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1.

Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.

Shmuel-Galia, Liraz; Humphries, Fiachra; Lei, Xuqiu; Ceglia, Simona; Wilson, Ruth; Jiang, Zhaozhao; Ketelut-Carneiro, Natalia; Foley, Sage E; Pechhold, Susanne; Houghton, JeanMarie; Muneeruddin, Khaja; Shaffer, Scott A; McCormick, Beth A; Reboldi, Andrea; Ward, Doyle; Marshak-Rothstein, Ann; Fitzgerald, Katherine A.

Immunity ; 54(6): 1137-1153.e8, 2021 06 08.

Artículo en Inglés | MEDLINE | ID: mdl-34051146

2.

Gasdermin D palmitoylation: to cleave or not to cleave?

Stine, Laurel; Humphries, Fiachra.

Trends Immunol ; 45(6): 403-405, 2024 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-38760304

3.

hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus.

Humphries, Fiachra; Fitzgerald, Katherine A.

Mol Cell ; 76(1): 8-10, 2019 10 03.

Artículo en Inglés | MEDLINE | ID: mdl-31585104

4.

cGAS-like receptors: back to the future.

Humphries, Fiachra.

Trends Immunol ; 44(10): 760-762, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37718174

5.

Targeting STING oligomerization with small-molecule inhibitors.

Humphries, Fiachra; Shmuel-Galia, Liraz; Jiang, Zhaozhao; Zhou, Jeffrey Y; Barasa, Leonard; Mondal, Santanu; Wilson, Ruth; Sultana, Nadia; Shaffer, Scott A; Ng, Sze-Ling; Pesiridis, G Scott; Thompson, Paul R; Fitzgerald, Katherine A.

Proc Natl Acad Sci U S A ; 120(33): e2305420120, 2023 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-37549268

6.

Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.

Chen, Yongzhi; Lei, Xuqiu; Jiang, Zhaozhao; Humphries, Fiachra; Parsi, Krishna Mohan; Mustone, Nicholas J; Ramos, Irene; Mutetwa, Tinaye; Fernandez-Sesma, Ana; Maehr, René; Caffrey, Daniel R; Fitzgerald, Katherine A.

Proc Natl Acad Sci U S A ; 120(47): e2308355120, 2023 Nov 21.

Artículo en Inglés | MEDLINE | ID: mdl-37963251

7.

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.

Hariharan, Vignesh N; Shin, Minwook; Chang, Ching-Wen; O'Reilly, Daniel; Biscans, Annabelle; Yamada, Ken; Guo, Zhiru; Somasundaran, Mohan; Tang, Qi; Monopoli, Kathryn; Krishnamurthy, Pranathi Meda; Devi, Gitali; McHugh, Nicholas; Cooper, David A; Echeverria, Dimas; Cruz, John; Chan, Io Long; Liu, Ping; Lim, Sun-Young; McConnell, Jill; Singh, Satya Prakash; Hildebrand, Samuel; Sousa, Jacquelyn; Davis, Sarah M; Kennedy, Zachary; Ferguson, Chantal; Godinho, Bruno M D C; Thillier, Yann; Caiazzi, Jillian; Ly, Socheata; Muhuri, Manish; Kelly, Karen; Humphries, Fiachra; Cousineau, Alyssa; Parsi, Krishna Mohan; Li, Qi; Wang, Yang; Maehr, René; Gao, Guangping; Korkin, Dmitry; McDougall, William M; Finberg, Robert W; Fitzgerald, Katherine A; Wang, Jennifer P; Watts, Jonathan K; Khvorova, Anastasia.

Proc Natl Acad Sci U S A ; 120(11): e2219523120, 2023 03 14.

Artículo en Inglés | MEDLINE | ID: mdl-36893269

8.

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.

Yang, Shuo; Wang, Bingwei; Humphries, Fiachra; Jackson, Ruaidhri; Healy, Marc E; Bergin, Ronan; Aviello, Gabriella; Hall, Barry; McNamara, Deirdre; Darby, Trevor; Quinlan, Aoife; Shanahan, Fergus; Melgar, Silvia; Fallon, Padraic G; Moynagh, Paul N.

Nat Immunol ; 14(9): 927-36, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23892723

9.

Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond.

Sciaudone, Anthony; Corkrey, Heather; Humphries, Fiachra; Koupenova, Milka.

Circ Res ; 132(10): 1272-1289, 2023 05 12.

Artículo en Inglés | MEDLINE | ID: mdl-37167360

10.

Development of LB244, an Irreversible STING Antagonist.

Barasa, Leonard; Chaudhuri, Sauradip; Zhou, Jeffrey Y; Jiang, Zhaozhao; Choudhary, Shruti; Green, Robert Madison; Wiggin, Elenore; Cameron, Michael; Humphries, Fiachra; Fitzgerald, Katherine A; Thompson, Paul R.

J Am Chem Soc ; 145(37): 20273-20288, 2023 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-37695732

11.

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

Yang, Shuo; Wang, Bingwei; Humphries, Fiachra; Hogan, Andrew E; O'Shea, Donal; Moynagh, Paul N.

Immunity ; 41(6): 973-87, 2014 Dec 18.

Artículo en Inglés | MEDLINE | ID: mdl-25526310

12.

TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.

Gross-Vered, Mor; Shmuel-Galia, Liraz; Zarmi, Batya; Humphries, Fiachra; Thaiss, Christoph; Salame, Tomer-Meir; David, Eyal; Chappell-Maor, Louise; Fitzgerald, Katherine A; Shai, Yechiel; Jung, Steffen.

J Immunol ; 204(3): 707-717, 2020 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-31882517

13.

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.

Humphries, Fiachra; Moynagh, Paul N.

Immunol Rev ; 266(1): 93-108, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-26085209

14.

Igniting the firestorm: The inflammasome in autoinflammatory syndromes.

Humphries, Fiachra; Fitzgerald, Katherine A.

J Allergy Clin Immunol ; 148(6): 1470-1472, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34403657

15.

Assembling the Inflammasome, Piece by Piece.

Humphries, Fiachra; Fitzgerald, Katherine A.

J Immunol ; 203(5): 1093-1094, 2019 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-31427397

16.

Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.

Hanuszkiewicz, Anna; Pittock, Paula; Humphries, Fiachra; Moll, Hermann; Rosales, Amanda Roa; Molinaro, Antonio; Moynagh, Paul N; Lajoie, Gilles A; Valvano, Miguel A.

J Biol Chem ; 289(27): 19231-44, 2014 Jul 04.

Artículo en Inglés | MEDLINE | ID: mdl-24841205

17.

Voices: Challenges and opportunities in regulating the immune system.

Chen, Yuezhou; Humphries, Fiachra; Li, Ming O; Kanneganti, Thirumala-Devi; Ye, Dan.

Cell Chem Biol ; 31(5): 830-832, 2024 May 16.

Artículo en Inglés | MEDLINE | ID: mdl-38759615

18.

ECSIT facilitates memory CD8⁺ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.

Yang, Yongbing; Wang, Yanan; Wang, Zhongcheng; Yan, Huanyu; Gong, Yi; Hu, Yingchao; Jiang, Yuying; Wen, Shuang; Xu, Feifei; Wang, Bingwei; Humphries, Fiachra; Chen, Yun; Wang, Xi; Yang, Shuo.

Nat Cell Biol ; 26(3): 450-463, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38326554

19.

Biochemical Methods for Assessing Gasdermin D Inactivation in Macrophages.

Humphries, Fiachra.

Methods Mol Biol ; 2641: 125-133, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37074646

20.

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.

Shmuel-Galia, Liraz; Humphries, Fiachra; Vierbuchen, Tim; Jiang, Zhaozhao; Santos, Nolan; Johnson, John; Shklyar, Boris; Joannas, Leonel; Mustone, Nicholas; Sherman, Shany; Ward, Doyle; Houghton, JeanMarie; Baer, Christina E; O'Hara, Aisling; Henao-Mejia, Jorge; Hoebe, Kasper; Fitzgerald, Katherine A.

Cell Metab ; 35(8): 1441-1456.e9, 2023 08 08.

Artículo en Inglés | MEDLINE | ID: mdl-37494932

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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.

Gasdermin D palmitoylation: to cleave or not to cleave?

hnRNPA2B1: Fueling Antiviral Immunity from the Nucleus.

cGAS-like receptors: back to the future.

Targeting STING oligomerization with small-molecule inhibitors.

Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.

Platelets and SARS-CoV-2 During COVID-19: Immunity, Thrombosis, and Beyond.

Development of LB244, an Irreversible STING Antagonist.

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.

Igniting the firestorm: The inflammasome in autoinflammatory syndromes.

Assembling the Inflammasome, Piece by Piece.

Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.

Voices: Challenges and opportunities in regulating the immune system.

ECSIT facilitates memory CD8⁺ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis.

Biochemical Methods for Assessing Gasdermin D Inactivation in Macrophages.

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.