Supercooling of the A phase of 3He.

Because of the extreme purity, lack of disorder, and complex order parameter, the first-order superfluid 3He A-B transition is the leading model system for first order transitions in the early universe. Here we report on the path dependence of the supercooling of the A phase over a wide range of pressures below 29.3 bar at nearly zero magnetic field. The A phase can be cooled significantly below the thermodynamic A-B transition temperature. While the extent of supercooling is highly reproducible, it depends strongly upon the cooling trajectory: The metastability of the A phase is enhanced by transiting through regions where the A phase is more stable. We provide evidence that some of the additional supercooling is due to the elimination of B phase nucleation precursors formed upon passage through the superfluid transition. A greater understanding of the physics is essential before 3He can be exploited to model transitions in the early universe.

Defect formation and local gauge invariance

We propose a new mechanism for formation of topological defects in a U(1) model with a local gauge symmetry. This mechanism leads to definite predictions, which are qualitatively different from those of the Kibble-Zurek mechanism of global theories. We confirm these predictions in numerical simulations, and they can also be tested in superconductor experiments. We believe that the mechanism generalizes to more complicated theories.

Improving chronic illness care: translating evidence into action.

The growing number of persons suffering from major chronic illnesses face many obstacles in coping with their condition, not least of which is medical care that often does not meet their needs for effective clinical management, psychological support, and information. The primary reason for this may be the mismatch between their needs and care delivery systems largely designed for acute illness. Evidence of effective system changes that improve chronic care is mounting. We have tried to summarize this evidence in the Chronic Care Model (CCM) to guide quality improvement. In this paper we describe the CCM, its use in intensive quality improvement activities with more than 100 health care organizations, and insights gained in the process.

The role of tobacco intervention in population-based health care: a case study.

Managed care organizations are in an excellent position to implement population-based, as well as patient-centered, approaches to reduce behavioral risk factors associated with major chronic diseases. Group Health Cooperative of Puget Sound employed a population-based model for smoking that contributed to a decrease from 25% to 15.5% in smoking prevalence in 10 years among its more than 550,000 adult enrollees in western Washington. This model may have application to other arenas where health systems can support beneficial behavior change.

Sheep mortality associated with paralytic shellfish poisons from the cyanobacterium Anabaena circinalis.

This is the first report of sheep mortalities associated with paralytic shellfish poisons (PSPs) from the cyanobacterium Anabaena circinalis Rabenhorst. Fourteen sheep died within 150 m of a farm dam containing a dense bloom of A. circinalis. Extracts from both the cyanobacterium and small intestine from a dead ewe were analysed by high-performance liquid chromtography (HPLC) and found to contain PSPs. The toxin profiles of the cyanobacterium contained a high proportion of C-toxins (70%), whereas toxins in the small intestine content were dominated by gonyautoxin 5 (87%). This observation could be explained by desulfation of the C-toxins in the gut of the sheep. The LD100 of bloom material calculated from HPLC data was consistent with mouse bioassay data (12-25 mg/kg). The symptoms of affected sheep, mouse bioassay data, coupled with HPLC analysis of toxins from the bloom samples and the intestine contents, and the absence of other cyanobacterial alkaloid toxins, indicate that PSPs were responsible for the deaths of the sheep.

Measuring clinical performance: comparison and validity of telephone survey and administrative data.

OBJECTIVE: To compare and validate self-reported telephone survey and administrative data for two Health Plan Employer Data and Information Set (HEDIS) performance measures: mammography and diabetic retinal exams. DATA SOURCES/STUDY SETTING: A telephone survey was administered to approximately 700 women and 600 persons with diabetes randomly chosen from each of two health maintenance organizations (HMOs). STUDY DESIGN: Agreement of survey and administrative data was assessed by using kappa coefficients. Validity measures were assessed by comparing survey and administrative data results to a standard: when the two sources agreed, that was accepted as the standard; when they differed, confirmatory information was sought from medical records to establish the standard. When confirmatory information was not available ranges of estimates consistent with the data were constructed by first assuming that all persons for whom no information was available had received the service and alternately that they had not received the service. PRINCIPAL FINDINGS: The kappas for mammography were .65 at both HMOs; for retinal exam they were .38 and .40. Sensitivity for both data sources was consistently high. However, specificity was lower for survey (range .44 to .66) than administrative data (.99 to 1.00). The positive predictive value was high for mammography using either data source but differed for retinal exam (survey .69 to .78; administrative data .99 to 1.00). CONCLUSIONS: Administrative and survey data performed consistently in both HMOs. Although administrative data appeared to have greater specificity than survey data the validity and utility of different data sources for performance measurement have only begun to be explored.

Inverse cascade in decaying three-dimensional magnetohydrodynamic turbulence.

We perform direct numerical simulations of three-dimensional freely decaying magnetohydrodynamic turbulence. For helical magnetic fields, an inverse cascade effect is observed in which power is transferred from smaller scales to larger scales. The magnetic field reaches a scaling regime with self-similar evolution, and power-law behavior at high wave numbers. We also find power-law decay in the magnetic and kinematic energies, and power-law growth in the characteristic length scale of the magnetic field.

Plasma alkaline phosphatase as a screening test for low zinc status in broiler hybrid chickens affected with 'clubbed down'.

Broiler chickens affected by 'clubbed down' on a number of Victorian farms had low liver zinc concentrations and low plasma alkaline phosphatase activities. The results indicated that the zinc status of affected flocks should be considered in future studies and that measurement of plasma alkaline phosphatase activity may be a useful means of screening large numbers of samples. Nutritional and genetic factors may be involved in the aetiology of 'clubbed down'.

Studies on a vaccine against infections bursal disease.

An infectious bursal disease vaccine, registered for use in breeder flocks, was studied for efficacy on the day-old offspring of vaccinated hens and for virulence in susceptible day-old and 6-week-old chickens. When given to susceptible day-old chicks and 6-week-old cockerels, the vaccine was found to induce atrophy and pathology of the bursa of Fabricius similar to that observed in field infections. Chicks vaccinated at day-old had markedly lowered titres in the haemagglutination inhibition test to Newcastle disease virus, when this was given 2 weeks later, but the response of the 6-week-old cockerel was similar to that of control birds. Maternal antibody induced by the vaccine protected chicks against infection at day-old.

Seroprevalence to Leptospira interrogans serovar hardjo in merino stud rams in South Australia.

A serological survey of 2160 Merino stud rams on 36 farms detected positive reactions greater than or equal to 1/100 in 42% of animals using the microscopic agglutination test (MAT) to Leptospira interrogans serovar hardjo. Twenty flocks had seroprevalence values greater than 30% with 15 flocks having values > or = 60%. The enzyme-linked immunosorbent assays showed that 47% and 3% of rams on the 36 farms were positive for IgG and IgM antibodies, respectively. Forty-five percent of hardjo reactions were in rams that had not been exposed to cattle. Significant correlations were found between IgM reactors and creek/dam water pumped into troughs, and between MAT/IgG reactors and total flock size. No statistical relationships were detected between positive reactors and two different annual average rainfall gradients, the time of the year in which samples were obtained, or agricultural regions of South Australia. Infections with an organism of the Sejroe serogroup is widespread in Merino stud rams.

Anasarca and myopathy in ostrich chicks.

Twenty ostrich chicks that died at, or within, 1 week after hatching were examined from 7 farms with poor (43 to 75%) hatchability. All chicks had anasarca and 15 had mild, generalised, acute degenerative changes in the complexus and pelvic limb muscles. One had fibrinoid degeneration of arterioles. Biochemical examinations produced no evidence of deficiencies of selenium, vitamin A or vitamin E. The syndrome was related to high relative humidity during incubation. Malpositioning also was a cause of embryo mortality.