RESUMEN
HLA-A*02:548 differs from A*02:01:01:01 by one nucleotide at position 367T > C resulting in histidine at codon 99.
Asunto(s)
Alelos , Sustitución de Aminoácidos , Antígeno HLA-A2/genética , Polimorfismo de Nucleótido Simple , Donantes de Tejidos , Secuencia de Bases , Trasplante de Médula Ósea , Codón , Exones , Expresión Génica , Antígeno HLA-A2/inmunología , Prueba de Histocompatibilidad , Humanos , Datos de Secuencia Molecular , Alineación de SecuenciaRESUMEN
HLA-B*35:08:17 differs from B*35:08:01:01 by a single nucleotide change in codon 105 (CCC > CCG).
Asunto(s)
Genes MHC Clase I , Antígenos HLA-B , Humanos , Alelos , Antígenos HLA-B/genética , Codón , Nucleótidos , Análisis de Secuencia de ADNRESUMEN
HLA-DRB1*03:85 differs from HLA-DRB1*03:06 by two nucleotides, position 257 A>T and position 258T>C, resulting in Valine at codon 57.
Asunto(s)
Alelos , Cadenas HLA-DRB1/genética , Secuencia de Bases , Exones/genética , Humanos , Datos de Secuencia Molecular , Alineación de SecuenciaRESUMEN
BACKGROUND: Co-infection with Plasmodium falciparum malaria and Parvovirus B19 in adults is an extremely rare occurrence and, apparently, only one case has been previously reported. Herein we describe a case of acute co-infection with severe anemia and renal failure. CASE PRESENTATION: The patient was a 34-year-old African man presenting myalgia, fatigue, headache, anemia and hepatosplenomegaly. A thin peripheral smear showed Plasmodium falciparum trophozoites and the patient was treated with oral mefloquine. After an initial amelioration, fever, fatigue and myalgia reappeared, the anemia worsened and there was evidence of acute renal failure. No malarial parasites were found with a blood smear. A bone marrow aspiration showed marked erythroid hypoplasia. Parvovirus B19-specific IgM and IgG and viremia were positive. The patient was treated with steroids and blood cell transfusions. After ten days, anemia and renal failure progressively decreased. When last seen, the patient was asymptomatic and the blood values were within the normal range. CONCLUSIONS: The diagnosis of Parvovirus B19 acute infection should be considered in any case of persistent severe anemia and/or renal failure, even in clinical conditions that are well-known causes of anemia and renal failure, such as malaria.
Asunto(s)
Anemia/etiología , Malaria Falciparum/complicaciones , Infecciones por Parvoviridae/complicaciones , Parvovirus B19 Humano/aislamiento & purificación , Plasmodium falciparum/aislamiento & purificación , Insuficiencia Renal/etiología , Adulto , Antiinflamatorios/uso terapéutico , Anticuerpos Antivirales/sangre , Antimaláricos/uso terapéutico , Transfusión Sanguínea , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Malaria Falciparum/tratamiento farmacológico , Malaria Falciparum/parasitología , Malaria Falciparum/patología , Masculino , Mefloquina/uso terapéutico , Infecciones por Parvoviridae/patología , Infecciones por Parvoviridae/virología , Esteroides/uso terapéutico , ViremiaRESUMEN
HLA-C*06:297 differs from C*06:02:01:01 by a single nucleotide change in codon-19 (CCC>TCC).
Asunto(s)
Antígenos HLA-C , Secuenciación de Nucleótidos de Alto Rendimiento , Alelos , Exones/genética , Genes MHC Clase I , Antígenos HLA-C/genética , HumanosRESUMEN
HLA-B*14:58 differs from B*14:02:01 by a polymorphism at position 506 a C instead a G.
Asunto(s)
Alelos , Antígenos HLA-B/genética , Secuencia de Bases , Humanos , Polimorfismo de Nucleótido Simple/genética , Alineación de SecuenciaRESUMEN
DRB1*14:172 homologous to DRB1*14:01 has been found with a variation in 314 A > G.