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1.
Pol J Radiol ; 79: 374-80, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25352941

RESUMEN

BACKGROUND: To compare the multidetector computed tomography (MDCT) arthrography (CTa) and magnetic resonance (MR) arthrography (MRa) findings with surgical findings in patients with femoroacetabular impingement (FAI) and to evaluate the diagnostic performance of these methods. MATERIAL/METHODS: Labral pathology and articular cartilage were prospectively evaluated with MRa and CTa in 14 hips of 14 patients. The findings were evaluated by two musculoskeletal radiologists with 10 and 20 years of experience, respectively. Sensitivity, specificity, accuracy, and positive predictive value were determined using surgical findings as the standard of reference. RESULTS: While the disagreement between observers was recorded in two cases of labral tearing with MRa, there was a complete consensus with CTa. Disagreement between observers was found in four cases of femoral cartilage loss with both MRa and CTa. Disagreement was also recorded in only one case of acetabular cartilage loss with both methods. The percent sensitivity, specificity, and accuracy for correctly assessing the labral tearing were as follows for MRa/CTa, respectively: 100/100, 50/100, 86/100 (p<0.05). The same values for acetabular cartilage assessment were 89/56, 40/60, 71/71 (p>0.05) and for femoral cartilage assessment were 100/75, 90/70, 86/71 (p>0.05). Inter-observer reliability value showed excellent agreement for labral tearing with CTa (κ=1.0). Inter-observer agreement was substantial to excellent with regard to acetabular cartilage assessment with MRa and CTa (κ=0.76 for MRa and κ=0.86 for CTa). CONCLUSIONS: Inter-observer reliability with CTa is excellent for labral tearing assessment. CTa seems to have an equal sensitivity and a higher specificity than MRa for the detection of labral pathology. MRa is better, but not statistically significantly, in demonstrating acetabular and femoral cartilage pathology.

2.
Cell Biochem Biophys ; 2024 Sep 12.
Artículo en Inglés | MEDLINE | ID: mdl-39266872

RESUMEN

Current treatment approaches cannot exactly regenerate cartilage tissue. Regarding some problems encountered with cell therapy, exosomes are advantageous because of their "cell-free" nature. This study examines the relationship between IL-10 and TGF-ß and Canonical Wnt/ß-catenin signal pathways in human adipose tissue-derived MSCs exosomes (hAT-MSCs-Exos) after in vitro chondrogenic differentiation. Human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) and, as a control group, human fetal chondroblast cells (hfCCs) were differentiated chondrogenically in vitro. Exosome isolation and characterization analyses were performed. Chondrogenic differentiation was shown by Alcian Blue and Safranin O stainings. The expression levels of IL-10, TGF-ß/SMAD signaling pathway genes, and Canonical Wnt/ß-catenin signaling pathway genes, which play an essential role in chondrogenesis, were analyzed by RT-qPCR. Conditioned media cytokine levels were measured by using the TGF-ß and IL-10 ELISA kits. IL-10 expression was upregulated in both chondrogenic differentiated hAT-MSC-Exos (dhAT-MSC-Exos) (p < 0.0001). In the TGF-ß signaling pathway, TGF-ß (p < 0.0001), SMAD2 (p < 0.0001), SMAD4 (p < 0.001), ACAN (p < 0.0001), SOX9 (p < 0.05) and COL1A2 (p < 0.0001) expressions were upregulated in dhAT-MSC-Exos. SMAD3 expression was upregulated in non-differentiated hAT-MSC-Exos. In the Canonical Wnt/ß-catenin signaling pathway, WNT (p < 0.0001) and CTNNB1(p < 0.0001) expressions were upregulated in dhAT-MSC-Exos. AXIN (p < 0.0001) expression was upregulated in non-differentiated hAT-MSC-Exos. TGF-ß and IL-10 levels were higher in dhAT-MSCs) (p < 0.0001). Related to these results, IL-10 may induce TGF-ß/SMAD and Canonical Wnt/ß-catenin signaling pathways in hAT-MSC exosomes obtained after chondrogenic differentiation. Therefore, using these exosomes for cartilage regeneration can lead to the development of treatment methods.

3.
Acta Orthop Traumatol Turc ; 57(4): 141-147, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37670447

RESUMEN

OBJECTIVE: The aims of this study were (i) to assess the radiological and functional outcomes of surgically treated displaced acetabular fractures and (ii) to analyze the predictive factors of poor outcomes following surgery. METHODS: A total of 119 patients (24 female, 95 male) who were operated between 2009 and 2019 were included in the study. The mean age was 47.5 years (range=18-61). The mean follow-up was 92.3 months (range=24-120). Failure to preserve the biological hip joint, as treated with total hip replacement or the Girdlestone procedure, was defined as a poor outcome. Patients' demographic information, comorbidities, fracture types, surgical approach, concomitant injuries, reduction quality, and complications were analyzed. Computed tomography was utilized to evaluate the fracture type and quality of reduction. Factors affecting poor outcomes were analyzed by logistic regression analysis. The modified Harris Hip Score was also used to evaluate the functional status. RESULTS: The poor outcome rate was 10.1%. Multivariate logistic regression analysis revealed that dislocation (odds ratio: 44.87, confi- dence interval: 3.18-633.22, P=.005), wound site problems (odds ratio: 9.09, confidence interval: 1.01-81.12, P=.04), reduction quality (odds ratio: 77.88, confidence interval: 5.95-1019.07, P = .001), and diabetes (odds ratio: 7.29, confidence interval: 1.01-52.07, P = .04) were associated with poor outcomes. Eight of the 12 patients with poor outcomes had a fair Harris Hip Score, and 4 had a poor Harris Hip Score. The relationship between poor outcomes and Harris Hip Score was found to be significant (P < .001). CONCLUSION: For a favorable functional outcome in acetabular fractures, preservation of the biological hip joint should be a top priority. The accompanying dislocation and the patient's diabetes appear to be uncontrollable factors for the poor prognosis. Good reduction qual- ity and wound infection protection are modifiable factors. LEVEL OF EVIDENCE: Level IV, Therapeutic Study.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Fracturas de Cadera , Luxaciones Articulares , Osteoartritis , Fracturas de la Columna Vertebral , Humanos , Femenino , Masculino , Persona de Mediana Edad , Articulación de la Cadera
4.
Gene ; 865: 147337, 2023 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-36878417

RESUMEN

This study aimed to investigate the differences between the exosomal microRNA-127-5p expression profiles of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) and human synovial fluid-derived mesenchymal stem cells (hSF-MSCs) during chondrogenesis in terms of regenerative treatment of cartilage. Synovial fluid-derived mesenchymal stem cells, adipose tissue-derived mesenchymal stem cells, and human fetal chondroblast cells (hfCCs) were directed to chondrogenic differentiation. Alcian Blue and Safranin O stainings were performed to detect chondrogenic differentiation histochemically. Exosomes derived from chondrogenic differentiated cells and their exosomes were isolated and characterized. microRNA-127-5p expressions were measured by Quantitative reverse transcription PCR (qRT-PCR). Significantly higher levels of microRNA-127-5p expression in differentiated hAT-MSCs exosomes, similar to human fetal chondroblast cells, which are the control group in the chondrogenic differentiation process, were observed. hAT-MSCs are better sources of microRNA-127-5p than hSF-MSCs for stimulating chondrogenesis or in the regenerative therapy of cartilage-related pathologies. hAT-MSCs exosomes are rich sources of microRNA-127-5p and can be an essential candidate for cartilage regeneration treatments.


Asunto(s)
Exosomas , Células Madre Mesenquimatosas , MicroARNs , Humanos , Líquido Sinovial/metabolismo , Exosomas/genética , Exosomas/metabolismo , Condrogénesis/genética , Diferenciación Celular , MicroARNs/genética , MicroARNs/metabolismo , Células Madre Mesenquimatosas/metabolismo , Células Cultivadas
5.
Arch Orthop Trauma Surg ; 132(9): 1281-5, 2012 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-22643805

RESUMEN

PURPOSE: The aim of this case series was to assess the effect of two common causes of inherited thrombophilia, factor V Leiden (FVL) and prothrombin mutation (PTM) on the development of osteonecrosis of the femoral head (ONFH) following the treatment of developmental dysplasia of the hip (DDH). METHODS: FVL and PTM analysis of 58 patients (45 females and 13 males; mean age 12.2 years) with ONFH due to DDH treatment was done. RESULTS: Rate of inherited thrombophilia (FVL plus PTM) was 15.5 %. Inherited thrombophilia was nearly four times higher in male patients than in female patients and this difference was mainly due to FVL (P < 0.05). This finding was against the common belief that, coagulation abnormalities were equally distributed across the sexes in normal population. Rates of overall inherited thrombophilia, FVL and PTM were not correlated with the type of ONFH (P > 0.05). CONCLUSION: Hereditary thrombophilia, especially FVL, may be one of the causative factors for the development of ONFH following DDH treatment in male patients. Further prospective, controlled studies are needed to undoubtedly enlighten this issue.


Asunto(s)
Necrosis de la Cabeza Femoral/etiología , Luxación Congénita de la Cadera/complicaciones , Trombofilia/genética , Niño , Factor V/genética , Femenino , Luxación Congénita de la Cadera/cirugía , Humanos , Masculino , Protrombina/genética , Trombofilia/complicaciones
6.
Acta Orthop Traumatol Turc ; 56(4): 240-244, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-35968615

RESUMEN

OBJECTIVE: This study aimed to determine the predictive factors affecting the 30-day mortality in geriatric hip fractures, investigate the effect of the timing of surgery, and thus determine the optimum cut-off time in delaying the surgery. METHODS: A total of 596 patients(205 men, 391 women; mean age = 78.3 years) were included in this retrospective study. All possible predictive factors encountered in the literature review, including age, sex, fracture type, comorbidities, American Society of Anesthesiologists (ASA) score, surgical delay time, anaesthesia type, surgery type, need for erythrocyte replacement, postoperative complications, and the need for postoperative intensive care were analyzed. The predictive factors that were found to be significant as a result of the univariate analysis were included in the multivariate logistic regression analysis. RESULTS: The reason for surgery was an extracapsular fracture in 359 patients (60.2%) and an intracapsular fracture in 237 (39.8%). Arthroplasty was performed in 256 patients (43%), while proximal femoral nails were used in 251 (42.1%), dynamic hips screws in 68 (11.4%), and cannulated screws in 21 (3.5%). 523 (87.8%) of the patients had an ASA score of 1 or 2, and 73 (12.2%) had an ASA score of 3 or 4. General anaesthesia was performed on 35.2% of the patients, while regional anaesthesia was administered to 64.8%. Major complications developed in 42 patients (7%), while minor complications were observed in 143 (24%). The mean surgical delay time was 3.21 days (1-9 days). The ASA score (P <0.001, OR: 56.83, CI: 5.26-2.820), anesthesia type (P = 0.036, OR: 3.225, CI: 0.079-2.264), surgical delay time (P <0.001, OR: 2.006, CI: 1.02-0.372) and major complication (P = 0.002, OR: 6.41, CI: 0.661-3.053) were determined to be predictive factors of 30-day mortality. CONCLUSION: This study found the median surgical delay time as three days in surviving patients and five days in deceased ones. Thus, a 3-day surgical delay may be acceptable and sufficient for medical optimization and the consensus of the multidisciplinary team. LEVEL OF EVIDENCE: Level IV, Therapeutic Study.


Asunto(s)
Fracturas de Cadera , Anciano , Comorbilidad , Femenino , Fracturas de Cadera/cirugía , Humanos , Masculino , Tempo Operativo , Complicaciones Posoperatorias/epidemiología , Estudios Retrospectivos
7.
Jt Dis Relat Surg ; 32(3): 713-720, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34842104

RESUMEN

OBJECTIVES: This study aims to evaluate functional outcomes of patients and to analyze complication rates of modular intercalary endoprosthetic reconstruction after resection of metastatic diaphyseal bone lesions. PATIENTS AND METHODS: Between December 2017 and February 2020, 22 patients (15 males, 7 females; median age: 64.2 years; range, 49 to 91) who underwent reconstruction with modular intercalary endoprostheses for metastatic bone tumors at five different centers were retrospectively analyzed. Age, sex, diagnosis, follow-up duration, previous treatments of patients, and resection lengths were recorded. The Musculoskeletal Tumor Society Scores (MSTS) were used to assess functional status of available patients at the final follow-up. Failures were categorized according to the Henderson classification. RESULTS: Locations of the resected tumors included 10 humeri (45.5%), five tibiae (22.7%), and seven femurs (31.8%). The length of the resected tissues ranged from 35 mm to 180 mm. Seven patients (31.8%) died of disease, and one patient died of pneumonia within follow-up period. The functional outcomes of surviving patients were satisfying with a median MSTS score of 86.9% (range, 70 to 100%) at a median follow-up of 17 (range, 8 to 26) months. There were two cases of type II (9%), one cases of type IIIa (4.5%), two cases of type IIIb (9%), and one case of type IV (4.5%) failure. Complications were most commonly observed in tibial reconstructions. CONCLUSION: The good short-term functional results were achieved in surviving patients. Uncomplicated patients were able to perform daily living activities without limitations. The overall rate of complications was relatively low and, among them, mechanical problems were the most commonly encountered problems.


Asunto(s)
Neoplasias Óseas , Neoplasias Óseas/cirugía , Femenino , Fémur , Humanos , Masculino , Persona de Mediana Edad , Prótesis e Implantes , Estudios Retrospectivos , Tibia/cirugía
8.
J Pediatr Orthop ; 30(7): 705-9, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20864857

RESUMEN

PURPOSE: Trigger thumb is a relatively uncommon condition in children. If it occurs or persists after 1 year of age, surgical release is the most traditional treatment method. The aim of this prospective study is to describe a technique for the percutaneous release of trigger thumb and to assess the clinical outcome of the presented technique in the pediatric age group. METHODS: This study includes 31 thumbs of 26 consecutive children with a mean age of 2.6 years. An 18-gauge needle that was connected to 10-cc saline filled syringe was used as the surgical instrument for release. Contrary to the earlier reports, the A1pulley was cut from distal pole of the Notta nodule towards the proximal direction. RESULTS: Mean follow-up period was 2.5 years. A successful release without any complication was obtained in all (97% of thumbs) but 1 thumb. Recurrence was seen in only 1 thumb at postoperative 3 weeks. CONCLUSION: The presented minimal invasive surgical procedure has a high rate of satisfactory outcome, a minimal rate of complications, and a high rate of parent satisfaction. As percutaneous release has satisfactory and encouraging results, it can be a preferred method by the parents for trigger thumb release. STUDY LEVEL: III.


Asunto(s)
Procedimientos Ortopédicos , Trastorno del Dedo en Gatillo/cirugía , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Satisfacción del Paciente , Complicaciones Posoperatorias , Estudios Prospectivos , Recurrencia , Factores de Tiempo , Resultado del Tratamiento
9.
Acta Orthop Traumatol Turc ; 53(4): 239-247, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31104885

RESUMEN

OBJECTIVE: The aim of this prospective study was to evaluate pre- and post-treatment MRI and CT findings of osteoid osteoma (OO) patients treated with radiofrequency thermo-ablation (RFTA) and to compare these findings with visual analog scale (VAS) scores. METHODS: Sixteen patients (4 females and 12 males; mean age of 18.87 ± 8.75 years (range: 8-37)) with OO were examined with CT and MRI, at baseline and at an average of 3 months following the procedure. On pre- and post-procedural CT and MRIs, OO-related findings were recorded. Treatment success was evaluated with VAS scores. RESULTS: Baseline VAS scores were 8 or 9 and follow-up scores were 0 or 1, indicating no early recurrences. Nidus diameters decreased significantly after the procedure (p = 0.027, p = 0.002, and p = 0.002; and p = 0.001, p = 0.001, p = 0.001 for AP, ML and CC nidus diameters for CT and MRI, respectively). The mean nidus volume were significantly decreased after the procedure (p = 0.001, for CT and MRI). On post-procedural images, cortical thickening, the signal intensity and contrast enhancement of the nidus and the extent of periostitis were significantly decreased (p = 0.019, p = 0.001, p = 0.001 and p = 0.034, respectively). There was no significant change in nidus calcification, perinidal cortical and intramedullary sclerosis, periosteal reaction, bone deformity, bone marrow and soft tissue edema, joint effusion and synovitis after the procedure (p = 0.253, p = 0.062, p = 0.245, p = 1, p = 1, p = 0.429, p = 0.371, p = 0.625, p = 1). CONCLUSION: Although the changes in imaging findings may be helpful in early follow-up of OO patients treated with RFTA, these changes alone cannot be used with accuracy in predicting treatment response. LEVEL OF EVIDENCE: Level IV, Therapeutic Study.


Asunto(s)
Neoplasias Óseas , Ablación por Catéter , Imagen por Resonancia Magnética/métodos , Osteoma Osteoide , Tomografía Computarizada por Rayos X/métodos , Adolescente , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/cirugía , Ablación por Catéter/efectos adversos , Ablación por Catéter/métodos , Niño , Femenino , Humanos , Masculino , Osteoma Osteoide/diagnóstico , Osteoma Osteoide/cirugía , Valor Predictivo de las Pruebas , Estudios Prospectivos , Evaluación de Síntomas , Resultado del Tratamiento , Escala Visual Analógica
10.
Acta Orthop Traumatol Turc ; 53(3): 195-198, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-31031128

RESUMEN

OBJECTIVE: The aim of this study was to determine the prevalence, demographic data of elastofibroma dorsi (ED) in adult population who had undergone chest CT examination and to discuss clinical, and radiological presentations, and treatment options of ED. METHODS: We retrospectively reviewed 4074 chest CT examinations for ED from July 2014 to April 2015. Lesion size, side, and patient demographics were analyzed for positive cases of ED. The initial radiology reports of patients with ED were also reviewed. RESULTS: Of the 4074 patients, 111 patients (2.73%) (77 women and 34 men; mean age: 68.2 years; range: 35-91 years) had a total of 168 ED. The females had a 1.96 -fold higher prevalence of ED than the males (OR, 1.96; 95% CI, 1.481-2.59). The mean lesion thickness was found to be significantly greater in the female patients compared with the male patients (p = 0.001). The prevalence of the disease was estimated to be 4.98 times higher in patients aged 65 years or older (CI 95%, 3.25-7.36). In 111 ED patients, the lesions were only noted in 9 patients' initial radiology report. CONCLUSION: Here, we present a prevalence study with the largest population in the literature concerning ED. Our study shows that ED is not as uncommon as previously thought and should be especially suspected in females and older age groups. LEVEL OF EVIDENCE: Level IV, Diagnostic Study.


Asunto(s)
Fibroma , Radiografía Torácica , Neoplasias de los Tejidos Blandos , Tomografía Computarizada por Rayos X/estadística & datos numéricos , Anciano , Femenino , Fibroma/diagnóstico por imagen , Fibroma/epidemiología , Fibroma/patología , Fibroma/terapia , Humanos , Masculino , Manejo de Atención al Paciente/métodos , Prevalencia , Radiografía Torácica/métodos , Radiografía Torácica/estadística & datos numéricos , Estudios Retrospectivos , Neoplasias de los Tejidos Blandos/diagnóstico por imagen , Neoplasias de los Tejidos Blandos/epidemiología , Neoplasias de los Tejidos Blandos/patología , Neoplasias de los Tejidos Blandos/terapia , Turquía/epidemiología
11.
Ulus Travma Acil Cerrahi Derg ; 24(2): 162-167, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29569689

RESUMEN

BACKGROUND: To investigate the outcomes of patients undergoing open reduction and internal fixation with olecranon osteotomy due to AO type13C fractures of the distal humerus. METHODS: Data of 39 patients (mean age, 44.7 years; males, 56.4%) undergoing surgery with the diagnosis of AO type 13C distal humeral fractures were retrospectively evaluated. Patients' demographic characteristics, medical history, and radiological and functional outcomes were recorded. The patients were evaluated at the final follow-up according to the Mayo Elbow Performance Index (MEPI). RESULTS: The mean degrees of flexion and extension loss were 102.2 degrees (range, 60-120 degrees) and 11.4 degrees (range, 0-25 degrees), respectively, at the final follow-up. According to the MEPI score, outcomes were excellent in seven, good in 12, fair in 13, and poor in seven patients. All patients achieved a radiological union of the fracture site within the first postoperative six months. It was found that the loss of extension was more severe, the range of flexion was decreased, and the mean MEPI score was lower in the patients with type C3 fractures than in those with type C1 and type C2 fractures. No significant difference was determined between fixation techniques (tension band vs. cannulated screw) regarding the functional outcomes. CONCLUSION: Our results revealed better prognosis in AO type C1 and type C2 fractures than in AO type C3 fractures and no different effects of two fixation techniques in olecranon osteotomy on the outcomes.


Asunto(s)
Fijación Interna de Fracturas , Fracturas del Húmero/cirugía , Olécranon/cirugía , Reducción Abierta , Osteotomía , Adulto , Femenino , Fijación Interna de Fracturas/métodos , Fijación Interna de Fracturas/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Reducción Abierta/métodos , Reducción Abierta/estadística & datos numéricos , Osteotomía/métodos , Osteotomía/estadística & datos numéricos , Rango del Movimiento Articular , Estudios Retrospectivos
12.
Korean J Radiol ; 8(5): 438-42, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17923787

RESUMEN

The association of intramuscular myxoma and fibrous dysplasia is a rare disease known as Mazabraud's syndrome. We present a case of Mazabraud's syndrome coexisting with a uterine tumor and resembling an ovarian sex cord tumor (UTROSCT). This uterine tumor showed a high mitotic index and cytological atypia. To the best of our knowledge, the coexistence of the two different entities has not been reported in the literature.


Asunto(s)
Displasia Fibrosa Monostótica/diagnóstico , Mixoma/diagnóstico , Neoplasias Ováricas/diagnóstico , Tumores de los Cordones Sexuales y Estroma de las Gónadas/diagnóstico , Neoplasias Uterinas/diagnóstico , Anciano , Biopsia , Nalgas/diagnóstico por imagen , Nalgas/patología , Nalgas/cirugía , Diagnóstico Diferencial , Femenino , Displasia Fibrosa Monostótica/complicaciones , Displasia Fibrosa Monostótica/cirugía , Humanos , Imagen por Resonancia Magnética , Mixoma/complicaciones , Mixoma/cirugía , Enfermedades Raras , Síndrome , Ultrasonografía , Neoplasias Uterinas/complicaciones , Neoplasias Uterinas/cirugía
13.
Saudi Med J ; 28(5): 713-6, 2007 May.
Artículo en Inglés | MEDLINE | ID: mdl-17457437

RESUMEN

OBJECTIVE: To evaluate the histological and ultrastructural alterations in rabbit knee joint cartilage and synovia induced by intraarticular injections of 2 water soluble contrast agents. METHODS: The study was conducted at the Department of Orthopedics and Traumatology, Medical Faculty, Osmangazi University, Eskisehir, Turkey in January 2002. To examine the effect of contrast agents on articular cartilage and synovial membrane, rabbit model was used. Specimens from 62 knee joints were examined by light microscopy and transmission electron microscopy one hour, one day, one week and 2 weeks after intraarticular administration of gadolinium-diethylenetriamine pentaacetic acid, iopromide or saline. RESULTS: In the knees injected with saline, light microscopic changes of the synovium consisted of edema only. Edema and hyperemia were seen in contrast agent injected knees. Ultrastructurally, numerous and large pinocytotic vesicles in A cells of the synovial membrane were seen in contrast agent injected groups. In the knees injected with saline the cartilage were ultrastructurally normal but contrast agent injected knees showed increased activation of chondrocytes with increase of dense glycogen accumulation, large lipid vacuoles and matrix material. There were very rare pycnotic cells in these samples. The rating scale has been used and the means of the total scores were determined for the groups. CONCLUSION: The effects of contrast agents reduced gradually on the cartilage and synovium in general but did not become completely normal in the observation period.


Asunto(s)
Cartílago Articular/efectos de los fármacos , Medios de Contraste/efectos adversos , Membrana Sinovial/efectos de los fármacos , Animales , Cartílago Articular/ultraestructura , Medios de Contraste/administración & dosificación , Gadolinio DTPA/administración & dosificación , Gadolinio DTPA/efectos adversos , Inyecciones Intraarticulares , Yohexol/administración & dosificación , Yohexol/efectos adversos , Yohexol/análogos & derivados , Articulación de la Rodilla/efectos de los fármacos , Conejos , Membrana Sinovial/ultraestructura
14.
J Pediatr Orthop B ; 15(3): 172-7, 2006 May.
Artículo en Inglés | MEDLINE | ID: mdl-16601584

RESUMEN

The correlations between the commonly used radiographic parameters, center-edge angle (CEA), acetabular-head index (AHI), acetabular index angle (AIA), acetabular angle (AA) and ACM angle, in normal, subluxated and dislocated hips were investigated in the radiographs of 364 normal, 23 subluxated and 19 dislocated hips of patients between 5 and 18 years of age. A significant correlation was observed between all the parameters in normal hips. A significant correlation between AIA and the other four parameters, and between CEA-AHI and AA-ACM, was noted in subluxated hips. AIA-AA and AIA-ACM had significant correlations in dislocated hips. It was concluded that measurement of more than one radiographic parameter might be better to exactly evaluate the radiographic hip anatomy in developmental dysplasia of the hip.


Asunto(s)
Luxación Congénita de la Cadera/diagnóstico por imagen , Articulación de la Cadera/diagnóstico por imagen , Radiografía/métodos , Acetábulo/anatomía & histología , Acetábulo/diagnóstico por imagen , Acetábulo/patología , Adolescente , Niño , Preescolar , Femenino , Cabeza Femoral/anatomía & histología , Cabeza Femoral/diagnóstico por imagen , Cabeza Femoral/patología , Articulación de la Cadera/patología , Humanos , Masculino , Valores de Referencia
15.
Acta Orthop Traumatol Turc ; 40(4): 285-90, 2006.
Artículo en Turco | MEDLINE | ID: mdl-17063051

RESUMEN

OBJECTIVES: The aim of this study was to evaluate the results of a newborn ultrasonographic hip screening program conducted at 3-4 weeks of life, and to assess its utility and feasibility in Turkey. METHODS: During a three-year period, parents of 1440 newborns were interviewed within 48 hours following birth to be informed in detail about developmental dysplasia of the hip (DDH) and its risk factors. They were asked to bring their infants for clinical and ultrasonographic examinations of the hips 3 to 4 weeks after birth. RESULTS: A total of 975 infants (67.7%; 488 girls, 487 boys; mean age 26 days; range 17 to 34 days) were available on the day of screening. According to the Graf's classification, 1664 hips (85.3%) were considered type I. Immediate treatment was initiated for 22 hips (1.2%) which were considered type IIc, D, or IIIa. All but one hip were found to be type I after eight weeks of treatment. Among type IIa hips with a complete follow-up, 12% required treatment. In total, 45 hips (2.3%) of 35 infants (3.6%) were treated preferably with a Pavlik harness. Of these, 10 infants (28.6%) had at least one risk factor for DDH, the most common being a positive family history (n=7, 20%). Of 45 treated hips, 12 hips (26.7%) exhibited positive clinical findings, the most common being asymmetry of the thigh/inguinal folds. CONCLUSION: Ultrasonographic hip screening program conducted at the age of 3 to 4 weeks is effective for early diagnosis and successful treatment of DDH. However, nearly one-thirds of the infants were not available at the appointed date, despite transmission of detailed information to the parents just after birth.


Asunto(s)
Luxación Congénita de la Cadera/diagnóstico por imagen , Luxación Congénita de la Cadera/epidemiología , Tamizaje Neonatal/métodos , Aceptación de la Atención de Salud/estadística & datos numéricos , Derivación y Consulta/estadística & datos numéricos , Diagnóstico Precoz , Estudios de Factibilidad , Femenino , Luxación Congénita de la Cadera/etiología , Luxación Congénita de la Cadera/patología , Hospitales Universitarios , Humanos , Recién Nacido , Masculino , Tamizaje Neonatal/estadística & datos numéricos , Padres/educación , Factores de Riesgo , Índice de Severidad de la Enfermedad , Turquía/epidemiología , Ultrasonografía
16.
Eklem Hastalik Cerrahisi ; 27(3): 160-6, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27902171

RESUMEN

OBJECTIVES: This study aims to assess the experience gained in a single institution in the treatment of mixed type femoroacetabular impingement (FAI) using safe surgical hip dislocation (SSHD) technique. PATIENTS AND METHODS: In this study, 22 hips of 21 patients (7 males, 14 females; mean age 33.8±10.6 years; range 19-52 years) treated by SSHD technique in our clinic between October 2009 and October 2014 were retrospectively evaluated. Preoperative and final Harris hip scores (HHS) and alpha angles were compared. Age, gender, laterality, impingement tests, preoperative HHS, cam and pincer type FAI radiographic indicators and intraoperative articular findings were assessed in terms of their influence to the final functional outcomes. RESULTS: Mean duration of the symptoms was 29.5 months. Groin pain, activated by flexion and internal rotation of the hip, was the main symptom. A radiographic diagnosis of "mixed type FAI" was made in all hips. Mean follow-up duration of 22 hips was 48 months. The difference between the mean preoperative and latest HHS was statistically significant (60.0 vs. 87.6 points, p<0.001). The treatment was considered satisfactory in 17 of 22 hips (77%) having a mean HHS of 95.0 points. Hips having a preoperative HHS of less than 60 points were more prone to unsatisfactory outcome. Among the investigated patient-dependent, clinical, radiographic variables and intraoperative articular findings, coxa profunda sign in a plain radiograph was found correlated with a higher rate of unsatisfactory outcome (p=0.040). CONCLUSION: Safe surgical hip dislocation procedure has a success rate of 77% after a mean follow-up of four years. Coxa profunda sign is associated with the unsatisfactory clinical outcome. Preoperative HHS of less than 60 points seems to be a negative predictive variable on the clinical outcome.


Asunto(s)
Pinzamiento Femoroacetabular/cirugía , Articulación de la Cadera/cirugía , Procedimientos Ortopédicos/métodos , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud , Complicaciones Posoperatorias/etiología , Estudios Prospectivos , Factores de Riesgo , Turquía , Adulto Joven
17.
J Pediatr Orthop B ; 14(2): 97-100, 2005 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15703518

RESUMEN

Ultrasonographic examinations of both hips of 133 children whose age ranged from 13 to 72 months were performed using the Graf's method. A standard plane which was mandatory prior to the hip typing could be obtained in 93, 91, 84, 79 and 66% of the sonograms for 13-24, 25-36, 37-48, 49-60 and 61-72 months age groups, respectively. The 61-72 months age group had the lowest percentage of valid sonograms and this difference was considered significant (P=0.001). It was concluded that plain radiography was still the gold standard imaging technique in developmental dysplasia of the hip, but hip ultrasonography by the Graf's method might be an alternative imaging technique in experienced hands for the evaluation of developmental dysplasia of the hip in children between 1 and 5 years of age.


Asunto(s)
Luxación Congénita de la Cadera/diagnóstico por imagen , Ultrasonografía Doppler/métodos , Factores de Edad , Niño , Preescolar , Estudios de Cohortes , Femenino , Luxación Congénita de la Cadera/fisiopatología , Humanos , Lactante , Masculino , Medición de Riesgo , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Factores Sexuales
18.
J Pediatr Orthop B ; 24(5): 385-8, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25856274

RESUMEN

The aim of this case series was to assess the data of 66 children (mean age 28 months) with a diagnosis of pulled elbow. The most common time interval of injury was 12-6 p.m. and spring was the peak season. Children younger than 2 years of age had a higher rate of atypical injury history. A successful reduction by supination and flexion maneuver was achieved at the first attempt in 57 of 66 patients. The patients admitted to the hospital within the first 2 h following the injury had a higher rate of successful reduction at the first attempt. The rate of radiographic examination was considerably high and a well-defined algorithm to avoid the complicacy in ordering a plain radiograph in such cases was suggested. All patients achieved full clinical recovery after a mean follow-up of 2 years, and recurrence was observed in 16 of 66 children.


Asunto(s)
Lesiones de Codo , Luxaciones Articulares/epidemiología , Preescolar , Femenino , Humanos , Lactante , Luxaciones Articulares/terapia , Masculino , Manipulación Ortopédica/métodos , Pronación , Rango del Movimiento Articular , Recurrencia , Supinación , Turquía/epidemiología
19.
Eklem Hastalik Cerrahisi ; 26(1): 2-5, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25741912

RESUMEN

OBJECTIVES: This study aims to define a quantitative measurement method for acetabular version in a standard anteroposterior hip radiograph, assess the intraobserver and interobserver agreements of this method, and compare it with the gold standard computed tomography (CT). PATIENTS AND METHODS: Anteroposterior standard hip radiographs and simultaneously taken transverse acetabular CT sections of 78 hips of 39 patients (10 males, 29 females; mean age 60 years; range 40 to 81 years) were used in the study. In standard anteroposterior hip radiographs, "acetabular anterior wall line" was identified as the line between the most lateral edge of the acetabulum and the inferolateral edge of the teardrop. "Acetabular posterior wall line" was identified as the line between the most lateral edge of the subchondral sclerosis and the outmost point of acetabulum posterior lunate surface sclerosis. To assess the reliability of this technique, mentioned angles in 78 hips were measured by two authors independently two weeks apart. Direct radiographic values were compared with the acetabular version measurement values in CT examination. RESULTS: Mean acetabular version angles of 78 hips in plain radiographs and CT were 18.0° (9-25°) and 17.2° (12-25°), respectively. Mean intraobserver measurement differences were 1.3° (0-5°) and 1.5° (0-6°). Mean interobserver measurement difference was 1.4° (0-5°). The mean difference between plain radiography measurements and CT measurements was 2.5° (0-6°). A significant correlation was detected between plain radiographic measurements and CT measurements. CONCLUSION: By this quantitative method, acetabular morphology may be measured less invasively, easily, quickly and reliably in plain radiograph in transverse plane.


Asunto(s)
Acetábulo/anatomía & histología , Acetábulo/diagnóstico por imagen , Articulación de la Cadera/diagnóstico por imagen , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Variaciones Dependientes del Observador , Reproducibilidad de los Resultados , Tomografía Computarizada por Rayos X
20.
Acta Orthop Traumatol Turc ; 36(2): 100-5, 2002.
Artículo en Turco | MEDLINE | ID: mdl-12510089

RESUMEN

OBJECTIVES: To determine the normal values of several radiographic acetabular angles in individuals of Eskisehir region. METHODS: The acetabular index (AI) angle, acetabular angle (AA) of Sharp and the ACM angle were measured in 1162 normal hips (n=581, 251 males, 330 females; mean age 33 years; range 5 to 75 years). For AI angle, Hilgenreiner's line and the line connecting the lower end points of the sclerotic lines of the acetabular roofs were used for reference in subjects between five to 11 years with an open Y cartilage and in those with closed Y cartilage, respectively. AA and ACM angles were measured by the same method in all subjects. RESULTS: The mean AI angle between 5-11 years was 12.9+/-4.5 degrees; the upper normal limit for the Hilgenreiner's AI angle was derived as 22 degrees. The mean AI angle above age 11 was 3.3+/-4.7 degrees and the upper normal limit for the AI angle defined by Tönnis after age 11 was found as 13 degrees. Significant linear correlations were found between the AI angle and age for 5-11 years (p=0.002) and above 11 years (p=0.001), respectively. The mean AA angle was 39.2+/-4.6 degrees. There was a significant linear correlation between the AA angle and age (p=0.001). The upper limits for the AA angle in normal juvenile, adolescent, and adult hips were found as 52 degrees, 49 degrees, and 45 degrees, respectively. The mean ACM angle was 41.9+/-3.3 degrees. A significant linear correlation was observed between the ACM angle and age (p=0.001). The upper limit for the ACM angle in normal hips was assessed as 49 degrees in all age groups. CONCLUSION: The authors of this study propose that the normal limits of acetabular angles obtained from our own population be used as reference values in interpreting standard radiographs of the hip.


Asunto(s)
Acetábulo/anatomía & histología , Fémur/anatomía & histología , Articulación de la Cadera/anatomía & histología , Acetábulo/diagnóstico por imagen , Acetábulo/crecimiento & desarrollo , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Fémur/diagnóstico por imagen , Fémur/crecimiento & desarrollo , Cabeza Femoral/anatomía & histología , Cabeza Femoral/diagnóstico por imagen , Cabeza Femoral/crecimiento & desarrollo , Cuello Femoral/anatomía & histología , Cuello Femoral/diagnóstico por imagen , Cuello Femoral/crecimiento & desarrollo , Articulación de la Cadera/diagnóstico por imagen , Articulación de la Cadera/crecimiento & desarrollo , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Valores de Referencia
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