RESUMEN
Increased transepidermal water loss (TEWL) and decreased skin capacitance are characteristic features of the disturbed epidermal barrier in atopic eczema (AE). The "acid mantle", which is a slightly acidic film on the surface of the skin has led to the development of acidic emollients for skin care. In this context, the effect of citric acid-coated textiles on atopic skin has not been examined to date. A textile carrier composed of cellulose fibres was coated with a citric acid surface layer by esterification, ensuring a constant pH of 5.5-6.5. Twenty patients with AE or atopic diathesis were enrolled in the study. In a double-blind, half-side experiment, patients had to wear these textiles for 12 h a day for 14 days. On day 0 (baseline), 7 and 14, tolerability (erythema, pruritus, eczema, wearing comfort) and efficacy on skin barrier were assessed by TEWL skin hydration (corneometry/capacitance), pH and clinical scoring of eczema (SCORAD). Citric acid-coated textiles were well tolerated and improved eczema and objective parameters of skin physiology, including barrier function and a reduced skin surface pH, with potential lower pathogenic microbial colonisation.
Asunto(s)
Antibacterianos/administración & dosificación , Ácido Cítrico/administración & dosificación , Dermatitis Atópica/tratamiento farmacológico , Adulto , Antibacterianos/efectos adversos , Celulosa , Ácido Cítrico/efectos adversos , Dermatitis Atópica/fisiopatología , Susceptibilidad a Enfermedades/fisiopatología , Método Doble Ciego , Portadores de Fármacos , Capacidad Eléctrica , Femenino , Humanos , Concentración de Iones de Hidrógeno/efectos de los fármacos , Masculino , Persona de Mediana Edad , Piel/química , Piel/fisiopatología , Textiles , Pérdida Insensible de Agua/efectos de los fármacos , Adulto JovenRESUMEN
Cherry angioma is a common, acquired, vascular proliferation, probably of a polygenic mode of inheritance. Segmental manifestation of multiple cherry angiomas associated with the development of non-segmental lesions has not yet been reported. We describe a 62-year-old Caucasian woman with early formation of segmental cherry angiomas after pregnancy, which are superimposed on non-segmental lesions of later onset after menopause. In this pattern, segmental cherry angiomas could be taken as a further example of superimposed segmental manifestation of a polygenic skin disorder. Molecular research would be needed to confirm this hypothesis.
Asunto(s)
Hemangioma/genética , Hemangioma/patología , Femenino , Humanos , Persona de Mediana Edad , Herencia MultifactorialRESUMEN
BACKGROUND: Mutations in NFKB1(nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) are associated with a variety of clinical symptoms, including lymphadenopathy, splenomegaly, hepatomegaly, autoimmune haemolytic anaemia, arthralgia, recurrent respiratory tract infections and post-operative necrotizing cellulitis. CASE PRESENTATION: We describe a case of a 47-year-old man, who presented with deep necrotizing cellulitis after incision of a submucous abscess by a dentist. Surgical intervention led to a massive progress. Pyoderma gangraenosum (PG) was diagnosed clinically and confirmed histopathologically. High dose corticosteroids and intravenous immunoglobulins (IVIG) improved wound healing dramatically. Until now, immune mediated inflammation events not only affected the skin, but also multiple inner organs, i.e. the heart, lungs and gut. Sequencing of all coding exons of NFKB1 revealed a heterozygous 1bp deletion in exon 23 predicting a frameshift starting at codon Ala891 and resulting in a subsequent stop codon at position 6 in the new reading frame: NM_003998.4: c.2671del; p.(Ala891Glnfs*6) Acute episodes were always successfully treated with corticosteroids, IVIG and concomitant antibiotics. To prevent further exacerbations, the patient receives IVIG once a month, low-dose corticosteroids and methotrexate. CONCLUSION: This is the first case of a patient with recurrent necrotizing cellulitis and immune mediated multi-organ involvement (heart, lungs, intestine) carrying the novel frameshift mutation c.2671del (p.Ala891Glnfs*6) in NFKB1 effectively treated with IVIG, low-dose corticosteroids and methotrexate.
Asunto(s)
Enfermedades Autoinmunes/genética , Celulitis (Flemón)/genética , Mutación del Sistema de Lectura , Subunidad p50 de NF-kappa B/genética , Enfermedades de Inmunodeficiencia Primaria/genética , Piodermia Gangrenosa/genética , Enfermedades Autoinmunes/diagnóstico , Celulitis (Flemón)/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Enfermedades de Inmunodeficiencia Primaria/diagnóstico , Piodermia Gangrenosa/diagnóstico , SíndromeAsunto(s)
Neoplasias de los Párpados/diagnóstico , Papulosis Linfomatoide/diagnóstico , Neoplasias Cutáneas/diagnóstico , Biopsia , Diagnóstico Diferencial , Neoplasias de los Párpados/patología , Herpes Simple/diagnóstico , Herpes Simple/patología , Humanos , Papulosis Linfomatoide/patología , Piel/patología , Neoplasias Cutáneas/patología , Sífilis Cutánea/diagnóstico , Sífilis Cutánea/patologíaAsunto(s)
Carcinoma de Células de Merkel/inmunología , ADN Viral/análisis , Poliomavirus de Células de Merkel , Infecciones por Polyomavirus/inmunología , Neoplasias Cutáneas/inmunología , Infecciones Tumorales por Virus/inmunología , Carcinoma de Células de Merkel/virología , Humanos , Queratina-19/análisis , Queratina-20/análisis , Metaloproteinasa 11 de la Matriz/análisis , Proteínas Proto-Oncogénicas c-kit/análisis , Neoplasias Cutáneas/virologíaRESUMEN
Psoriasis is characterized by an apoptosis-resistant and metabolic active epidermis, while a hallmark for allergic contact dermatitis (ACD) is T cell-induced keratinocyte apoptosis. Here, we induced ACD reactions in psoriasis patients sensitized to nickel (n = 14) to investigate underlying mechanisms of psoriasis and ACD simultaneously. All patients developed a clinically and histologically typical dermatitis upon nickel challenge even in close proximity to pre-existing psoriasis plaques. However, the ACD reaction was delayed as compared to non-psoriatic patients, with a maximum intensity after 7 days. Whole genome expression analysis revealed alterations in numerous pathways related to metabolism and proliferation in non-involved skin of psoriasis patients as compared to non-psoriatic individuals, indicating that even in clinically non-involved skin of psoriasis patients molecular events opposing contact dermatitis may occur. Immunohistochemical comparison of ACD reactions as well as in vitro secretion analysis of lesional T cells showed a higher Th17 and neutrophilic migration as well as epidermal proliferation in psoriasis, while ACD reactions were dominated by cytotoxic CD8+ T cells and a Th2 signature. Based on these findings, we hypothesized an ACD reaction directly on top of a pre-existing psoriasis plaque might influence the clinical course of psoriasis. We observed a strong clinical inflammation with a mixed psoriasis and eczema phenotype in histology. Surprisingly, the initial psoriasis plaque was unaltered after self-limitation of the ACD reaction. We conclude that sensitized psoriasis patients develop a typical, but delayed ACD reaction which might be relevant for patch test evaluation in clinical practice. Psoriasis and ACD are driven by distinct and independent immune mechanisms.