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2.
Curr Gastroenterol Rep ; 12(4): 263-9, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20532708

RESUMEN

Since the original postmortem diagnosis of "intestinal lipodystrophy" by Dr. George H. Whipple in 1907, the complexities of Whipple's disease have been elucidated through case reports. Universally fatal prior to the advent of antibiotics, Tropheryma whipplei is increasingly recognized as an organism that can be treated only if the clinician seeks to identify it. Whipple's disease is primarily a gastrointestinal disease manifesting as a malabsorption syndrome, and is detected through endoscopy and intestinal biopsy. Nongastrointestinal manifestations of the disease, although less common, are reported and have aided in its recognition as a multiorgan disease entity. Because of its rarity, treatment recommendations are currently based on observational studies and on one recent prospective study, which outlined induction therapy followed by several months of suppressive maintenance therapy to prevent relapse, which is often characterized by neurologic symptoms.


Asunto(s)
Tropheryma/patogenicidad , Enfermedad de Whipple/diagnóstico , Antibacterianos/uso terapéutico , Enfermedad Crónica , Humanos , Reacción en Cadena de la Polimerasa , Enfermedades Raras/diagnóstico , Enfermedades Raras/tratamiento farmacológico , Enfermedades Raras/microbiología , Resultado del Tratamiento , Tropheryma/genética , Enfermedad de Whipple/tratamiento farmacológico , Enfermedad de Whipple/microbiología
3.
Curr Gastroenterol Rep ; 10(4): 404-8, 2008 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-18627654

RESUMEN

Clostridium difficile infection has become one of the most common causes of diarrhea in patients frequenting hospitals, skilled nursing facilities, and physicians' offices. Although the pathogenesis and clinical description were well elucidated three decades ago, cure during the initial episode now occurs in fewer than two thirds of patients exhibiting clinical illness. The past decade has brought a new strain with more toxin. Frequent relapses in elderly patients are now the norm rather than a rarity. This review is intended to update clinicians regarding diagnosis, infection control, and treatment, including treatment of the difficult-to-treat patient with multiple relapses of C. difficile infection.


Asunto(s)
Clostridioides difficile , Infecciones por Clostridium/diagnóstico , Enterocolitis Seudomembranosa/diagnóstico , Clostridioides difficile/metabolismo , Infecciones por Clostridium/tratamiento farmacológico , Infecciones por Clostridium/transmisión , Diarrea/microbiología , Enterocolitis Seudomembranosa/tratamiento farmacológico , Enterocolitis Seudomembranosa/transmisión , Enterotoxinas/biosíntesis , Humanos
4.
Cutis ; 71(6): 469-72, 2003 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12839258

RESUMEN

Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a cutaneous condition that typically occurs as tender red plaques or nodules. However, atypical presentations may occur and, in our case, Sweet's syndrome masqueraded as facial cellulitis and soft tissue infections of the extremities in a sporotrichoid pattern. Despite treatment with broad-spectrum antibiotics, the cutaneous lesions progressed. Results of skin biopsy specimens of the facial plaque and a nodule on the right upper extremity were diagnostic of Sweet's syndrome. Simultaneous to diagnosis, the patient also was found to have acute myelogenous leukemia (AML).


Asunto(s)
Celulitis (Flemón)/diagnóstico , Leucemia Mieloide Aguda/diagnóstico , Síndrome de Sweet/diagnóstico , Antineoplásicos/uso terapéutico , Celulitis (Flemón)/complicaciones , Celulitis (Flemón)/terapia , Citarabina/uso terapéutico , Diagnóstico Diferencial , Cara , Femenino , Humanos , Idarrubicina/uso terapéutico , Leucemia Mieloide Aguda/complicaciones , Leucemia Mieloide Aguda/tratamiento farmacológico , Persona de Mediana Edad , Síndrome de Sweet/complicaciones , Síndrome de Sweet/tratamiento farmacológico , Resultado del Tratamiento
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