Hybridization of layered double hydroxides with functional particles.

Layered double hydroxides (LDHs) are a class of materials with useful properties associated with their anion exchange abilities as well as redox and adsorptive properties for a wide range of applications including adsorbents, catalysts and their supports, electrodes, pigments, ceramic precursors, and drug carriers. In order to satisfy the requirements for each application as well as to find alternative applications, the preparation of LDHs with the desired composition and particle morphology and post-synthetic modification by the host-guest interactions have been examined. In addition, the hybridization of LDHs with various functional particles has been reported to design materials of modified, improved, and multiple functions. In the present article, the preparation, the heterostructure and the application of hybrids containing LDHs as the main component are overviewed.

Preparation of MgGa Layered Double Hydroxides and Possible Compositional Variation.

Layered double hydroxides (LDHs), shown as the general formula of [M2+1-xM3+x(OH)2]x+(An-)x/n∙yH2O, are useful for various applications such as anion exchangers/adsorbents, catalysts and catalysts' supports, and drug/gene carriers due to their structural, compositional and morphological characteristics and their variation. The x value (M3+/(M2+ + M3+) ratio) in layered double hydroxides (LDHs), corresponding to the layer charge density, is one of the important parameters for controlling the properties of LDHs. The x values in commonly available LDHs are limited (0.2 < x < 0.3). In order to obtain LDHs with x < 0.2, Mg2+ Ga3+-LDHs with interlayer iodide were examined. The linear correlation between lattice parameter a and x value in the products with x of 0.06-0.24 was seen, suggesting the successful substitution of Mg2+ in the brucite-like sheet with Ga3+. Carbonate and dodecyl sulfate types MgGa-LDH were prepared by ion exchange with carbonate anion and reconstruction in aqueous solution of sodium dodecyl sulfate. The products with x of 0.06 were dispersed in water and hexanol better than those with x of 0.24 for MgGa-LDHs containing carbonate and dodecyl sulfate, respectively, suggesting effects of the lower layer charge density on the dispersion.

Biodegradable Periodic Mesoporous Organosilica (BPMO) Loaded with Daunorubicin: A Promising Nanoparticle-Based Anticancer Drug.

Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B-labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR-loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR-loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK.

Layered Silicates as a Possible Drug Carrier.

The potential of layered silicates as drug carrier is overviewed. Due to their large surface area and expandable interlayer space to accommodate drug molecules, layered silicates have a potential as carrier of various molecules. In addition to the electrostatic interactions between negatively charged layered silicates and positively charged drug molecules, the organic modification of the surface of layered silicates has been applied to accommodate a variety of drug molecules not only cationic ones. The in vitro release experiment of the accommodated drug molecules has been reported under the acidic conditions. In order to discuss the future direction of layered silicates as drug carrier, materials' variation of layered silicates and their modification, and the reported stimuli-responsive hybrids based on layered silicates were introduced.

Mechanochemical methods for the preparation of intercalation compounds, from intercalation to the formation of layered double hydroxides.

Due to increasing interest in the development of advanced nanomaterials from nanosheets as building blocks, methods for the preparation of nanosheet materials and their hybrids have been studied carefully and extensively. In this review, studies of mechanochemical methods (solid-solid reactions under ambient conditions or solvent-free synthesis) for the preparation of intercalation compounds are summarized. Mechanochemical reactions without using solvent have operational advantages, such as their environmentally benign nature and the fact that separating and drying the products is not necessary. In addition to their advantages from green chemistry viewpoints, solid-state reactions have potential for the preparation of novel intercalation compounds which are not accessible by conventional solution-based methods.