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2.
Food Chem Toxicol ; 116(Pt B): 77-85, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29649490

RESUMEN

The knowledge of aggregate exposure to different types of products is paramount in the risk assessment. The aim of this study was to compare the relative contribution of essential oils compared to cosmetics on the daily dermal exposure to limonene, an ubiquitous fragrance compound that can be an allergen depending on its degree of oxidation. Aggregate daily exposure to limonene was calculated among a panel of French volunteers using both essential oils and cosmetics, for 4 different specific zones, i.e. face and neck, chest, upper limbs and lower limbs. Calculations were made using a probabilistic Monte Carlo method and sensitivity analysis. The main strength of this work was the inclusion of essential oils in addition to cosmetics in the model. For the first time, the generated data could be used to compare the contribution of these two products in dermal exposure. Essential oils appear to be significant contributors to exposure to limonene particularly for the face. This work is a first step that will permit to determine the exposure to other fragrance compounds with sensitizing potential. These data will be useful for risk managers to consider the inclusion of essential oils in the overall burden of this pathology.


Asunto(s)
Cosméticos/farmacología , Ciclohexenos/farmacología , Exposición a Riesgos Ambientales/análisis , Aceites Volátiles/farmacología , Perfumes/farmacología , Piel/efectos de los fármacos , Terpenos/farmacología , Adolescente , Adulto , Anciano , Cosméticos/administración & dosificación , Ciclohexenos/administración & dosificación , Femenino , Francia , Humanos , Limoneno , Masculino , Persona de Mediana Edad , Aceites Volátiles/administración & dosificación , Perfumes/administración & dosificación , Probabilidad , Medición de Riesgo , Encuestas y Cuestionarios , Terpenos/administración & dosificación , Adulto Joven
3.
Food Chem Toxicol ; 88: 123-32, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26763610

RESUMEN

Only few published data are available in the literature about consumption and exposure, for hair dye products. The aim of this study was to assess the use of 10 different hair dye products in French Women with a focus on consumption of hair dye in different places of use (at home and at the hairdressers) in order to assess the corresponding dermal exposures. The assessment was performed on a total of 4237 women older than 15 years old, thanks to three national web surveys. The percentage of hair dye users among the French women population was about 64%.The mean frequency of use ranged between 2.23 and 14.22 times per year depending on the studied product and age category of women. This study provided the first data available for exposure to hair dye products with mean exposures ranging between 1.48 and 6.49 mg/kg bw/day depending on the product studied and age category of women. Moreover, consumption data obtained in this study might be useful to perform safety assessment of hair dye products thanks to the knowledge of the age categories of the population having the highest percentage of users and/or frequency of use.


Asunto(s)
Seguridad de Productos para el Consumidor , Tinturas para el Cabello , Adolescente , Adulto , Femenino , Francia , Humanos , Persona de Mediana Edad , Medición de Riesgo , Adulto Joven
4.
Rev Med Interne ; 30(11): 988-90, 2009 Nov.
Artículo en Francés | MEDLINE | ID: mdl-19299047

RESUMEN

Euthyroid Graves' disease is defined as an ophtalmopathy without any clinical or biological signs of thyroid dysfunction. It highlights the apparent dissociation between orbitopathy and thyroid disease. Diagnosis is often too late while early treatment could really improve functional prognosis. We report a 57-year-old woman who presented with this entity and that illustrates both the diagnostic difficulty and disease course after intravenous corticosteroid therapy.


Asunto(s)
Oftalmopatía de Graves , Femenino , Oftalmopatía de Graves/diagnóstico , Oftalmopatía de Graves/tratamiento farmacológico , Humanos , Persona de Mediana Edad
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