Relationship between Timed Up and Go performance and quantitative biomechanical measures of balance.

Traumatic brain injury (TBI) impairs sensory-motor functions, with debilitating consequences on postural control and balance, which persist during the chronic stages of recovery. The Timed Up and Go (TUG) test is a reliable, safe, time-efficient, and one of the most widely used clinical measures to assess gait, balance, and fall risk in TBI patients and is extensively used in inpatient and outpatient settings. Although the TUG test has been used extensively due to its ease of performance and excellent reliability, limited research has been published that investigates the relationship between TUG performance and quantitative biomechanical measures of balance. The objective of this paper was to quantify the relationship between biomechanical variables of balance and the TUG scores in individuals with chronic TBI. Regression models were constructed using six biomechanical variables to predict TUG scores. The model that conservatively removed gait speed (i.e., TUG-1/GS) gave the best results, achieving a root-mean-square error of ∼±2 s and explaining over 69% of the variability.

Motor-Cognitive Virtual Reality Training to Improve Gait and Balance in Young Adults with TBI.

Traumatic Brain Injury (TBI) is one of the leading causes of motor and cognitive deficits in adults, and often results in motor control and balance impairments. Motor deficits include gait dysfunction and decreased postural control & coordination; leading to compromised functional ambulation and reduced quality of life. Research has shown that cognitive (attention and executive) function contributes to motor deficits and recovery. Hence, targeting the motor and the cognitive domains simultaneously by increasing cognitive and motor effort to perform the task may lead to improved ambulation recovery. The objective of this investigation was to evaluate the efficacy of simultaneous motor & cognitive training (MCT) using virtual reality to improve ambulation; assessed using biomechanical, cognitive, and functional outcomes. Preliminary data is presented for three participants with chronic TBI who received MCT. The results show improved cognition, speed, endurance, step length, gait cycle time, static & reactive balance, dual-task performance, and progression towards healthy ambulation. These preliminary results suggest that integrated cognitive motor training has the potential to induce functional recovery in young adults with TBI.Clinical Relevance - Preliminary data provides initial evidence for MCT as a therapeutic intervention for gait and balance rehabilitation in young adults with TBI.

Enhancing Anticipatory and Compensatory Postural Responses to Improve Balance in Individuals with TBI.

Traumatic Brain Injury (TBI) is one of the leading causes of sensorimotor deficits in adults and often results in balance impairments. Two types of postural mechanisms are employed to achieve balance during perturbations: Anticipatory Postural Adjustments (APA) and Compensatory Postural Adjustments (CPA). People with TBI have reduced APA/CPA responses due to sensory-motor deficits from the injury. The objective of this feasibility study was to evaluate a Perturbation-based Balance Training program with visual cues (PBTvc) to target both APA/CPA responses to improve balance. The evaluation included biomechanical (reactive balance during random perturbation) and functional (Berg Balance Scale, Timed Up and Go and Falls Efficacy Scale) metrics. Preliminary data is presented for two participants with chronic TBI who received 16 sessions of PBTvc. The results show an improved range of trunk oscillation and time to stability during random perturbation tasks with corresponding improvements in Berg Balance Scale, Timed Up & Go, and Falls Efficacy Scale. The results suggest that PBTvc has the potential to improve APA/CPA mechanisms for functional recovery.Clinical Relevance- Preliminary data provides initial evidence for PBTvc as a therapeutic intervention for balance rehabilitation in adults with TBI.

A Novel Core Strengthening Intervention for Improving Trunk Function, Balance and Mobility after Stroke.

This paper a novel core-strengthening intervention (CSI) delivered using the AllCore360°, a device that targets trunk muscles through a systematic, high-intensity rotating-plank exercise. Three individuals (age: 61.7 ± 3.2 years; range: 58-64 years) with post-stroke hemiplegia participated in 12-sessions of the CSI. The participants completed up to 142 rotating planks at inclination angles (IAs) that ranged from 40° to 65°, over 12 sessions. The interventional effects on the functional outcomes of trunk performance, balance and mobility were assessed using the Trunk Impairment Scale (TIS), the Berg Balance Scale (BBS), the Timed-Up and Go (TUG) test, the 10-m walk test (10MWT), and the 6-min walk test (6MWT). Postural outcomes were assessed using the center of pressure (CoP) data recorded during quiet standing on a balance platform, and neuromuscular outcomes were assessed using electromyography (EMG) during AllCore360° rotations. All participants completed the CSI (minimum of 120 rotations), demonstrating the feasibility of the CSI in chronic stroke. The CoP data suggested improved lateral control of posture during standing across participants (averaging an over 30% reduction in lateral sway), while the EMG data revealed the ability of the CSI to systematically modulate trunk muscle responses. In summary, the current investigation presents the feasibility of a novel delivery method for core strengthening to maximize rehabilitation outcomes in the chronic phase of stroke.

Wearable devices for tracking physical activity in the community after an acquired brain injury: A systematic review.

OBJECTIVE: The application of wearable devices in individuals with acquired brain injury (ABI) resulting from stroke or traumatic brain injury (TBI) for monitoring physical activity (PA) has been relatively recent. The current systematic review aims to provide insights into the adaption of these devices, the outcome metrics, and their transition from the laboratory to the community for PA monitoring of individuals with ABI. LITERATURE SURVEY: The PubMed and Google Scholar databases were systematically reviewed using appropriate search terms. A total of 20 articles were reviewed from the last 15 years. METHODOLOGY: Articles were classified into three categories: PA measurement studies, PA classification studies, and validation studies. The quality of studies was assessed using a quality appraisal checklist. SYNTHESIS: It was found that the transition of wearable devices from in-lab to community-based studies in individuals with stroke has started but is not widespread. The transition of wearable devices in the community has not yet started for individuals with TBI. Accelerometer-based devices were more frequently chosen than pedometers and inertial measurement units. No consensus on a preferred wearable device (make or model) or wear location could be identified, although step count was the most common outcome metric. The accuracy and validity of most outcome metrics used in the community were not reported for many studies. CONCLUSIONS: To facilitate future studies using wearable devices for PA measurement in the community, we recommend that researchers provide details on the accuracy and validity of the outcome metrics specific to the study environment. Once the accuracy and validity are established for a specific population, wearable devices and their derived outcomes can provide objective information on mobility impairment as well as the effect of rehabilitation in the community.

A Novel Core-Strengthening Program for Improving Trunk Function, Balance and Mobility after Stroke: a Case Study.

The objective of the current investigation was to evaluate the feasibility of a core-strengthening program delivered to a chronic stroke participant using a novel robotic device, AllCore360°, which targets trunk muscles through a systematic, consistent, high-intensity exercise. A 58-year old male with hemiplegia post stroke (time since injury: 18 years) was enrolled and performed 12-sessions of the core-strengthening program on AllCore360°. The participant completed a total of 142 360°-rotating-planks (called as 'spins') at four inclination angles, over 12 sessions. Assessments at baseline and follow up included posturography during quiet standing, electromyography (EMG) during AllCore360° spins, and assessments for trunk function (Trunk Impairment Scale (TIS)), balance (Berg Balance Scale (BBS) and mobility (Timed-Up and Go (TUG), 10-meter Walk test (10MWT), 6-minute Walk Test (6MWT)). Clinically meaningful improvements were observed in the TIS (73%), the BBS (45.2%), and the TUG test (22.7%). Medial-lateral Center of Pressure (MLCoP) data showed reduced RMS and range by 32.3% and 29.2%, respectively. EMG data from left and right rectus abdominis (RAB) muscles showed increased levels of activations for both inclination angles, 65° (LRAB: 74%, RRAB: 48.4%) and 55° (LRAB: 22.3%, RRAB: 28.7%). The participant rated the core-strengthening program 71 (scale: 0-126) on Physical ACtivity Enjoyment Scale at the follow up, showing a high level of satisfaction and engagement toward the training program. The preliminary results suggest that the novel robotic design and enhanced engagement of neuromuscular mechanisms features of AllCore360° core-strengthening program could facilitate improvements in trunk function, balance and mobility post stroke. A study with a large sample and an appropriate control group needs to be performed in the future.Clinical Relevance- The majority of clinical programs include core-stability exercises for improving trunk function. The current investigation presents a novel robotic-device based core-strengthening program that can provide systematic, consistent, and repetitive practice for optimal functional gains.

Accuracy comparison of machine learning algorithms at various wear-locations for activity identification post stroke: A pilot analysis.

Objective and accurate activity identification of physical activities in everyday life is an important aspect in assessing the impact of various post-stroke rehabilitation therapies and interventions. Since post-stroke hemiparesis affects gait and balance in individuals with stroke, activity identification algorithms that consider stroke-specific movement irregularities are needed. While wearable physical activity monitors provide the means to detect activities in the free-living, algorithms using their data are specific to the wear location of the device. This pilot study builds, validates, and compares three machine learning algorithms (linear support vector machine, Random Forest, and RUSBoosted trees) at three popular wear locations (wrist, waist, and ankle) to identify and accurately distinguish mobility-related activities (sitting, standing and walking) in individuals with chronic stroke. A total of 102 minutes of data from two lab visits of three-stroke participants was used to build the classifiers. A 5-fold cross-validation technique was used to validate and compare the accuracy of classifiers. RUSBoosted trees using data from waist and ankle activity monitors, with an accuracy of 99.1%, outperformed other classifiers in detecting three activities of interest.Clinical Relevance- One of the major aims of post-stroke rehabilitation is improving mobility, which may be facilitated by understanding the structure and pattern of everyday mobility through real-world, objective outcomes. Accurate activity identification, as shown in this pilot investigation, is an essential first step before developing objective outcomes for monitoring mobility and balance in everyday life of these individuals.

Socio-economic determinants of prenatal anaemia in rural communities of South-West Nigeria: a preliminary report.

BACKGROUND: Anaemia is common worldwide and pregnant women are one of the most vulnerable group. Although, anaemia in the general population including pregnant women is multi-factorial in aetiology, the most frequent cause in pregnancy worldwide is iron deficiency. In Nigeria, an estimated prevalence of anaemia among pregnant women ranges from 35-75%. Anaemia in pregnancy (AIP) is associated with significant perinatal and maternal morbidity and mortality including premature birth and low birth weight. AIM: The aim of this study was to determine the prevalence, demographic and socio-economic determinants of anaemia in pregnancy in a rural community of South-West Nigeria. MATERIALS AND METHODS: One-hundred and fifty consenting pregnant women aged 18-42 years in the three trimesters were recruited from four primary health centres of Ikene Local Government of Ogun State of Nigeria after ethical approval was obtained from the Ethics Unit of the Medical officer of Health of the Local Government. Pre-tested interviewer-administered questionnaire was used to collect data on socio-demographic information and 24-hour dietary recall. Using a finger prick, the haemoglobin concentration of each respondent was determined with a haemoglobinometer (DG-300HB manufactured by DouBle, China). Data was analyzed using the Statistical Package for Social Sciences (SPSS) version 20. RESULTS: All the respondents belonged to low socio-economic class. The mean haemoglobin (Hb) concentration obtained in this study was 10.22±1.60 g/dL with a range of 6-14.8 g/dL. Using WHO cut-off Hb concentration of 11 g/dL, the prevalence of anaemia in this study was 67.3%. The frequency of anaemia increased with increase in age group. P=0.010. About 21.4% of those with adequate dietary iron intake were anaemic when compared with 72.1% (98 of 136) of those with inadequate dietary iron intake who were anaemic. AOR-0.090; 95% CI- 0.018-0.457; P=0.004. CONCLUSION: Increasing age, low socio-economic status, poor health education and low dietary iron intake were the predominant socio-economic determinants of prenatal anaemia in the population studied. Efforts must be intensified to alleviate poverty in rural areas and give health education on iron-rich foods to girls and women of children-bearing age in the rural communities.

Evaluating Sensory Acuity as a Marker of Balance Dysfunction After a Traumatic Brain Injury: A Psychophysical Approach.

There is limited research on sensory acuity i.e., ability to perceive external perturbations via body-sway during standing in individuals with a traumatic brain injury (TBI). It is unclear whether sensory acuity diminishes after a TBI and if it is a contributing factor to balance dysfunction. The objective of this investigation is to first objectively quantify the sensory acuity in terms of perturbation perception threshold (PPT) and determine if it is related to functional outcomes of static and dynamic balance. Ten individuals with chronic TBI and 11 age-matched healthy controls (HC) performed PPT assessments at 0.33, 0.5, and 1 Hz horizontal perturbations to the base of support in the anterior-posterior direction, and a battery of functional assessments of static and dynamic balance and mobility [Berg balance scale (BBS), timed-up and go (TUG) and 5-m (5MWT) and 10-m walk test (10MWT)]. A psychophysical approach based on Single Interval Adjustment Matrix Protocol (SIAM), i.e., a yes-no task, was used to quantify the multi-sensory thresholds of perceived external perturbations to calculate PPT. A mixed-design analysis of variance (ANOVA) and post-hoc analyses were performed using independent and paired t-tests to evaluate within and between-group differences. Pearson correlation was computed to determine the relationship between the PPT and functional measures. The PPT values were significantly higher for the TBI group (0.33 Hz: 2.97 ± 1.0, 0.5 Hz: 2.39 ± 0.7, 1 Hz: 1.22 ± 0.4) compared to the HC group (0.33 Hz: 1.03 ± 0.6, 0.5 Hz: 0.89 ± 0.4, 1 Hz: 0.42 ± 0.2) for all three perturbation frequencies (p < 0.006 post Bonferroni correction). For the TBI group, the PPT for 1 Hz perturbations showed significant correlation with the functional measures of balance (BBS: r = -0.66, p = 0.037; TUG: r = 0.78, p = 0.008; 5MWT: r = 0.67, p = 0.034, 10MWT: r = 0.76, p = 0.012). These findings demonstrate that individuals with TBI have diminished sensory acuity during standing which may be linked to impaired balance function after TBI.

Anticipatory and Compensatory Postural Responses during Perturbed Standing in Individuals with Traumatic Brain Injury.

Anticipatory postural adjustments (APA) and compensatory postural adjustments (CPA) are neuromuscular responses generated to stabilize the body and achieve balance during perturbations. The impaired sensory integration after a traumatic brain injury (TBI) can limit the ability to perceive perturbations and potentially affect the ability to generate APA and CPA responses. The main objective of this investigation is to explore the existence of APA and CPA generation in tibialis anterior (TA) and gastrocnemius (GAST) muscles during base of support perturbations in healthy controls (HC) as well as individuals with TBI. The secondary objective is to explore the effectiveness of a novel computerized biofeedback based intervention (CBBI) at improving APA and CPA responses in individuals with TBI. We observed that all three groups - HC (n=5), TBI-control (n=5), and TBI-Intervention (n=4) showed the presence of only CPA responses for the TA muscle, however, these responses were longer and variable for both TBI groups, compared to the short and consistent responses of the HC group. The GAST was involved in both APA and CPA for all groups. After the 4-week CBBI period, the TBI-I group showed increased APA responses for both TA and GAST. Further, the TBI-I group showed reduced CPA responses for both TA and GAST after the intervention. The elevated and longer CPA responses of TA and GAST and lower APA responses of GAST could suggest impaired postural control. Due to their significance and potential link to the balance dysfunction, these mechanisms need to be studied comprehensively in larger samples in order to effectively optimize the rehabilitation approaches for improving balance and avoiding falls in individuals with TBI.

Improving Perception of Perturbations and Balance Using a Novel Dynamic Computerized Biofeedback Based Intervention after Traumatic Brain Injury.

Traumatic Brain Injury (TBI) impairs the integration and organization of the visual, auditory, and somatosensory inputs that permit body position awareness in relation to self and environment resulting in balance dysfunction (BD). The sensitivity levels to which the environmental perturbations are perceived are also critical for attaining the position awareness and the equilibrium. Undetectable perturbations, however small they may be, can result in fatal falls, especially after TBI. In this investigation, we used a novel dynamic computerized biofeedback based (CBB) intervention aimed at improving the perception of external perturbations, and static and dynamic balance in individuals with TBI. The effect of the CBB intervention on balance was accessed using a clinical measure - Berg Balance Scale (BBS), a novel psychophysical measure - perception of perturbation threshold (PPT), and biomechanical measures derived from center of pressure (COP) data during controlled sinusoidal varied-amplitudes anterior-posterior perturbations of 0.33 Hz, 0.5 Hz, and 1 Hz to the base of support. At baseline, the TBI-Control (TBI-C) group (n=5) and the TBI-Intervention (TBI-I) group (n=2) showed impaired balance compared to the healthy control (HC) group (n=5). This was shown by lower BBS and elevated values of PPT and COP measures (RMS COP, COP velocity, Phase Plane Indices (PPI)). Post CBB intervention, TBI-I group showed increased BBS and reduction in PPTs, COP measures (velocity and PPI), suggesting improvements in postural stability and balance. This investigation explores a potential link between the perception of perturbations and balance and demonstrates the applicability of the CBB intervention for improving interpretation and organization of multisensory information in a task-specific environment to improve balance post-TBI.