Enhanced emission from hBN in sputtered microcavities.

In this observational study, we embed few-layer hexagonal boron nitride (hBN) inside a planar Fabry-Perot cavity fabricated using a pulsed DC magnetron sputtering system and show that the hBN retains its inherent visible range, defect-based luminescent properties following relatively energetic deposition processing. The observed surface-normal emission enhancement factor of ∼40 is in good agreement with theoretical predictions. We also found that embedded hBN subjected to a rapid thermal annealing treatment exhibits a cracking effect where the edges of the material glow distinctly brighter than adjacent regions. Our results might inform future efforts involving monolithic integration of hBN active layers.

Ultrasound sensing at thermomechanical limits with optomechanical buckled-dome microcavities.

We describe the use of monolithic, buckled-dome cavities as ultrasound sensors. Patterned delamination within a compressively stressed thin film stack produces high-finesse plano-concave optical resonators with sealed and empty cavity regions. The buckled mirror also functions as a flexible membrane, highly responsive to changes in external pressure. Owing to their efficient opto-acousto-mechanical coupling, thermal-displacement-noise limited sensitivity is achieved at low optical interrogation powers and for modest optical (Q ∼ 103) and mechanical (Q ∼ 102) quality factors. We predict and verify broadband (up to ∼ 5 MHz), air-coupled ultrasound detection with noise-equivalent pressure (NEP) as low as ∼ 30-100 µPa/Hz1/2. This corresponds to an ultrasonic force sensitivity ∼ 2 × 10-13 N/Hz1/2 and enables the detection of MHz-range signals propagated over distances as large as ∼ 20 cm in air. In water, thermal-noise-limited sensitivity is demonstrated over a wide frequency range (up to ∼ 30 MHz), with NEP as low as ∼ 100-800 µPa/Hz1/2. These cavities exhibit a nearly omnidirectional response, while being ∼ 3-4 orders of magnitude more sensitive than piezoelectric devices of similar size. Easily realized as large arrays and naturally suited to direct coupling by free-space beams or optical fibers, they offer significant practical advantages over competing optical devices, and thus could be of interest for several emerging applications in medical and industrial ultrasound imaging.

Polymer transfer technique for strain-activated emission in hexagonal boron nitride.

We present a hexagonal boron nitride (hBN) polymer-assisted transfer technique and discuss subtleties about the process. We then demonstrate localized emission from strained regions of the film draped over features on a prepatterned substrate. Notably, we provide insight into the brightness distribution of these emitters and show that the brightest emission is clearly localized to the underlyin-g substrate features rather than unintentional wrinkles present in the hBN film. Our results aide in the current discussion surrounding scalability of single photon emitter arrays.

Pressure sensing with high-finesse monolithic buckled-dome microcavities.

We describe the use of on-chip buckled-dome Fabry-Perot microcavities as pressure sensing elements. These cavities, fabricated by a controlled thin-film buckling process, are inherently sealed and support stable optical modes (finesse >103), which are well-suited to coupling by single-mode fibers. Changes in external pressure deflect the buckled upper mirror, leading to changes in resonance wavelengths. Experimental shifts are shown to be in good agreement with theoretical predictions. Sensitivities as large as ∼1nm/kPa, attributable to the low thickness (<2µm) of the buckled mirror, and resolution ∼10Pa are demonstrated. We discuss potential advantages over traditional low-finesse, quasi-planar Fabry-Perot pressure sensors.

Monolithically integrated membrane-in-the-middle cavity optomechanical systems.

We describe curved-mirror Fabry-Perot cavities with embedded silicon nitride membranes, fabricated using a monolithic surface-micromachining process. The presence of the suspended membranes was confirmed by confocal microscopy, and their properties were verified through optical studies and thermomechanical calibration of mechanical/vibrational noise spectra measured at room temperature and atmospheric pressure. The cavities exhibit reflectance-limited finesse (F ∼ 103) and wavelength-scale mode volumes (VM ∼ 10·λ3). The short cavity length (L ∼ 2·λ) results in large optomechanical coupling, which is desirable for numerous applications in sensing and quantum information.

Liquid infiltration of monolithic open-access Fabry-Perot microcavities.

We describe a monolithic approach to fabricating large-scale arrays of high-finesse and low-mode-volume Fabry-Perot microcavities with open access to the air core. A stress-driven buckling self-assembly technique was used to form half-symmetric curved-mirror cavities, and a dry etching process was subsequently used to create micropores through the upper mirror. We show that the cavities retain excellent optical properties, with reflectance-limited finesse ∼2500 and highly predictable Laguerre-Gaussian modes. We furthermore demonstrate the ability to introduce liquids into the cavity region by microinjection through the pores. Applications in sensing, optofluidics, and cavity quantum electrodynamics are envisioned.

Widely tunable bandpass filter based on resonant optical tunneling.

We describe a tunable bandpass filter and polarizer based on resonant tunneling through an air gap between two hemi-cylindrical prisms coated with 4-layer a-Si/SiO2 matching stacks. Tuning is achieved by simultaneous variations in the incident angle and the air gap thickness, enabling the pass-band center wavelength to be continuously adjusted over a very wide range (potentially ~1000 - 1800 nm) with an approximately fixed fractional bandwidth (Δλ/λ ~1%). An analytical derivation of the conditions required to produce a flat-top TE pass-band at a desired wavelength is given. The filter provides excellent out-of-band rejection and strong suppression of the orthogonal TM polarization over the entire tuning range. For applications involving collimated light, it could be a useful alternative to existing widely tunable filters based on gratings or liquid crystals.

Quantifying the tangling of trajectories using the topological entropy.

We present a simple method to efficiently compute a lower limit of the topological entropy and its spatial distribution for two-dimensional mappings. These mappings could represent either two-dimensional time-periodic fluid flows or three-dimensional magnetic fields, which are periodic in one direction. This method is based on measuring the length of a material line in the flow. Depending on the nature of the flow, the fluid can be mixed very efficiently which causes the line to stretch. Here, we study a method that adaptively increases the resolution at locations along the line where folds lead to a high curvature. This reduces the computational cost greatly which allows us to study unprecedented parameter regimes. We demonstrate how this efficient implementation allows the computation of the variation of the finite-time topological entropy in the mapping. This measure quantifies spatial variations of the braiding efficiency, important in many practical applications.

Toxicological assessment of kretek cigarettes: Part 2: kretek and American-blended cigarettes, smoke chemistry and in vitro toxicity.

Two commercial kretek cigarettes typical for the Indonesian market and a reference kretek cigarette were compared to the American-blended reference cigarette 2R4F by smoke chemistry characterization and in vitro cytotoxicity and mutagenicity assessments. Despite the widely diverse designs and deliveries of the selected kretek cigarettes, their smoke composition and in vitro toxicity data present a consistent pattern when data were normalized to total particulate matter (TPM) deliveries. This confirms the applicability of the studies' conclusions to a wide range of kretek cigarette products. After normalization to TPM delivery, nicotine smoke yields of kretek cigarettes were 29-46% lower than that of the 2R4F. The yields of other nitrogenous compounds were also much lower, less than would be expected from the mere substitution of one third of the tobacco filler by clove material. Yields of light molecular weight pyrolytic compounds, notably aldehydes and hydrocarbons, were reduced, while yields of polycyclic aromatic hydrocarbons were unchanged and phenol yield was increased. The normalized in vitro toxicity was lowered accordingly, reflecting the yield reductions in gas-phase cytotoxic compounds and some particulate-phase mutagenic compounds. These results do not support a higher toxicity of the smoke of kretek cigarettes compared to American-blended cigarettes.

Ultrasonic spectroscopy of sessile droplets coupled to optomechanical sensors.

We describe a system for interrogating the acoustic properties of sub-nanoliter liquid samples within an open microfluidics platform. Sessile droplets were deposited onto integrated optomechanical sensors, which possess ambient-medium-noise-limited sensitivity and can thus passively sense the thermally driven acoustic spectrum of the droplets. The droplet acoustic breathing modes manifest as resonant features in the thermomechanical noise spectrum of the sensor, in some cases hybridized with the sensor's own vibrational modes. Excellent agreement is found between experimental observations and theoretical predictions, over the entire ∼0-40 MHz operating range of our sensors. As an application example, we used the technique to monitor the temporal evolution of evaporating droplets. With suitable control over droplet size and morphology, this technique has the potential for precision acoustic sensing of small-volume biological and chemical samples.

Topological constraints on magnetic relaxation.

The final state of turbulent magnetic relaxation in a reversed field pinch is well explained by Taylor's hypothesis. However, recent resistive-magnetohydrodynamic simulations of the relaxation of braided solar coronal loops have led to relaxed fields far from the Taylor state, despite the conservation of helicity. We point out the existence of an additional topological invariant in any flux tube with a nonzero field: the topological degree of the field line mapping. We conjecture that this constrains the relaxation, explaining why only one of three example simulations reaches the Taylor state.

Left vagal nerve stimulation in children with refractory epilepsy. Preliminary observations.

OBJECTIVE: To observe the tolerance and efficacy of periodic left vagal nerve stimulation in a group of children with medically intractable epilepsies. DESIGN: A vagal nerve stimulator (Cyberonics Inc, Webster, Tex) was implanted in 12 children with medically and surgically refractory epilepsies. These children were followed up for 2 to 14 months. OUTCOME MEASUREMENTS: (1) The number of seizures recorded during the final month of observation was compared with the number recorded during the month before the implantation of the vagal nerve stimulator. (2) Parents were asked to compare overall status of their child, relative to the period prior to using the vagal nerve stimulator, on a global rating scale. (3) The number of antiepileptic drugs at the last visit was compared with the number before the use of this device. (4) Adverse events were recorded. RESULTS: Five of the 12 patients had a greater than 90% reduction in the number of monthly seizures. Global evaluation scores indicated that there were no deteriorations from baseline and that there was a considerable number with improved status. Four patients were able to reduce the number of antiepileptic drugs used. No significant adversities were noted. CONCLUSIONS: The vagal nerve stimulator is well tolerated in children with intractable epilepsies, and it may have a role in their medical management. We were unable to determine specific epilepsies or seizures that were sensitive to this intervention.

Nitrate in drinking water. A case-control study on primary brain tumours with an embedded drinking water survey in Germany.

BACKGROUND: Nitrate is known to be a precursor in the endogenous formation of N-nitroso compounds which are thought to be associated with the development of brain tumours. METHODS: We conducted a population-based case-control study on the aetiology of primary brain tumours in adults in which the nitrate concentration in drinking water was investigated as a quantitative variable. For this purpose, an additional drinking water survey was performed. RESULTS: Analysis of 173 incident cases and 418 controls did not show any relationship between exposure to nitrate in drinking water and risk of developing primary brain tumours. We found mean nitrate concentrations of 15.98 mg/l (SD 15.61) in the drinking water history of the cases and of 16.16 mg/l (SD 15.72) for controls. In addition, we compared the quantitative history of nitrate contamination of the study participants to a semi-quantitative assessment by a stick method. Although we found good agreement between these methods we would recommend the use of detailed water surveys for retrospective studies on contaminants in drinking water. CONCLUSION: The results suggest the absence of an association between nitrate levels in drinking water and the risk of brain tumours. However in order to draw definite conclusions quantitative prospective studies are needed.

Slit defect of the diaphragma sellae with valve effect: observation of a "slit valve".

Malformations of the diaphragma sellae may permit transdiaphragmatic cerebrospinal fluid pulsations that lead to expansion of the sella turcica. The purpose of this report is to describe an intrasellar arachnoid cyst observed during surgery being filled by the action of an apparent one-way valve.

Flushing in relation to a possible rise in intracranial pressure: documentation of an unusual clinical sign. Report of five cases.

This report documents clinical features in five children who developed transient reddening of the skin (epidermal flushing) in association with acute elevations in intracranial pressure (ICP). Four boys and one girl (ages 9-15 years) deteriorated acutely secondary to intracranial hypertension ranging from 30 to 80 mm Hg in the four documented cases. Two patients suffered from ventriculoperitoneal shunt malfunctions, one had diffuse cerebral edema secondary to traumatic brain injury, one was found to have pneumococcal meningitis and hydrocephalus, and one suffered an intraventricular hemorrhage and hydrocephalus intraoperatively. All patients were noted to have developed epidermal flushing involving either the upper chest, face, or arms during their period of neurological deterioration. The response was transient, typically lasting 5 to 15 minutes, and dissipated quickly. The flushing reaction is postulated to be a centrally mediated response to sudden elevations in ICP. Several potential mechanisms are discussed. Flushing has clinical importance because it may indicate significant elevations in ICP when it is associated with neurological deterioration. Because of its transient nature, the importance of epidermal flushing is often unrecognized; its presence confirms the need for urgent treatment.

Osteolytic skull lesions secondary to trauma. Report of two cases.

Two patients with posttraumatic osteolytic skull lesions are presented and discussed. One was operated on, and pathological examination confirmed an inflammatory reactive process within the bone lesion.

The effect of furosemide on intracranial pressure and hemorrhage in preterm rabbits.

The hypothesis that intracranial hypotension due to excessive postnatal fluid loss places the premature infant at risk for germinal matrix and intraventricular hemorrhage (GM-IVH) was tested in preterm rabbits delivered at 28 and 29 days of gestation (term 32 days). Furosemide administered to newborn pups induced a diuresis that resulted in a 11% to 22% loss in body weight and a concomitant decline in muscle water (13% to 16%) and sodium (18% to 21%). Paradoxically, no change occurred in the water or electrolyte content of the brain even though cerebrospinal fluid and brain tissue pressure, but not blood pressure, declined. These changes were absent in littermates treated with saline. Microscopic examination of brain sections revealed a greater incidence of intracranial hemorrhage, particularly in the germinal matrix and choroid plexus, in furosemide-treated than in saline-treated preterm rabbit pups. These results are consistent with the hypothesis that intracranial hypotension promotes the incidence of GH-IVH in preterm animals.

Role of contextual stimuli in tolerance to stress-induced analgesia.

The present study was conducted to determine whether tolerance to stress-induced analgesia was mediated by contextual cues. Following baseline measurement of analgesia using a tail curl test, rats were exposed to nine sessions of 30 min of intermittent inescapable shock (tolerance development phase) in which one half of the rats began in context A and the other half in context B. A tail-curl test immediately followed each shock session. On the 10th day, 4 days after tail-curl latencies returned to baseline, the contexts were switched, and the rats were exposed to the same shock parameters as before. The results revealed a significant increase in tail-curl latency when the context was switched compared with the last day of the tolerance development phase. These data suggest that tolerance to stress-induced analgesia may at least in part be associatively mediated by the context.

Adverse events in children receiving intermittent left vagal nerve stimulation.

The purpose of this study was to determine the frequency of unexpected events during intermittent vagal nerve stimulation in 24 patients stimulated for a total of 61 patient years. The charts of 24 children undergoing periodic stimulation of the left vagal nerve on research protocols were reviewed to determine the nature and frequency of adverse events and the total length of time they were stimulated. Fifteen adverse events were discovered in 12 patients. Thirteen were likely related to the device, and four other events might have been related. Two of these resulted in voluntary termination of vagal nerve stimulation, and the rest were treatable. Vagal nerve stimulation was tolerated in this series of patients. As opposed to the more standard drug therapies, adverse events during vagal nerve stimulation do not necessitate termination of therapy, but these events frequently lead to unforeseen surgery under general anesthesia.

Intestinal perforation by peritoneal shunt tubing: report of two cases.

Patients with cerebrospinal shunts have multiple complications. Two cases are reported in which peritoneal tubing perforated the intestine and intermittently protruded through the anus. The literature is reviewed and therapeutic considerations are discussed.