A SOC Design of ORICA-based Highly Effective Real-time Multi-channel EEG System.

Independent component analysis (ICA) has been wildly used to improve EEG based application such as brain computer interface (BCI). However, some well know ICA algorithm, such as Infomax ICA, suffering from the problem of convergence latency and make it hard to be apply on real-time application. This paper proposes a highly efficient chip implementation of multi-channel EEG real-time system based on online recursive independent component analysis algorithm (ORICA). The core size of the chip is 1.5525-mm2 using 28nm CMOS technology. The EEG demonstration board will be implemented with the ORICA chip. The operation frequency and power consumption of the chip are 100 MHz and 17.9 mW respectively. The proposed chip was validated with a real-time circuit integrated system and the average correlation coefficient between simulations results and chip processing results is 0.958.

A SOC Design of ORICA-based Highly Effective Real-time Multi-channel EEG System.

Independent component analysis (ICA) has been wildly used to improve EEG based application such as brain computer interface (BCI). However, some well know ICA algorithm, such as Infomax ICA, suffering from the problem of convergence latency and make it hard to be apply on real-time application. This paper proposes a highly efficient chip implementation of multi-channel EEG real-time system based on online recursive independent component analysis algorithm (ORICA). The core size of the chip is 1.5525-mm2 using 28nm CMOS technology. The EEG demonstration board will be implemented with the ORICA chip. The operation frequency and power consumption of the chip are 100 MHz and 17.9 mW respectively. The proposed chip was validated with a real-time circuit integrated system and the average correlation coefficient between simulations results and chip processing results is 0.958.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

A focused library of furanopyrimidine (350 compounds) was rapidly synthesized in parallel reactors and in situ screened for Aurora and epidermal growth factor receptor (EGFR) kinase activity, leading to the identification of some interesting hits. On the basis of structural biology observations, the hit 1a was modified to better fit the back pocket, producing the potent Aurora inhibitor 3 with submicromolar antiproliferative activity in HCT-116 colon cancer cell line. On the basis of docking studies with EGFR hit 1s, introduction of acrylamide Michael acceptor group led to 8, which inhibited both the wild and mutant EGFR kinase and also showed antiproliferative activity in HCC827 lung cancer cell line. Furthermore, the X-ray cocrystal study of 3 and 8 in complex with Aurora and EGFR, respectively, confirmed their hypothesized binding modes. Library construction, in situ screening, and structure-based drug design (SBDD) strategy described here could be applied for the lead identification of other kinases.

The water-soluble Roussin's red ester acting as a potential photochemical NO-delivery agent: photolysis reactions, DNA cleavage and anticancer activity.

The water-soluble Roussin's red ester [(NO)(2)Fe(mu-SCH(2)CH(2)P(O)(CH(2)OH)(2))(2)Fe(NO)(2)] (1), a potential photochemical prodrug of an NO precursor, was synthesized from the reaction of HSCH(2)CH(2)P(O)(CH(2)OH)(2) (F) and [Fe(CO)(2)(NO)(2)]. The IR v(NO) stretching frequencies of complex 1 appear at 1759 (s), 1784 (s) and 1816 (w) cm(-1) in buffer (pH = 7.4). NO was released with a stoichiometry ratio Delta[NO]/Delta[1] = 3.6 +/- 0.2 when complex 1 was exposed to UV in deaerated aqueous phosphate buffer solution. Here light acts as an On/Off switch for NO release. Incubation of pBR322 supercoiled DNA with complex 1, followed by irradiation, produced DNA strand breakage. In contrast to the addition of carboxy-PTIO (NO radical scavenger), DNA strand breakage was not inhibited when the scavengers of hydroxyl radical and singlet oxygen were added. Complex 1 irradiated under a N(2) atmosphere exhibited the same cleavage efficiency as complex 1 irradiated under air. The results show that DNA strand cleavage efficiency depends on the concentration of complex 1, the pH value of the buffer, and the duration of the photolysis of complex 1. The conversion rate from supercoiled (SC form) to nicked circular (NC form) of complex 1 was 2.96 x 10(-2) s(-1). The results of a T4 ligase enzymatic assay reveals the nonhydrolytic DNA breakage mechanism. The NO-release ability of complexes 1, 2, and 3 follows the order 1 > 2 > 3. Upon UV-irradiation, complex 1 exhibits cytotoxicity against B16-F10 mouse melanoma cells.