports. On the basis of meta-data, it was concluded that Cd mobility depends on multiple factors: such as pH, redox state, and ionic strength, dissolved organic (DOC) and inorganic carbon (DIC). A substantially high Cd concentration has been reported in Lagos, Nigeria (0.130 mg/L). In India, groundwater is continuing to be contaminated by Cd in the proximity of industrial, agricultural areas, high concentrations (>8.20 mg/L) were reported in Tamil Nadu and Maharashtra. Depending on chemical behavior and ionic radius cadmium disseminate into the food chain and ultimately cause health hazard that can be measured by various index-based assessment tools. Instead of chemical adsorbents, nanoparticles, phytoextraction, and bioremediation techniques can be very useful in the remediation and management of Cd polluted groundwater at a low-cost. For Cd pollution, the development of a comprehensive framework that links the hydro-geological, bio-geochemical processes to public health is important and need to be further studied.